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During

Annelise During, Talence FR

Patent application numberDescriptionPublished
20090188899METHOD AND DEVICE FOR PREVENTIVE TREATMENT OF AN OPTICAL SURFACE DESIGNED TO BE EXPOSED TO A LASER FLUX - A device for preventive treatment of an optical surface designed to be exposed to a laser flow including a thermal excitation source for providing a localized thermal annealing of a site of the optical surface) by means of a beam applied to the site. The device further includes a measuring member for measuring, in real time said during said localized thermal annealing, a quantity representing the temperature of the site of the optical surface) and at least one control member for increasing the linear power density of the beam applied to the site by the excitation source and, when the quantity reaches a predetermined set point, for gradually decreasing the linear power density.07-30-2009

Martin During, Schruns AT

Patent application numberDescriptionPublished
20100314981IMMOBILIZATION DEVICE FOR LOCKING A FURNITURE PART MOVABLY SUPPORTED IN OR ON A FURNITURE PART - The invention relates to an immobilization device for locking a furniture part that is movably supported in or on a piece of furniture, particularly a drawer, in a closed end position, comprising at least one locking unit, which has a receiving element for an engagement element and a blocking mechanism for the releasable fixation of the receiving element in a position that locks the engagement element when the movable furniture part is in the closed end position, wherein the receiving element or the engagement element is disposed on the furniture and the other element is disposed on the moved furniture part, wherein the locking unit has an overload safety mechanism, which comprises at least two parts connected movably to each other and allows damage-free opening of the movable furniture part even if the receiving element is fixed in a position that locks the engagement element by means of the blocking mechanism.12-16-2010
20100320888LOCKABLE EJECTOR DEVICE FOR A FURNITURE PART MOVABLY SUPPORTED IN PIECE OF FURNITURE - The invention relates to a lockable ejector device for a furniture part that is movably supported in a piece of furniture, comprising a fixing device for locking the movable furniture part in place in a closed end position, and at least one ejector element for moving the movable furniture part from the closed end position into an open position, wherein the fixing device comprises at least two locking units, which are coupled to each other and each have a receiving element for an engagement element, wherein at least two locking units are operatively connected to each other by way of a synchronization mechanism, which has at least two coupling elements, each associated with different locking units, and at least one synchronization unit, wherein the coupling elements are coupled by way of the synchronization unit with respect to the movements thereof12-23-2010
20100327719IMMOBILIZATION DEVICE FOR LOCKING A FURNITURE PART MOVABLY SUPPORTED IN OR ON AN ARTICLE OF FURNITURE - The invention relates to an immobilization device for locking a furniture part that is movably supported in or on a piece of furniture, particularly a drawer, in a closed end position, comprising at least one locking element, which has a receiving element for an engagement element, wherein the receiving element or the engagement element is disposed on the piece of furniture and the other element is disposed on the movable furniture part, and the two elements are operatively connected at least in the closed end position of the movable furniture part, wherein the relative position of the receiving element to the engagement element in the depth of the piece of furniture can be varied in a linear fashion by means of an adjusting unit, which is configured to convert a rotational movement into a translatory movement.12-30-2010

Matthew During, Columbus, OH US

Patent application numberDescriptionPublished
20100093058High Transgene Expression Of A Pseudotyped Adeno-Associated Virus Type - The present invention related to methods and compositions comprising recombinant vectors comprising chimeric capsids and recombinant pseudotyped vectors with non-native capsid protein(s). The recombinant vectors of the invention confer an altered tropism that permits selective targeting of desired cells.04-15-2010
20100143458GLUTAMIC ACID DECARBOXYLASE (GAD) BASED DELIVERY SYSTEM - The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus.06-10-2010

Matthew J. During, Columbus, OH US

Patent application numberDescriptionPublished
20100168215METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGICAL DISEASE - The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional fragment thereof in the target cell(s) provides therapeutic benefit for subjects afflicted with a neurological disorder.07-01-2010
20100221200COMPOSITIONS AND METHODS FOR SKIN CARE - The present disclosure contemplates compositions and methods for skin care. In some embodiments, the compositions may comprise delta opioid receptor agonists. The skin care composition may comprise peptide delta opioid receptor agonists, non-peptide delta opioid receptor agonists, or combinations thereof. In further embodiments, the peptide delta opioid receptor agonists may be chosen from enkephalins and/or deltorphins. In yet other embodiments, the delta opioid receptor agonists may be conjugated to another molecule. For example, the delta opioid receptor agonist may be conjugated to a lipid in order to facilitate entry across the stratum corneum. Further disclosed herein is the cosmetic use of at least one combination as described above, in a composition suitable for topical application to the skin, as an agent for smoothing out wrinkles and fine lines, such as expression wrinkles.09-02-2010

Matthew J. During, New York, NY US

Patent application numberDescriptionPublished
20100191218INFUSION DEVICE AND METHOD FOR INFUSING MATERIAL INTO THE BRAIN OF A PATIENT - A fluid infusion device and a method of using the same. The device includes an outer, flexible guide catheter having a distal end for introduction beneath the skull of a patient and a proximal end remaining external of the patient. A flexible infusion fiber is located within the guide catheter and has a distal end extending outwardly from the guide catheter to be located in a target area within the patient's brain. The infusion fiber can be fixed or axially movable within the guide catheter. In the latter embodiment, the proximal end of the infusion fiber extending outwardly from the guide catheter can be manipulated to locate the distal end of the infusion fiber in the target area. An infusion pump is connected to the proximal end of the infusion fiber to infuse a minute quantity of fluid at an extremely low flow rate into the brain of the patient.07-29-2010

Patent applications by Matthew J. During, New York, NY US