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Fahr
Alfred Fahr, Colbe DE
| Patent application number | Description | Published |
|---|---|---|
| 20100273803 | Oral Formulations for Tetrapyrrole Derivatives - Oral formulations and method of formulating photosensitive agents for oral administration during photodynamic therapy (PDT) and Antimicrobial photodynamic therapy (APDT) treatment are presented. The oral formulated photosensitizers show increased solubility and permeability, thus improving the bioavailability of photosensitizers at the treatment site. An orally administered photosensitizer is suitably formulated for mucosal adhesion and absorption via gastrointestinal mucosal membranes. Oral formulation provided herein use lipids and known proteins as carriers for photosensitizers by oral route. Carriers for encapsulating preselected photosensitizers include conventional liposomes, pegylated liposomes, nanoemulsions, nanocrystrals, nanoparticles, fatty emulsions, lipidic formulations, hydrosols, SMEDDS, Alpha-Feto protein (AFP), and Bovine-Serum-Albumin (BSA), fatty emulsions, hot-melt-extrudates and nanoparticles. The oral formulation, in case of a hydrophobic photosensitizer in the present invention, is stabilized using suitable surfactants/solubilizers thus preventing aggregation of the drug in the stomach and until it is absorbed in the duodenum and the small intestine. Oral formulations can be administered in the form of liquid, capsule, tablet, powder, paste or gel. Formulated drugs can be administered orally as one single dose or in multiple doses before administering PDT. In one embodiment Temoporfin (m-THPC) is used as a photosensitizer in the oral formulations. Temoporfin like many hydrophobic photosensitizers are especially suitable to be administered orally because there is no known enzyme system in the mammalian body which can metabolize Temoporfin or similar photosensitizers. Temoporfin can reach the blood system unchanged and fully active after absorption of the formulation in the gastrointestinal tract. | 10-28-2010 |
Bruce Fahr, Foster City, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100298342 | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease - The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved. | 11-25-2010 |
Bruce Fahr, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100093698 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH - Provided herein are Heteroaryl Compounds of formula (I): | 04-15-2010 |
Gerald J. Fahr, Wappingers Falls, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080256281 | SYSTEM AND METHOD FOR PROVIDING AN ADAPTER FOR RE-USE OF LEGACY DIMMS IN A FULLY BUFFERED MEMORY ENVIRONMENT - A system and method for providing an adapter for re-use of legacy DIMMS in a fully buffered memory environment. The system includes a memory adapter card having two rows of contacts along a leading edge of a length of the card. The rows of contacts are adapted to be inserted into a socket that is connected to a daisy chain high-speed memory bus via a packetized multi-transfer interface. The memory adapter card also includes a socket installed on the trailing edge of the card. In addition, the memory adapter card includes a hub device for converting the packetized multi-transfer interface into a parallel interface having timings and interface levels that are operable with a memory module having a parallel interface that is inserted into the socket. In addition, the hub device converts the packetized multi-transfer interface into a parallel interface having timings and interface levels that are operable with a memory module having a parallel interface that is inserted into the socket. The hub device also converts the parallel interface into the packetized multi-transfer interface. | 10-16-2008 |
| 20090055002 | ARBITRATION SYSTEM FOR REDUNDANT CONTROLLERS, WITH OUTPUT INTERLOCK AND AUTOMATIC SWITCHING CAPABILITIES - An arbitration mechanism is provided for arbitrating between redundant controllers having outputs electrically connected together and provided as input to at least one device under control. The arbitration mechanism includes logic for automatically determining which controller of the redundant controllers is active controller, and a hardware output interlock for the redundant controllers to ensure that output controlled by only the active controller is enabled as input to the at least one device. The arbitration mechanism also includes logic for monitoring the active controller for failure, and upon detection of failure, for automatically switching active control to another controller of the redundant controllers transparent to the at least one device. | 02-26-2009 |
| 20100264731 | POWER CONVERSION, CONTROL, AND DISTRIBUTION SYSTEM - A power conversion, control, and distribution system includes multiple bulk power regulator (BPR) subassemblies, a bulk power distribution (BPD) subassembly, and a bulk power controller and hub (BPCH) subassembly. The BPR subassemblies are each configured to provide regulated DC power from both AC input power and DC input power. The BPD subassembly is configured to distribute the regulated DC power. The BPCH subassembly is coupled to the multiple BPR subassemblies and the BPD subassembly. The BPCH subassembly is configured to monitor and control the BPR assemblies and the BPD assembly. | 10-21-2010 |
Matthias Fahr, Bad Fredrichshall DE
| Patent application number | Description | Published |
|---|---|---|
| 20100147251 | Piston Of An Internal Combustion Engine With an Increased Inclination of The Box Walls of the Piston - A piston of an internal combustion engine has a piston crown with annular grooves and a shaft part disposed on the piston crown. The shaft part has bearing shaft wall sections which are connected to one another via inclined connecting walls which are retracted with respect to the outer diameter of the piston. Piston-pin bosses for accommodating a piston pin are disposed in connecting walls. The connecting walls are retracted at such an angle that, in progressing from the lower edge over an intermediate region which lies further back than the lower edge, into an end region which lies further back than the intermediate region the connecting walls to over flush into a hub supporting region below the piston crown. | 06-17-2010 |
Torsten Fahr, Dresden DE
| Patent application number | Description | Published |
|---|---|---|
| 20100243903 | METHOD AND SYSTEM FOR MATERIAL CHARACTERIZATION IN SEMICONDUCTOR PRODUCTION PROCESSES BASED ON FTIR WITH VARIABLE ANGLE OF INCIDENCE - During the processing of complex semiconductor devices, dielectric material systems comprising a patterned structure may be analyzed in a non-destructive manner by using an FTIR technique in combination with a plurality of angles of incidence. In this manner, topography-related information may be obtained and/or data analysis may be made more efficient due to the increased amount of information obtained by the plurality of angles of incidence. | 09-30-2010 |