Edith
Edith Aberdam, Nice FR
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20100233136 | ISOLATED POPULATIONS OF CELLS AND METHODS OF GENERATING AND USING SAME - An isolated homogeneous population of cells comprising a plurality of human ectodermal progenitor cells. Also provided are methods of generating and using the population of cells. | 09-16-2010 |
Edith Antonatus, Mutterstadt DE
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20080224357 | Method for Producing Foamed Slabs - A process for producing foam moldings from prefoamed foam particles which have a polymer coating under pressure in a mold in the absence of steam, and also foam moldings produced therefrom and their use. | 09-18-2008 |
20080248198 | Method for Producing Foam Plates - The invention relates to a process for producing foam moldings from prefoamed foam particles which have a polymer coating in a mold under pressure, wherein the polymer coating comprises an amphiphilic or hydrophobic organic compound, and also foam moldings produced therefrom and their use. | 10-09-2008 |
Edith Basserie, Voreppe FR
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20090274510 | System for tightly covering a supporting element in the area of a recess - The invention relates to a system for tightly covering a supporting element ( | 11-05-2009 |
Edith Beerdsen, Amsterdam NL
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20100121122 | HYDROCARBON CONVERSION USING MOLECULAR SIEVE SSZ-75 - The present invention relates to new crystalline molecular sieve SSZ-75 prepared using a tetramethylene-1,4-bis-(N-methylpyrrolidinium) dication as a structure-directing agent, and its use in catalysts for hydrocarbon conversion reactions. | 05-13-2010 |
20100121124 | HYDROCARBON CONVERSION USING MOLECULAR SIEVE SSZ-75 - The present invention relates to new crystalline molecular sieve SSZ-75 prepared using a tetramethylene-1,4-bis-(N-methylpyrrolidinium) dication as a structure-directing agent, and its use in catalysts for hydrocarbon conversion reactions. | 05-13-2010 |
Edith Beigne, Meaudre FR
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20080214108 | Contactless Communications Method Based On Asynchronous Modulations And Demodulations - The invention relates to a method for exchanging information by inductive coupling or without contact between a reader ( | 09-04-2008 |
20080284407 | ELECTRONIC CIRCUIT POWER SUPPLY DEVICE AND ELECTRONIC CIRCUIT - An electronic circuit power supply device configured to selectively apply at least one first voltage or one second voltage to a power supply terminal of the electronic circuit that includes elements for applying to the power supply terminal a voltage variable from a value equal to the first voltage to a value equal to the second voltage and elements designed for selecting application of the second voltage to the power supply terminal when the variable voltage reaches the second voltage. | 11-20-2008 |
20110029795 | DEVICE FOR POWERING AN ELECTRONIC CIRCUIT, IN PARTICULAR A DIGITAL CIRCUIT, AND ASSOCIATED METHOD - A device for powering an electronic circuit that applies at least a first voltage or a second voltage, different from the first voltage, to the electronic circuit. The device includes a performance monitor that receives an item of information defining a constraint and determines a first duration and a second duration, such that the operation of the electronic circuit at a first frequency associated with the first voltage for the first duration, and at a second frequency associated with the second voltage for the second duration, complies with the constraint. The device applies the first voltage and the first frequency to the circuit for the first duration and the second voltage and the second frequency for the second duration. | 02-03-2011 |
20130338951 | ELECTRONIC SYSTEM WITH EMBEDDED SENSORS, METHOD FOR ESTIMATING AN OPERATING PHYSICAL QUANTITY, AND CORRESPONDING COMPUTER PROGRAM - A system comprising: an electronic circuit exhibiting, in operation, a value | 12-19-2013 |
Edith Benningshof-Hulsbos, Woerden NL
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20100285234 | Actinic radiation-curable coating composition - The invention relates to an actinic radiation-curable coating composition comprising a compound having at least two isocyanate groups, a compound having at least two hydroxyl groups, and a photolatent catalyst for the isocyanate-hydroxyl addition reaction, wherein the photolatent catalyst is an organic metal compound comprising a latent catalytically active metal, and wherein the latent catalytically active metal atom in the organic metal compound has no bonds to other metal atoms. The invention further relates to a process for forming a coating on a substrate. | 11-11-2010 |
Edith Bigot-Corbel, Nantes Cedex 01 FR
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20150204876 | PROTEIN MICROARRAY FOR CHARACTERIZING THE SPECIFICITY OF THE MONOCLONAL IMMUNOGLOBULINS OF MGUS OR MYELOMA PATIENTS - The present invention concerns materials and methods for characterizing monoclonal immunoglobulin specificity of a Monoclonal Gammopathy of Undetermined Significance (MGUS) or Myeloma patients using a protein microarray comprising (a) a substrate, (b) antigens immobilized on the substrate, said antigens being selected from a defined group consisting of infectious agent antigens and/or self-antigens. In particular said protein microarray may be used to improve diagnosis, for the prognosis of myeloma or MGUS, for preventing transformation of MGUS toward myeloma, for adapting treatment of MGUS and myeloma or for monitoring the response to therapy of MGUS and myeloma patients. | 07-23-2015 |
Edith Bonnelye, Lyon FR
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20100119505 | Estrogen Related Receptor, ERRalpha, A Regulator of Bone Formation - Methods and pharmaceutical compositions are provided for modulating bone formation in a mammal. Methods are also provided for screening compounds for their efficacy as modulators of bone formation. | 05-13-2010 |
