| Patent application number | Description | Published |
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| 20090017035 | HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4 - An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The human anti-hDll4 antibody or antibody fragment binds hDll4 with an affinity of 300 pM or better, as measured by surface plasmon resonance. | 01-15-2009 |
| 20090142354 | HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4 - An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The human anti-hDll4 antibody or antibody fragment binds dimeric hDll4 with an affinity of 75 pM or better, as measured by surface plasmon resonance. | 06-04-2009 |
| 20090246199 | THERAPEUTIC METHODS FOR INHIBITING TUMOR GROWTH WITH DLL4 ANTAGONISTS - Disclosed is a therapeutic method for inhibiting development or growth of tumors that are resistant to the blockade of delta-like ligand 4 (Dll4), or vascular endothelial growth factor (VEGF), or to other therapeutic agents, by administering the combination of Dll4 antagonist and VEGF antagonist. The combined administration of these two agents, concurrently or sequentially, exhibits synergistic effects on blood vessel development and growth, thereby more effectively inhibiting the tumor growth than an administration of either agent alone. The Dll4 antagonist can be an anti-Dll4 antibody or antibody fragment capable of inhibiting the binding of Dll4 to a Notch receptor, or a fusion protein comprising the extracellular domain of Dll4 or a soluble Notch receptor, or a fragment thereof, fused to a multimerizing component. The VEGF antagonist can be a VEGF trap, anti-VEGF antibody or antibody fragment capable of inhibiting the binding of VEGF to a VEGF receptor. | 10-01-2009 |
| 20100316627 | Human antibodies to human IL-6 receptor - A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K | 12-16-2010 |
| 20100316636 | Method of Treating Rheumatoid Arthritis with an IL-6R Antibody - The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof. | 12-16-2010 |
| 20100331527 | Readily Isolated Bispecific Antibodies with Native Immunoglobulin Format - A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A. | 12-30-2010 |
| 20110150905 | HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4 - The present invention provides methods of treating, ameliorating, or inhibiting tumor growth, cancer, or pathological angiogenesis by administering to a subject in need thereof a human antibody or fragment thereof that specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The anti-hDll4 antibody or fragment thereof of the present invention have a high affinity with the K | 06-23-2011 |
| 20120003697 | HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR - A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K | 01-05-2012 |
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| 20080246460 | Method and apparatus for measuring the output current of a switching regulator - One embodiment of the present invention provides an apparatus that measures the average-output-current produced by a switching regulator within an electronic device. The apparatus includes current-sensing-circuitry coupled to a switching field-effect-transistor (FET) within the switching regulator, wherein the current-sensing-circuitry is configured to bypass a small sense current from the conducting current of the switching-FET according to a sense ratio, wherein the conducting current is controlled by a control signal for the switching regulator. The apparatus also includes a current-to-voltage-converter coupled to the current-sensing-circuitry which is configured to convert the sense current into a sense voltage. The apparatus further includes voltage-averaging-circuitry which is configured to produce an average-sense-voltage from the sense voltage. This sense voltage is coupled to the input of the voltage-average-circuitry through a switch, which is gated by the control signal. The average-output-current of the switching regulator is indicated by the average-sense-voltage. | 10-09-2008 |
| 20100020004 | LED BACKLIGHT DRIVER SYNCHRONIZATION AND POWER REDUCTION - A method and apparatus for providing a LED backlight to a LCD display screen is disclosed. In one embodiment, the apparatus includes: N LED strings, wherein N is an integer greater than or equal to two; a first circuit operable to synchronize a LED clock signal to a LCD timing signal; and a second circuit operable to generate N PWM drive signals synchronized with the LED clock signal, wherein the N PWM drive signals are phase offset from each other by a multiple of 360/N degrees and used to drive respective ones of the N LED strings. | 01-28-2010 |
| 20110208980 | METHODS AND APPARATUS FOR INTELLIGENTLY PROVIDING POWER TO A DEVICE - Methods and apparatus for intelligently powering an electronic device. In one embodiment of the invention, a systems management controller controls a power interface to intelligently negotiate power distribution with a peer, client, or a host device. The primary data path is unaffected by the system management controller communications. Various aspects of the present invention are demonstrated with respect to an exemplary implementation of a unified interface, consisting of an optical link (data path) and a USB link (power). As described, one exemplary embodiment of the invention provides a device with power at levels which are much increased over prior art USB solutions. | 08-25-2011 |
