Patent application number | Description | Published |
20090263826 | MEANS AND METHOD FOR DIAGNOSING HEMOLYTIC ANEMIA - The present invention relates to a method for diagnosing hemolytic anemia or a predis-position thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject. | 10-22-2009 |
20110091929 | MEANS AND METHODS FOR ASSESSING LIVER ENZYME INDUCTION - The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, galactose, 3- and 5-Methoxysphingosine, Cholesterol, Threonic acid, 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, Glycerol, Glycerophosphate, Dodecanol, myo-Inositol-2-monophosphate. | 04-21-2011 |
20110129933 | MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION - The present invention pertains to the field of toxicological as for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18:cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18:cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidyl-choline (C18:0/C22:6). Different multimarker sets are proposed for male and female subjects. | 06-02-2011 |
20110163226 | MEANS AND METHODS FOR ASSESSING LIVER TOXICITY - The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol, myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (d18:1, C24:1), Ceramide (d18:2, C24:0), Sphingomyelin (d18:1, C16:0), 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, Coenzyme Q9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides. | 07-07-2011 |
20120132797 | MEANS AND METHODS FOR DIAGNOSING THYROID DISORDERS - The present invention relates to a method for diagnosing thyroid disorders. It also relates to a method of determining whether a compound is capable of inducing a thyroid disorder in a subject and to a method of identifying a drug for treating a thyroid disorder. Furthermore, the present invention relates a device for diagnosing a thyroid disorder and diagnostic uses. | 05-31-2012 |
20140186964 | MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION - The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject. | 07-03-2014 |
Patent application number | Description | Published |
20120209535 | METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS - The present invention relates to methods for evaluating biomarkers. In particular, the invention relates to a method for establishing at least one pattern for at least one pre-defined effector having at least one effect on a biological system, which effect is capable of being determined, to a method of establishing a class of effectors for a pre-defined effect or group of effects, to a method for identifying at least one effect of a pre-defined effector and to a computer program and a computer adapted to carry out these methods. | 08-16-2012 |
20140342379 | Means and Methods for Assessing Gonadal Toxicity - The present invention pertains to the field of diagnostics for gonadal toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing gonadal toxicity. It also relates to a method for determining whether a compound is capable of inducing such gonadal toxicity in a subject and to a method of identifying a drug for treating gonadal toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing gonadal toxicity. | 11-20-2014 |
20150011423 | MEANS AND METHODS FOR ASSESSING KIDNEY TOXICITY - The present invention pertains to the field of diagnostics for kidney toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing kidney toxicity. It also relates to a method for determining whether a compound is capable of inducing such kidney toxicity in a subject and to a method of identifying a drug for treating kidney toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing kidney toxicity. | 01-08-2015 |
20150017667 | MEANS AND METHODS FOR ASSESSING LIVER DISORDERS - The present invention pertains to the field of diagnostics for liver disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver disorders. It also relates to a method for determining whether a compound is capable of inducing such liver disorders in a subject and to a method of identifying a drug for treating liver disorders. Furthermore, the present invention relates to a device and a kit for diagnosing liver disorders. | 01-15-2015 |
20150018237 | MEANS AND METHODS FOR ASSESSING BONE DISORDERS - The present invention pertains to the field of diagnostics for bone disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing a bone disorder. It also relates to a method for determining whether a compound is capable of inducing such a bone disorder in a subject and to a method of identifying a drug for treating a bone disorder. Furthermore, the present invention relates to a device and a kit for diagnosing a bone disorder. | 01-15-2015 |
20150018244 | MEANS AND METHODS FOR ASSESSING HYPERTHYROIDISM - The present invention pertains to the field of diagnostics for hyperthyroidism and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing hyperthyroidism. It also relates to a method for determining whether a compound is capable of inducing such hyperthyroidism in a subject and to a method of identifying a drug for treating hyperthyroidism. Furthermore, the present invention relates to a device and a kit for diagnosing hyperthyroidism. | 01-15-2015 |
