Patent application number | Description | Published |
20140072973 | LMNA GENE AND ITS INVOLVEMENT IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS) AND ARTERIOSCLEROSIS - Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described. Oligonucleotides and other compounds for use in examples of the described methods are also provided, as are protein-specific binding agents, such as antibodies, that bind specifically to at least one epitope of a Lamin A variant protein preferentially compared to wildtype Lamin A, and methods of using such antibodies in diagnosis, treatment, and screening. Also provided are kits for carrying out the methods described herein. | 03-13-2014 |
20160002307 | LMNA GENE AND ITS INVOLVEMENT IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS) AND ARTERIOSCLEROSIS - Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), methods of treating such conditions, methods of selecting treatments, methods of screening for compounds that influence Lamin A activity, and methods of influencing the expression of LMNA or LMNA variants are also described. Oligonucleotides and other compounds for use in examples of the described methods are also provided, as are protein-specific binding agents, such as antibodies, that bind specifically to at least one epitope of a Lamin A variant protein preferentially compared to wildtype Lamin A, and methods of using such antibodies in diagnosis, treatment, and screening. Also provided are kits for carrying out the methods described herein. | 01-07-2016 |
Patent application number | Description | Published |
20130192021 | BRUSHROLL CLEANING FEATURE WITH RESILIENT LINKAGE TO REGULATE USER-APPLIED FORCE - A cleaning device agitator system having an agitator and one or more cleaning members. The agitator has first and second ends, a longitudinal axis and one or more agitating devices. One or more friction surfaces may project from the spindle. The cleaning members are adjacent the agitator and adapted to move between a first position and a second position. In at least the second position, the cleaning members engage the agitator, such as by engaging the friction surfaces, to remove debris. Agitator and cleaning members may be incorporated into a cleaning head having an inlet nozzle and a chamber in which the agitator rotates, and there may be an activation mechanism using, for example, a resilient member to move the cleaning members. An overload protection device may be provided, and may adjust its sensitivity depending on whether the cleaning devices are in the first or second position. | 08-01-2013 |
20130192022 | BRUSHROLL CLEANING FEATURE WITH SPACED BRUSHES AND FRICTION SURFACES TO PREVENT CONTACT - A cleaning device agitator system having an agitator and one or more cleaning members. The agitator has first and second ends, a longitudinal axis and one or more agitating devices. One or more friction surfaces may project from the spindle. The cleaning members are adjacent the agitator and adapted to move between a first position and a second position. In at least the second position, the cleaning members engage the agitator, such as by engaging the friction surfaces, to remove debris. Agitator and cleaning members may be incorporated into a cleaning head having an inlet nozzle and a chamber in which the agitator rotates, and there may be an activation mechanism using, for example, a resilient member to move the cleaning members. An overload protection device may be provided, and may adjust its sensitivity depending on whether the cleaning devices are in the first or second position. | 08-01-2013 |
20130192023 | AUTOMATED BRUSHROLL CLEANING - A cleaning device agitator system having an agitator and one or more cleaning members. The agitator has first and second ends, a longitudinal axis and one or more agitating devices. One or more friction surfaces may project from the spindle. The cleaning members are adjacent the agitator and adapted to move between a first position and a second position. In at least the second position, the cleaning members engage the agitator, such as by engaging the friction surfaces, to remove debris. Agitator and cleaning members may be incorporated into a cleaning head having an inlet nozzle and a chamber in which the agitator rotates, and there may be an activation mechanism using, for example, a resilient member to move the cleaning members. An overload protection device may be provided, and may adjust its sensitivity depending on whether the cleaning devices are in the first or second position. | 08-01-2013 |
