Patent application number | Description | Published |
20090312415 | Remedy/preventive for vascular disorders and hypertension and method of screening the same - It is intended to clarify a transportation system participating in the uric acid uptake in vascular smooth muscle cells (VSMCs) and provide a novel remedy, a preventive or a treating agent for vascular disorders, hypertension and renal disorders with the use of a drug participating in this transportation system. It is also intended to provide a novel screening system for a remedy, a preventive or a treating agent for vascular disorders, hypertension and renal disorders with the use of such a transportation system. Namely, a medicinal composition for healing, preventing or treating vascular disorders, hypertension and renal disorders which comprises a drug having an effect of inhibiting the uric acid uptake by a uric acid transporter URAT1 and a pharmaceutically acceptable carrier; and a method of screening a substance efficacious for healing, preventing or treating vascular disorders, hypertension and renal disorders which comprises using a cell line expressing URAT1 in the presence or absence of a test compound and assaying the uric acid uptake level, cell proliferation ability or the amount of a monocyte chemotactic factor produced by the cells. | 12-17-2009 |
20100216976 | Sodium-independent transporter carrying acidic amino acid and its gene - It is intended to provide a sodium-independent transporter carrying an acidic amino acid and its gene. A protein having the amino acid sequence represented by SEQ ID NO: 1 and being capable of sodium-independently transporting an acidic amino acid and its analogs; a gene encoding this protein; a fused protein of the above protein with an auxiliary factor enabling the expression of its function; a gene encoding the same; a method of analyzing the function of a transporter using the same: and utilization thereof. | 08-26-2010 |
20120083588 | Neutral amino acid transporter and gene thereof - The present invention relates to an amino acid transporter protein having the ability to mediate the transport of amino acids into a cell, a gene encoding the protein, an antibody having a reactivity with the protein, a cell which produces the antibody, related kits and methods. | 04-05-2012 |
20140106377 | BIOMARKER FOR BREAST CANCER - A method for the diagnosis of breast cancer using an anti-LAT1 monoclonal antibody. Among intraductal breast neoplastic lesions, duct carcinoma in situ, which is malignant, expresses LAT1 at a significantly high level, as compared to intraductal breast papilloma, which is benign. An anti-LAT1 monoclonal antibody is useful for the discrimination between these two lesions. Further, LAT1 is expressed at a high level in most of triple negative infiltrating carcinomas, which are negative for all of ER, PgR, and HER2 that are conventional molecular targeting markers for breast cancer. Therefore, LAT1 can be used as a novel molecular targeting marker for the triple negative breast cancer. | 04-17-2014 |
Patent application number | Description | Published |
20100061751 | IMAGE FORMING APPARATUS - The present invention provides an image forming apparatus, which is able to prevent the adherence of toner on the surface of toner controlling means and around a toner passage hole, and to stably carry out toner passage ON/OFF control when forming an image using the direct recording method. This image forming apparatus includes: a toner carrier; recording medium means; toner controlling means, disposed between the toner carrier and recording medium means, and having a plurality of toner passage holes; and cloud electrode means disposed between the toner carrier and toner controlling means, a toner cloud being formed by applying an AC bias between the toner carrier and cloud electrode means. A control electrode and a common electrode are disposed in toner controlling means, and when the toner of the toner carrier is able to pass through the toner controlling means toward recording medium means, a loop-shaped line of electric force is formed between the recording medium means side and the toner controlling means common electrode, the loop-shaped line by-passing the control electrode. | 03-11-2010 |
20100183342 | IMAGE FORMING DEVICE BASED ON DIRECT RECORDING METHOD AND IMAGE FORMING APPARATUS INCLUDING THE SAME - An image creating apparatus includes a casing that stores therein an agent, an agent carrier rotatably supported by the casing, a hole defining member defining a plurality of holes therein and opposed to the agent carrier, a plurality of spray electrodes provided on the hole defining member respectively corresponding to the holes and forming an electric field for selectively causing the agent to be sprayed from the agent carrier towards the holes, and a positioning member provided on the casing to cover the agent carrier and positioning the hole defining member with respect to the agent carrier so that the agent carrier and the hole defining member are in a predetermined positional relationship. The angle of the positioning member is adjustable relative to the casing about a rotation shaft that is coaxial with the agent carrier. | 07-22-2010 |
20130071147 | DEVELOPMENT DEVICE AND IMAGE FORMING APPARATUS INCORPORATING SAME - A development device includes a developer bearer to carry by rotation developer to a development range facing a latent image bearer, and a planar metal developer regulator to adjust an amount of developer carried by the developer bearer to the development range. The developer bearer includes a developer carrying range having surface unevenness, and the developer regulator includes a fixed end portion held by a regulator holder and a free end portion to contact a surface of the developer bearer. | 03-21-2013 |
20130071148 | DEVELOPMENT DEVICE AND IMAGE FORMING APPARATUS INCORPORATING SAME - A development device includes a developer bearer to carry by rotation developer to a development range facing a latent image bearer, a planar developer regulator disposed to contact a surface of the developer bearer to adjust an amount of developer carried to the development range, and a lateral end seal to contact an axial end portion of the developer bearer. The developer bearer includes an uneven surface range having projections and recesses and including an axial center of the developer bearer and smooth surface ranges positioned outside the uneven surface range in an axial direction of the developer bearer, and the lateral end seal is disposed astride the uneven surface range and the smooth surface range of the developer bearer. | 03-21-2013 |
20130209143 | DEVELOPING DEVICE AND IMAGE FORMING APPARATUS - A developing device including: a toner bearing member configured to bear a toner on a surface of the toner bearing member and configured such that the surface thereof is rotated to supply the toner to and develop a latent electrostatic image on a surface of a latent electrostatic image bearing member in a developing region which faces the latent electrostatic image bearing member; and a regulating member configured to regulate an amount of the toner to be moved towards the developing region, wherein the surface of the toner bearing member has regularly arranged convex portions, and wherein a non-electrostatic adhesive force between the toner and the surface of the toner bearing member is less than 9.0 nN. | 08-15-2013 |
20130216250 | DEVELOPMENT DEVICE AND IMAGE FORMING APPARATUS INCORPORATING SAME - A development device includes a developer bearer to carry by rotation developer to a development range facing a latent image bearer, and a developer regulator to adjust an amount of developer transported to the development range by the developer bearer. Multiple projections are formed in a surface of the developer bearer, and the developer bearer rotates in a reverse direction to a direction of rotation for image development while image development is not performed. The developer regulator includes a blade having a first end held by a regulator holder and a second end that contacts the multiple projections formed in the surface of the developer bearer and is disposed in a direction counter to the direction of rotation of the developer bearer for image development. | 08-22-2013 |
20130216276 | DEVELOPMENT DEVICE, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE INCORPORATING SAME - A development device includes a developer bearer to carry by rotation developer to a development range facing a latent image bearer and a developer regulator to adjust an amount of developer transported to the development range by the developer bearer. The developer bearer includes a developer carrying range having surface unevenness; and a surface of the developer bearer is coated with a coating material including a resin material and particles to roughen the surface. | 08-22-2013 |
20130216277 | DEVELOPMENT DEVICE, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE INCORPORATING SAME - A development device includes a developer bearer to carry by rotation developer to a development range facing a latent image bearer, and a developer regulator to adjust an amount of developer transported to the development range by the developer bearer. Multiple projections are formed in a surface of the developer bearer, and, in a direction in which the developer bearer rotates, a downstream end of each of the multiple projections is higher than an upstream end of the projection. | 08-22-2013 |