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Emilia
Emilia Albesiano, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090117095 | Methods and compositions for diagnosis and treatment of b cell chronic lymphocytic leukemia - Provided are isolated and purified preparations of a combination of a light chain antibody gene and a heavy chain antibody gene, where the light chain and heavy chain antibody genes are the same among more than one patient with B cell chronic lymphocytic leukemia (B-CLL). Vectors comprising those genes and cells comprising those vectors are also provided, as are isolated and purified antibodies encoded by the antibody genes. Anti-idiotype antibodies, peptides, and aptamers that bind to the antigen-binding region of an antibody encoded by the antibody genes are additionally provided, as are multimeric molecules comprising multiple binding sites that bind to the antigen-binding region of an antibody encoded by the antibody genes. Methods of determining whether a patient with B cell chronic lymphocytic leukemia (B-CLL) has a form of B-CLL that is susceptible to treatment directed to eliminating idiotype specific B cell receptor-bearing B-CLL cells are also provided, as are methods of following the progression of treatment of B-CLL in the patient. Additionally, methods of treating a patient having B-CLL are provided, as are methods of identifying a therapeutic agent for B-CLL. | 05-07-2009 |
Emilia Bramanti, Pietrasanta IT
| Patent application number | Description | Published |
|---|---|---|
| 20100227351 | METHOD OF DETECTING AND SEPARATING SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) ISOFORMS IN A SAMPLE OF BIOLOGICAL FLUID AND THE ENZYME ISOFORMS THEREBY OBTAINED - A method is described for detecting the gamma-glutamyl transferase enzyme isoforms (GGT, EC 2.3.2.2) in a sample of biological fluid, such as for example plasma or serum. The method comprises an HPLC separation step of the sample proteins based on the molecular size and a second step for detecting the GGT isoforms by post-column reaction with a GGT enzyme substrate capable of generating a detectable final product, preferably by spectrophotometric or fluorimetric means. The GGT isoforms can be separated by ultra-centrifugation, thereby obtaining three enzymatic isoforms characterised by molecular weights of approximately 2000, 940, and 140 KDa, respectively. | 09-09-2010 |
Emilia Bukala, Poznan PL
| Patent application number | Description | Published |
|---|---|---|
| 20100217062 | COMPOSITION AND METHOD FOR STABILIZING ENVIRONMENTALLY-HARMFUL SUBSTANCES; USE OF NON-FERROUS METAL SALTS AND OXIDES TO STABILIZE ENVIRONMENTALLY-HARMFUL SUBSTANCES WITH CAUSTIC MAGNESIUM OXIDE - A composition for binding environmentally-harmful substances in solid or semi-liquid state contains caustic magnesium oxide, non-ferrous metal salts as a hardener, non-ferrous metal oxides catalyzing formation of radial crystalline structures, and optionally water and other additives. A method of stabilization of environmentally-harmful substances binds these substances in the solid state or semi-liquid state in the composition containing caustic magnesium oxide, wherein the environmentally-harmful substances are supplemented by the composition containing caustic magnesium oxide, non-ferrous metal salts as hardener, non-ferrous metal oxides catalyzing formation of radial crystalline structures, and optionally water and other additives. A form of paste is obtained, followed by leaving the mixture for solidification and stabilization of the product. Use of non-ferrous metal salts in connection with non-ferrous metal oxides catalyzing formation of radial crystalline structures stabilizes the environmentally-harmful substance with the use of caustic magnesium oxide. | 08-26-2010 |
Emilia Madarász, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20100047792 | LABEL-FREE OPTICAL DETECTION METHOD - The present provides optical sensor based sensitive, label-free binding assay methods and kits for isothermal real-time detection of the binding of specific analytes (such as nucleic acids, proteins and low molecular weight antigenic or receptor binding ligands) present in low amount in different biological samples. In the binding assays of the invention, the analyte is captured at the specifically pretreated solid surface of optical biosensors in specific recognition reactions (such as hybridization, specific protein-protein interactions and receptor-ligand interactions). The specificity of the methods of the invention is further enhanced by a second specific recognition step using a padlock probe comprising an indicator sequence designed to keep the products of a subsequently performed isothermal nucleic acid amplification method (e.g. rolling circle amplification: RCA) anchored on the sensor surface, enhancing thereby the sensitivity of the detection of the specific binding of the analyte occurred on the sensor surface. | 02-25-2010 |
Emilia Madarász, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20100047792 | LABEL-FREE OPTICAL DETECTION METHOD - The present provides optical sensor based sensitive, label-free binding assay methods and kits for isothermal real-time detection of the binding of specific analytes (such as nucleic acids, proteins and low molecular weight antigenic or receptor binding ligands) present in low amount in different biological samples. In the binding assays of the invention, the analyte is captured at the specifically pretreated solid surface of optical biosensors in specific recognition reactions (such as hybridization, specific protein-protein interactions and receptor-ligand interactions). The specificity of the methods of the invention is further enhanced by a second specific recognition step using a padlock probe comprising an indicator sequence designed to keep the products of a subsequently performed isothermal nucleic acid amplification method (e.g. rolling circle amplification: RCA) anchored on the sensor surface, enhancing thereby the sensitivity of the detection of the specific binding of the analyte occurred on the sensor surface. | 02-25-2010 |
Emilia Maneiro Pampín, Madrid ES
| Patent application number | Description | Published |
|---|---|---|
| 20100248286 | BIOSENSORS BASED ON MICROALGAE FOR THE DETECTION OF ENVIRONMENTAL POLLUTANTS - The present invention provides biosensors based on microalgae for the determination of the presence of toxic compounds in a sample, characterized by the high sensitivity and specificity thereof with respect to the target toxic substance. The biosensors are based on the measurement of the photosynthetic activity of algae by means of monitoring the molecular oxygen production by the microalgae by using a luminescent compound the emission of which depends on the amount of oxygen in the medium. | 09-30-2010 |
Emilia Maneiro Pampín, Madrid ES
| Patent application number | Description | Published |
|---|---|---|
| 20100248286 | BIOSENSORS BASED ON MICROALGAE FOR THE DETECTION OF ENVIRONMENTAL POLLUTANTS - The present invention provides biosensors based on microalgae for the determination of the presence of toxic compounds in a sample, characterized by the high sensitivity and specificity thereof with respect to the target toxic substance. The biosensors are based on the measurement of the photosynthetic activity of algae by means of monitoring the molecular oxygen production by the microalgae by using a luminescent compound the emission of which depends on the amount of oxygen in the medium. | 09-30-2010 |
Emilia Mollova, Mountain View, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100120101 | REACTION CHAMBER - A chamber in which an agent, like genomic DNA, may be harvested and optionally manipulated rapidly (e.g., on the order of a few hours), without shearing or fragmentation. | 05-13-2010 |
Emilia Selinheimo, Espoo FI
| Patent application number | Description | Published |
|---|---|---|
| 20090203882 | NOVEL MICROBIAL ENZYMES AND THEIR USE - Extracellular tyrosinases obtainable from | 08-13-2009 |
Emilia Tiitinen, Helsinki FI
| Patent application number | Description | Published |
|---|---|---|
| 20100036079 | USE OF TOCOPHEROL - The present invention relates to the use of tocopherol as a co-catalyst in the ring opening polymerisation of cyclic siloxanes. The present invention further relates to a method for manufacturing hydrophilic polysiloxanes, wherein a hydrido-containing cyclic siloxane is reacted with a hydrophilic molecule comprising a carbon-carbon double bond, having the general formula (I) H | 02-11-2010 |