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Epstein, CA

Alan Epstein, La Canada, CA US

Patent application numberDescriptionPublished
20110002920COMBINATION CANCER IMMUNOTHERAPY WITH CO-STIMULATORY MOLECULES - Provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer by administering an effective amount of a soluble form of a co-stimulatory molecule from an antigen presenting cell and by reducing the activity of immunoregulatory T cells in the individual. Methods of reduction in the activity of immunoregulatory T cells involve removing them ex vivo or depleting or inactivating them in vivo. Also provided are cancer therapeutic compositions comprising a soluble form of a co-stimulatory molecule from an antigen presenting cell and an antibody specific for an intracellular antigen.01-06-2011
20110002921COMBINATION CANCER IMMUNOTHERAPY WITH CO-STIMULATORY MOLECULES - Provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer by administering an effective amount of a soluble form of a co-stimulatory molecule from an antigen presenting cell and by reducing the activity of immunoregulatory T cells in the individual. Methods of reduction in the activity of immunoregulatory T cells involve removing them ex vivo or depleting or inactivating them in vivo. Also provided are cancer therapeutic compositions comprising a soluble form of a co-stimulatory molecule from an antigen presenting cell and an antibody specific for an intracellular antigen.01-06-2011

Alan L. Epstein, La Canada, CA US

Patent application numberDescriptionPublished
20090274653INTERLEUKIN-2 MUTANTS WITH REDUCED TOXICITY - Interleukin-2 (IL-2) mutants having reduced toxicity, which include full-length IL-2, truncated forms of IL-2 and forms of IL-2 that are linked to another molecule are disclosed herein. Particular substitutions within IL-2, particularly within the permeability enhancing peptide region of IL-2 achieve substantial reduction of vasopermeability activity as compared to a wildytpe form of the mutant IL-2 while retaining many of the immune activating properties of IL-2. Invention IL-2 mutants can be used to stimulate the immune system of an animal and may be used in the treatment of various disorders and conditions.11-05-2009
20110091413THERAPEUTIC USE OF INTERLEUKIN-2 MUTANTS - Interleukin-2 (IL-2) mutants having reduced toxicity, which include full-length IL-2, truncated forms of IL-2 and forms of IL-2 that are linked to another molecule are disclosed herein. Particular substitutions within IL-2, particularly within the permeability enhancing peptide region of IL-2 achieve substantial reduction of vasopermeability activity as compared to a wildytpe form of the mutant IL-2 while retaining many of the immune activating properties of IL-2. Invention IL-2 mutants can be used to stimulate the immune system of an animal and may be used in the treatment of various disorders and conditions.04-21-2011
20120076804CANCER TARGETED INNATE IMMUNITY - Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a CpG oligodeoxynucleotide. Also provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer, comprising administering an effective amount of the cancer therapeutic agent. The methods may also include reducing immunoregulatory T cell activity in the individual.03-29-2012

Patent applications by Alan L. Epstein, La Canada, CA US

Alan L. Epstein, Pasadena, CA US

Patent application numberDescriptionPublished
20120276004HUMAN MYELOID DERIVED SUPPRESSOR CELL CANCER MARKERS - Provided herein are methods for determining the presence of cancer (malignant versus benign), monitoring the progression of cancer, monitoring cancer relapse, monitoring the response to cancer therapy, or cancer staging in a subject, by evaluating CD3311-01-2012

Allen Epstein, Calabasas, CA US

Patent application numberDescriptionPublished
20110300527TEACHING METHOD - Aspects of the present invention include one or more of capturing educational presentations by presenters using instructional aids, making presentations available via the World Wide Web to users of educational services, aiding users in the selection of a particular topic and a particular presenter, rewarding students for achievement, and financially compensating presenters in accordance with the popularity of their educational presentations.12-08-2011

