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Eberwine, PA
James Eberwine, Philadelphia, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080199854 | Methods and compositions for identifying RNA-binding proteins - The present invention includes compositions, methods and kits for the identification of a polypeptide that binds to a predetermined RNA sequence. The invention comprises, in part, a photoreactive moiety to aid in identification of such a polypeptide. | 08-21-2008 |
| 20090325174 | Rapid, Sensitive and Quantitative Methods for Tissue and Cell-Based Proteomics via Consecutive Addition of Quantifiable Extenders - Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter. | 12-31-2009 |
| 20100159525 | Extranuclear RNA Splicing in Neuronal Dendrites - The present invention relates to methods of synaptic network remodeling by means of extranuclear RNA splicing. The present invention also provides methods of extranuclear RNA splicing, and methods of protein translation based on extranuclear RNA splicing. | 06-24-2010 |
| 20110033934 | Transcriptome Transfer Produces Cellular Phenotype Conversion - The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome. | 02-10-2011 |
James H Eberwine, Phiadelphia, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100041025 | Compositons, methods and kits for real-time nucleic acid analysis in live cells - The present invention includes compositions, methods and kits for the real-time detection of transcription and translation in live cells, tissues and organisms. The present invention further provides method for the rapid sequencing of nucleic acids without using conventional sequencing techniques or reactions. | 02-18-2010 |
James H. Eberwine, Philadelphia, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090023593 | In situ cloning from pathological tissue specimens - The present invention pertains to methods related to cloning nucleic acids from biological samples, particularly pathological tissue samples. This method includes hybridizing a population of oligonucleotide sequence probes comprising degenerate sequence tags to a fixed tissue, isolating the hybridized oligonucleotide sequence probes and amplifying the sequence tags in the hybridized oligonucleotide sequence probes. This method can be utilized to identify genes associated with disease and to quantitate the expression of disease-related transcripts. The method can also be used to identify truncated mRNAs. | 01-22-2009 |
| 20100203629 | Cytoplasmic BKca Channel Intron-Containing mRNAs Contribute to the Intrinsic Excitability of Hippocampal Neurons - The invention relates to a method of modulating neuronal function by modulating the cytoplasmic level in a neuron of an intron-containing mRNA. The methods are useful in diagnostic, research and therapeutic applications. | 08-12-2010 |
| 20100216652 | Low Level Fluorescence Detection at the Light Microscopic Level - The present invention discloses methods of removing unwanted fluorescence from a sample by photobleaching said sample to enhance detection of proteins and fragments thereof, polynucleotides and fragments thereof, and biomolecules and fragments thereof in a sample by contacting said proteins, polynucleotides and biomolecules with a fluorescent reporter, wherein said fluorescent reported comprises a fluorescent semiconductor crystal or SCN, wherein said SCN further comprises a targeting moiety. | 08-26-2010 |