20130195863 | Methods and Pharmaceutical Compositions for the Treatment of Bone Density Related Diseases - The invention relates to methods and pharmaceutical compositions for the treatment of bone density related diseases. More particularly, the present invention relates to a ROBO1 modulator for use in a method for the treatment of a bone mineral density related disease in a subject. In a particular embodiment the ROBO1 modulator is selected from the group consisting of small organic molecules, antibodies, aptamers or polypeptides. In another particular embodiment said bone mineral density related disease is selected from the group consisting of ghosal hematodiaphyseal dysplasia syndrome (GHDD), osteoporosis, osteoporosis associated to pseudoglioma, osteoporosis and oculocutaneous hypopigmentation syndrome, osteoporosis due to endocrinological dysfunction, osteogenesis imperfecta osteopenia, Paget's disease, osteomyelitis, hypercalcemia, osteonecrosis, hyperparathyroidism, lytic bone metastases, periodontitis, bone loss due to immobilization and osteoporosis associated with a disease selected from the group consisting of cachexia, anorexia, alopecia, rheumatoid arthritis, psoriatic arthritis, psoriasis, and inflammatory bowel disease. | 08-01-2013 |
20130316359 | METHOD FOR DETERMINING CANCER PROGNOSIS - The present invention concerns an in vitro method for determining cancer prognosis for a patient suffering from early-stage or low-grade cancer, said method comprising measuring the expression level of ERRα in a biological sample comprising cancer cells. The invention further pertains to an in vitro method for determining bone metastases prognosis for a patient suffering from bone metastases comprising measuring the expression level of ERRα. Finally, the invention pertains to in vitro methods for selecting a patient suffering from cancer, and/or from cancer-derived metastasis, suitable to be treated with a preventive/aggressive therapy. | 11-28-2013 |
Edith Bouey, Lorgies FR
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20100004159 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES - The present invention relates to polysubstituted imidazolone derivatives, to the pharmaceutical compositions comprising them and to the therapeutic uses thereof in the human and animal health fields. The present invention also relates to a process for preparing these derivatives. | 01-07-2010 |
Edith Bourret-Courchesne, Berkeley, CA US
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20090148375 | Novel Alkali Metal Hafnium Oxide Scintillators - The present invention provides for a composition comprising an inorganic scintillator comprising an alkali metal hafnate, optionally cerium-doped, having the formula A | 06-11-2009 |
20090166585 | Novel Alkali Metal and Alkali Earth Metal Gadolinium Halide Scintillators - The present invention provides for a composition comprising an inorganic scintillator comprising a gadolinium halide, optionally cerium-doped, having the formula A | 07-02-2009 |
20090212395 | Identifying New Semiconductor Detector Materials by D.C. Ionization Conductivity - Herein is described a method for identifying semiconductor radiation detector materials based on the mobility of internally generated electrons and holes. It was designed for the early stages of exploration, when samples are not available as single crystals, but as crystalline powders. Samples are confined under pressure in an electric field and the increase in current resulting from exposure to a high-intensity source of ionization current (e.g., | 08-27-2009 |
20110165422 | Novel Lanthanide Doped Strontium Barium Mixed Halide Scintillators - The present invention provides for a composition comprising an inorganic scintillator comprising a lanthanide-doped strontium barium mixed halide useful for detecting nuclear material. | 07-07-2011 |
20110168901 | Novel Lanthanide Doped Barium Phosphorous Oxide Scintillators - The present invention provides for a composition comprising an inorganic scintillator comprising a lanthanide-doped barium phosphorous oxide useful for detecting nuclear material. | 07-14-2011 |
20120193539 | Novel Lanthanide Doped Strontium-Barium Cesium Halide Scintillators - The present invention provides for a composition comprising an inorganic scintillator comprising an optionally lanthanide-doped strontium-barium, optionally cesium, halide, useful for detecting nuclear material. | 08-02-2012 |
Edith Chow, New South Wales AT
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20100276302 | CHEMIRESISTOR FOR USE IN CONDUCTING ELECTROLYTE SOLUTION - The present invention provides a chemiresistor-based sensor for measuring the presence or amount of analyte in an electrolyte solution; said chemiresistor comprising (i) a chemiresistor film wherein the impedance of said nanoparticle film changes in the presence of an analyte; and (ii) two electrically conducting electrodes in electrical contact with said nanoparticle film; wherein said electrically conducting electrodes are adapted to be connected to a device for measuring the impedance of said chemiresistor film under a voltage signal and wherein the impedance of the double layer capacitor formed by the two electrically conducting electrodes in the presence of the electrolyte solution, is larger than the impedance of the chemiresistor film either before or after exposure of the chemiresistor film to the analyte. A method of using said chemiresistor-based sensor to measure the presence or amount of analyte is also provided. Further provided is a method of determining the partition coefficient of an analyte using said chemiresistor-based sensor. | 11-04-2010 |
Edith Czech, North Vancouver CA