20150031572 | MEANS AND METHODS FOR ASSESSING NEURONAL TOXICITY - The present invention pertains to the field of diagnostics for neuronal toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing neuronal toxicity. It also relates to a method for determining whether a compound is capable of inducing such neuronal toxicity in a subject and to a method of identifying a drug for treating neuronal toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing neuronal toxicity. | 01-29-2015 |
20150037825 | Means and Methods for Assessing Hematopoietic Toxicity - The present invention pertains to the field of diagnostics for hematopoietic toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing hematopoietic toxicity. It also relates to a method for determining whether a compound is capable of inducing such hematopoietic toxicity in a subject and to a method of identifying a drug for treating hematopoietic toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing hematopoietic toxicity. | 02-05-2015 |
20150044702 | MEANS AND METHODS FOR ASSESSING DISORDERS RELATED TO IMPAIRED IRON ADSORPTION OR ENERGY METABOLISM - The present invention pertains to the field of diagnostics for iron adsorption disorder or impaired energy metabolism and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing iron adsorption disorder or impaired energy metabolism. It also relates to a method for determining whether a compound is capable of inducing such iron adsorption disorder or impaired energy metabolism in a subject and to a method of identifying a drug for treating iron adsorption disorder or impaired energy metabolism. Furthermore, the present invention relates to a device and a kit for diagnosing iron adsorption disorder or impaired energy metabolism. | 02-12-2015 |
Patent application number | Description | Published |
20090057459 | APPARATUS AND METHOD FOR TAPERED CORE DRUM PACKAGE PAYOFF - Arrangements and methods for welding wire payoff sources. A tapered core and base plate, optionally along with a wire guide insert, are configured with a payout drum package and a cover containing a welding wire stack such that the welding wire may be payed off smoothly from the wire stack during an arc welding operation, without the welding wire flipping or tangling. | 03-05-2009 |
20090057460 | WIRE GUIDE INSERT AND METHOD FOR DRUM PACKAGE PAYOFF - Arrangements and methods for welding wire payoff sources. A tapered core and base plate, optionally along with a wire guide insert, are configured with a payout drum package and a cover containing a welding wire stack such that the welding wire may be payed off smoothly from the wire stack during an arc welding operation, without the welding wire flipping or tangling. | 03-05-2009 |
20100230525 | WIRE DISPENSING APPARATUS FOR PACKAGED WIRE - A container includes side walls and a floor panel for packaging coiled wire, which may be welding wire. A wire dispensing apparatus is included that pays-off wire from the coil without tangling or twisting. The wire dispensing apparatus incorporates a plurality of flexible protrusions that extend from a base constructed to minimally contact the coil of wire. In particular, the wire dispensing apparatus incorporates an angled or curved base that rests against an inner circumference of the coiled wire. | 09-16-2010 |
20110000998 | WIRE DISPENSING APPARATUS FOR PACKAGED WIRE - A container includes side walls and a floor panel for packaging coiled wire, which may be welding wire. A wire dispensing apparatus is included that pays-off wire from the coil without tangling or twisting. The wire dispensing apparatus incorporates a plurality of flexible protrusions that extend from a base constructed to minimally contact the coil of wire. In particular, the wire dispensing apparatus incorporates an angled or curved base that rests against an inner circumference of the coiled wire. | 01-06-2011 |
Patent application number | Description | Published |
20100270354 | ERGONOMIC ROTARY TACKER - A tacker for applying a rotary tack, including a tacker for applying a rotary tack, including a handle with a first trigger assembly and a second trigger assembly, the trigger assemblies being coupled to an articulated applicator arm which is disposed through a drive shaft connected to the handle, the first trigger assembly operative to apply a rotary tack from a distal end of the applicator arm and the second trigger assembly operative to bend the distal end of the applicator arm, wherein a longitudinal axis of the handle is tilted with respect to the drive shaft. | 10-28-2010 |
20100274266 | ROTARY TACK - A rotary tack including a helical body constructed of a resorbable material and having a closed-loop base and a helix of spiral coils that extend from the base which terminate in a tip for piercing tissue, wherein each of the coils has a cross-section with an inner perimeter including an arcuate portion and a straight portion contiguous to each other. | 10-28-2010 |
20110105845 | ENDOSCOPIC DEVICE WITH FLUID CLEANING - A method for enhancing performance of an endoscope ( | 05-05-2011 |
20120101336 | ENDOSCOPIC SYSTEM WITH FLUID CLEANING - An endoscopic system for use with an endoscope, including an irrigation tube that provides a flow of irrigation fluid for cleaning a body lumen, and a suction tube for sucking material from the body lumen, wherein the suction tube is connected to a branch connector and one branch of the branch connector is connected to a suction source tube which is connected to a suction source and another branch of the branch connector is connected to a vent tube, and wherein the suction source tube and the vent tube pass through a double pinch valve. | 04-26-2012 |
