Patent application number | Description | Published |
20090209624 | COMPOSITIONS AND THEIR USES FOR GENE THERAPY OF BONE CONDITIONS - In certain preferred embodiments, the present invention provides compositions and methods for the treatment of bone conditions associated with low bone density. In preferred embodiments, the present invention provides compositions and methods for the treatment of osteoprotegerin-responsive conditions. | 08-20-2009 |
20120039929 | NOVEL THERAPY FOR LYSOSOMAL ENZYME DEFICIENCIES - The present invention provides a therapeutic delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload trapping molecule and a payload molecule, wherein the payload molecule and the payload trapping molecule are soluble in the same solvent system wherein the payload molecule supplements the function of the deficient lysosomal enzyme. The invention further provides methods of making and methods of using the therapeutic delivery system. | 02-16-2012 |
20120270206 | Systems and Methods for Analyzing Nucleic Acid Sequences - The invention relates to systems and methods for analyzing clinically relevant nucleic acid sequences. | 10-25-2012 |
20130065941 | COMPOSITIONS AND THEIR USES FOR GENE THERAPY OF BONE CONDITIONS - In certain preferred embodiments, the present invention provides compositions and methods for the treatment of bone conditions associated with low bone density. In preferred embodiments, the present invention provides compositions and methods for the treatment of osteoprotegerin-responsive conditions. | 03-14-2013 |
20140350066 | COMPOSITIONS AND THEIR USES FOR GENE THERAPY OF BONE CONDITIONS - In certain preferred embodiments, the present invention provides compositions and methods for the treatment of bone conditions associated with low bone density. In preferred embodiments, the present invention provides compositions and methods for the treatment of osteoprotegerin-responsive conditions. | 11-27-2014 |
Patent application number | Description | Published |
20080228208 | INTRALUMENAL MATERIAL REMOVAL USING A CUTTING DEVICE FOR DIFFERENTIAL CUTTING - Intralumenal material removal systems are provided using an advanceable and rotatable cutter assembly designed for differential cutting. The intralumenal material removal system includes a cutter assembly positionable in the body cavity of a mammalian subject. One embodiment of the cutter assembly comprises a cutter with blades that are designed and arranged to form an acute blade angle of attack with the matter-to-be-removed. The cutter assembly is axially advanceable by translating the drive shaft and rotatable by rotating the drive shaft. The occlusive material is scraped by the cutter assembly and may be aspirated to remove the material from the body cavity. The cutter assembly may provide aspiration ports positioned between facing surfaces of the blades. | 09-18-2008 |
20100324472 | DELIVERY AND ADMINISTRATION OF COMPOSITIONS USING INTERVENTIONAL CATHETERS - Systems and methods for delivery of therapeutic and/or diagnostic compositions to an interventional site having diseased or newly treated tissue are provided. Integrated interventional catheter systems incorporating surfaces coated with a therapeutic composition, or tissue penetration members for scoring or disrupting tissue prior to or during administration of a therapeutic composition are provided. Infusion of therapeutic composition(s) may also be provided. | 12-23-2010 |
20110040238 | INTERVENTIONAL CATHETER ASSEMBLIES INCORPORATING GUIDE WIRE BRAKE AND MANAGEMENT SYSTEMS - Interventional catheter assemblies that operate over a guide wire and incorporate guide wire management systems are disclosed. Specifically, a guide wire buffer zone is provided between a proximal end of the interventional catheter and the guide wire clamp that accommodates variable lengths of exposed guide wire in an unrestrained condition when the guide wire is clamped, allowing the distal end of the operating catheter to be advanced and retracted over the distal end of the guide wire without repositioning and reclamping the proximal end of the guide wire. The configuration of the guide wire buffer zone may be adjusted prior to or during an intervention based on the anticipated range of axial motion of the catheter and operating head relative to the guide wire. | 02-17-2011 |
20110071440 | INTERVENTIONAL CATHETERS INCORPORATING ASPIRATION AND/OR INFUSION SYSTEMS - An interventional catheter assembly comprising a catheter for insertion and guidance to a target site in a body lumen or a cavity and an operating head mounted in proximity to a distal end of the catheter and comprising a system for removing obstructive material from the target site is provided. In certain embodiments, the catheter assembly includes at least one aspiration port located proximal to the operating head that communicates with a first sealed lumen for withdrawing fluids and obstructive material from the target site, together with at least one liquid infusion port penetrating the catheter and located proximal to the at least one aspiration port that communicates with a second sealed lumen for supplying fluid to a location in proximity to the target site. | 03-24-2011 |
