Patent application number | Description | Published |
20080200720 | PROCESS FOR THE SYNTHESIS OF ENANTIOMERIC INDANYLAMINE DERIVATIVES - A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or pressure hydrogenation in the presence of an optically active catalyst to reduce 1-indanones. The chiral product, either (S)- or (R)-indanols undergo nucleophilic substitution to produce the named product. In an additional aspect, the invention relates to novel intermediates and compounds, namely, substituted indanones, substituted (S)-indanols and substituted (R)-indanols. | 08-21-2008 |
20090275653 | POLYMORPHIC FORMS OF LADOSTIGIL TARTRATE - The invention provides for solid state chemistry of ladostigil tartrate, particularly polymorphic forms of ladostigil tartrate, and processes for the preparation thereof. | 11-05-2009 |
20110152381 | 3-KETO-N-PROPARGYL-1-AMINOINDAN - The subject invention provides a pharmaceutical composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of 3-keto-N-propargyl-1-aminoindan or a salt thereof. | 06-23-2011 |
20120101168 | DEUTERIUM ENRICHED RASAGILINE - The subject invention provides deuterated rasagiline, its salts and uses. | 04-26-2012 |
20130089610 | R(+)-N-METHYL-PROPARGYL-AMINOINDAN - The subject invention provides R(+)-N-methyl-propargyl-aminoindan or a pharmaceutically acceptable salt thereof and a composition containing R(+)-N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of R(+)-N-methyl-propargyl-aminoindan or a salt thereof. | 04-11-2013 |
20130089611 | RASAGILINE CITRAMIDE - The subject invention provides rasagiline citramide and a composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of rasagiline citramide or a salt thereof. | 04-11-2013 |
20130089612 | R(+)-N-FORMYL-PROPARGYL-AMINOINDAN - The subject invention provides R(+)-N-formyl-propargyl-aminoindan and a composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of R(+)-N-formyl-propargyl-aminoindan. | 04-11-2013 |
20150045445 | 3-KETO-N-PROPARGYL-1-AMINOINDAN - The subject invention provides a pharmaceutical composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of 3-keto-N-propargyl-1-aminoindan or a salt thereof. | 02-12-2015 |