Emilia
Emilia Albesiano, Baltimore, MD US
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20090117095 | Methods and compositions for diagnosis and treatment of b cell chronic lymphocytic leukemia - Provided are isolated and purified preparations of a combination of a light chain antibody gene and a heavy chain antibody gene, where the light chain and heavy chain antibody genes are the same among more than one patient with B cell chronic lymphocytic leukemia (B-CLL). Vectors comprising those genes and cells comprising those vectors are also provided, as are isolated and purified antibodies encoded by the antibody genes. Anti-idiotype antibodies, peptides, and aptamers that bind to the antigen-binding region of an antibody encoded by the antibody genes are additionally provided, as are multimeric molecules comprising multiple binding sites that bind to the antigen-binding region of an antibody encoded by the antibody genes. Methods of determining whether a patient with B cell chronic lymphocytic leukemia (B-CLL) has a form of B-CLL that is susceptible to treatment directed to eliminating idiotype specific B cell receptor-bearing B-CLL cells are also provided, as are methods of following the progression of treatment of B-CLL in the patient. Additionally, methods of treating a patient having B-CLL are provided, as are methods of identifying a therapeutic agent for B-CLL. | 05-07-2009 |
20120141462 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA - This invention provides an anti-idiotype antibody that binds to the antigen-binding region of an antibody encoded by antibody genes selected from the group consisting of Set I, Set II, Set III, Set IV, Set V, Set VIa, Set VIb, Set VIc, Set VId, Set VIe, Set VII, and Set VIII, hybridomas and methods of treatments using such. | 06-07-2012 |
Emilia Bramanti, Pietrasanta IT
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20100227351 | METHOD OF DETECTING AND SEPARATING SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) ISOFORMS IN A SAMPLE OF BIOLOGICAL FLUID AND THE ENZYME ISOFORMS THEREBY OBTAINED - A method is described for detecting the gamma-glutamyl transferase enzyme isoforms (GGT, EC 2.3.2.2) in a sample of biological fluid, such as for example plasma or serum. The method comprises an HPLC separation step of the sample proteins based on the molecular size and a second step for detecting the GGT isoforms by post-column reaction with a GGT enzyme substrate capable of generating a detectable final product, preferably by spectrophotometric or fluorimetric means. The GGT isoforms can be separated by ultra-centrifugation, thereby obtaining three enzymatic isoforms characterised by molecular weights of approximately 2000, 940, and 140 KDa, respectively. | 09-09-2010 |
Emilia Bukala, Poznan PL
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20100217062 | COMPOSITION AND METHOD FOR STABILIZING ENVIRONMENTALLY-HARMFUL SUBSTANCES; USE OF NON-FERROUS METAL SALTS AND OXIDES TO STABILIZE ENVIRONMENTALLY-HARMFUL SUBSTANCES WITH CAUSTIC MAGNESIUM OXIDE - A composition for binding environmentally-harmful substances in solid or semi-liquid state contains caustic magnesium oxide, non-ferrous metal salts as a hardener, non-ferrous metal oxides catalyzing formation of radial crystalline structures, and optionally water and other additives. A method of stabilization of environmentally-harmful substances binds these substances in the solid state or semi-liquid state in the composition containing caustic magnesium oxide, wherein the environmentally-harmful substances are supplemented by the composition containing caustic magnesium oxide, non-ferrous metal salts as hardener, non-ferrous metal oxides catalyzing formation of radial crystalline structures, and optionally water and other additives. A form of paste is obtained, followed by leaving the mixture for solidification and stabilization of the product. Use of non-ferrous metal salts in connection with non-ferrous metal oxides catalyzing formation of radial crystalline structures stabilizes the environmentally-harmful substance with the use of caustic magnesium oxide. | 08-26-2010 |
Emilia Cappelliti, Siena IT
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20130315959 | COMPOUNDS - The invention provides a synthetic | 11-28-2013 |
Emilia Entcheva, Stony Brook, NY US
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20130274838 | OPTICAL CONTROL OF CARDIAC FUNCTION - The invention features an optically-controlled biological device that includes a biological component comprising a non-excitable cell expressing a light-gated ion channel protein and capable of forming gap junction channels with a target cell, and an optical stimulation unit. | 10-17-2013 |
Emilia Garcia Moruno, Asti IT
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20130209609 | BIOLOGICAL DEGRADATION OF OCHRATOXIN A INTO OCHRATOXIN ALPHA - The invention relates to the use of a microorganism of the genus | 08-15-2013 |
Emilia Gustafsson, Zurich CH
