Eva-Maria
Eva Maria Becker-Pelster, Wuppertal DE
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20140128386 | Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use - The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders. | 05-08-2014 |
20140142069 | SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF - The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders. | 05-22-2014 |
20140179672 | Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use - The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders. | 06-26-2014 |
20150152050 | N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE - The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases. | 06-04-2015 |
20150174113 | SUBSTITUTED AMINOINDANE- AND AMINOTETRALINECARBOXYLIC ACIDS AND THE USE THEREOF - The present application relates to novel substituted aminoindane- and aminotetralinecarboxylic acids, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular and cardiopulmonary diseases. | 06-25-2015 |
20150274719 | AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE - The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders. | 10-01-2015 |
Eva Maria Brandtner, Singapore SG
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20140023693 | PROTECTION OF MICROBIAL CELLS FROM ACIDIC DEGRADATION - A simple cellulose sulphate based microencapsulation technology has been applied to encapsulate bacterial or other microbial cells, which produce and release digestive enzymes and thereby provides an acid resistant shelter for these microbial cells. Surprisingly, the resulting spheres were found to provide sufficient protection for encapsulated cells from treatment with aqueous acidic solutions. Thereby the cellulose sulphate microencapsulated cells, such as probiotics are now enabled to survive passage, for example, through the stomach after consumption by a human or animal with a higher survival rate than those not within a microcapsule. After passing the stomach these cells are delivering products produced by them, e.g. enzymes or other nutrition factors. This technology therefore proves to be very useful in providing digestive or otherwise beneficial enzymes and/or of living microbial cells, into the lower gastrointestinal tract, where they could confer their health benefit to the host. | 01-23-2014 |
20150233800 | METHOD OF PAINTING MICROVESICLES - The present invention relates to a method to modify and/or to isolate exosomes and other naturally occurring plasma membrane derived microvesicles, by incubation with a reactant, consisting of at least a membrane anchor domain or moiety and a hydrophilic functional domain or moiety. The invention also relates to modification using the same of artificially-prepared lipid bilayer vesicles called liposomes (composed of natural phospholipids) and non-biological or “synthetic” block copolymer membrane mimics which also form vesicles in aqueous solution called polymersomes.. | 08-20-2015 |
Eva Maria Brun Sanchez, Alaquas (valencia) ES
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20140234876 | Method And System For Detection Of Natural High Intensity Sweeteners That Contain Hydroxyl Groups - The present invention provides a hapten derivative and conjugate of a natural high intensity sweetener containing hydroxyl groups. The conjugate can be used to produce antibodies specific against the natural high intensity sweetener. The present invention further provides a kit and method for detecting and quantifying the natural high intensity sweetener in a sample. | 08-21-2014 |
Eva Maria Carrasco Rilova, Sabadell ES
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20150157489 | FASTENING DEVICE FOR PEOPLE WITH REDUCED MOBILITY CONDITIONS - Fastening device for people with reduced mobility conditions, of the variety employed in chairs or arm chairs in domestic, geriatric, care or hospital environments, comprising fixation means ( | 06-11-2015 |
Eva Maria Cespedes Montoya, Madrid ES
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20140144426 | COVERING THAT SELECTIVELY ABSORBS VISIBLE AND INFRARED RADIATION, AND METHOD FOR THE PRODUCTION THEREOF - The present invention relates to a covering that selectively absorbs visible and infrared radiation, which comprises: (a) a first anti-diffusion barrier layer ( | 05-29-2014 |
Eva Maria Ferruelo Nicolas, Madrid ES