20130192024 | BRUSHROLL CLEANING FEATURE WITH OVERLOAD PROTECTION DURING CLEANING - A cleaning device agitator system having an agitator and one or more cleaning members. The agitator has first and second ends, a longitudinal axis and one or more agitating devices. One or more friction surfaces may project from the spindle. The cleaning members are adjacent the agitator and adapted to move between a first position and a second position. In at least the second position, the cleaning members engage the agitator, such as by engaging the friction surfaces, to remove debris. Agitator and cleaning members may be incorporated into a cleaning head having an inlet nozzle and a chamber in which the agitator rotates, and there may be an activation mechanism using, for example, a resilient member to move the cleaning members. An overload protection device may be provided, and may adjust its sensitivity depending on whether the cleaning devices are in the first or second position. | 08-01-2013 |
20130198995 | VACUUM CLEANER AGITATOR CLEANER WITH POWER CONTROL - A vacuum cleaner agitator system having an agitator, an electric motor to rotate the agitator, a power source, and an agitator cleaner. The cleaner moves between a first position in which it is spaced from the agitator and a second position in which it engages the agitator to remove debris while the agitator rotates. The system also has a detector configured to indicate when the cleaner is in the second position. A drive control system connects the electric motor, electric power source, and agitator cleaning detector. The drive control system has a first drive mode to drive the electric motor at a first power level, and a second drive mode, activated upon receiving an indication from the detector that the cleaner is in the second position, to drive the electric motor at a second power level that is greater than the first power level. | 08-08-2013 |
20140304941 | CLEANING NOZZLE FOR A VACUUM CLEANER - A vacuum cleaner nozzle having a rotatable member arranged around a longitudinal axis for picking up particles from a surface to be cleaned, and a cleaning arrangement for removing articles entangled on the rotatable member. The cleaning arrangement has at least one support surface provided on at least one radially projecting member, and at least one cleaning member movable between a resting position in which the cleaning member is arranged at a distance from the support surface and at least one cleaning position In the vicinity of the rotatable member. In cleaning position, the cleaning member, during rotation of the rotatable member, co-operates with at least one segment of the support surface to remove entangled articles from the rotatable member. The cleaning member includes a resilient sheet member capable of providing resilient contact with a segment of the support surface in the cleaning position during rotation of the rotatable member. | 10-16-2014 |
20140331446 | CLEANING NOZZLE FOR A VACUUM CLEANER - A vacuum cleaner nozzle having a rotatable member arranged around a longitudinal axis for picking up particles from a surface to be cleaned, and a cleaning arrangement for removing articles entangled on the rotatable member. The cleaning arrangement has at least one support surface provided on at least one radially projecting member of the rotatable member, and at least one cleaning member movable between a resting position in which the cleaning member is arranged at a distance from the support surface and at least one cleaning position in the vicinity of the rotatable member. In the cleaning position, the cleaning member co-operates with at least one segment of the support surface to remove any entangled articles from the rotatable member as the rotatable member rotates. The at least one support surface comprises a number of segments arranged at an individual respective radius in relation to the longitudinal axis. | 11-13-2014 |
20140352104 | VACUUM CLEANER BRUSHROLL CLEANER CONFIGURATION - A vacuum cleaner head with a housing having a front end, a back end, a lower surface extending from the front end to the back end, and a suction opening through the lower surface. An agitator chamber is the suction opening, and a suction passage extends from the agitator chamber towards the back end. An agitator having a spindle and agitating devices is rotatably mounted to the housing. A cleaning member is movably mounted to the housing to move between a first position in which it does not engage the agitator, and a second position in which it engages the agitator to remove debris from the agitator during rotation of the agitator. A pedal extends from the back end of the housing and moves between a first pedal and a second pedal position to place the cleaning member in the second cleaning member position. | 12-04-2014 |