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20080317665 | COMPOSITIONS AND METHODS FOR GENERATING HYDROGEN FROM WATER - The present invention relates to methods, compositions and systems for producing hydrogen from water involving reacting metal particles with water in the presence of an effective amount of catalyst. In particular the invention pertains to methods, compositions and systems for producing hydrogen upon reaction of metal particles selected from the group consisting of aluminum (Al), magnesium (Mg), silicon (Si) and zinc (Zn) with water, in the presence of an effective amount of a catalyst, wherein the catalyst is a water-soluble inorganic salt. | 12-25-2008 |
20100150826 | MICROPOROUS METALS AND METHODS FOR HYDROGEN GENERATION FROM WATER SPLIT REACTION - The present invention relates to hydrogen generating microporous metals, methods for preparing microporous metals, and methods for producing hydrogen from water using the metals and systems of the invention. In particular, microporous metals selected from the group comprising aluminum (Al), magnesium (Mg), silicon (Si), Iron (Fe) and zinc (Zn), capable of producing hydrogen upon reaction of the metal with water having a neutral pH are provided. Methods for preparing microporous metals comprising the steps of selecting a metal that is sufficiently electropositive (i.e. water reactive); and introducing microporosity in the selected metal by means of mechanical deformation, or metallurgical techniques, in order to generate the microporous metal are also provided, as is a method for producing hydrogen comprising reacting a microporous metal powder with water at a pH of between 4 and 10. | 06-17-2010 |
Edith Dellacherie, Malzeville FR
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20120003320 | Particles which are surface coated with hyaluronan or one of the derivatives thereof and the use of same as biological vectors for active substances - Particles comprising a core based on at least one biodegradable organosoluble polymer. At least a part of the surface of the particles is coated with at least one hyaluronan or a derivative thereof, the hyaluronan being a water-soluble, amphiphilic hyaluronan of which the carboxylic functions are in part transformed to form hydrophobic groups. | 01-05-2012 |
20130071480 | Particles which are surface coated with hyaluronan or one of the derivatives thereof and the use of same as biological vectors for active substances - Particles having a core based on at least one biodegradable organosoluble polymer. At least a part of the surface of the particles is coated with at least one hyaluronan or a derivative thereof, the hyaluronan being a water-soluble, amphiphilic hyaluronan of which the carboxylic functions are in part transformed to form hydrophobic groups. | 03-21-2013 |
Edith Dijoud Delphine, Paris FR
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20100047066 | EXTERNAL FAN DUCT CASING IN A TURBOMACHINE - Twin-flow turbo-jet engine, comprising a cylindrical casing externally defining an annular flow space for a secondary flow, wherein the cylindrical casing is formed from a lattice framework and from removable cowling panels fixed to the framework, said framework comprising an upstream annular flange for fixing to an intermediate housing, a downstream annular flange for connecting to an exhaust housing and rigid beams parallel or inclined relative to the axis of the turbo-jet engine, connecting the two flanges to one another. | 02-25-2010 |
Edith Grall-Maes, Saint-Pouange FR
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20150073650 | METHOD FOR MONITORING A DEGRADATION IN AN ON-BOARD DEVICE OF AN AIRCRAFT WITH AUTOMATIC DETERMINATION OF A DECISION THRESHOLD - A method for monitoring a degradation in an on-board device of an aircraft, comprising a step of comparing an abnormality score obtained for a given flight of said aircraft with a decision threshold (S) and a step of transmitting an alert in the event of said decision threshold (S) being exceeded, said decision threshold (S) being automatically determined for a given probability of alert Pa, corresponding to the probability of an alert being transmitted during the monitoring method when said on-board device is healthy, by means of a plurality of steps, including a step of reading the antecedent of the continuous adjusted division function for the value 1−Peac, said antecedent corresponding to said decision threshold (S), with Peac being the elementary probability of exceeding the threshold for confirmation per k exceedances of threshold during n consecutive flights and being a function of the probability of alert Pa. | 03-12-2015 |
20150134198 | METHOD FOR MONITORING A DEGRADATION OF AN ON-BOARD DEVICE OF AN AIRCRAFT WITH AUTOMATIC DETERMINATION OF A DECISION THRESHOLD - A method for monitoring degradation of an on-board device of an aircraft includes comparing an abnormality score obtained for a given aircraft flight to a decision threshold and emitting an alarm when the decision threshold is exceeded. The decision threshold is determined automatically for a given alarm probability Pa, corresponding to probability of an alarm being emitted during the monitoring when the on-board device is undamaged, by: calculating plural abnormality scores for plural flights of the aircraft without degradation to obtain a probability density distribution of the abnormality score, the distribution being specific to a physical nature of the on-board device; adjusting the distribution using a non-parametric estimator of the probability density to obtain a continuous adjusted distribution function; calculating a continuous adjusted allocation function from the continuous adjusted distribution function; and reading precedent of the continuous adjusted allocation function for value 1-Pa, the precedent corresponding to the decision threshold. | 05-14-2015 |
Edith Gudernatsch, Stuttgart DE