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20110017354 | MATERIALS FOR THE PRODUCTION OF ECOLOGICAL AMMUNITION AND OTHER APPLICATIONS - The present invention provides an ODS type material (Oxide dispersion strengthened or particle dispersion) which comprises an alloy metal matrix and a dispersion of strengthening particles distributed therein which provide the same with optimum density and deformability. Said metal matrix is constituted by an alloy of zinc and bismuth, of zinc and aluminium, of tin and bismuth, or of tin and zinc, the strengthening material being of tungsten or ferro tungsten, oxides of both, carbides of both, or derivatives of the same. Said new material can substitute for lead in the production of ecological ammunition, hooks for fishing, inertial counterweights in automobiles, X-rays and ionising radiation screens, golf sticks, water pipes and plumbing fittings, as well as in electrical and magnetic applications. The invention also provides an ecological ammunition manufactured from said composite material, such as, for example, pellets. | 01-27-2011 |
Eva Maria Garcia Biosca, Madrid ES
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20110121228 | REVALUATION OF AQUEOUS WASTE STREAMS IN THE PROPYLENE OXIDE/STYRENE CO-PRODUCTION PROCESS - The present disclosure describes a method for the revaluation of aqueous waste streams generated in the propylene oxide and styrene co-production processes. In particular, it discloses a method of reducing the organic contaminant load from a highly contaminated aqueous stream and recovery from said stream of organic compounds that may be recirculated or used as fuel in the co-generation of energy, and which comprises: acidification of said aqueous stream with inorganic acid at a pH less than 4.5; separation of the two resulting phases at a temperature greater than 40° C.; washing of the organic phase produced in the previous step with an aqueous solution of excess acid and separation of the two resulting phases. | 05-26-2011 |
Eva Maria Krüdewagen, Monheim DE
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20140294968 | POLYACRYLATE-BASED ACTIVE COMPOUND-COMPRISING PARTICLES - The invention relates to novel polyacrylate-based active compound-comprising particles which bind to hair, and to the use of these particles for preparing medicaments, in particular for veterinary medicine. The particles comprise uncharged and cationic polyacrylate and are at most 10 um big. | 10-02-2014 |
Eva Maria Martin De La Nava, Madrid ES
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20080269284 | Compounds and Methods for Treating Dyslipidemia - Compounds of Formula I wherein n, q, Y, R | 10-30-2008 |
20100160340 | PROTEIN KINASE INHIBITORS - The present invention provides a compound of formula (I): | 06-24-2010 |
20120142724 | OXAZOLO[5-4-b]PYRIDIN-5-YL COMPOUNDS - The present invention provides oxazolo[5,4-b]pyridin-5-yl compounds useful in the treatment of cancer. | 06-07-2012 |
Eva Maria Martin De La Nava, Alcobendas-Madrid ES
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20100204207 | Compounds and Methods for Treating Dyslipidemia - Compounds of Formula (I): wherein n, m, p, q, Y, R1, R2, R3a, R3b, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed. | 08-12-2010 |
Eva Maria Novoa Rojas, Madrid ES
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20110156397 | UNDERWATER ELECTRICAL GENERATOR FOR THE HARNESSING OF BIDIRECTIONAL FLOOD CURRENTS - Underwater electrical energy generator with a three-blade propeller for the harnessing of energy from the water in the direction of its axis, in both directions. The propeller drives an alternating current generator located in a central dome from which there extend three arms joined to floats which close the Y-shaped structure by means of tie beams. The assembly has neutral floatability and is set into position by means of an anchoring system with a set of buoys joined to the bottom by one or more cables. An end of the generator is joined to an anchoring line by means of a horizontal cable in one of the main directions of the current. From the other end another two horizontal cables, open at an angle with respect to the direction of the current, are joined to another two anchoring lines. The assembly can be ballasted to go from an operating vertical underwater position to a horizontal floating position to facilitate maintenance tasks. | 06-30-2011 |
Eva Maria Pellicer Vila, Oliana (lleida) ES