20140359968 | ACTUATOR MECHANISM FOR A BRUSHROLL CLEANER - A vacuum cleaner head having a housing, supports extending downward from the housing to a support point, a suction opening, an agitator chamber above and in fluid communication with the suction opening, an agitator with a spindle rotatably mounted to the housing and one or more agitating devices projecting from the spindle, a cleaning member movably mounted to the housing to move to a position where it engages the agitator to remove debris from the agitator during rotation of the agitator, and a pedal connected to the housing and movable to a position to place the cleaning member in the cleaning position. The pedal has an activation surface configured to receive an activation force from an operator, and the activation surface is configured such that application of the activation force on the pedal generates a moment force to bias the agitator away from the downward direction. | 12-11-2014 |
20140366300 | CLEANING ARRANGEMENT FOR A NOZZLE OF A VACUUM CLEANER - The present invention relates to a cleaning arrangement for a nozzle of a vacuum cleaner. The cleaning arrangement comprises a socket for receiving the vacuum cleaner nozzle and a cleaning member arranged in the socket for removing articles entangled to a rotatable member of the vacuum cleaner nozzle during rotation of the rotatable member. | 12-18-2014 |
20150208888 | CLEANING NOZZLE FOR A VACUUM CLEANER - A vacuum cleaner nozzle having a rotatable member arranged around a longitudinal axis for picking up particles from a surface to be cleaned, and a cleaning arrangement for removing articles entangled on the rotatable member. The nozzle includes a nozzle cover that at least partly is made of transparent material such that the rotatable member may be visible through the nozzle cover. | 07-30-2015 |
20150230676 | CLEANING NOZZLE FOR A VACUUM CLEANER - A vacuum cleaner nozzle having a rotatable member for picking up particles from a surface, and a cleaning arrangement for removing articles entangled to the rotatable member. The rotatable member rotates around a longitudinal axis. The cleaning arrangement has at least one support surface provided on a radially projecting member, and at least one cleaning member movable between a resting position in which the cleaning member is arranged at a distance from the support surface and a cleaning position in the vicinity of the rotatable member. In the cleaning position, the cleaning member cooperates with the support surface to remove entangled articles from the rotatable member during rotation of the rotatable member. The cleaning member includes a resilient sheet member capable of providing resilient contact with at least one segment of the at least one support surface in the cleaning position during rotation of the rotatable member. | 08-20-2015 |
Patent application number | Description | Published |
20110019578 | METHOD AND ARRANGEMENT FOR THE POWER MANAGEMENT OF A DIGITAL COMMUNICATION LINE - The present invention relates to a method and an arrangement for the power management of a digital communication line such as a digital subscriber line DSL. A problem addressed by the invention is that the transitioning of the digital subscriber line from a low transmission power state to a high transmission power state can cause disturbance to adjacent lines. This problem is solved by the current invention by an access node AN that is arranged to step-wise increase the power state until the high transmission power state has been reached. The invention also comprises embodiments of monitoring and detecting traffic events that serve as triggers of the transitioning. | 01-27-2011 |
20110293271 | SYSTEMS AND METHODS FOR ENABLING DIFFERENT NETWORK NODES OF A NETWORK ACESS SYSTEM TO SHARE A BACKHAUL COMMUNICATIONS LINK - Systems and methods for enabling different network nodes of a network access system to share a backhaul communication link are disclosed. In one embodiment, the method includes: connecting a first modem to a first node of the network access system; connecting a second modem to a second node of the network access system; connecting the first modem to a first port of a splitter filter; connecting the second modem to a second port of the splitter filter; and connecting a backhaul communication link to a third port of the splitter filter, which is configured to multiplex signals transmitted by the modems onto the backhaul communication link, wherein the frequency spectrum of the signal transmitted by the first modem does not overlap substantially with the frequency spectrum of the signal transmitted by the second modem. | 12-01-2011 |