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20080251445 | Method For the Production of Tubular Membranes - The invention relates to a method for producing tubular membranes. In order to create a very inexpensive production method while obtaining very high output rates for tubular membranes, a tubular member ( | 10-16-2008 |
Edith Gurewitsch, Baltimore, MD US
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20100086906 | Obstructed Delivery Simulation System - Maternal and fetal birthing simulators are disclosed. The maternal simulator has a rotatable pelvis, legs articulated at the hip and knee joints, and a deformable covering that simulates the feel of the skin and underlying tissues. The fetal simulator has an extensible neck, a movable head, movable clavicles, and arms articulated at the shoulder and elbow joints, and may include sensors to measure spinal extension, head rotation, applied traction force, and brachial plexus displacement. | 04-08-2010 |
Edith Harmon-Weiss, Swampscott, MA US
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20090013559 | Mechanical cushioning system for footwear - An element forming at least part of a midsole for footwear includes a top portion, a bottom portion, and at least two strut members disposed between the top and bottom plates for supporting the top plate a distance away from the bottom plate. The top, bottom and struts may be formed of different materials. Adjacent strut members have a C shaped cross-section facing in the same direction when the midsole resting its top or bottom portion is viewed from the side. The midsole element may further comprise a heel cleft to increase the flexibility of the sole. In a preferred embodiment, the strut members on the medial side are arranged at an angle to the strut members on the lateral side of the sole. The directional design provides flexibility and stiffness anisotropically to the sole in the longitudinal and lateral directions of the sole respectively. | 01-15-2009 |
20100071231 | Shoe sole element for stabilization - The present invention provides a stabilizing device that helps to prevent over-pronation or over-supination and a shoe which includes such a stabilizing device. The stabilizing device is provided along a side of the midsole and preferably extends laterally between about 20% and about 35% of a width of the sole towards the opposite side thereof. The stabilizing device includes an elongated portion and a sidewall portion that extends transversely from the elongated portion. The sidewall portion forms part of an outer peripheral wall of the shoe. The sidewall portion has a stiffness which varies along the length of the stabilizing device to provide a predetermined support profile along the side of the sole. The elongated portion can also vary in stiffness along its length. The stabilizing device can be formed of a resilient material using an injection molding procedure or similar technique. | 03-25-2010 |
Edith Hirtenstein, Chicago, IL US
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20120095927 | SYSTEM AND METHOD FOR PROVIDING A SCORE FOR A USED VEHICLE - One embodiment of the system and method described herein provides a score generator system that generates an automated vehicle specific valuation of a used car based on the physical and historical attributes of that vehicle. This score may indicate the likelihood that the vehicle will be on the road in a specific period of time. The score may give an absolute percentage of such likelihood or it may give a value relative to all other used vehicles in a database, all other used vehicles of the same make/model/year, or a certain subset of the vehicles in a database. In one embodiment, the score generator system includes a data link module for linking vehicle data and filter module for applying a multi-level filters that process the linked vehicle data. | 04-19-2012 |
20130173481 | SYSTEM AND METHOD FOR PROVIDING A SCORE FOR A USED VEHICLE - One embodiment of the system and method described herein provides a score generator system that generates an automated vehicle specific valuation of a used car based on the physical and historical attributes of that vehicle. This score may indicate the likelihood that the vehicle will be on the road in a specific period of time. The score may give an absolute percentage of such likelihood or it may give a value relative to all other used vehicles in a database, all other used vehicles of the same make/model/year, or a certain subset of the vehicles in a database. In one embodiment, the score generator system includes a data link module for linking vehicle data and filter module for applying a multi-level filters that process the linked vehicle data. | 07-04-2013 |
Edith Huland, Hamburg DE
Edith Kopinits, Landegg AT
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20110092434 | MIMOTOPES OF ALPHA-SYNUCLEIN AND VACCINES THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS - The present invention relates to the use of at least one compound comprising the amino acid sequence: (X | 04-21-2011 |
20110171243 | COMPOUNDS FOR TREATING AMYLOIDOSES - The present invention relates to the use of mimotopes in the treatment of β-Amyloidoses including but not limited to Alzheimer's disease, whereby said mimotopes are able to induce the in vivo formation of antibodies directed to non truncated Aβ1-40/42, and N-terminally truncated forms AβpE3-40/42, Aβ3-40/42, Aβ11-40/42, AβpE11-40/42 and Aβ14-40/42 without interfering with physiological functions of APP signalling. | 07-14-2011 |
Edith Kussener, Le Revest Les Eaux FR
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20140290376 | RESISTIVE DEVICE COMPRISING A SILICON-NANOWIRE-COMPRISING STRAIN GAUGE AND METHOD FOR OPTIMIZING THE ELECTRICAL CONSUMPTION OF SUCH A DEVICE - A resistive device includes at least one strain gauge ( | 10-02-2014 |
Edith Mana, Voreppe FR
