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Eleonora Amici, East Cowes GB

Patent application numberDescriptionPublished
20090149597Method of Producing Fine Particles - A method of producing cross-linked polymerisation hardened droplets in a continuous aqueous medium in a microchannel device is provided. At least two aqueous streams are brought together before entering a hydrophobic phase and thus forming droplets. One aqueous phase comprises an acid source and another comprises a metal ion salt. The slow release of metal ions slows down the rate of polymerisation so that it does not interfere with the droplet formation process.06-11-2009

Eleonora Baldelli, Bologna IT

Patent application numberDescriptionPublished
20080242864Process for the Semisynthesis of Deserpidine - The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).10-02-2008

Eleonora Beljaars, Groningen NL

Patent application numberDescriptionPublished
20080267877Peptide-based carrier devices for stellate cells - A compound includes a carrier molecule wherein the carrier molecule is linked to a further molecule, wherein the further molecule is at least one cyclic peptide in which the cyclic peptide portion thereof contains at least one sequence encoding a cell receptor recognizing peptide (RRP) and with the proviso that the compound is not a naturally occurring receptor agonist or antagonist. Preferably, the RRP is a receptor specific for Hepatic Stellate Cells (HSC) or a receptor that is up-regulated on HSC during disease. The RFP may be chosen from among a PDGF receptor, a collagen type VI receptor, cytokine receptor(s) such as TGBβ, INFα and interleukinβ. The cyclic portion of the peptide can contain at least one amino acid sequence RGD or KPT. The compounds can be used as an active targeting ingredient for manufacturing a pharmaceutical composition for therapy, prophylaxis or diagnosis of a disease chosen from fibrotic disease, sclerotic disease, and chronic or acute inflammatory processes including glomeruloscherosis, interstitial fibrosis, lung fibrosis, atherosclerosis, rheumatoid arthritis, Crohns disease, colitis ulcerosa, glomerulonephritis and sepsis, and particularly for targeting HSC. Pharmaceutical compositions contain the above-compound(s).10-30-2008

Eleonora Dinisman-Zavulunov, Afula IL

Patent application numberDescriptionPublished
20090143360Oxcarbazepine Formulation - The present invention relates to novel uncoated, color-stable tablet formulations comprising oxcarbazepine, a disintegrant and iron oxide pigments. The oxcarbazepine of the present invention has a particle size of about 14 to about 30 microns with a maximum residue on a 40 micron sieve from about 10% to about 35%. The present invention further provides for a process of preparing the tablet formulations, and a method of treating mammals in need of oxcarbazepine with the novel formulation.06-04-2009

Eleonora Doucet-Liem, Leiden NL

Patent application numberDescriptionPublished
20090169286DEVICE FOR APPLYING A SPREADABLE COMPOSITION TO A PART OF THE HUMAN OR ANIMAL BODY - A device for applying a spreadable composition to a part of the human or animal body, wherein the device comprises a container containing the spreadable composition, an applicator for the spreadable composition and means for urging the spreadable composition out of the container and into contact with the applicator, provided with positioning means connected to the container for positioning the applicator in a position in which composition urged out of the container can be brought into contact with the applicator.07-02-2009

Eleonora Franchi Scarselli, Bologna IT

Patent application numberDescriptionPublished
20110319014ELECTRONIC CIRCUIT FOR COMMUNICATING THROUGH CAPACITIVE COUPLING - A device and method to compensate for distortions of amplitude that afflict systems for communicating through capacitive coupling. A circuit includes a first transmitter stage, a first receiver stage, and a first coupling capacitor, coupled between the first transmitter stage and the first receiver stage. The first receiver stage includes a calibration amplifier of a variable-gain type coupled between the first coupling capacitor and an output of the electronic circuit. The electronic circuit includes a reference channel formed by: a transmission calibration stage; a reception calibration stage; and a reference capacitor coupled between the transmission calibration stage and the reception calibration stage. The reception calibration stage includes: a reception amplifier of a variable-gain type, having an input coupled to the reference capacitor, and a gain controller, having an input coupled to an output of the reception amplifier and an output coupled to control terminals of the reception and calibration amplifiers.12-29-2011
20110319015METHOD FOR VERIFYING THE ALIGNMENT BETWEEN INTEGRATED ELECTRONIC DEVICES - A method for verifying alignment between first and second integrated devices coupled together using a reference and a coupling capacitor, including: transmitting a reference signal on a transmission electrode of the reference capacitor; receiving a coupling signal on a reception electrode of the reference capacitor; amplifying the coupling signal, generating a reception reference signal; generating a reception control signal as a function of the reception reference signal; transmitting a communication signal on an electrode of the coupling capacitor; receiving a reception signal on an electrode of the coupling capacitor; amplifying the reception signal, generating a first compensated signal; controlling a level of amplification of amplifying the coupling signal and the reception signal as a function of the reception control signal; and detecting a possible misalignment between the first and second devices based on an amplitude of the communication signal and an amplitude of the compensated signal.12-29-2011