20120020668 | Method And An Interconnecting Node For Use In An Access Network - The invention relates to an interconnecting node for use in interconnecting a passive optical network (PON) and a copper wire xDSL access network, wherein said interconnecting node comprises an optical network unit (ONU) arranged to be connected to an optical line termination (OLT) over the PON network; and at least one xDSL access device connectable to at least one user end xDSL equipment over the copper wire xDSL access network. The interconnecting node is characterized in thatit further comprises a clocking interconnect between the ONU unit and the at least one xDSL access device arranged to distribute a clock signal obtained from optical network transmissions received in the ONU unit over the PON network to an timing reference input of the at least one xDSL access device. The invention also relates to a further interconnecting node, methods for use in interconnecting nodes, a central office optical network apparatus and an access network. | 01-26-2012 |
20120183026 | Crosstalk Limitation between Modems - A device for providing access to a data communication network for modems is connected to the modems via a set of communication lines. The modems include a first group supporting vectoring and a second group not supporting vectoring. The device investigates the expected value of an element in a synchronization interval to be received by a modem in the second group, investigates the value of an element of at least one data sequence assigned to the communication line of this modem, compares the values, selects the element of the investigated data sequence for transmission if the element value corresponds to the expected value and transmits the selected element and corresponding elements of a number of pilot sequences assigned to the first group of modems via the set of communication lines. | 07-19-2012 |
20120320959 | METHOD AND ARRANGEMENT IN A DSL VECTORING SYSTEM - Method and arrangement in a Vectoring Control Entity, VCE, for handling disorderly events in a Digital Subscriber Line, DSL, system. The method involves a number of actions, to be performed when a disorderly event occurs on a line min a vectored group of DSL lines, and the transmission on line m is continued. The method comprises obtaining( | 12-20-2012 |
20130136254 | Method In A Communication System - Method and arrangement in a Vector Control Entity for efficient selection of which crosstalk to cancel when applying partial vectoring in a DSL communication system. The method comprises calculating a respective crosstalk effect indicator, CEI | 05-30-2013 |
20130142319 | Method In A Communication System - A method and arrangement are disclosed in a Vector Control Entity for enabling a fair bit rate distribution among lines of similar priority in a vectoring group, when applying partial vectoring in a DSL communication system. The method comprises calculating a rate balancing metric, RBM, for each line i within a priority group A, indicative of the ratio between the bit rate of a line i with a current vectoring resource allocation, and the estimated bit rate of line i assuming approximately no crosstalk within the vectoring group. The method further comprises allocating partial-vectoring resources to the line/s within the group A, based on the calculated RBMs, such as to reduce the difference in RBM between the lines. The method further comprises calculating an updated RBM for any line within the group A subjected to changes in vectoring resource allocation. The method may be iterated until certain criteria are fulfilled. The arrangement is adapted to enable the performance of the above described method. | 06-06-2013 |
20130145041 | Optimizing Timing Packet Transport - The invention relates to networking in general and in particular to an improved packet timing transport mechanism. The present invention provides a method of optimizing timing packet transport in a network comprising a first network node connected to a second network node. The method comprises forwarding a timing packet received at the first network node to the second network node, and transmitting the timing packet from the second network node a pre-determined duration K after receiving the timing packet at the first network node. | 06-06-2013 |
20130272110 | Method for Handling Transmission Errors On a Telecommunications Transmission Line - When data retransmission is used to handle errors caused by impulse noise, buffer memory requirements may be reduced and/or data rate increased by detecting impulse noise at the transmitting equipment and initiating retransmission in response to such detection rather than waiting for a retransmission indication from the receiving end. The decision to retransmit may be made dependent on the strength or other properties of the detected noise burst. The decision criterion may be made adaptive by correlating noise burst properties with received retransmission indications or the absence thereof. | 10-17-2013 |
