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Elcombe
Clifford R. Elcombe, Blairgowrie GB
| Patent application number | Description | Published |
|---|---|---|
| 20120029079 | PHARMACEUTICAL COMPOSITIONS CONTAINING FLUORINATED OR PERFLUORINATED CARBOXYLIC ACIDS - The molecules of formula (I) are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipis of eicosanoid status or functions may be desirable. Formula (I): Z | 02-02-2012 |
Clifford Roy Elcombe, Meigle GB
| Patent application number | Description | Published |
|---|---|---|
| 20100240751 | Methods - A perfluoroctanoic acid or a salt or an ester thereof; perfluorosuberic acid, perfluoroheptanoic acid, perfluorohexanoic acid, perfluoropentanoic acid, perfluorobutanoic acid or perfluoropropionic acid or a salt or an ester any thereof; or perfluoroctane are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or function may be desirable. | 09-23-2010 |
Clifford Roy Elcombe, Dundee GB
| Patent application number | Description | Published |
|---|---|---|
| 20100138935 | Detection of cellular stress - We provide reporter gene constructs incorporating nucleic acid sequences from a promoter region of a gene or set of genes whose expression is modified in response to external or internal changes in the cellular environment such as biochemical stress or toxic conditions. The promoters are operatively linked to nucleic acid sequences chosen on the basis of the ease with which their transcription and/or translation products may be assayed so that the reporter gene constructs can provide a system capable of detecting intracellular conditions. Also described are transfected cell lines including the constructs and transgenic non-human animal models including the constructs. | 06-03-2010 |
| 20110119780 | SCREENING FOR NON-GENOTOXIC CARCINOGENS - The invention relates to a method for screening for the effects of non-genotoxic carcinogens in an animal model. The invention also relates to animal models that are suitable for use in such a method, and cell lines derived from these animals for in vitro screening purposes. More specifically, the invention relates to a transgenic rodent animal which has been humanised for the nuclear transcription factors CAR, PXR and PPARĪ±, and in which the endogenous equivalent genes have been rendered inoperable. | 05-19-2011 |