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D'Souza, US
Ajit Joseph M. D'Souza, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110313363 | Medical Components Having Coated Surfaces Exhibiting Low Friction and Low Reactivity - This invention relates to medical articles, such as a syringe assemblies, including a substrate having a coating on a surface thereof, the coating including: (1) at least one organopolysiloxane and (2) a deposition product applied to the at least one organopolysiloxane by plasma-enhanced chemical vapor deposition of a composition including at least one monomer selected from the group consisting of N-vinyl pyrrolidone, vinyl acetate, ethylene oxide, alkyl acrylate, alkyl methacrylate, acrylamide, acrylic acid, and mixtures thereof, and methods of making and using the same. | 12-22-2011 |
Ajit M. D'Souza, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080226729 | STABLE POWDER FORMULATIONS OF ALUM-ADSORBED VACCINES - The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum-adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided. | 09-18-2008 |
| 20110159047 | STABLE POWDER FORMULATIONS OF ALUM-ADSORBED VACCINES - The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum-adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided. | 06-30-2011 |
Andrew S. D'Souza, Little Canada, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20100126618 | MICROPHERE-CONTAINING INSULATION - An insulated article having a first insulation region comprising a first polymeric material and first hollow ceramic microspheres and a second insulation region comprising a second polymeric material and second hollow ceramic microspheres. The first insulation region has a thermal conductivity that is no greater than the thermal conductivity of the first polymeric material and a volumetric heat capacity in a range of 60% to 90% of the volumetric heat capacity of the first polymeric material. The second insulation region has a thermal conductivity that is no greater than 90% of the thermal conductivity of the second polymeric material and a volumetric heat capacity that is less than 60% of the volumetric heat capacity of the second polymeric material. A method for making a composition for insulating an article is also described. | 05-27-2010 |
Andrew S. D'Souza, Shoreview, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20110027592 | AQUEOUS BINDER OR SIZING COMPOSITION - A binder or sizing composition that is provided that demonstrates improved hydrolytic stability of the bond between a SiO containing substrate, such as glass, and a matrix polymer, such as polypropylene, which is especially useful in reinforced plastics. A water-based composition is provided that contains at least one amino-functional coupling agent, and acid or anhydride modified polyolefin, and an epoxy functional compound. This composition is useful as a glass binder or sizing to provide a strong bond between glass and a polymer. | 02-03-2011 |
Christian Andre D'Souza US
| Patent application number | Description | Published |
|---|---|---|
| 20090039855 | Scientific method to accurately regulate point of load power distribution using remote sense connection point switchover - A power regulation system for providing a regulated voltage to a load is provided. The system includes an energy source or a power source and a switching device. The switching device switches a sensing voltage input of the energy source between a voltage input of a power-line controller and a voltage input of the load based on a status input. A method for providing a regulated voltage to a load is also described. | 02-12-2009 |
Christopher A. D'Souza, Suffern, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090155166 | Methods and Compositions for F-18 Labeling of Proteins, Peptides and Other Molecules - The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled by the described methods. Preferably, the F-18 may be conjugated to a targeting molecule by formation of a metal complex and binding of the F-18-metal complex to a chelating moiety. Alternatively, the metal may first be conjugated to the chelating group and subsequently the F-18 bound to the metal. In other embodiments, the F-18 labeled moiety may comprise a targetable construct used in combination with a bispecific or multi specific antibody to target F-18 to a disease-associated antigen, such as a tumor-associated antigen. The F-18 labeled targetable construct peptides are stable in serum at 37° C. for a sufficient time to perform PET imaging analysis. | 06-18-2009 |
| 20090246130 | Methods and Compositions for F-18 Labeling of Proteins, Peptides and Other Molecules - The present application discloses compositions and methods of synthesis and use of | 10-01-2009 |
Christopher A. D'Souza, Pomona, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20110076233 | Delivery System for Cytotoxic Drugs by Bispecific Antibody Pretargeting - The present invention relates to methods and compositions for pretargeting delivery of therapeutic agents. In preferred embodiments, the pretargeting method comprises: a) administering a bispecific antibody with a first binding site for a disease-associated antigen and a hapten on a targetable construct; b) administering a targetable construct comprising at least one therapeutic agent. In preferred embodiments, the bispecific antibody is made by the dock-and-lock (DNL) technique. In a more preferred embodiment, the targetable construct comprises one or more SN-38 moieties. | 03-31-2011 |
| 20110110854 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules - The present application discloses compositions and methods of synthesis and use of | 05-12-2011 |
| 20110280801 | Methods and Compositions for F-18 Labeling of Proteins, Peptides and Other Molecules - The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled by the described methods. Preferably, the F-18 may be conjugated to a targeting molecule by formation of a metal complex and binding of the F-18-metal complex to a chelating moiety. Alternatively, the metal may first be conjugated to the chelating group and subsequently the F-18 bound to the metal. In other embodiments, the F-18 labeled moiety may comprise a targetable construct used in combination with a bispecific or multispecific antibody to target F-18 to a disease-associated antigen, such as a tumor-associated antigen. The F-18 labeled targetable construct peptides are stable in serum at 37° C. for a sufficient time to perform PET imaging analysis. | 11-17-2011 |