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20100304607 | VERY HIGH POWER CONNECTOR - The present invention relates to a coaxial connector comprising: | 12-02-2010 |
Edith Mathiowitz, Brookline, MA US
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20080311191 | Multi-Layer Tablets and Bioadhesive Dosage Forms - Bioadhesives coatings increase the gastrointestinal retention time of orally-ingested medicaments. Certain bioadhesive coatings producing a fracture strength of at least 100 N/m | 12-18-2008 |
20090018033 | Cell Aggregation and Encapsulation Device and Method - The invention is a cell aggregation device comprising a hydrogel substrate having at least one, preferably a plurality, of cell-repellant compartments recessed into the uppermost surface. Each compartment is composed of an upper cell suspension seeding chamber having an open uppermost portion and a bottom portion, and one, or more than one, lower cell aggregation recess connected to the bottom portion of the upper cell suspension seeding chamber by a port. The diameter of the port may be fully contiguous with the walls of the chambers and walls of the recesses, or the diameter of the port may be more narrow than the walls of the chamber but fully contiguous with the walls of the recesses or more narrow than both the walls of the chamber and the walls of the recesses. The upper cell suspension seeding chambers are formed and positioned to funnel the cells into the lower cell aggregation recesses through gravitational force. The aggregation recesses are formed and positioned to promote cellular aggregation by coalescing cells into a finite region of minimum gravitational energy, increasing intercellular contact and minimizing or preventing cell adherence to the substrate. A device for encapsulating aggregates of live cells is provided. The device comprises (i) a biocompatible, bio-sustainable substrate having a cell-encapsulating face composed of one or more biocompatible, bio-sustainable, spaced-apart, cell-encapsulating compartments extending therefrom and (ii) a coating layer composed of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and the cell-encapsulating compartments. A method for making the device is also provided. | 01-15-2009 |
20090022777 | Methods for progenitor cell recruitment and isolation - The invention relates to the use of one or more growth factors in a drug delivery system, optionally with an external mesh housing, to recruit and optionally harvest progenitor cells. These cells include those that normally reside in the bone marrow. | 01-22-2009 |
20090217840 | CELLULAR OR ORGANELLE-ENTRAPPED NANOPARTICLES - The invention provides tissue marking pigment or dye particle retained within a tissue cell, the cellular cytoplasm, or one or more intracellular organelles. Also, the invention provides nanoparticles, which are phagocytosed, engulfed or otherwise entrapped by cells. | 09-03-2009 |
20090311295 | PARTICLES WITH HIGH UNIFORM LOADING OF NANOPARTICLES AND METHODS OF PREPARATION THEREOF - Methods to produce polymeric microparticles containing nanoparticles such, as pigments, dyes and other chromophores for cosmetic use, plastic surgery therapeutic use, and tattoos have been developed. The microparticles contain within the polymer a very uniform dispersion of dye particles. The methods by which the particles are made ensure a homogeneous mixture and high loading. The microparticles are made using air, one of a number of known methods such as phase inversion, solvent evaporation, and melt processing. The improvement is in the use of a method that makes, a stable dispersion of the nanoparticles in the liquid polymer before formation of the microparticles. This is achieved through selection of appropriate solvent, optionally including surfactant, and then subjecting the dispersion to mechanical processing that stabilizes the dispersion within the polymer solvent, so that the nanoparticles remain suspended for at least thirty minutes, in some cases two hours to 48 hours, sometimes up to three months. The mechanical processing can be sonication and/or production of shear forces, for examples, resulting from use of an open blade or rotor stator mixer or milling with a concentric shaft, at a speed such as between 5000 and 25,000 RPM. | 12-17-2009 |
20100172998 | PROCESS FOR PREPARING MICROPARTICLES THROUGH PHASE INVERSION PHENOMENA - A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles. | 07-08-2010 |
20110166218 | METHODS FOR MICRONIZATION OF HYDROPHOBIC DRUGS - The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use. | 07-07-2011 |
20120009267 | NANOPARTICLE COMPOSITIONS AND METHODS FOR IMPROVED ORAL DELIVERY OF ACTIVE AGENTS - Nanoparticles, compositions, and methods for the improved uptake of active agents are disclosed herein. The compositions contain a monodisperse population of nanoparticles, preferably including an active agent, where the nanoparticles are formed from a polymeric material possessing specified bioadhesion characteristics. Following enteral administration, preferably oral administration, the nanoparticles exhibit total intestinal uptakes of greater than 20%, preferably greater than 45%, more preferably greater than 65%. When compared to uptake of the same composition in the absence of the bioadhesive polymeric material, the nanoparticles have significantly increased uptake with intestinal uptake of the increased by more than 100%, preferably even greater than 500%. Further disclosed herein is a method of producing multi-walled nanoparticles, as well as methods of using thereof. Multi-walled particles prepared using the method disclosed herein are useful for controlling the release of active agents. | 01-12-2012 |
