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| 20090306521 | NONINVASIVE MEASUREMENT OF CAROTENOIDS IN BIOLOGICAL TISSUE - A method and apparatus are provided for the determination of carotenoid antioxidants and similar chemical compounds in biological tissue such as living skin. The method and apparatus provide a noninvasive, rapid, accurate, and safe determination of carotenoid levels which in turn can provide diagnostic information of the antioxidant status of tissue. Reflection spectroscopy is used to measure the concentrations of carotenoids and similar substances in tissue. White light is directed upon the area of tissue that is of interest. A small fraction of diffusively scattered light is collected and measured. The tissue is pressured to temporarily squeeze blood out of the measured tissue volume while the reflection spectrum is continuously monitored, displayed, and analyzed in near real time. After an optimal time period of typically 15 seconds, the influence of the dominating hemoglobin and oxyhemoglobin tissue absorptions on the reflection spectra are minimized. | 12-10-2009 |
| 20100179435 | NONINVASIVE MEASUREMENT OF FLAVONOID COMPOUNDS IN BIOLOGICAL TISSUE - Methods and apparatus are disclosed which facilitate the rapid, noninvasive and quantitative measurement of the concentration of flavonoid compounds, as well as their isomers and metabolites, in biological tissue such as human skin. Low-intensity, visible-light illumination of intact tissue provides for high spatial resolution, and allows for precise quantification of the flavonoid levels in the tissue. The preferred embodiments malce use of a previously unknown, low-oscillator strength, optical absorption transition of flavonoids. This malces it possible to optically excite flavonoids in living human tissue outside the absorption range of other, potentially confounding skin chromophores. A system constructed in accordance with the invention includes a source of light for illuminating a localized region of tissue with light that overlaps the absorption bands of a flavonoid compound; a device for detecting the fluorescence emitted by the flavonoid compound resulting from the illumination; and a processor for determining the concentration level of the flavonoid compound based upon the detected fluorescence. | 07-15-2010 |
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| 20080269076 | Multiple Capillary Device and Method for Synthesis and Dispensing - A system and method for synthesizing a peptide, a nucleic acid sequence, an oligonucleotide, a DNA sequence, an RNA sequence, or the like, inside an array of capillary tubes, is provided. The system can comprise an array of capillary tubes. Each of the capillary tubes in the array of capillary tubes can comprise a first end, a second end, an inner wall, and a sequence linker bonded to the inner wall. The system can comprise a pressure control source that can be in fluid communication with each of the first ends of the array of capillary tubes. The system can comprise a reagent container support, wherein the second end of each of the capillary tubes can be adapted to move towards and/or away from the reagent container support. | 10-30-2008 |
| 20100200094 | SURFACE TENSION CONTROLLED VALVES - The present teachings relate to surface tension controlled valves used for handling biological fluids. The valves controlled by optically actuating an electro-wetting circuit. | 08-12-2010 |
| 20110020179 | Systems and Methods for Multiple Analyte Detection - Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials. | 01-27-2011 |
| 20110124524 | Fluid Processing Device for Oligonucleotide Synthesis and Analysis - The present teachings provide a fluid processing device adapted to produce different oligomers in a plurality of respective reaction sites. The fluid processing device can comprise a first manifold for delivering reactants to the plurality of reaction sites, and a second manifold for removing waste from, and optionally delivering wash fluid to, the plurality of reaction sites. Surface tension control valves can be disposed in fluid communication with the first manifold and can selectively allow reactants and/or fluids into the reaction sites. A method of making oligonucleotides is also provided. | 05-26-2011 |
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| 20090280497 | Multiplex Detection Compositions, Methods, and Kits - The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in a sample, the methods employing employ single molecule detection techniques to individually detect at least one molecular complex or at least part of a molecular complex. | 11-12-2009 |
| 20100105886 | COMPOSITIONS, METHODS, AND KITS FOR FABRICATING CODED MOLECULAR TAGS - The present teachings generally relate to probes and probes sets for detecting analytes. The teachings also relates to compositions, methods, and kits for assembling probes comprising at least one coded molecular tag. | 04-29-2010 |
| 20100112572 | COMPOSITIONS, METHODS, AND KITS FOR FABRICATING CODED MOLECULAR TAGS - The teachings herein generally relates to probes comprising fabricated coded molecular tags for detecting analytes. The teachings also relate to compositions, methods, and kits for fabricating coded molecular tags comprising a multiplicity or reporter groups in an ordered pattern. | 05-06-2010 |
