| Patent application number | Description | Published |
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| 20100202968 | Method of Providing Disease-Specific Binding Molecules and Targets - Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described. | 08-12-2010 |
| 20100330075 | MONOCLONAL HUMAN TUMOR-SPECIFIC ANTIBODY - Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described. | 12-30-2010 |
| 20110123447 | METHOD OF PROVIDING HUMAN TUMOR-SPECIFIC ANTIBODIES - Provided are novel tumor-specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigens and that are obtained from a tumor patient who shows at least partial clinical response or is symptom-free. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of tumors are described. | 05-26-2011 |
| 20110171688 | METHOD OF PROVIDING IMMUNOGLOBULIN SECRETING B LYMPHOCYTES AND HUMAN ANTIBODIES - Provided is a method for producing a clone of an immortalized human B memory lymphocyte, comprising the step of inducing or enhancing telomerase activity in the B lymphocyte in the presence of a polyclonal B cell activator. The method is particularly useful in a method for producing a clone of an immortalized human B memory lymphocyte capable of producing a human monoclonal antibody with desired antigen specificity. | 07-14-2011 |
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| 20090205215 | MINIMUM CLEARANCE BORE GAUGE - A method of measuring an interior diameter of a bore with an expandible gauge having relatively movable first and second components and placing an adhesive on at least one of the first and the second components for adhesively bonding the first and the second components to one another. Inserting the expandible gauge into a tool hole in a bore bar and sliding the bore bar into the bore so that the tool hole is located within the bore. Allowing the expandible gauge to expand to a diameter of a bore to be measured and adhesively bond the first and the second components to one another. Removing the expandable gauge and determining the diameter of the bore by measuring a length of the expandible gauge. | 08-20-2009 |
| 20090277316 | GROOVE CUTTING ASSEMBLY - A groove cutting assembly comprising a cutter housing, a cutter assembly with a cutting edge, and the cutter assembly being accommodated by the cutter housing, and a drive mechanism, coupled to the cutter assembly, for indexing the cutter assembly one of radially inward and radially outward relative to the cutter housing upon rotation of the cutter assembly past an indexing member. The drive mechanism comprises a barrel assembly, engaged with the cutter assembly, and a feed member which threadedly engages with the barrel assembly. Rotation of the feed member, in a first rotational direction, indexes the cutter assembly radially outwardly away from the cutter housing, while rotation of the feed member, in an opposite rotational direction, indexes the cutter assembly radially inwardly toward the cutter housing. | 11-12-2009 |
| 20100189522 | FEED MECHANISM FOR A BORING BAR - A boring bar feed mechanism comprising a boring bar and a rotation mechanism for rotating the boring bar, a feed shaft, a feed coupling the feed shaft with the boring bar for axially translating the boring bar, and the boring bar is rotationally mounted with respect to but axially fixed to a second end of the feed coupler. A cam is rotationally fixed to the boring bar for rotating with the boring bar and a cam follower interacts with the cam. A plunger housing is supported by an extension of the cam follower and the plunger housing accommodates at least one feed plunger. A converter gear is supported by the feed shaft and the feed plunger interacts with the converter gear to facilitate indexing of the converter gear. The plunger housing is pivotally supported by the extension of the cam follower to permit the plunger housing and the feed plunger to have a limited pivoted motion, relative to the cam follower, as the cam follower oscillates back and forth and indexes the feed shaft. | 07-29-2010 |
| 20110024394 | BORE WELDING DEVICE WITH WORM DRIVE AND ADJUSTABLE CLAMPING SPINDLE - A bore welding mechanism comprising a casing having spindle bushings rotationally and axially supporting a rotatable and axially translatable spindle for supporting a bore repair mechanism in alignment with a bore. The spindle has an axially extending keyway and a worm gear thread extending for at least a part of a length of the spindle. A spindle drive gear is coupled to the spindle by a drive key engaging with the keyway of the spindle so that the spindle is rotationally fixed to the spindle drive gear and axially translatable with respect to the spindle drive gear. A drive shaft extends through the casing, transversely to and offset from an axis of the spindle, and includes a drive shaft worm gear rotationally fixed to the drive shaft. The worm gear engages with the spindle drive gear to rotate the spindle drive gear and the spindle due to rotation of the drive shaft. | 02-03-2011 |