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20150197426 | MESOPOROUS, HIGHLY ORDERED MAGNESIUM AND NIOBIUM BASED TERNARY OXIDE COMPOUND, PROCESS FOR ITS PREPARATION AND USES - The present invention concerns a Magnesium (Mg) and Niobium (Nb) ternary oxide with very high morphological order degree having Mg | 07-16-2015 |
Eva Maria Perez-Prat Vineusa, Brussels BE
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20120225802 | DISHWASHING METHOD - The present invention relates to a method of manually cleaning dishware using a liquid hand dishwashing detergent composition comprising an anionic surfactant and a cationic polymer having a MW below or equal to 2,100,000; and a charge density above or equal to 0.45 meq/g, wherein such composition will have a coacervation index upon dilution of at least 2.5%; to provide skin care. | 09-06-2012 |
Eva Maria Trost-Gross, Wolfratshausen DE
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20120309679 | IGF-I POLY (ETHYLENE GLYCOL) CONJUGATES - Herein is reported a method for producing of a polypeptide conjugated to one poly (ethylene glycol) comprising a) providing a nucleic acid encoding an expression construct comprising in 5′ to 3′ direction a nucleic acid encoding a polypeptide, and a nucleic acid encoding a trypsin site of SEQ ID NO: 01, b) expressing the nucleic acid of a) in a cell and recovering the expression construct from the cell and/or the cultivation medium, c) providing a target peptide with an amino acid sequence of SEQ ID NO: 02 covalently conjugated to a poly (ethylene glycol) at the C-terminal lysine residue, d) incubating the expression construct and the target peptide with the trypsin mutant D189K, K60E, N143H, E151H, and e) recovering and thereby producing the polypeptide conjugated to one poly (ethylene glycol) from the incubation mixture. | 12-06-2012 |
Eva-Maria Baerthlein, Hamburg DE
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20150162144 | LOAD TAP CHANGER - A method of switching taps by an on-load tap changer includes providing at least two fingers each comprising an impedance and a mechanical switch. When first and second mechanical switches of the first and second fingers are closed, they provide a connection between the first and second impedances of the first and second fingers and a power terminal of the on-load tap changer. The on-load tap changer is triggered to shift at least one of the fingers from a first tap to a second tap of the on-load tap changer when a tap change signal is received. A solid state switch connected between the first and second impedances is switched on to commutate a current from the first finger to the second finger during the tap change operation. | 06-11-2015 |
20150213971 | SYSTEM AND METHOD FOR OPERATING AN ON-LOAD TAP CHANGER - A system for operating an on-load tap changer (OLTC) includes a plurality of legs that include mechanical switches. At least one leg switches from a first to a second tap of the OLTC on receipt of a tap change signal. At least one mechanical switch is activated to establish an electrical connection between one of the first and the second tap and a power terminal of the OLTC. Further, the system includes semiconductor switches that are parallel to the mechanical switches and when activated electrically couple one of the first and the second tap and the power terminal. The system includes a processing unit that selectively activates and deactivates the mechanical and semiconductor switches in such a way that electrical contact is maintained between at least one of the taps and the power terminal during the transition of at least one leg from the first tap to the second tap. | 07-30-2015 |
20150301538 | LOAD TAP CHANGER - A method of switching taps of an on-load tap changer includes providing a main finger, a first side finger including a first solid state switch and a second side finger including a second solid state switch. The main finger, the first side finger and the second side finger are utilized to provide a connection between the taps and a power terminal of the on-load tap changer. The method also includes triggering the on-load tap changer to shift the fingers from a first tap to a second tap of the on-load tap changer when a tap change signal is received and utilizing the first solid state switch and the second solid state switch to commutate a current during the tap change operation. | 10-22-2015 |
