Patent application number | Description | Published |
20090061416 | Surfaces and methods for biosensor cellular assays - Disclosed is an apparatus for measuring ligand-induced cell activity as defined herein, the apparatus including: an optical biosensor having a contact surface including a compatibilizer zone, an optional surface modifier zone, and a live cell zone. The disclosure also provides a method of making the apparatus and methods for measuring ligand-induced live cell activity with the apparatus. | 03-05-2009 |
20100087332 | High-Throughput High-Information Content Label-Free Cell Biology Screening Methods - A method for hit compound identification in a high throughput, label-free biosensor cellular assay, one method including, for example:
| 04-08-2010 |
20100129854 | LIVER CELL TOXICITY ASSAY - The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein. | 05-27-2010 |
20100129856 | Methods and Devices for Cell Signaling Under Pulse Stimulation - The disclosure provides a device for measuring cellular responses under controlled environments. The disclosure also provides an array of devices for measuring cellular responses under controlled environments. The disclosure also provides methods to study cell signaling using the devices. By using microfluidics, the disclosure enables study of cell signaling under well-defined environment conditions. Such capability can be used for differentiating long-acting ligands from short-acting ligands, for determining the kinetics of receptor resensitization and functional recovery of receptor signaling, and for differentiating the sensitivity of a cell type to laminar flow-induced stress force. Through combination with conventional static label-free cell assays, the full spectrum of a drug compound can be studied in details, thus creating a complete representation of its pharmacology acting on living cells. | 05-27-2010 |
20100130725 | METHODS FOR CHARACTERIZING MOLECULES - Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules. | 05-27-2010 |
20100130736 | METHODS OF CREATING AN INDEX - Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules. | 05-27-2010 |
20110020843 | LABEL-FREE METHODS RELATED TO PHOSPHODIESTERASES - 196. Disclosed are methods of incubating cells on biosensors, and methods using the disclosed incubation techniques to identify PDE4 modulators. | 01-27-2011 |
20120061258 | SURFACES AND METHODS FOR BIOSENSOR CELLULAR ASSAYS - Disclosed is an apparatus for measuring ligand-induced cell activity as defined herein, the apparatus including: an optical biosensor having a contact surface including a compatibilizer zone, an optional surface modifier zone, and a live cell zone. The disclosure also provides a method of making the apparatus and methods for measuring ligand-induced live cell activity with the apparatus. | 03-15-2012 |
20120135423 | Methods for GPCR signaling pathway determination using biosensor-cell assays - A system and method for GPCR signaling pathway analysis and elucidation using a biosensor, a live-cell, and a pathway active compound, as defined herein. | 05-31-2012 |
20120289432 | PI3K MODULATORS, RHO KINASE MODULATORS AND METHODS OF IDENTIFYING AND USING SAME - Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not. | 11-15-2012 |
20120295965 | FUSED THIOPHENES AS DUAL INHIBITORS OF EGFR/VEGFR AND THEIR USE IN THE TREATMENT OF CANCER - Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR. | 11-22-2012 |
20120301914 | High Resolution Label-Free Sensor - An optical sensor for label-independent detection, having improved spatial resolution and reduced angular sensitivity, the sensor including:
| 11-29-2012 |
20120329865 | MOLECULES RELATED hERG ION CHANNELS AND THE USE THEREOF - Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R | 12-27-2012 |
20130281323 | DEVICE AND METHOD FOR CELL-EXCLUSION PATTERNING - This disclosure relates to devices and methods for cell-exclusion patterning. Specifically, this disclosure provides a device and method to exclude cells in selected areas during cell seeding and create cell-free arrays that can be used for cell migration and related studies and assays. | 10-24-2013 |
20140099653 | DUAL-TARGET BIOSENSOR CELL ASSAYS - A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type. | 04-10-2014 |
20140243243 | DEVICE AND METHOD FOR CELL-EXCLUSION PATTERNING - This disclosure relates to devices and methods for cell-exclusion patterning. Specifically, this disclosure provides a device and method to exclude cells in selected areas during cell seeding and create cell-free arrays that can be used for cell migration and related studies and assays. | 08-28-2014 |