20130119108 | DRIVE MECHANISM FOR ARTICULATING TACKER - A tacker for applying a rotary tack, including a drive shaft coupled to a trigger assembly, wherein operating the trigger assembly causes rotation of the drive shaft, a distal portion of the drive shaft passing into an articulated arm that holds rotary tacks, wherein upon operation of the trigger assembly, the drive shaft rotates to cause deployment of the tacks distally out of the articulated arm, and wherein the drive shaft includes a cable on which are located a plurality of axially spaced drive links that transfer rotational motion of the drive shaft to rotation of the tacks. | 05-16-2013 |
20130261390 | ENDOSCOPIC ACCESSORY FOR ENDOSCOPIC DEVICE - An endoscopic system including an accessory that fits over an endoscopic device, the accessory including at least one collapsible tube which has a collapsed state and an expanded state, wherein in the collapsed state, the accessory increases an outer perimeter of the endoscopic device by not more than 10%, and in the expanded state, the at least one collapsible tube has fluid that flows therethrough and the accessory increases the outer perimeter of the endoscopic device by at least 10%. | 10-03-2013 |
20130325042 | PYLORUS PLUG AND ANASTOMOSIS - A method for creating an anastomosis between a stomach and a portion of a small intestine, and simultaneously controlling passage of stomach contents through a pylorus with a pylorus plug that includes a valve operative to either close or at least partially open passageway through the pylorus. | 12-05-2013 |
20140155693 | ENDOSCOPIC DELIVERY SYSTEM - An endoscopic delivery system including an endoscope including at least one imaging device and a working channel, and a catheter arranged to pass through the working channel, wherein the catheter is formed with an observation window on a side portion thereof, the window being in a line of sight of the at least one imaging device. | 06-05-2014 |
20140155928 | LONG-TERM OBSTRUCTION DEVICE - An obstruction device including a proximal obstruction balloon and a distal obstruction balloon mounted on a shaft, wherein a neck portion of said shaft provides a gap between a distal end of said proximal obstruction balloon and a proximal end of said distal obstruction balloon. | 06-05-2014 |
20140309669 | POSITIONING TOOL FOR ANASTOMOSIS - An assembly including a positioning tool that includes a probe affixed to a portion of a grasping tool, wherein a distal tip of the probe protrudes distally from the grasping tool a distance corresponding to a position for placing a magnet with the grasping tool. | 10-16-2014 |
20140309682 | INFLATION AND DEFLATION OF OBSTRUCTION DEVICE - An assembly including an obstruction device including a proximal obstruction balloon and a distal obstruction balloon mounted on a shaft, the balloons being inflatable via an inflation lumen, and a delivery system that includes an insertion tool and an injection site assembly assembled with one of the balloons, the insertion tool including a connector which is connectable to the injection site assembly and which permits passing tools and injection fluid therethrough. | 10-16-2014 |
20140350588 | OBSTRUCTION DEVICE - An obstruction device ( | 11-27-2014 |
20140371791 | SUTURING ASSEMBLY WITH SPACER - A suturing assembly including a first puncture element including a sharp distal end for puncturing tissue, a second puncture element including a sharp distal end for puncturing tissue, the distal ends of the first and second puncture elements being spaced from each other by a gap, and a spacer arranged for sliding distally and proximally on at least one of the first and second puncture elements. | 12-18-2014 |
Patent application number | Description | Published |
20100288422 | LOW-TEMPERATURE METHOD FOR JOINING GLASS AND THE LIKE FOR OPTICS AND PRECISION MECHANICS - The present invention relates to a method for joining two or more components made of glass, ceramic, and/or glass ceramic, using a soluble glass joining solution having sodium, potassium, and/or lithium ions and/or a silica sol, the joining solution being applied to joint surfaces between the components to be joined and solidified at mild temperatures, the method being either characterized in that the joining solution comprises an additive selected among boric acid, boron compounds from which boric acid can result by hydrolysis, aluminum acetates, aluminum silicate/NH | 11-18-2010 |
20130048214 | METHOD FOR THE SILICEOUS BONDING OF COATED AND UNCOATED OPTICAL BODIES - The present invention pertains to a process for the silicate bonding of joined surfaces, facing one another, of two components by means of an aqueous, alkaline, silicon-cation-containing joining solution for the purpose of producing an optical element, characterized in that one or both of said joined surfaces ( | 02-28-2013 |
20140298864 | Laser-Based Splicing of Glass Fibers Onto Optical Components - The invention relates to a method for laser-based splicing of a glass fiber ( | 10-09-2014 |