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Echwald, Humlebaek
Soren M. Echwald, Humlebaek DK
| Patent application number | Description | Published |
|---|---|---|
| 20080220423 | Oligonucleotide probes useful for detection and analysis of microRNA precursors - The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNA precursors and their targets. The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease, such as cancer. | 09-11-2008 |
| 20090023221 | Oligonucleotide probes useful for detection and analysis of microrna precursors - The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNA precursors and their targets. The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease, such as cancer. | 01-22-2009 |
Soren Morgenthaler Echwald, Humlebaek DK
| Patent application number | Description | Published |
|---|---|---|
| 20090023594 | REAGENTS FOR LABELLING NUCLEIC ACIDS AND USES THEREOF - The present invention relates to labelling kits containing novel non-natural nucleotide monomers and to methods of making and using such compounds. The invention further relates to a method of detecting the presence of a nucleic acid, e.g., RNA, of interest in a sample, the method having the following steps: providing the sample; ligating a nucleic acid of interest with a labelling reagent according to the instant invention; providing a nucleic acid array having probes directed to the nucleic acid of interest; hybridizing the labelled nucleic acid fragments to said nucleic acid array; and determining the extent of hybridization to said probes to determine the presence of the nucleic acid of interest. | 01-22-2009 |
| 20090053718 | NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF microRNAs AND THEIR TARGET mRNAs - The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs). The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g. alterations associated with human disease, such as cancer. | 02-26-2009 |
| 20090137504 | MICRORNA TARGET SITE BLOCKING OLIGOS AND USES THEREOF - The present invention related to nucleic acids designed to prevent the binding of endogenous or exogenous microRNA and diagnostic and therapeutic uses thereof. | 05-28-2009 |
| 20090239815 | Novel human microRNAs associated with cancer - The invention provides new sequences for human microRNAs associated with cancer which may be used as molecular markers for cancer diagnostics or as therapeutic targets or agents. | 09-24-2009 |
Søren Morgenthaler Echwald, Humlebaek DK
| Patent application number | Description | Published |
|---|---|---|
| 20090326049 | BLOCKING OLIGOS FOR INHIBITION OF MICRORNA AND SIRNA ACTIVITY AND USES THEREOF - The present invention relates to methods of identifying sites in the 3′- and/or 5′-UTR of mRNA involved in the binding of miRNA and/or siRNA to their target sites and nucleic acids designed to prevent the binding of endogenous or exogenous miRNA and/or siRNA to their target mRNA and uses thereof. | 12-31-2009 |
| 20100113284 | SMALL INTERFERING RNA (SIRNA) TARGET SITE BLOCKING OLIGOS AND USES THEREOF - The present invention relates to nucleic acids designed to prevent the binding of single strand RNA in protein complexes originatig from small interfering RNA (siRNA) or small hairpin RNA (shRNA) and uses thereof. | 05-06-2010 |
| 20100286044 | DETECTION OF TISSUE ORIGIN OF CANCER - Disclosed is a method for determining the cellular or tissue origin of tumor cells. The method entails determining the presence of at least one micro RNA (miRNA) in a sample derived from tumor tissue and based on the said determination establishing a miRNA expression profile and comparing this with pre-established miRNA expression profiles from cells, tissues or tumors. The determination uses short oligonucleotide probes comprising modified affinity-enhancing nucleobases. | 11-11-2010 |
| 20110076675 | NOVEL METHODS FOR QUANTIFICATION OF MICRORNAS AND SMALL INTERFERING RNAS - The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids. | 03-31-2011 |