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20150250565 | INSERTION TOOL - Insertion tool for transmitting torque from a drive tool to a dental implant, having a tool shaft including, at its apical end a dental implant engagement section including a torque applying unit to engage the dental implant such that torque can be transmitted from the insertion tool to the implant, a drive tool engagement section coronal of the dental implant engagement section including a primary torque receiving unit to engage the drive tool such that torque can be transmitted from the drive tool to the insertion tool, and a break zone arranged between the drive tool and dental implant engagement sections and designed to break upon application of a predetermined amount of torque. The shaft includes, between the dental implant engagement section and the break zone, an auxiliary torque receiving unit to engage a drive tool such that torque can be transmitted from the drive tool to the insertion tool. | 09-10-2015 |
Emilia Madarász, Budapest HU
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20100047792 | LABEL-FREE OPTICAL DETECTION METHOD - The present provides optical sensor based sensitive, label-free binding assay methods and kits for isothermal real-time detection of the binding of specific analytes (such as nucleic acids, proteins and low molecular weight antigenic or receptor binding ligands) present in low amount in different biological samples. In the binding assays of the invention, the analyte is captured at the specifically pretreated solid surface of optical biosensors in specific recognition reactions (such as hybridization, specific protein-protein interactions and receptor-ligand interactions). The specificity of the methods of the invention is further enhanced by a second specific recognition step using a padlock probe comprising an indicator sequence designed to keep the products of a subsequently performed isothermal nucleic acid amplification method (e.g. rolling circle amplification: RCA) anchored on the sensor surface, enhancing thereby the sensitivity of the detection of the specific binding of the analyte occurred on the sensor surface. | 02-25-2010 |
Emilia Madarász, Budapest HU
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20100047792 | LABEL-FREE OPTICAL DETECTION METHOD - The present provides optical sensor based sensitive, label-free binding assay methods and kits for isothermal real-time detection of the binding of specific analytes (such as nucleic acids, proteins and low molecular weight antigenic or receptor binding ligands) present in low amount in different biological samples. In the binding assays of the invention, the analyte is captured at the specifically pretreated solid surface of optical biosensors in specific recognition reactions (such as hybridization, specific protein-protein interactions and receptor-ligand interactions). The specificity of the methods of the invention is further enhanced by a second specific recognition step using a padlock probe comprising an indicator sequence designed to keep the products of a subsequently performed isothermal nucleic acid amplification method (e.g. rolling circle amplification: RCA) anchored on the sensor surface, enhancing thereby the sensitivity of the detection of the specific binding of the analyte occurred on the sensor surface. | 02-25-2010 |
Emilia Maneiro Pampín, Madrid ES
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20100248286 | BIOSENSORS BASED ON MICROALGAE FOR THE DETECTION OF ENVIRONMENTAL POLLUTANTS - The present invention provides biosensors based on microalgae for the determination of the presence of toxic compounds in a sample, characterized by the high sensitivity and specificity thereof with respect to the target toxic substance. The biosensors are based on the measurement of the photosynthetic activity of algae by means of monitoring the molecular oxygen production by the microalgae by using a luminescent compound the emission of which depends on the amount of oxygen in the medium. | 09-30-2010 |
Emilia Maneiro Pampín, Madrid ES
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20100248286 | BIOSENSORS BASED ON MICROALGAE FOR THE DETECTION OF ENVIRONMENTAL POLLUTANTS - The present invention provides biosensors based on microalgae for the determination of the presence of toxic compounds in a sample, characterized by the high sensitivity and specificity thereof with respect to the target toxic substance. The biosensors are based on the measurement of the photosynthetic activity of algae by means of monitoring the molecular oxygen production by the microalgae by using a luminescent compound the emission of which depends on the amount of oxygen in the medium. | 09-30-2010 |
Emilia Mollova, Mountain View, CA US
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20100120101 | REACTION CHAMBER - A chamber in which an agent, like genomic DNA, may be harvested and optionally manipulated rapidly (e.g., on the order of a few hours), without shearing or fragmentation. | 05-13-2010 |
Emilia Olson, La Jolla, CA US
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20150148667 | METHOD AND SYSTEM FOR IN VIVO HYDROGEN PEROXIDE DETECTION WITH ULTRASOUND - A method and system are provided for detection of localized hydrogen peroxide within tissue by introducing a catalase-containing material into at location of interest, positioning an ultrasound transducer over the location, and generating an ultrasound image to detect microbubbles, where the presence of microbubbles indicate the presence of localized hydrogen peroxide. The catalase-coated surface may be the inner surface of a microtube, on the surface of or incorporated within a nanosphere or micro sphere, or an implantable device. | 05-28-2015 |