20150303861 | SYSTEM AND METHOD OF ONLINE FILTERING OF PHOTOVOLTAIC SIGNALS - A system for online filtering of photovoltaic (PV) output signals includes a programmable filter that is programmed to decompose measured PV output power into an estimated low-frequency signal component, based substantially on movement of the sun and an estimated high-frequency signal component, based substantially on cloud shading. An open loop controller generates a reactive power compensation signal based on at least one of the low-frequency signal component and the high-frequency signal component. The low-frequency signal component is defined by a positive portion of a sine curve that is based substantially on movement of the sun. | 10-22-2015 |
Eva-Maria Gerosch, Igualada ES
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20100282646 | METHOD AND UNIT FOR THE SEPARATION OF NON-FERROUS METALS AND STAINLESS STEEL IN BULK MATERIAL HANDLING - A method and unit for the separation of non-ferrous, ferrous and non-metal portions in bulk material handling, particularly for the recycling of materials for subsequent use, wherein the method comprises: the application of eddy currents for the separation of portions of non-ferrous and conductive materials that jump with respect to portions of the remaining material stream; the detection of metals in portions of materials by means of an analysis of the metals using electromagnetic sensors, and the separation of said metals by mechanical expulsion means, achieving the separation of metallic material portions, such as stainless steel, and others from the portions of non-metals. The unit comprises a first conveyor belt of the portions and eddy current (Foucault) separators, while a second conveyor belt includes electromagnetic metal sensors and selective expulsion means which are controlled by said electromagnetic metal sensors. | 11-11-2010 |
Eva-Maria Hoiser, Hitzendorf AT
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20110262494 | LOW-OIL PHARMACEUTICAL EMULSION COMPOSITIONS COMPRISING PROGESTOGEN - Described are sterile, ready-to-use, pharmaceutical oil-in-water emulsion compositions for parenteral administration comprising: | 10-27-2011 |
20110262495 | PHARMACEUTICAL EMULSION COMPOSITIONS COMPRISING PROGESTOGEN - Described are a sterile, ready-to-use, pharmaceutical oil-in water emulsion compositions for parenteral administration comprising: | 10-27-2011 |
20140147474 | PHARMACEUTICAL EMULSION COMPOSITIONS COMPRISING PROGESTOGEN - Described are a sterile, ready-to-use, pharmaceutical oil-in water emulsion compositions for parenteral administration comprising: | 05-29-2014 |
20140335133 | LOW-OIL PHARMACEUTICAL EMULSION COMPOSITIONS COMPRISING PROGESTOGEN - Described are sterile, ready-to-use, pharmaceutical oil-in-water emulsion compositions for parenteral administration comprising: | 11-13-2014 |
Eva-Maria Holbig, Konstanz DE
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20110186116 | METHOD FOR PRODUCING A SOLAR CELL HAVING A TWO-STAGE DOPING - Method for producing solar cells with a two-stage doping ( | 08-04-2011 |
Eva-Maria Keitzl, Muehldorf DE
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20150126424 | Surfactant Solutions Containing N-Methyl-N-Oleylglucamines And N-Methyl-N-C12-C14-Acylglucamines - The invention relates to a surfactant solution containing: (a) 28 to 65 wt.-% of a mixture of (a1) 5 to 20 wt.-% of N-methyl-N-oleylglucamine, (a2) 50 to 93 wt.-% of N-methyl-N—C | 05-07-2015 |
Eva-Maria Kruedewagen, Monheim DE
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20110105388 | NOVEL POSSIBILITY OF CONTROLLING GIARDIOSIS - The present invention relates to the use of nifurtimox for the treatment of giardiosis, in particular in dogs and cats. | 05-05-2011 |
Eva-Maria Kupsch, Waedenswil CH
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20150217543 | FILMS CONTAINING FUNCTIONAL ETHYLENE-BASED POLYMER COMPOSTIONS - The invention provides a film comprising at least two layers, a first layer and a second layer; and wherein the first layer is formed from a first composition comprising a polyester and/or a polylactic acid; and wherein the second layer is formed from a second composition comprising at least the following: A) a functionalized ethylene-based polymer, and B) at least one ethylene/alkylacrylate copolymer. | 08-06-2015 |