Ethan Epstein, San Diego, CA US

Patent application numberDescriptionPublished
20110275939Ergonomic Sensor Pad with Feedback to User and Method of Use - A portable system is provided for sensing and training a user to maintain correct posture while seated in a chair with a seat portion and a back portion. The system includes a first pad attachable to the seat portion of a chair, said first pad having a front area and a rear area, and a second pad attachable to the back portion of a chair and having a lower area and an upper area. There is a first sensor located in the first pad capable of sensing that a user is seated in the seat portion of the chair, a second sensor located in the first pad capable of sensing whether the lower posterior portion of the user's body is in contact with the rear area of the first pad, a third sensor operably attached to the lower area of the second pad capable of sensing whether the user's lumbar region is in contact with the second pad, a fourth sensor operably attached to the upper area of the second pad capable of sensing the distance between the user's upper back and the upper area of the second pad and a neck-position sensor operably attached to the second pad and capable of sensing the distance between the neck-position sensor and the user's neck. The system also includes a microprocessor operably connected to the first sensor, second sensor, third sensor, fourth sensor and neck-position sensor and capable of collecting data from each of the first sensor, second sensor, third sensor, fourth sensor and neck position sensor. The system also includes software for a personal computer, which configures the personal computer to receive the data from the microprocessor and to display the data received from the microprocessor, so that the user can utilize the ergonomic seat pad to receive feedback regarding his posture and over time, improve his posture.11-10-2011

Evan David Epstein, Costa Mesa, CA US

Patent application numberDescriptionPublished
20120245674VASCULAR REMODELING DEVICE - A vascular remodeling device is provided. The device includes an anchor portion, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. The device also includes a distal portion that is sized for deployment in a blood vessel. The distal portion is radially expandable from a collapsed state to an expanded state and, in some embodiments, has a distal face that is sufficiently occlusive in the distal-to-proximal direction to perform a therapeutic blocking function at an aneurysm. Some embodiments have an intermediate portion that connects a distal end of the anchor portion and a proximal end of the distal portion, and in some embodiments, the anchor portion and distal portion are able to pivot relative to each other at or near the intermediate portion.09-27-2012
20120245675VASCULAR REMODELING DEVICE - A vascular remodeling device is provided. The device has an anchor portion, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. The device also includes a distal portion sized for deployment in a blood vessel. The distal portion is radially expandable from a collapsed state to an expanded state and has a distal face that is sufficiently occlusive in the distal-to-proximal direction to perform a therapeutic blocking function in an aneurysm neck. The device also has an intermediate portion that interconnects a distal end of the anchor portion and a proximal end of the distal portion. In some embodiments, the anchor portion and/or distal portion has a plurality of interconnected struts.09-27-2012

