Patent application number | Description | Published |
20080287710 | Methods for the preparation of chemically misaminoacylated tRNA via protective groups - The present invention relates to methods for the preparation of chemically aminoacylated tRNAs for the purpose of introduction of markers into nascent proteins. The present invention also relates to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system utilizing chemically aminoacylated tRNAs. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. | 11-20-2008 |
20090061437 | Nucleotide Analogs - The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. | 03-05-2009 |
20090186351 | NUCLEOTIDE ANALOGS - The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. | 07-23-2009 |
20090186771 | NUCLEOTIDE ANALOGS - The invention provides nucleotide analogs for use in sequencing nucleic acid molecules. | 07-23-2009 |
20090263868 | Nucleotide Compositions Comprising Photocleavable Markers And Methods Of Preparation Thereof - Labelled nucleotides and polynucleotides useful in the sequencing of nucleic acids are described. Methods of preparing photocleavable marker nucleotides and photocleavable marker-polynucleotide conjugates are described. Such photocleavable marker nucleotides can be incorporated into nucleic acid so as to create photocleavable marker-polynucleotide conjugates. | 10-22-2009 |
20120040340 | NUCLEOTIDE ANALOGS - The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. | 02-16-2012 |