20140036684 | METHOD AND ARRANGEMENT FOR THE POWER MANAGEMENT OF A DIGITAL COMMUNICATION LINE - The present invention relates to a method and an arrangement for the power management of a digital communication line such as a digital subscriber line DSL ( | 02-06-2014 |
20140161163 | METHOD AND ARRANGEMENT IN A DSL VECTORING SYSTEM - Method and arrangement in a Vectoring Control Entity, VCE, for handling disorderly events in a Digital Subscriber Line, DSL, system. The method involves a number of actions, to be performed when a disorderly event occurs on a line m in a vectored group of DSL lines, and the transmission on line m is continued. The method comprises obtaining error samples from Customer Premises Equipments, CPEs, connected to other lines in the vectored group of DSL lines. The method further comprises—calculating an estimate of the channel coefficients changed due to the disorderly event, based on the error samples, thus providing a partial channel estimate. Further, the method comprises—modifying a downstream precoder, at least partly based on the partial channel estimate, such that retraining of the other lines in the vectored group due to the disorderly event is avoided. | 06-12-2014 |
20140169489 | Method for Saving Power in a Telecommunications System - In a vectoring-capable DSL system, power can be saved by a low power mode wherein data transmission is reduced or halted, but synch symbols continue to be transmitted, so that estimation of crosstalk coefficients may continue during the low power mode. When crosstalk coefficient estimates are up to date, a line may exit low power mode without causing problematic changes of crosstalk noise in other lines, since the vectoring functionality will eliminate or reduce the crosstalk. | 06-19-2014 |
20140219074 | Adjusted Transmission in XDSL - Method and transmitting node for adjusting transmission over xDSL lines connected to the transmitting node. The method involves transmitting ( | 08-07-2014 |
20140240194 | SMALL-CELL ANTENNA ARRANGEMENT - The present invention relates to a small-cell antenna arrangement. The antenna arrangement comprises an antenna mounting unit and an active antenna element. The antenna mounting unit is arranged with fastening means from which the active antenna element is detachable. Further, the antenna mounting unit is arranged with a signalling interface via which signals are arranged to be transferred between the active antenna element and a remotely located base station with which the antenna arrangement communicates. Moreover, the antenna mounting unit is arranged with an interface via which the active antenna element is powered. | 08-28-2014 |
20140269245 | METHOD AND SYSTEM FOR INITIATING BI-DIRECTIONAL COMMUNICATION IN A TIME-DIVISION DUPLEX COMMUNICATION SYSTEM - The present invention relates to a method and a system for initiating bi-directional communication in a time-division duplex (TDD) communication system between a customer premises equipment (CPE) modem, such as a DSL modem, and an operator modem, such as a DSLAM. The invention is characterized in that the transmission of the CPE modem is aligned with the time-division duplex timing structure present in received crosstalk noise when transmitting initiation signals, so-called handshake tones. | 09-18-2014 |
20140307763 | Single Ended Line Test Methods for Time Duplex Division Devices - The present disclosure relates to a Time Duplex Division (TDD) modem and a method in such a modem for making Single Ended Line Test (SELT) measurements. The device comprises a transmitter and a receiver and it has a normal mode of TDD communication. In these devices, Time Domain Reflectometry (TDR) is used as line measurement. It has a number of drawbacks, and for overcoming said drawbacks, Frequency Domain Reflectometry (FDR) measurement techniques adapted for TDD devices are suggested. | 10-16-2014 |
20150155913 | METHOD AND ARRANGEMENT IN A DSL VECTORING SYSTEM - Method and arrangement in a Vectoring Control Entity, VCE, for handling disorderly events in a Digital Subscriber Line, DSL, system. The method involves a number of actions, to be performed when a disorderly event occurs on line m in a vectored group of DSL lines, and the transmission on line m is continued. The method comprises obtaining error samples from Customer Premises Equipments, CPEs, connected to other lines in the vectored group of DSL lines. The method further comprises—calculating an estimate of the channel coefficients changed due to the disorderly event, based on the error samples, thus providing a partial channel estimate. Further, the method comprises—modifying a downstream precoder, at least partly based on the partial channel estimate, such that retraining the other lines in the vectored group due to the disorderly event is avoided. | 06-04-2015 |