Gordon Epstein, Livermore, CA US

Patent application numberDescriptionPublished
20110230874ABLATION METHOD - A method of ablating a uterine fibroid using a particular trocar is disclosed. The trocar comprises a plurality of ablation stylets mounted for movement from within the trocar to positions extending from the trocar. The trocar is adjustable to assume a plurality of configurations, each of the configurations having the stylets extended to a different extent from the trocar. A region to be ablated is imaged. The region may correspond to all or a portion of a uterine fibroid. The size of the region to be ablated is noted. The size of the region to be ablated is compared to a matrix of known ablation regions, each of the known ablation regions being associated with one of the configurations of the particular trocar, and each of the known ablation regions being associated with a position of the trocar relative to the known ablation region. The region to be ablated is associated with a most nearly matching known ablation region by comparison of the region to be ablated to the known ablation regions. A trocar of the design of the particular trocar is inserted into the uterine fibroid at a position, with respect to the region to be ablated, which more closely matches the position of the particular trocar with respect to the known ablation region. The stylets are deployed from the trocar to an extent corresponding to the configuration associated with the most nearly matching known ablation region.09-22-2011
20120245575USER INTERFACE AND NAVIGATIONAL TOOL FOR REMOTE CONTROL OF AN ANCHORED RF ABLATION DEVICE FOR DESTRUCTION OF TISSUE MASSES - The invention provides a system and method for a practitioner to interact remotely with a radiofrequency ablation device via a graphical user interface (GUI) which displays a hierarchical system of menu and submenu choices prior to and during a surgical procedure to ablate and coagulate a tissue mass such as a fibroid tumor without breaking the sterile field of the surgical procedure. The inventive system comprises an ablation device, a computer software program, a GUI, a navigational tool for scrolling and selecting through a series of menu and submenu choices by the practitioner displayed on the GUI, and a foot pedal used by the practitioner for operating the ablation device to ablate and coagulate a tissue mass of a patient. The menus and submenus allow for entry of patient data as well as for the control of certain parameters and operation of the ablation device.09-27-2012
20120245576MERGED IMAGE USER INTERFACE AND NAVIGATIONAL TOOL FOR REMOTE CONTROL OF SURGICAL DEVICES - The invention provides a system for remote control of a surgical device, comprising a first imaging device of a first type having a first image output. The first imaging device is positioned to image an area being subject to surgery. A second imaging device of a second type has a second image output. The second imaging device is positioned to image the area being subjected to surgery. A computer is coupled to receive the first and second image outputs and merge the first and second image outputs into a unitary image output representing a unitary image. Software, resident in the computer generates a graphic user interface including a menu and submenu items. A surgical device is coupled to the computer. Software, resident in said computer, receives and displays information received from the surgical device and/or controls the operation of the surgical device. A display as coupled to the computer for displaying the graphic user interface and the unitary image.09-27-2012

Gordon Epstein, Palo Alto, CA US

Patent application numberDescriptionPublished
20090221998ANCHORED RF ABLATION DEVICE FOR THE DESTRUCTION OF TISSUE MASSES - An anchoring member which comprises a support structure and at least one anchor secured to the anchoring member is disclosed. An anchor deflection member is disposed generally externally to and at least partially surrounding and extending along the perimeter of the anchoring member. The anchor deflection member supports the anchoring member for sliding longitudinal movement in directions which result in advancement and retraction of a point on the anchor. The anchor deflection member defines a guide surface positioned on the inside of the anchor deflection member. The guide surface extends longitudinally, and it is configured and dimensioned to slidingly guide the cylindrical anchoring member. A deflection lip is positioned relatively inwardly with respect to the guide surface. The deflection lip is positioned to outwardly deflect the point of the anchor as the anchor is advanced from a position removed from the deflection lip toward the deflection lip into contact with the deflection lip and beyond the deflection lip.09-03-2009

Gordon Epstein, Pleasanton, CA US

Patent application numberDescriptionPublished
20090138011INTERMITTENT ABLATION RF DRIVING FOR MODERATING RETURN ELECTRODE TEMPERATURE - An ablation system comprising a source of electrical ablation energy having first second and third power outputs it is disclosed. A first conductor is coupled to the first power output on the source of electrical energy. A second conductor is coupled to the second power output on the source of electrical energy, the source of electrical energy creates a first output ablation voltage between the first and second power outputs. The first output ablation voltage varies between a first higher average value during a first period of time and a first lower average value for a second period of time. The first lower average value is greater than or equal to zero. A third conductor is coupled to a third power output on the source of electrical energy. The source of electrical energy creates a second output ablation voltage between the first and third power outputs. The second output ablation voltage varies between a second higher average value during a third period of time and a lower average value for a fourth period of time. The lower average value is greater than or equal to zero. An ablation probe is coupled to the first conductor.05-28-2009
20090187177IMPEDANCE RESPONSIVE ABLATION RF DRIVING FOR MODERATING RETURN ELECTRODE TEMPERATURE - The inventive method for ablating a tissue mass associated with a human or animal patient being treated comprises positioning an ablating electrode in a tissue mass to be ablated. A plurality of return electrodes are positioned on the patient. Electrical energy is applied between the return electrodes and the ablating electrode. The temperature of the return electrodes is measured to generate a temperature measurement signal which is used to control ablation current through the return electrodes.07-23-2009