Emilia Peuhu, Abo FI
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20130281381 | PHARMACEUTICAL COMPOSITIONS COMPRISING 8-SUBSTITUTED DIBENZYLBUTYROLACTONE LIGNANS - Therapeutic compositions comprising at least one 8-substituted-dibenzylbutyrolactone lignan, preferably a lignan is selected from the group of nortrachelogenin, diasteromeric forms of nortrachelogenin, isomeric forms of nortrachelogenin and combinations thereof as well as 8-methylmatairesinol and 8-methyldimethylmatairesinol, for use in a method of treating cancer or a similar condition wherein the growth factor signaling pathway of a mammal is deregulated. The invention also provides therapeutic pharmaceutical combinations comprising a hydroxy-dibenzylbutyrolactone lignan and at least one TRAIL receptor agonist. The hydroxy-dibenzylbutyrolactone lignans and a TRAIL receptor agonist can be used as a combined preparation for administration to a patient simultaneously, separately or spaced out over a period of time in treating cancer. | 10-24-2013 |
Emilia Peuhu, Turku FI
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20140135377 | COMBINATION THERAPY - The invention is based on a finding that silencing PME-1 gene sensitizes cancer cells for apoptosis-inducing activity of certain small molecule chemotherapeutic agents. Thus, the invention is directed to a respective combination therapy, sensitization method and pharmaceutical compositions. | 05-15-2014 |
20150202180 | Pharmaceutical compositions of Anisomelic acid and the use thereof - A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a co-solvents or surfactant or a combination thereof. A method of treating or preventing of cancer in a mammal, wherein the p53 pathway is deregulated by viral oncoproteins, is also provided. | 07-23-2015 |
Emilia Rico-Munoz, Knoxville, TN US
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20140051614 | ON-SITE DRY SILICONE LUBRICANT PRODUCTION - A dry silicone lubricant concentrate is mixed with a liquid on-site to manufacture a RTU dry silicone conveyor lubricant. The dry silicone lubricant concentrate is composed of a silicone emulsion with 1-99% silicone oil. In some embodiments, other components are added to the mixture to modify selected qualities and characteristics of the resultant dry silicone lubricant. | 02-20-2014 |
20140356231 | Automated KleenSan System - Systems and processes to dispense, clean and sanitize the key exposure points in the filling process to reduce risk of mold, yeast, or bacteria product spoilage, with minimal downtime. In some embodiments, a process uses a chemical solution that includes a liquid including potable water or another liquid—such as paramagnetic water, ultrapure water, R.O. water or any other kind of modified water—and a biocide solution such as sodium hypochlorite, stabilized chlorine dioxide, etc. at concentrations between 0.5 and 200 ppm or any of the components of electrochemical activated (EAC) water. In some embodiments, the water has a low enough chemical concentration to allow application without a follow-up rinse. The high ORP water at high pressure and flow removes the statically charged particles, preventing micro growth in between sprays, and effectively cleaning and sanitizing in a single step. | 12-04-2014 |
Emilia Selinheimo, Espoo FI
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20090203882 | NOVEL MICROBIAL ENZYMES AND THEIR USE - Extracellular tyrosinases obtainable from | 08-13-2009 |
Emilia Tiitinen, Helsinki FI
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20100036079 | USE OF TOCOPHEROL - The present invention relates to the use of tocopherol as a co-catalyst in the ring opening polymerisation of cyclic siloxanes. The present invention further relates to a method for manufacturing hydrophilic polysiloxanes, wherein a hydrido-containing cyclic siloxane is reacted with a hydrophilic molecule comprising a carbon-carbon double bond, having the general formula (I) H | 02-11-2010 |
Emilia Wolowiec-Korecka, Zgierz PL
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20160102377 | DEVICE FOR INDIVIDUAL QUENCH HARDENING OF TECHNICAL EQUIPMENT COMPONENTS - Device for individual quenching of gears, pinions, bearing rings and other similar components of technical devices, operating in a vacuum furnace installation, whereby the quenching chamber of the installation is fitted with tightly-sealed doors for workpiece loading and unloading. The following elements are fitted inside the quenching chamber: removable table on which an individual workpiece is placed, along with a surrounding set of removable nozzles; the inlet of the quenching chamber features an attached tank supplying the cooling medium to the nozzles—preferably air or nitrogen, or argon or helium, or hydrogen or carbon dioxide, or mixtures thereof—while the outlet of the quenching chamber is connected to the inlet of a tank receiving expanded cooling medium from the chamber; moreover, there is a compressor connected in between the two tanks, ensuring closed-loop flow of the cooling medium. | 04-14-2016 |