20150256453 | METHODS AND APPARATUSES FOR HANDLING COMMUNICATION IN A COMMUNICATION SYSTEM COMPRISING AN ACCESS POINT AND A WIRE LINE NETWORK NODE CONNECTED VIA WIRE LINE TO THE ACCESS POINT - A method is provided performed by an access point for handling uplink communication in a communication system comprising the access point and a wire line network node connected via wire line to the access point. The method comprises receiving an encrypted and/or integrity protected packet data unit, PDU, from a user equipment (UE) wirelessly connected to the access point and detecting type of the received PDU, the type of PDU being any of a signaling radio bearer type or a data radio bearer type. The method further comprises encapsulating the received PDU by setting a header to the PDU, which header comprises an identity indicating the detected type of PDU and an identity indicating a source address and/or a destination address of the PDU, and sending the encapsulated PDU to the wire line network node. Provided is also a corresponding method performed in the wire line network node. | 09-10-2015 |
20150296344 | DETERMINING POSITION OF A WIRELESS DEVICE USING REMOTE RADIO HEAD DEVICES - It is presented a method for assisting the determining of a position of a wireless device, the method being performed in a network node connected to a plurality of remote radio head devices via a combiner. The method comprises the steps of: receiving an uplink signal via the combiner; comparing a carrier frequency of the uplink signal with a set of manipulation schemes for a carrier frequency of uplink signals, wherein the manipulation schemes are different for at least some of the plurality of remote radio head devices; and providing a proximity indication that the position of the wireless device is in the vicinity of a remote radio head device the frequency manipulation scheme of which best matches the uplink signal. A corresponding network node, computer program, and computer program product are also presented. | 10-15-2015 |
20150327140 | METHOD AND APPARATUS RELATED TO WIRE LINE BACKHAUL - Presented are methods and arrangements for adapting the load in a cell based on information on upcoming events related to a backhaul link. The upcoming events related to the backhaul link may be delayed in order to give enough time for an RBS to complete activities related to the load adaptation. Thus, UEs may be handed over to neighboring cells proactively, before the cell becomes overloaded due to events related to the backhaul link. | 11-12-2015 |
20150341487 | Mitigation of Disconnect Events in Vectoring Based DSL Systems - There is provided mitigation of disconnect events in a vectoring based digital subscriber line, DSL, system. A method performed by a digital subscriber line access multiplexer,DSLAM, comprises detecting a loss of signal or disconnect event of a line in a vectored group of DSL lines,the loss of signal or disconnect event causing a negative impact on the DSL system. The method further comprises detecting a change in at least one downstream, DS, crosstalk coefficient of at least one line in said vectored group of DSL lines. The method further comprises determining a magnitude of said change. The method further comprises determining where the loss of signal or disconnect event has occurred by processing precoding coefficients of the vectored group of DSL lines. The method further comprises determining,on basis of the determined magnitude and where the loss of signal or disconnect event has occurred, an action to be performed by the DSLAM so as to mitigate for said negative impact. | 11-26-2015 |
20150349938 | BANDWIDTH ASSIGNMENT FOR MULTI-LINE TDD SYSTEMS - Transceiver node and method therein for enabling dynamic bandwidth assignment in bi-directional Time Division Duplexing (TDD) multicarrier communication over wire lines. The transceiver node is operable to be coupled to a plurality of loops, wherein each loop is terminated by a respective network terminal (NT). The method comprises collecting traffic reports from local and remote queues associated with uplink and downlink traffic on the plurality of loops, and determining an actual demand for upstream and downstream bandwidth, respectively, for each of the plurality of loops, based on the collected traffic reports. The method further comprises deriving an Upstream/Downstream (US/DS) frame partitioning based on the determined actual demand for upstream and downstream bandwidth, and providing an indication of the derived US/DS frame partitioning to the NTs. NTs are then scheduled in accordance with the derived partitioning. | 12-03-2015 |