Gordon Epstein, Pleasant, CA US

Patent application numberDescriptionPublished
20090187182RF ABLATION DEVICE WITH JAM-PREVENTING ELECTRICAL COUPLING MEMBER - The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen within the cannula and a cannula axis. A plurality of conductors contained within the lumen, each of the conductors has a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled at the respective proximal end of the stylet to the distal end of a respective conductor, the stylets comprise a deflectable material, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula. A deflection surface positioned between the trocar point and the proximal end of the cannula, the deflection surface being configured and positioned to deflect, in response to axial movement of the stylets in a direction from the proximate end of the cannula to the distal end of the cannula, at least some of the stylets laterally with respect to the cannula axis in different directions along substantially straight paths, the paths defining an ablation volume.07-23-2009

Gordon Epstein, Fremont, CA US

Patent application numberDescriptionPublished
20080228180Ablation system and heat preventing electrodes therefor - An ablation system comprising a source of electrical ablation energy having first, second and third power outputs it is disclosed. A first conductor is coupled to the first power output on the source of electrical energy. A second conductor is coupled to the second power output on the source of electrical energy, the source of electrical energy creates a first output ablation voltage between the first and second power outputs. The first output ablation voltage varies between a first higher average value during a first period of time and a first lower average value for a second period of time. The first lower average value is greater than or equal to zero. A third conductor is coupled to a third power output on the source of electrical energy. The source of electrical energy creates a second output ablation voltage between the first and third power outputs. The second output ablation voltage varies between a second higher average value during a third period of time and a lower average value for a fourth period of time. The lower average value is greater than or equal to zero. An ablation probe is coupled to the first conductor.09-18-2008
20090187183TEMPERATURE RESPONSIVE ABLATION RF DRIVING FOR MODERATING RETURN ELECTRODE TEMPERATURE - The inventive method for ablating a tissue mass associated with a human or animal patient being treated comprises positioning an ablating electrode in a tissue mass to be ablated. A plurality of return electrodes are positioned on the patient. Electrical energy is applied between the return electrodes and the ablating electrode. The temperature of the return electrodes is measured to generate a temperature measurement signal which is used to control ablation current through the return electrodes.07-23-2009

Gordon E. Epstein, Fremont, CA US

Patent application numberDescriptionPublished
20120165813RADIO FREQUENCY ABLATION DEVICE FOR THE DESTRUCTION OF TISSUE MASSES - The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen within the cannula and a cannula axis. A plurality of conductors contained within the lumen, each of the conductors has a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled at the respective proximal end of the stylet to the distal end of a respective conductor, the stylets comprise a deflectable material, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula.06-28-2012

Joe Epstein, Pleasanton, CA US

Patent application numberDescriptionPublished
20130086550REORGANIZATION OF VIRTUALIZED COMPUTER PROGRAMS - In an embodiment, a data processing method comprises obtaining access to computer program code; identifying a plurality of code segments in the computer program code; reorganizing the computer program code into reorganized code, by re-ordering the plurality of code segments into a new order that is potentially different than an original order of the plurality of code segments; wherein the new order is unpredictable based on the original order; rewriting one or more pointers of the reorganized code to point to new locations in the reorganized code consistent with the order of the reorganized code; wherein the method is performed by one or more computing devices.04-04-2013

Jonathan Epstein, Pt. Richmond, CA US

Patent application numberDescriptionPublished
20110299932DEPLOYABLE OPTICAL FIBER CARTRIDGE - A spool has a cylinder, a first flange coupled to a first end of the cylinder and a second flange coupled to a second end of the cylinder. A compressible material surrounds the cylinder and an optical fiber is wrapped around the compressible material. When tension is applied to the optical fiber the compressible material can be deformed to reduce the tension on the optical fiber. When submerged underwater the water pressure will not compress the compressible material.12-08-2011