20150217544 | MULTILAYERED POLYOLEFIN-BASED FILMS - Disclosed are multilayer structures comprising a polyolefin layer, a tie layer and a barrier layer wherein the tie layer is a formulation comprising a crystalline block copolymer composite (CBC) comprising i) an ethylene polymer (EP) comprising at least 90 mol % polymerized ethylene; ii) an alpha-olefin-based crystalline polymer (CAOP) and iii) a block copolymer comprising (a) an ethylene polymer block comprising at least 90 mol % polymerized ethylene and (b) a crystalline alpha-olefin block (CAOB). | 08-06-2015 |
Eva-Maria Leppainen, Lempaala FI
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20090067408 | CENTRALIZED CALL LOG AND METHOD THEREOF - The present invention relates to a method and system thereof, which comprises a communication network having at least a serving session network node, through which communication initiation requests of the communication network are routed. The system further comprises an application services providing network node, which interfaces with the serving session network node. The application services providing network node is configured for providing functions related to a group of several terminal devices of one user. A communication initiation request is addressed to the user on the basis of a user related identifier associated with the group of several terminal devices and comprised by the communication initiation request. A protocol network node is configured for registering protocol information about a communication session upon reception of a detection signalization indicating the communication initiation request to the user having the corresponding service available. | 03-12-2009 |
Eva-Maria Muchitsch, Vienna AT
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20100115637 | MODELS OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND METHODS OF USE THEREOF - The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP. | 05-06-2010 |
20110072524 | Transgenic Mouse Lacking Endogenous FVIII and VWF - A Model of Hemophilia A - The present invention relates, generally, to a transgenic non-human animal model of hemophilia A, wherein the transgenic animal is deficient in endogenous Factor VIII and endogenous von Willebrand Factor, and methods to treat hereditary or acquired hemophilia A or von Willebrand Disease (VWD) by administration of exogenous human VWF. | 03-24-2011 |
Eva-Maria Muchitsch, Wien AT
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20140271611 | SUBCUTANEOUS ADMINISTRATION OF ADAMTS13 - This invention relates to methods of subcutaneous administration of ADAMTS13 formulations to a treat a disease or condition associated with ADAMTS13 and VWF dysfunction. Furthermore, evidence of the unexpectedly high bioavailability of ADAMTS13 formulations administered subcutaneously is provided herein. | 09-18-2014 |
Eva-Maria Reis-Walther, Breuberg DE
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20130236386 | COOLING AND/OR LUBRICATING FLUIDS FOR WAFER PRODUCTION - The invention relates to the use of modified polyglycols for production of cooling and/or lubricating fluids, to novel cooling and/or lubricating fluids, to the use of the cooling and/or lubricating fluids in the removal of material, especially in the cutting of wafers, and to wafers produced with the aid of the cutting fluid. | 09-12-2013 |
20140171320 | Composition Comprising A Pesticide And An Alkoxylate Of 2-Isopropyl-5-Methylhexane-1-Amine - The present invention relates to a composition comprising a pesticide and an alkoxylate. The invention further relates to the alkoxylate, to a method for the production thereof and to the use thereof as adjuvant in pesticide-comprising spray mixtures. The invention further relates to a method for controlling phytopathogenic fungi and/or undesirable plant growth and/or undesirable insect or mite infestation and/or for regulating the growth of plants, wherein the composition is allowed to act on the respective pests, the habitat thereof or the plants to be protected from the respective pest, on the soil and/or on undesirable plants and/or the crop plants and/or the habitat thereof. Furthermore, the invention relates to seed comprising the composition. | 06-19-2014 |
Eva-Maria Rumpfhuber, Houston, TX US
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20110255371 | Hydrocarbon Detection With Passive Seismic Data - Method for using seismic data from earthquakes to address the low frequency lacuna problem in traditional hydrocarbon exploration methods. Seismometers with frequency response Select Receivers of Desired Frequency Ranges and Design Survey Seismometer Configuration down to about | 10-20-2011 |
