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| 20100129386 | Composotions And Methods For The Identification And Treatment Of Immune-Mediated Inflammatory Diseases - Compositions and methods for the therapy and diagnosis of immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention or treatment of immune-mediated inflammatory disease. | 05-27-2010 |
| 20100284999 | CHARACTERIZATION OF THE CBIR1 ANTIGENIC RESPONSE FOR DIAGNOSIS AND TREATMENT OF CROHN'S DISEASE - This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's Disease in an individual by determining the presence or absence of anti-Cbir1 reactivity and the presence or absence of TLR5 risk variants. In another embodiment, the present invention provides methods to diagnose Crohn's Disease by determining the presence or absence of NFKB1 haplotype H3 and/or ASCA expression. In another embodiment, the present invention provides methods of diagnosing Crohn's Disease by determining the presence or absence of Cbir1 specific peripheral blood T cell proliferation. | 11-11-2010 |
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| 20110258290 | Bandwidth-Proportioned Datacenters - A system including at least one storage node and at least one computation node connected by a switch is described herein. Each storage node has one or more storage units and one or more network interface components, the collective bandwidths of the storage units and the network interface components being proportioned to one another to enable communication to and from other nodes at the collective bandwidth of the storage units. Each computation node has logic configured to make requests of storage nodes, an input/output bus, and one or more network interface components, the bandwidth of the bus and the collective bandwidths of the network interface components being proportioned to one another to enable communication to and from other nodes at the bandwidth of the input/output bus. | 10-20-2011 |
| 20110258483 | Data Layout for Recovery and Durability - A Metadata server described herein is configured to generate a metadata table optimized for data durability and recovery. In generating the metadata table, the metadata server associates each possible combination of servers with one of the indices of the table, thereby ensuring that each server participates in recovery in the event of a server failure. In addition, the metadata server may also associate one or more additional servers with each index to provide added data durability. Upon generating the metadata table, the metadata server provides the metadata table to clients or servers. Alternatively, the metadata server may provide rules and parameters to clients to enable those clients to identify servers storing data items. The clients may use these parameters and an index as inputs to the rules to determine the identities of servers storing or designated to store data items corresponding to the index. | 10-20-2011 |
| 20110258488 | Server Failure Recovery - A metadata server configured to maintain storage assignment mappings in non-persistent storage is described herein. The tract storage assignment mappings associate servers with storage assignments, the storage assignments representing the data stored on the servers. Responsive to a failure, the metadata server receives the storage assignments from the servers and rebuilds the storage assignment mappings from the storage assignments. The metadata server is also configured to enable clients to operate during a recovery process for a failed server by providing the storage assignment mappings to the clients during the recovery process. Also during the recovery process, the replacement server for the failed server conditionally overwrites stored data with other data received from other servers as part of the recovery process. The replacement server conditionally overwrites based on version information associated with the data and version information associated with the other data, the version information being associated with one or more versions of the storage assignment mappings | 10-20-2011 |
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| 20090210388 | EFFICIENTLY DISCOVERING AND SYNTHESIZING MAPS FROM A LARGE CORPUS OF MAPS - Intent of a user is determined with respect to mapping information. A search is performed for relevant maps from a plurality of disparate sources. A subset of maps from a superset of available maps are identified that correlate to the determined intent, and the subset of maps are fused or synthesized to create a single map view that aggregates and combines relevant content from respective maps of the subset. | 08-20-2009 |
| 20090324134 | SPLITTING FILE TYPES WITHIN PARTITIONED IMAGES - The claimed subject matter provides a system and/or a method that facilitates optimally and efficiently utilizing an image file format. A server can host an image that is partitioned into two or more tiles, wherein the two or more tiles collectively represent the image in entirety and are defined in at least one image file format. A tile generator can evaluate at least one tile to identify a suitable image file format based upon at least one of a characteristic of such file format or a context of a use for the tile. A browser can utilize the tile in the identified file format in order to render a portion of the image. | 12-31-2009 |
| 20100287618 | Executing Native-Code Applications in a Browser - Techniques for leveraging legacy code to deploy native-code desktop applications over a network (e.g., the Web) are described herein. These techniques include executing an application written in native code within a memory region that hardware of a computing device enforces. For instance, page-protection hardware (e.g., a memory management unit) or segmentation hardware may protect this region of memory in which the application executes. The techniques may also provide a narrow system call interface out of this memory region by dynamically enforcing system calls made by the application. Furthermore, these techniques may enable a browser of the computing device to function as an operating system for the native-code application. These techniques thus allow for execution of native-code applications on a browser of a computing device and, hence, over the Web in a resource-efficient manner and without sacrificing security of the computing device. | 11-11-2010 |
| 20100312858 | NETWORK APPLICATION PERFORMANCE ENHANCEMENT USING SPECULATIVE EXECUTION - A speculative web browser engine may enable providing transmission of content between a server and a client prior to a user-initiated request for the content hidden in imperative code (event handlers), which may reduce user-perceived latency when the user initiates the imperative code. In some aspects, a speculative browser state may be created from an actual browser state and used to run the event handlers. The event handlers may be modified to direct actions of the event handler to update the speculative browser state. Speculative content may be transmitted between the server and the client in response to an execution of the modified code. The speculative content may be stored in a cache and made readily available for use when the user initiates the event handler and finds that the desired content has already been fetched. | 12-09-2010 |
| 20100318630 | Leveraging Remote Server Pools for Client Applications - Techniques for enabling client computing devices to leverage remote server pools for increasing the effectiveness of applications stored on the client computing device are described herein. In some instances, the server pools comprise a “cloud”, “cluster” or “data center” that comprises hundreds or thousands of servers connected together by a network that has an extremely low latency and high bandwidth relative to the network through which the client computing device connects to the server pool. The client computing device may request that the server pool perform a certain task for an application whose canonical state resides on the client. After computation of a result of the task, a server of the server pool then provides the result to the client. By doing so, the techniques dramatically increase the amount of resources working on the request of the client and, hence, dramatically increase the speed and effectiveness of the client-side application. | 12-16-2010 |
| 20110258297 | Locator Table and Client Library for Datacenters - A system including a plurality of servers, a client, and a metadata server is described herein. The servers each store tracts of data, a plurality of the tracts comprising a byte sequence and being distributed among the plurality of servers. To locate the tracts, the metadata server generates a table that is used by the client to identify servers associated with the tracts, enabling the client to provide requests to the servers. The metadata server also enables recovery in the event of a server failure. Further, the servers construct tables of tract identifiers and locations to use in responding to the client requests. | 10-20-2011 |
| 20110258482 | Memory Management and Recovery for Datacenters - A system including a plurality of servers, a client, and a metadata server is described herein. The servers each store tracts of data, a plurality of the tracts comprising a byte sequence and being distributed among the plurality of servers. To locate the tracts, the metadata server generates a table that is used by the client to identify servers associated with the tracts, enabling the client to provide requests to the servers. The metadata server also enables recovery in the event of a server failure. Further, the servers construct tables of tract identifiers and locations to use in responding to the client requests. | 10-20-2011 |