Jonathan Epstein, San Francisco, CA US

Patent application numberDescriptionPublished
20120327125SYSTEM AND METHOD FOR CLOSE-RANGE MOVEMENT TRACKING - A system and method for close range object tracking are described. Close range depth images of a user's hands and fingers or other objects are acquired using a depth sensor. Using depth image data obtained from the depth sensor, movements of the user's hands and fingers or other objects are identified and tracked, thus permitting the user to interact with an object displayed on a screen, by using the positions and movements of his hands and fingers or other objects.12-27-2012

Jonathan A. Epstein, San Francisco, CA US

Patent application numberDescriptionPublished
20090025024AUDIENCE DETERMINATION FOR MONETIZING DISPLAYABLE CONTENT - The present disclosure relates to the measurement of the audience characteristics or demographics which is or can be exposed to displayed interactive content depicted on a screen. The audience can include persons who are engaged in interacting with the interactive content as well as persons who are observers of the interactive content and/or the active participants. The content can include one or more targeted advertisements contained in or associated with interactive content, and can be varied based on the audience characteristics or demographics. The audience characteristics or demographics can be used to accurately charge advertisers for the impressions created by the content displayed and can also or alternatively be used to determine and/or trigger what content is actually displayed.01-22-2009
20110093877AUDIENCE DETERMINATION FOR MONETIZING DISPLAYABLE CONTENT - The present disclosure relates to the measurement of the audience characteristics or demographics which is or can be exposed to displayed interactive content depicted on a screen. The audience can include persons who are engaged in interacting with the interactive content as well as persons who are observers of the interactive content and/or the active participants. The content can include one or more targeted advertisements contained in or associated with interactive content, and can be varied based on the audience characteristics or demographics. The audience characteristics or demographics can be used to accurately charge advertisers for the impressions created by the content displayed and can also or alternatively be used to determine and/or trigger what content is actually displayed.04-21-2011

Joseph Epstein, Pleasanton, CA US

Patent application numberDescriptionPublished
20120307792WI-FI VIRTUAL PORT UPLINK MEDIUM ACCESS CONTROL - Uplink medium access control on per-wireless device level. An access point sends a beacon frame to a wireless device. The beacon frame includes a BSSID that is unique to the wireless device. The beacon frame also includes embedded uplink configurations specifying uplink medium access for the wireless device. In one embodiment, a controller recognizes a device or user associated with the device, and sends corresponding uplink configurations for embedding in a subsequent beacon frame.12-06-2012

Karen Epstein, Encino, CA US

Patent application numberDescriptionPublished
20100180292TV tutorial widget - In certain implementations, a television tutorial Widget method involves providing a tutorial Widget running on a television processor to produce video images rendered as a video overlay that overlays the picture on a television display. The tutorial Widget: loading upon receipt of a command to run the tutorial Widget; identifying an operating state of the television set; retrieving and presenting a list of available tutorial videos associated with the operating state of the television set in the video overlay; identifying a tutorial video selected by a user; and retrieving and playing the tutorial video selected by the user in the video overlay. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.07-15-2010

Lewis Epstein, San Mateo, CA US

Patent application numberDescriptionPublished
20100302454Personal Control Apparatus And Method For Sharing Information In A Collaborative Workspace - A method and apparatus for selecting information from a video source to be displayed on at least a first common display screen in a collaborative workspace having a switching device, the method comprising the steps of providing a selectable control interface that includes at least one indicator that can indicate at least first and second different states, associating a video source with the switching device so that video information from the video source is presented to the switching device, when the video source is associated with the switching device, causing the at least one indicator to indicate a first state and when the selectable control interface is selected, causing the at least one indicator to indicate the second state and providing the video information from the video source to the common display screen via the switching device.12-02-2010