20120179031 | METHODS AND SYSTEMS FOR PROLONGED LOCALIZATION OF DRUG DELIVERY - An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. The method includes localization of therapeutic agents that are nanoparticulated or nanoencapsulated. Attractive forces between an orally administered magnetic dose and an external magnet were monitored and internal dose motion in real time using biplanar videofluoroscopy was visualized. Tissue elasticity was quantified as a measure of tissue health by combining data streams. The methods address safety, efficacy, and monitoring capacity of magnetically localized doses and show a platform for testing the benefits of localized drug delivery. | 07-12-2012 |
20130095188 | Method of Encapsulating a Material Using Solvent Removal Technique, and Microspheres/Nanospheres/Matrix Made Therefrom Having Sustained Release Properties - A method of encapsulating a material includes providing a polymer solution including a solvent, and an aqueous solution including a hydrophilic material, mixing the polymer and aqueous solutions, sonicating the mixed solution to obtain a water-in-oil (W/O) emulsion, mixing the water-in-oil emulsion with an oil solution, sonicating the mixed solution to obtain a water-in-oil-in-oil (W/O/O) emulsion, and stirring the water-in-oil-in-oil emulsion in a bath to form a precipitate of encapsulated material and separate the solvent. | 04-18-2013 |
20130137702 | ANTICOAGULANT REVERSAL AGENTS - Novel anticoagulant reversal compounds are disclosed, as well as methods of making the compounds, pharmaceutical compositions including the compounds, methods of using the compounds to reverse the anticoagulant effects of coagulation inhibitors, and diagnostic assays comprising the compounds. | 05-30-2013 |
20130189366 | DRUG DELIVERY SYSTEMS AND METHODS OF USE - Disclosed herein are systems for delivery of one or more molecules (such as a drug, for example, a small molecule, polypeptide, and/or nucleic acid) to a subject, for example to a targeted location in the subject. In some embodiments, the delivery system includes an encapsulated inducing agent or repressing agent and a plurality of cells. In some examples, the inducing agent or repressing agent and the cells are each separately encapsulated. In other examples, the encapsulated inducing agent or repressing agent and the cells are co-encapsulated. The cells include one or more genes which are operably linked to an inducible promoter or a repressible promoter which is inducible or repressible by the encapsulated inducing agent or repressing agent, respectively. Methods of use of the delivery systems, for example to treat or inhibit a disease or disorder in a subject, are also disclosed. | 07-25-2013 |
20130280319 | Compositions, methods and kits for therapeutic treatment with wet spun microstructures - Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various embodiments, the therapeutic agent includes at least one selected from the group of: a drug, a protein, a sugar, a carbohydrate, and a nucleotide sequence. In related embodiments, the composition is a fiber, a suture, a sphere, an implant, or a scaffold. | 10-24-2013 |
20140120162 | Bioadhesive Drug Delivery Compositions - Compositions containing one or more active agents, one or more bioadhesives elements, and one or more charge masking agents are described herein. In some embodiments, the one or more active agents are biomolecules or macromolecules, such as polysaccharides, proteins, peptides, or nucleic acids, which are charged at physiological pH. The one or more charge masking agents are selected based on the nature of the charge on the active agent. The compositions may also contain one or more controlled release materials, such as extended or sustained release materials or delayed release materials, in order to modify release of the active agent. | 05-01-2014 |
20140178479 | Concentrated Felbamate Formulations for Parenteral Administration - Formulations of a neuroprotective agent for parenteral administration are described herein. The formulation is in the form of a concentrated (supersaturated) solution or a concentrated suspension of microparticles. The suspension medium or the solution solvent carrier may also contain dissolved neuroprotective agent. For the supersaturated solutions, the agent is dissolved at high concentrations of at least about 1% by weight, 5% by weight, 10% by weight, 15% by weight, or 20% by weight in a solvent suitable for parenteral administration. For the concentrated suspension, the microparticles have an effective particle size from about 100 nm to about 5 microns, preferably from about 50 nm to about 3 microns, more preferably from about 10 nm to about 2 microns. The formulations described herein can be used to treat a variety of neurological diseases/disorders and/or neurological injury or trauma. | 06-26-2014 |
20140207105 | Methods for Effectively and Rapidly Desensitizing Allergic Patients - Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by introducing small quantities of antigen into the lymphatic system. In preferred embodiments, the compositions are administered to yield therapeutically effective levels of antigen within the lymph, where macrophages reside in the greatest concentration, by intradermal administration, using for example, microneedles or microparticles, oral administration, using for example, enteric coated capsules or tablets, or autologous transfusion. In some embodiments, the methods and compositions for delivering antigens orally achieve uptake by the Peyer's patches of the small intestines. | 07-24-2014 |