20110151463 | METHODS AND SYSTEMS FOR BIOLOGICAL SAMPLE COLLECTION AND ANALYSIS - Filtration devices for collection and filtration of biological samples are disclosed. Devices having a filtration element oriented in a generally vertical orientation are provided, as well as filtration devices that incorporate a cooling mechanism to reduce the temperature of collected solids. Tissue collection devices, such as aspiration assemblies, tissue sampling devices, and the like incorporating filtration devices are disclosed. Methods of collecting biological samples and separating biological solids from a liquid/solids mixture are also disclosed, together with analytical techniques and protocols for analyzing biological samples. | 06-23-2011 |
20130304030 | MEDICAL GUIDEWIRE SYSTEM WITH PLURAL PARALLEL GUIDEWIRES - Guidewire system includes a guidewire jacket, at least two guidewires, and a handle. The guidewires are initially constraint within the guidewire jacket and may be introduced into a diagnostic or other catheter to deliver the guidewires to a target region in a patient's vasculature. The handle detachably retains the guidewires so that they may be advanced simultaneously with the guidewire jacket. The guidewires may be then detached and manipulated individually to locate them properly within the region. After removing the guidewire jacket and the diagnostic catheter, the two or more guidewires provide a trackable yet flexible path for the introduction of interventional catheter or sheath. | 11-14-2013 |
20130345676 | INTERVENTIONAL CATHETER ASSEMBLIES, CONTROL SYSTEMS AND OPERATING METHODS - An interventional catheter assembly has an operating head and catheter system that are inserted and navigated within a patient's body while an operator controls the system externally of the operating head. An operating head is positioned at or near a distal end of the catheter system and coupled to a drive shaft and drive system for rotation. A guidewire brake control system interrupt prevents the drive system from being actuated when the guidewire brake is in a released position, and a selectable guidewire brake interrupt override control permits an operator to translate and/or rotate the drive shaft and operating head while the guidewire is simultaneously moved. This allows withdrawal of the guide wire and the operating head from the target site while rotating the operating head. | 12-26-2013 |
20140107481 | DELIVERY AND ADMINISTRATION OF COMPOSITIONS USING INTERVENTIONAL CATHETERS - Systems and methods for delivery of therapeutic and/or diagnostic compositions to an interventional site having diseased or newly treated tissue are provided. Integrated interventional catheter systems incorporating surfaces coated with a diagnostic or therapeutic composition, or ports for infusing a diagnostic or therapeutic composition prior to, during or following an interventional procedure are provided. | 04-17-2014 |
20140163384 | INTERVENTIONAL CATHETERS INCORPORATING ASPIRATION AND/OR INFUSION SYSTEMS - An interventional catheter assembly comprising a catheter for insertion and guidance to a target site in a body lumen or a cavity and an operating head mounted in proximity to a distal end of the catheter and comprising a system for removing obstructive material from the target site is provided. In certain embodiments, the catheter assembly includes at least one aspiration port located proximal to the operating head that communicates with a first sealed lumen for withdrawing fluids and obstructive material from the target site. The catheter assembly may also include at least one liquid infusion port that communicates with a second sealed lumen for supplying fluid to a location in proximity to the target site. Kits including the interventional catheter assembly with an aspiration and/or infusion conduit are also provided. | 06-12-2014 |
20150025558 | INTERVENTIONAL CATHETERS HAVING CUTTER ASSEMBLIES AND DIFFERENTIAL CUTTING SURFACES FOR USE IN SUCH ASSEMBLIES - A rotatable operating head for removal of obstructive material from a target site in a body lumen or cavity is operably connected to a rotatable, translatable drive shaft, that is driven by a drive motor and received through an elongated catheter. The operating head includes a plurality of differential cutting blades, with at least one of the cutting blades being a stepped blade, the stepped blade comprising a raised cutting surface positioned adjacent, or in proximity to, a shoulder region. | 01-22-2015 |