Eva-Maria Van Dijkman, Frankfurt DE
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20150324107 | METHOD AND SYSTEM FOR DISPLAY OF VISUAL INFORMATION - A method for displaying a map location of a camera providing video information, the method comprising: | 11-12-2015 |
Eva-Maria Van Dijkman, Frankfurt Am Main DE
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20160065669 | LOCATION-ORIENTED TEAM INTERCOMMUNICATION - A system and method for intercommunication among the members of a team employing user devices, organized around maps of the locations of the team members presented on the display screens of the user devices. Team members manage intercommunications among themselves by selections made according to the displayed maps and icons thereon. The maps provide a flexible framework around which to structure various modalities of intercommunication including chat, voice, audio-video camera streaming, or a data stream from a sensor, which are graphically indicated on the maps. Organizing and managing according to icons of team members on the maps provides flexible intercommunication without excessive constraint, facilitating intuitive and easy operation. When posting of geographical location of a team member is not desired, a ghost mode permits a team member to freely interact with the group without divulging location. | 03-03-2016 |
Eva-Maria Wenzig, Graz AT
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20110045083 | USE LARCH WOOD FOR TREATING INFLAMMATION - The application of raw wood material from a tree of the genus | 02-24-2011 |
20120114715 | USE OF LARCH WOOD FOR TREATING INFLAMMATION - The application of wood material from a tree of the genus | 05-10-2012 |
Eva-Maria Wikker, Dusseldorf DE
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20120151683 | LIQUID WASHING OR CLEANING AGENT HAVING A POLYMER PREVENTING GRAYING - The invention relates to the use of an anionic polymer in a liquid washing or cleaning agent for inhibiting graying when washing and/or cleaning textile web materials, and acrylic acid homopolymers comprising liquid washing and cleaning agents. | 06-21-2012 |
Eva-Maria Wikker, Monheim DE
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20140187461 | POLYMERIC AGENTS THAT IMPROVE PRIMARY WASHING EFFICIENCY - The primary washing power of washing and cleaning agents was to be improved, in particular with respect to oil- and/or fat-containing stains. This was achieved substantially by the incorporation of polymers that derive from N,N-dimethylacrylamide. | 07-03-2014 |
20140187462 | POLYMERIC AGENTS THAT IMPROVE PRIMARY WASHING EFFICIENCY - The primary washing power of washing and cleaning agents was to be improved, in particular with respect to oil- and/or fat-containing stains. This was achieved substantially by the incorporation of polymers having an aggregation parameter X | 07-03-2014 |
20150252293 | POLYALKOXYLATED POLYAMINES WHICH IMPROVE PRIMARY DETERGENCY - A detergent or cleaning agent and method for removing soils from textiles or hard surfaces, in particular against soils from preparations containing fruit, comprising polyalkoxylated polyamines obtained by reacting polyamines with ethylene oxide and propylene oxide, wherein the content of propylene oxide in the total quantity of the alkylene oxide is 2 mol-% to 18 mol-%. | 09-10-2015 |
20150275134 | DETERGENT AND CLEANING AGENT WITH POLYALKOXYLATED POLYAMINE AND ADJUSTED NON-IONIC SURFACTANT - The primary washing power of detergents and cleaning agents, particularly with regard to protein-containing soiling, was to be improved. This was achieved substantially by incorporating a combination of polyalkoxylated polyamine with alkoxylated C | 10-01-2015 |
Eva-Maria Zebedin-Brandl, Wien AT
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20130344038 | METHOD FOR ENHANCING ENGRAFTMENT OF HAEMATOPOETIC STEM CELLS - The present invention provides a novel method for enhancing engraftment of haematopoetic stem cells by an ex-vivo pretreatment comprising the steps of obtaining a sample containing haematopoetic stem cells and admixing a prostacyclin analogue to obtain a mixture, incubating said mixture for a period of time sufficient to stimulate G alphas-signalling in said cells and optionally and isolating said stimulated cells. Further, a composition comprising a prostacyclin analogue for use in the treatment of individuals undergoing haematopoetic stem cell transplantation is provided. | 12-26-2013 |