| Patent application number | Description | Published |
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| 20090010846 | Nitro-Imidazole Hypoxia Imaging Agents - The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography. | 01-08-2009 |
| 20090123372 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY - The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents. | 05-14-2009 |
| 20100317842 | Development of Molecular Imaging Probes for Carbonic Anhydrase-IX Using Click Chemistry - The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents. | 12-16-2010 |
| 20110002850 | Nitro-Imidazole Hypoxia Imaging Agent - The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography. | 01-06-2011 |
| 20110046378 | Novel Imaging Agents for Detecting Neurological Dysfunction - Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease | 02-24-2011 |
| 20110091382 | NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION - Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease. | 04-21-2011 |
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| 20080237470 | Polymeric composite scintillators and method for making same - A scintillation detector comprising nano-scale particles of a scintillation compound embedded in a plastic matrix is provided. The nano-scale particles may be made from metal oxides, metal oxyhalides, metal oxysulfides, or metal halides. Methods are provided for preparing the nano-scale particles. The particles may be coated with organic compounds or polymers prior to incorporation in the plastic matrix. A technique for matching the refractive index of the plastic matrix with the nano-scale particles by incorporating nano-scale particles of titanium dioxide is also provided. The scintillator may be coupled with one or more photodetectors to form a scintillation detection system. The scintillation detection system may be adapted for use in X-ray and radiation imaging devices, such as digital X-ray imaging, mammography, CT, PET, or SPECT, or may be used in radiation security detectors or subterranean radiation detectors. | 10-02-2008 |
| 20080241041 | Nano-scale metal oxyhalide and oxysulfide scintillation materials and methods for making same - Crystalline scintillator materials comprising nano-scale particles of metal oxides, metal oxyhalides and metal oxysulfides are provided. The nano-scale particles are less than 100 nm in size. Methods are provided for preparing the particles. In one method, used to form oxyhalides and oxysulfides, metal salts are dissolved in water, and then precipitated out as fine particles using an aqueous base. After the particles are separated from the solution, they are annealed under a flow of a water saturated hydrogen anion gas, such as HCl or H | 10-02-2008 |
| 20080296503 | HIGH ENERGY RESOLUTION SCINTILLATORS HAVING HIGH LIGHT OUTPUT - A scintillator composition includes a matrix material, where the matrix material includes an alkaline earth metal and a lanthanide halide. The scintillator composition further includes an activator ion, where the activator ion is a trivalent ion. In one embodiment, the scintillator composition includes a matrix material represented by A | 12-04-2008 |
| 20090140150 | INTEGRATED NEUTRON-GAMMA RADIATION DETECTOR WITH ADAPTIVELY SELECTED GAMMA THRESHOLD - An integrated radiation detector having a pulse-mode operating photosensor optically coupled to a gamma sensing element and a neutron sensing element is disclosed. The detector includes pulse shape and processing electronics package that uses an analog to digital converter (ADC) and a charge to digital converter (QDC) to determine scintillation decay times and classify radiation interactions by radiation type. The pulse shape and processing electronics package determines a maximum gamma energy from the spectrum associated with gamma rays detected by the gamma sensing element to adaptively select a gamma threshold for the neutron sensing element. A light pulse attributed to the neutron sensing element is a valid neutron event when the amplitude of the light pulse is above the gamma threshold. | 06-04-2009 |
| 20100136302 | ARTICLES USING PERSISTENT PHOSPHORS - An article of manufacture that comprises a structure that is a security system device (or portion thereof) or a fire system device (or portion), where a persistent phosphor and/or a persistent phosphor blend is either integrated in a coating on the structure; applied on the structure; or integrated in the structure, wherein the persistent phosphor comprises certain phosphors or phosphor blends. The present invention has been described in terms of specific embodiment(s), and it is recognized that equivalents, alternatives, and modifications, aside from those expressly stated, are possible and within the scope of the appending claims. | 06-03-2010 |
| 20100230601 | COMPOSITION, ARTICLE, AND METHOD - A polycrystalline scintillator composition is provided. The polycrystalline scintillator composition is capable of being sintered to form a body having a pulse height resolution that is less than about 20 percent at 662 kilo electron volts. Also, an article formed form the polycrystalline scintillator composition is provided, as well as a radiation detector including the article. | 09-16-2010 |
| 20110024685 | NANO-SCALE METAL OXYHALIDE AND OXYSULFIDE SCINTILLATION MATERIALS AND METHODS FOR MAKING SAME - Crystalline scintillator materials comprising nano-scale particles of metal oxides, metal oxyhalides and metal oxysulfides are provided. The nano-scale particles are less than 100 nm in size. Methods are provided for preparing the particles. In one method, used to form oxyhalides and oxysulfides, metal salts are dissolved in water, and then precipitated out as fine particles using an aqueous base. After the particles are separated from the solution, they are annealed under a flow of a water saturated hydrogen anion gas, such as HCl or H | 02-03-2011 |