20140271931 | Anti-Acne Topical Films - Topical formulations containing one or more pharmaceutically acceptable bioadhesive film-forming agent, one or more anti-acne agent, and an aqueous solvent in the form of a solution or suspension are described herein. The formulation may further contain one or more excipients, including evaporation suppressants, humectants, or plasticizers. When the formulation is contacted with the skin of a patient, the solvent evaporates and forms a thin, transparent, and solid bioadhesive film. The bioadhesive film adheres to the skin surface for a prolonged period of time and the anti-acne agent is released into the skin over a prolonged period of time. Typically, the bioadhesive film adheres to the skin for at least 60 minutes following administration of the formulation, preferably for at least 8 hours following administration, more preferably up to 24 hours following administration. The prolonged retention of the anti-acne agent at the site increases the amount of uptake into the skin. | 09-18-2014 |
20150196478 | PERSONALIZING SUBSTANCE FOR APPLICATION TO THE SKIN OR ADDITION TO TATTOO INK AND METHODS OF PREPARATION THEREOF - Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time. | 07-16-2015 |
20150216935 | Autologous Cell-Based Therapy for Treating Obesity - Compositions and methods for producing autologous brown adipose cells in vitro or in vivo are provided. In particular, a drug delivery device is described that recruits adipose stem cells (ASCs) to a site in the body of a subject. These ASCs may then be isolated and induced to differentiate into autologous brown adipose cells. Alternatively, the drug delivery device may also include differentiation factors that induce differentiation of the recruited ASCs into brown adipose cells in vivo. The brown adipose cells produced by these methods may be used therapeutically to treat conditions, such as obesity and diabetes. | 08-06-2015 |
20150320158 | ARTICLES OF JEWELRY CONTAINING A PERSONALIZING ADDITIVE SUCH AS DNA AND METHODS OF MAKING - The present invention relates to jewelry or a metal composition containing an additive or personalizing substance such as a nucleic acid, sand or other suitable component intended to have personal significance to the wearer. A nucleic acid personalizing substance may comprise human DNA of amplified repeat sequences. The jewelry may be made by using a cold or warm metallurgical technique. Prior to being integrated into the article of jewelry, the additive may be encapsulated to provide a protective layer around the personalizing substance. The protective layer can prevent degradation of the personalizing substance during manufacture of the article of jewelry. The personalizing substance can also be added to a polymer solution which is cast to form a continuous matrix of polymer including the personalizing substance. | 11-12-2015 |
Edith Mathiowitz, Providence, RI US
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20130137155 | METHODS AND DEVICES FOR ENCAPSULATING CELLS - Molds for making cell aggregation devices include upper and lower surfaces. Methods of aggregating cells include depositing cells on in a seeding chamber, incubating the cells and removing aggregated cells. Devices for encapsulating aggregates of cells include biocompatible, bio-sustainable substrates compartments and a coating of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and cell-encapsulating compartments. | 05-30-2013 |
Edith Monteagudo, Pomezia (rm) IT
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20150218112 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC - The present invention relates to compounds of formula (I) and (IV), and pharmaceutically acceptable salts, tautomers, stereoisomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are for use in the treatment of disorders that are ameliorated by inhibition of HDAC such as cancer and hemoglobinopathies like β-thalassemia or sickle cell anemia. | 08-06-2015 |
20150299163 | COMPOUNDS FOR USE IN THE TREATMENT OF PARASITIC DISEASES - The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as | 10-22-2015 |
Edith Pighetti, Binningen CH
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20090176906 | In-can stabilizer blend - The invention relates to a radiation curable coating or an ink composition comprising a photoinitiator and a stabilizer blend of a sterically hindered nitroxyl radical and a quinone methide. | 07-09-2009 |
20110319535 | IN-CAN STABILIZERS - The invention relates to the use of highly sterically hindered nitroxyl radicals or of quinone methides or of mixtures thereof as in-can stabilizers for UV-curable resins. | 12-29-2011 |
Edith Puchelle, Tauriac FR
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20100210585 | USE OF HYALURONIC ACID FOR THE PREPARATION OF COMPOSITIONS INTENDED FOR IMPROVING IN PARTICULAR THE PROTECTIVE FUNCTION OF THE SKIN, THE EYE AND THE MUCOUS - The present invention relates to the use of hyaluronic acid for the preparation of compositions intended for improving the protective function of the skin, the eye and the mucous membranes, in particular of the upper and lower airways and the intestinal mucosa. | 08-19-2010 |
Edith Schallmeiner, Uppsala SE
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20100021890 | METHOD FOR ANALYTE DETECTION USING PROXIMITY PROBES - The present invention relates to a method for detecting an analyte in a sample, comprising (a) contacting said sample with at least one set of at least first, second and third proximity probes, which probes each comprise an analyte-binding domain and a nucleic acid domain and can simultaneously bind to the analyte, the nucleic acid domain of said third proximity probe being a splint which is capable of hybridising at least to the nucleic acid domains of said first and second proximity probes, wherein when all of the at least three proximity probes bind to said analyte, the nucleic acid domains of said first and second proximity probes are conjugatable by means of an interaction mediated by said hybridised splint of said third proximity probe; (b) conjugating the nucleic acids, of said first and second proximity probes; and (c) detecting said conjugation. Also provided is a kit for use in such a method. | 01-28-2010 |
Edith Schneider, Nienburg DE