Lewis Mark Epstein, San Mateo, CA US

Patent application numberDescriptionPublished
20090260547CONFERENCE TABLE ASSEMBLY - A conferencing assembly for use with at least one computer, the assembly including a table top forming a table top opening, a leg support structure, a display screen supported adjacent the top surface, a switcher for controlling input to the display screen, a plurality of handsets, each hand set including a selector button usable to send a signal to the switcher thereby causing the switcher to link a computer associated with the selector button to the display, a plurality of handset cables, each handset cable having first and second ends linked to the switcher and an associated selector button, respectively, for passing signals from the selector buttons to the switcher, a take up assembly including a separate weight for each of the handset cables, the take up assembly disposed below the top member and aligned with the top opening, each handset cable linked to an associated weight, each weight applying a force tending to pull the second end of the associated handset cable into the opening.10-22-2009

Marc Epstein, Los Gatos, CA US

Patent application numberDescriptionPublished
20120096133System and Method for Serving and Managing Independent Access Devices - A third party service provider can provide data, management, and configuration services to a plurality of unrelated entities. The services are separated from the management and configuration aspect, and a system of trust is arranged to avoid the unrelated parties affecting one another.04-19-2012

Natan Epstein, Beverly Hills, CA US

Patent application numberDescriptionPublished
20100317333Wireless Messaging System - Messages are routed via a cellular communications network to multiple cellular communications receivers configured for answering calls placed to a common subscriber number, such that a message originated with a single cellular call may reach multiple recipients. The geographic area of message distribution may be controlled by selectively enabling different cell sites for calling particular subscriber numbers. The cellular receivers may have message storage capabilities for subsequent replay of received messages. Message storage may be provided by downloading messages to a conventional telephone answering device also connected for landline telephone call answering, thereby adding received cellular messages to recorded landline telephone messages.12-16-2010

Patent applications by Natan Epstein, Beverly Hills, CA US

Peter Epstein, Palo Alto, CA US

Patent application numberDescriptionPublished
20080209452METHOD AND APPARATUS FOR NOTIFICATION ON AN ELECTRONIC HANDHELD DEVICE USING AN ATTENTION MANAGER - A method and system for notification in a palm-sized computer system. Specifically, the present invention discloses an Attention Manager that manages application demand for a user's attention. The Attention Manager receives multiple attention requests from varying applications. With each new attention request received that indicates a record needs a user's attention, the Attention Manager stores the request in memory and determines if there are other outstanding attention requests that have not been cleared. Depending on the number of outstanding requests, the Attention Manager sends a request for record information in list or detail format. If there are multiple outstanding attention requests, the Attention Manager displays a notification dialog in a list format. If there is only one outstanding attention request, the Attention Manager displays the notification dialog in detail format. Additionally, a simple user interface to navigate to the application and record entry requiring attention is provided.08-28-2008

Rhonda Epstein, San Diego, CA US

Patent application numberDescriptionPublished
20110275939Ergonomic Sensor Pad with Feedback to User and Method of Use - A portable system is provided for sensing and training a user to maintain correct posture while seated in a chair with a seat portion and a back portion. The system includes a first pad attachable to the seat portion of a chair, said first pad having a front area and a rear area, and a second pad attachable to the back portion of a chair and having a lower area and an upper area. There is a first sensor located in the first pad capable of sensing that a user is seated in the seat portion of the chair, a second sensor located in the first pad capable of sensing whether the lower posterior portion of the user's body is in contact with the rear area of the first pad, a third sensor operably attached to the lower area of the second pad capable of sensing whether the user's lumbar region is in contact with the second pad, a fourth sensor operably attached to the upper area of the second pad capable of sensing the distance between the user's upper back and the upper area of the second pad and a neck-position sensor operably attached to the second pad and capable of sensing the distance between the neck-position sensor and the user's neck. The system also includes a microprocessor operably connected to the first sensor, second sensor, third sensor, fourth sensor and neck-position sensor and capable of collecting data from each of the first sensor, second sensor, third sensor, fourth sensor and neck position sensor. The system also includes software for a personal computer, which configures the personal computer to receive the data from the microprocessor and to display the data received from the microprocessor, so that the user can utilize the ergonomic seat pad to receive feedback regarding his posture and over time, improve his posture.11-10-2011