| Patent application number | Description | Published |
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| 20090087414 | Materials and methods for altering an immune response to exogenous and endogenous immunogens, including syngeneic and non-syngeneic cells, tissues or organs - Disclosed herein are materials and methods for modulating an immunologically adverse response to an exogenous or endogenous immunogen, including a cell, tissue, or organ associated immunogen. An implantable material comprising cells, such as but not limited to endothelial cells, anchored or embedded in a biocompatible matrix can modulate an adverse immune or inflammatory reaction to exogenous or endogenous immunogens, including response to non-syngeneic or syngeneic cells, tissues or organs, exogenous immunogens or stimuli, as well as ameliorate an autoimmune condition. The implantable material can be provided prior to, coincident with, or subsequent to occurrence of the immune response or inflammatory reaction. The implantable material can induce immunological acceptance in a transplant patient, reduce graft rejection and reduce donor antigen immunogenicity. | 04-02-2009 |
| 20090220588 | Simultaneous Delivery of Receptors and/or Co-Receptors for Growth Factor Stability and Activity - The compositions and methods of the present invention relate to the co-delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of the invention, the invention may improve delivery of growth factors by co-delivering these growth factors with their receptors and co-receptors, such as syndecans. Co-delivery of growth factors with syndecans, for example, may protect growth factors from proteolysis, enhance their activity, and target the growth factors to the cell surface to facilitate growth factor signaling. This novel approach to growth factor therapy could be extended to other systems and growth factors enabling the enhancement of multiple signaling pathways to achieve a desired therapeutic outcome. | 09-03-2009 |
| 20100042200 | METHOD AND APPARATUS FOR STENTING - A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. | 02-18-2010 |
| 20100092532 | Materials and Methods for Treating and Managing Angiogenesis-Mediated Diseases - Disclosed herein are materials and methods suitable for treating sites of pathological angiogenesis and abnormal neovascularization. Sites of pathological angiogenesis or abnormal neovascularization can be treated by contacting a surface at or adjacent or in the vicinity of an area of pathological angiogenesis or abnormal neovascularization with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected site. The composition can be a flexible planar material or a flowable composition. Diseases susceptible to treatment with the present invention include, for example, macular degeneration, rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic inflammatory diseases, and treatment of tumors by surgical resection, radiation therapy or chemotherapy. | 04-15-2010 |
| 20100114302 | ENDOVASCULAR DEVICES WITH AXIAL PERTURBATIONS - Endovascular devices are provided. The endovascular devices include a conformable scaffold with one or more outpocketings. The outpocketing in the endovascular device creates a corresponding outpocketing of a vessel wall, thereby altering local fluid dynamics. | 05-06-2010 |
| 20100228280 | METHODS AND DEVICES FOR TREATMENT OF LUMENAL SYSTEMS - The invention provides a variety of catheters and methods for using such catheters. An exemplary catheter includes an elongate body having a proximal end a distal end. The elongate body defines a longitudinal axis of the catheter. The exemplary catheter further includes at least one inflatable member disposed on the elongate body proximate the distal end of the elongate body. The interior of the inflatable member is in fluid communication with an inflation lumen in the elongate body. The exemplary catheter also includes a first filter adapted and configured to capture emboli in a patient's bloodstream as the bloodstream passes through the first filter along a first direction. The exemplary catheter further includes a second filter adapted and configured to capture emboli in a patient's bloodstream as the bloodstream passes through the second filter along a second direction, wherein the second direction is generally opposite to the first direction. | 09-09-2010 |
| 20100239671 | Tissue-Engineered Endothelial and Epithelial Implants Differentially and Synergistically Regulate Tissue Repair - Endothelial implants restore vascular homeostasis after injury without reconstituting vascular architecture. Endothelial cells line the vascular epithelium and underlying vasa vasorum precluding distinction between cellular controls. Unlike blood vessels, the airway epithelium is highly differentiated and distinct from endothelial cells that line the bronchial vasa allowing investigation of the differential control tissue engineered cells may provide in airways and blood vessels. Through airway injury and cell culture models, tissue engineered implants of the bronchial epithelium and endothelium were found to promote synergistic repair of the airway through biochemical regulation of the airway microenvironment. While epithelial cells modulate local tissue composition and reaction, endothelial cells preserve the epithelium; together their relative impact was enhanced suggesting both cell types act synergistically for airway repair. | 09-23-2010 |
| 20100318173 | ENDOVASCULAR DEVICES/CATHETER PLATFORMS AND METHODS FOR ACHIEVING CONGRUENCY IN SEQUENTIALLY DEPLOYED DEVICES - A stent alignment system includes an implantable stent and catheter that allows the ability to precisely control translational and rotational position in a vessel of the implantable stent and catheter. | 12-16-2010 |
| 20110004293 | ENDOVASCULAR PLATFORMS FOR THE DIFFERENTIAL TARGETING OF MOLECULES TO VESSEL WALL AND VESSEL LUMEN - A drug delivering medical system intended for placement into a blood vessel is provided. The drug delivering medical system includes a stent device having a plurality of interconnected distinct strut elements comprising distinct strut element surfaces. At least some of the distinct strut surfaces are neither in contact with the lumen wall nor in contact with wall-contacting flow recirculation zones. The stent device releases at least one biologically active compound intended for distal delivery and provides sufficient surface area for delivering the required drug dose to a distal tissue. | 01-06-2011 |
| 20110085712 | Method For Imaging Biomaterial Erosion In Vivo - A method for imaging the erosion of a biomaterial is disclosed. More specifically, the present invention provides a method for imaging a labeled biomaterial so that the erosion of the biomaterial is measured in vivo over a period of time. A biomaterial such as, for example, a hydrogel including polyethylene glycol (PEG) is labeled with a fluorescent or bioluminescent marker. The labeled biomaterial is then employed in the construction of an implanted medical device such as, for example, an endovascular stent. Furthermore, the labeled biomaterial may be utilized to form a drug delivery system that releases a controlled amount of a drug into a local region within a patient. The erosion of the biomaterial is monitored through a noninvasive imaging method. | 04-14-2011 |
| 20110112630 | SYSTEMS AND METHODS FOR TREATING LUMENAL VALVES - The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter. | 05-12-2011 |