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20110305612 | NOX STORAGE CATALYST WITH IMPROVED HYDROCARBON CONVERSION ACTIVITY - Described is a nitrogen oxide storage catalyst comprising: | 12-15-2011 |
20110305613 | Fe-BEA/Fe-MFI Mixed Zeolite Catalyst And Process For The Treatment Of NOx In Gas Streams - Disclosed is a catalyst, preferably for use in selective catalytic reduction (SCR), said catalyst comprising one or more zeolites of the MFI structure type, and one or more zeolites of the BEA structure type, wherein at least part of the one or more zeolites of the MFI structure type and at least part of the one or more zeolites of the BEA structure type respectively contain iron (Fe). Furthermore, an exhaust gas treatment system is described, comprising said catalyst as well as a process for the treatment of a gas stream comprising NO | 12-15-2011 |
Edith Smith, Brooker, FL US
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20150150170 | Asclepias plant named 'Charlotte's Blush' - A distinct cultivar of | 05-28-2015 |
Edith Stenhäuser, Berlin DE
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20140242264 | FORMALDEHYDE-FREE ELECTROLESS COPPER PLATING SOLUTION - The invention relates to an electroless aqueous copper plating solution, comprising a source of copper ions, a source of glyoxylic acid as reducing agent, and at least one polyamino disuccinic acid or at least one polyamino monosuccinic acid, or a mixture of at least one polyamino disuccinic acid and at least one polyamino monosuccinic acid as complexing agent, as well as to a method for electroless copper plating utilizing said solution and the use of the solution for the plating of substrates. | 08-28-2014 |
Edith Suzarte Portal, Arroyo Naranjo, La Habana CU
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20150328304 | DENGUE VIRUS VACCINE COMPOSITION - Vaccine compositions that comprise at least one antigen based on the dengue virus (DV) capsid protein and the oligonucleotide identified as SEQ ID NO 1. The vaccine composition that comprises a fusion protein formed by the DV2 capsid and domain III of the envelope protein of the same serotype, together with the oligonucleotide identified as SEQ ID NO 1, gives rise to higher levels of cellular immune response and protection in mice as compared with that produced by formulations of the same antigen together with oligonucleotides with potential adjuvant capacity which were reported previously. The efficacy of the compositions that comprise the SEQ ID NO 1 oligonucleotide has been demonstrated in non-human primates. These compositions may be monovalent, bivalent or tetravalent and are combined in different immunization regimes with a view to inducing a functional immune response to the four viral serotypes. | 11-19-2015 |
Edith Torres-Chavolla, Baltimore, MD US
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20140024026 | METALLIC NANOPARTICLE SYNTHESIS WITH CARBOHYDRATE CAPPING AGENT - The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides. | 01-23-2014 |
Edith Torries-Chavolla, Baltimore, MD US
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20150152485 | MYCOBACTERIUM TUBERCULOSIS DETECTION USING TRANSRENAL DNA - The present invention relates to the field of | 06-04-2015 |
Edith Von Aspern, Hanstedt DE
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20140121174 | ANTI-DANDRUFF HAIR CARE PRODUCTS WITH SELECTIVE ACTIVE INGREDIENTS AND A CATIONIC KERATIN - Hair treatment agents include selected cationic alkyloligoglucosides and selected polyglycerol esters as care-providing substances. | 05-01-2014 |
20140248230 | HAIR CARE TREATMENT AGENT - Hair treatment agents include at least one quaternary ammonium compound according to formula (I), in which n denotes an integer from 10 to 24 and X | 09-04-2014 |
Edith Wörnhör, Augsburg DE
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20100119180 | PAPER VALVE SACK WITH INNER CATCH - A description is given of a paper valve bag with an inner panel which is located at the paper-bag end which is located opposite the paper-bag end with valve, and, on its surface which is directed toward the sack interior, the inner panel has an opening aid which has a higher modulus of elasticity than the inner panel. The opening aid, which may be a tear-open strip or a tear-open thread, projects beyond the inner panel at at least one surface-area end of the latter. Such paper valve bags are used for fine-grain, pulverulent and/or free-flowing materials, in particular ready-to-use mortar. | 05-13-2010 |
Edith Wörnhör, Augsburg DE
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20100119180 | PAPER VALVE SACK WITH INNER CATCH - A description is given of a paper valve bag with an inner panel which is located at the paper-bag end which is located opposite the paper-bag end with valve, and, on its surface which is directed toward the sack interior, the inner panel has an opening aid which has a higher modulus of elasticity than the inner panel. The opening aid, which may be a tear-open strip or a tear-open thread, projects beyond the inner panel at at least one surface-area end of the latter. Such paper valve bags are used for fine-grain, pulverulent and/or free-flowing materials, in particular ready-to-use mortar. | 05-13-2010 |
Edith Zimmermann, Graitschen DE
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20100136596 | DEVICE FOR RECEIVING, TREATING, AND STORING SMALL VOLUME SAMPLES - A device is provided by means of which biomolecules in samples in a volume range from <1 μl to 500 μl can be received, treated and stored in a quick, reproducible and loss-free manner as easily, effortlessly and practically as possible, and without any risk of damaging the device. The device includes sample vessels that are configured, in terms of size and shape, as dimensionally and positionally stable capillaries that are open at both ends, the longitudinal walls of which are completely or partially made of a semi-permeable membrane. | 06-03-2010 |