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Engleman
Edgar Engleman, Atherton, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090004295 | USE OF A CHEMICALLY-STABILIZED CHLORITE SOLUTION FOR INHIBITING AN ANTIGEN-SPECIFIC IMMUNE RESPONSE - Methods of using a stabilized chlorite solution to inhibit antigen-specific immune responses are disclosed. The stabilized chlorite solution, when administered to a mammal in need thereof, can prevent the presentation of antigens by antigen presenting cells. The stabilized chlorite solution therefore is useful in treating, inter alia, auto-immune diseases, treating diseases caused by an inappropriate immune response, treating lymphoproliferative disease and in inhibiting rejection in transplant patients. | 01-01-2009 |
| 20110076344 | USE OF A CHEMICALLY-STABILIZED CHLORITE SOLUTION FOR INHIBITING AN ANTIGEN-SPECIFIC IMMUNE RESPONSE - Methods of using a stabilized chlorite solution to inhibit antigen-specific immune responses are disclosed. The stabilized chlorite solution, when administered to a mammal in need thereof, can prevent the presentation of antigens by antigen presenting cells. The stabilized chlorite solution therefore is useful in treating, inter alia, auto-immune diseases, treating diseases caused by an inappropriate immune response, treating lymphoproliferative disease and in inhibiting rejection in transplant patients. | 03-31-2011 |
Edgar G. Engleman, Atherton, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080214480 | Method for Treating Sickle Cell Disease and Sickle Cell Disease Sequalae - The present invention is directed to methods of treating sickle cell disease and its sequelae, including vaso-occlusive crisis. The method comprises administering to a subject in need thereof a pharmaceutical composition comprising an elective amount of a polyanionic polysaccharide, such as pentosan sulfate, sulodexide, or its pharmaceutically acceptable salts thereof. The methods of the present invention are useful in reducing the incidence, severity, or duration of SCD and its sequelae. The compound of the present method can also be used in conjunction with other therapeutic agents useful to treat sickle cell disease thus enhancing the therapeutic elect of reducing the required dosed to treat sickle cell disease. | 09-04-2008 |
| 20090053283 | Compositions And Methods For Treating Diseases - This invention relates to compositions and methods for treatment of vascular conditions. The invention provides arginine polymers and arginine homopolymers for the treatment and/or prevention of glaucoma, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, erectile dysfunction, Raynaud's syndrome, heparin overdose, vulvodynia, and wound healing. The invention also provides arginine polymers and arginine homopolymers for use in organ perfusate and preservation solutions. | 02-26-2009 |
| 20090069535 | Ligand (ACT-4-L) to a Receptor on the Surface of Activated CD4+ T-Cells - The invention provides ligands and fragments thereof to a receptor on the surface of activated CD4 | 03-12-2009 |
| 20100240873 | LIGAND (ACT-4-L) TO A RECEPTOR ON THE SURFACE OF ACTIVATED CD4+ TCELLS - The invention provides ligands and fragments thereof to a receptor on the surface of activated CD4 | 09-23-2010 |
| 20110124584 | Compositions and methods for treating diseases - This invention relates to compositions and methods for treatment of vascular conditions. The invention provides arginine polymers and arginine homopolymers for the treatment and/or prevention of glaucoma, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, erectile dysfunction, Raynaud's syndrome, heparin overdose, vulvodynia, and wound healing. The invention also provides arginine polymers and arginine homopolymers for use in organ perfusate and preservation solutions. | 05-26-2011 |
James Engleman, Ephrata, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110283417 | Secreted Insecticidal Protein and Gene Compositions from Bacillus Thuringiensis and Uses Therefor - The present invention relates to the isolation and characterization of nucleotide sequences encoding novel insecticidal proteins secreted into the extracellular space from | 11-17-2011 |
Joseph Scott Engleman, Dubois, WY US
| Patent application number | Description | Published |
|---|---|---|
| 20110272655 | Hoist Apparatus - A screwable hoisting apparatus to aid in elevating objects is described. The apparatus is embedded into a tree with one hand while the tree climber is free to use his other hand to secure himself to the tree. A method for using the same is disclosed. | 11-10-2011 |
Peter G. Engleman, Knoxville, TN US
| Patent application number | Description | Published |
|---|---|---|
| 20110204700 | IN-SITU COMPOSITE FORMATION OF DAMAGE TOLERANT COATINGS UTILIZING LASER - A coating steel component with a pattern of an iron based matrix with crystalline particles metallurgically bound to the surface of a steel substrate for use as disc cutters or other components with one or more abrading surfaces that can experience significant abrasive wear, high point loads, and large shear stresses during use. The coated component contains a pattern of features in the shape of freckles or stripes that are laser formed and fused to the steel substrate. The features can display an inner core that is harder than the steel substrate but generally softer than the matrix surrounding the core, providing toughness and wear resistance to the features. The features result from processing an amorphous alloy where the resulting matrix can be amorphous, partially devitrified or fully devitrified. | 08-25-2011 |
Peter G. Engleman, Painesville, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20100297432 | ARTICLE AND METHOD OF MANUFACTURING RELATED TO NANOCOMPOSITE OVERLAYS - Composite layers are formed on substrates, particularly heat sensitive substrates. A uniform composite mixture is prepared from powdered nanoscale ceramic phase particulates and a particulate matrix phase precursor that contains a fusible matrix former. The composite mixture is applied to the substrate surface where it forms a composite mixture layer that is thin relative to the substrate. The composite mixture layer is subjected to a rapid high flux heating pulse of energy to fluidize the fusible matrix former, followed by a rapid quenching step that occurs at least in part because of heat transfer to the substrate, but without significantly damaging the overall temper properties of the substrate. The nanoscale ceramic phase is present in the composite layer in an amount that is greater than its percolation threshold, so the resulting fused composite layer does not tend to flow or sag while the matrix former is in the fluid state. Also, the grain size of the matrix is minimized by the presence of the nanoscale ceramic phase. | 11-25-2010 |
Wesley Darrel Engleman, Evansville, WY US
| Patent application number | Description | Published |
|---|---|---|
| 20110272655 | Hoist Apparatus - A screwable hoisting apparatus to aid in elevating objects is described. The apparatus is embedded into a tree with one hand while the tree climber is free to use his other hand to secure himself to the tree. A method for using the same is disclosed. | 11-10-2011 |