Eleonora Maldacena, Buenos Aires AR

Patent application numberDescriptionPublished
20090264334Cleaning compositions - The present invention discloses cleaning compositions comprising a combination of surfactants and viscosity modifying agent including electrolyte, that upon dilution thickens so as to form a gel. The compositions are useful for household cleaning activities such as dishwashing. They provide enhanced and progressive retention of surfactant in carriers, thus avoid excessive product consumption and providing more yield.10-22-2009

Eleonora Marsich, Trieste IT

Patent application numberDescriptionPublished
20090197832POLYMER MIXTURES OF ANIONIC AND CATIONIC POLYSACCHARIDES AND USE THEREOF - Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behaviour with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behaviour renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.08-06-2009
20090202640HYDROGELS OF POLYSACCHARIDE MIXTURES FOR TISSUE ENGINEERING AND AS CARRIERS OF ACTIVE COMPOUNDS - The present invention describes the preparation of hydrogels (or 3D matrices) obtainable from aqueous solutions of mixtures of acid polysaccharides and derivatives of basic polysaccharides, such as oligosaccharide derivatives of chitosan. Said solutions are suitably gelled with either chemical or physical gelling agents with the aim of encapsulating either cells, isolated or in multicellular associations, or pharmacologically active molecules, in solution or suspension, for use in the biomedical and pharmaceutical field.08-13-2009
20110123589THREE-DIMENSIONAL NANOCOMPOSITE MATERIALS CONSISTING OF A POLYSACCHARIDIC MATRIX AND METALLIC NANOPARTICLES, PREPARATION AND USE THEREOF - In the present invention nanocomposite materials in form of three-dimensional structure formed by a polymeric matrix consisting of a polysaccharidic composition of neutral or anionic polysaccharides and a branched cationic polysaccharides, in which metallic nanoparticles are uniformly dispersed and stabilized, are described. Using appropriate techniques of gelification or by means of an appropriate dehydration, the nanocomposite materials are three-dimensional matrices having different shapes in hydrated form as hydrogels, or in non-hydrated form. These nanocomposite materials have a broad-spectrum of strong bactericidal activity, but do not show any cytotoxicity. The particular antibacterial properties associated with metallic particle nano-scale and the presence of biological signals on the polymeric chains along with the lack of cytotoxicity may be exploited in developing new-generation biomaterials provided with antimicrobial properties and for many other applications in biomedical, pharmaceutical and food field.05-26-2011
20110129536NANOCOMPOSITE MATERIALS BASED ON METALLIC NANOPARTICLES STABILIZED WITH BRANCHED POLYSACCHARIDES - The present invention provides nanocomposite systems made of metallic nanoparticles stabilized with branched cationic polysaccharides, in particular alditolic or aldonic mono- and oligo-saccharidic derivatives of chitosan, and their preparation obtainable with aqueous solutions of these polysaccharides in the presence or absence of reducing agents. The peculiar chemical and physical-chemical features of these polysaccharides allow to form metallic nanoparticles homogeneously dispersed in the polysaccharidic matrix and an effective stabilization thereof. The properties associated with the nanometric dimensions and the presence of biological signals on polymeric chains may be exploited in applications with antimicrobial activities and of molecular biosensors.06-02-2011

Eleonora Zanderigo, London GB

Patent application numberDescriptionPublished
20100212666System for Controlling Administration of Anaesthesia - A system for controlling administration of a respiratory depressant drug or mixture of drugs to a spontaneously breathing patient comprises a drug delivery unit (08-26-2010