Jollin D'Souza, Somers, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20080260964 | VISION SYSTEM AND METHOD FOR DIRECT-METAL-DEPOSITION (DMD) TOOL-PATH GENERATION - New tool paths are automatically created for rapid prototyping and additive manufacturing processes, facilitating the fabrication of new or repaired parts with superior geometries and/or compositional characteristics. The profile of a source part is imaged from camera picture and point wise offset adjustments. Part profile and process points are automatically generated without teaching by an operator. In the preferred embodiment, point-by-point process variable settings (i.e., laser power, speed and powder flow) are coupled to a closed-loop, direct-metal deposition (DMD) process to fabricate or repair production components using a tool path derived from the profile of the source part. The preferred method includes the steps of detecting the edge of the source part; generating a point-to-point database of the source part based upon the detected edge; and assigning one or more process parameters associated with the additive manufacturing process used to fabricate or repair the production part. | 10-23-2008 |
Lestan D'Souza, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090299954 | Method and system for data file processing - A library of jobs is created, with the jobs performing predetermined functions. The jobs include a termination indication, which is success or failure. Input file formats of known file types are determined and a job stream to process the input files is constructed of the jobs linked according to the termination success or failure of the preceding job. | 12-03-2009 |
Martin J. D'Souza, Duluth, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20090081306 | MICROENCAPSULATED MATERIALS AND METHOD OF MAKING SAME - A method of forming microspheres of a bioactive material, such as a protein polymer or drug by nebulizing a solubilized form of a material to be encapsulated and an encapsulating material, such as albumin, in a stirred chilled solvent system comprising a vegetable oil, mineral oil and/or a lower alcohol such that the formed microspheres demonstrate intracellular bioactivity when taken up by macrophages. | 03-26-2009 |
| 20100111984 | NANOSPHERES ENCAPSULATING BIOACTIVE MATERIAL AND METHOD FOR FORMULATION OF NANOSPHERES - A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous medium in a first vessel; contacting the dissolved polymer matrix with a crosslinking agent, such as glutaraldehyde, to crosslink the polymer matrix and the crosslinking agent; neutralizing with sodium bisulfate any excess crosslinking agent remaining after crosslinking is substantially complete; solubilizing in a second vessel a bioactive material in an aqueous solution; mixing the solubilized bioactive material together with the neutralized crosslinked polymer matrix in solution to form a mixture; and, spray drying the mixture to produce nanospheres, whereby substantial bioactivity of the biomaterial is retained upon cellular uptake. | 05-06-2010 |
Maurice Gerard D'Souza, Plano, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20120044799 | METHOD AND APPARATUS OF IMPLEMENTING AN INTERNET PROTOCOL SIGNALING CONCENTRATOR - Communication between base station controllers and a mobile switching center may be provided by a consolidating device that operates between the BSCs and the MSCs. One example method of operation may include initiating an active process on an active network device and a standby process on a redundant network device configured as a backup to the active network device. Other operations may include receiving a data message from at least one base station controller on the active network device, and detecting a communication failure by at least one of the active process and the standby process, in response to the received data message. Other operations may include automatically configuring the redundant network device to become the active network device. | 02-23-2012 |
Ollencio D'Souza, Farmington, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20110001812 | Context-Aware Alarm System - An alarm system ( | 01-06-2011 |
Richard D'Souza, Houston, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20080267716 | SHALLOW/INTERMEDIATE WATER MULTIPURPOSE FLOATING PLATFORM FOR ARCTIC ENVIRONMENTS - A method and apparatus for conducting simultaneous drilling and production are provided. The apparatus can include a ship shape floating vessel, wherein the ship shape floating vessel includes at least two drilling derricks, at least two drilling modules, and at least one production module, all situated on the upper surface of the ship shape floating vessel. The drilling modules are adapted for conducting drilling operations; the production module is adapted for conducting production operations. The apparatus can include at least two marine risers, wherein each marine riser depends from a drilling or production module toward a hydrocarbon bearing zone or sea floor and is adapted for conducting drilling and/or production operations; at least one production turret located on the lower surface of the ship shape floating vessel; and at least one production riser, wherein the production riser depends from the production turret, extends toward the sea floor, and is adapted for conducting production operations. | 10-30-2008 |
| 20090035069 | METHODS AND APPARATUS FOR PROTECTING OFFSHORE STRUCTURES - Protective structures for offshore installations and methods for using same are provided. The protective structure can include a body adapted to be disposed at least partially about a primary structure of an offshore installation, and a support system can be disposed on the body. One or more protrusions can be disposed about an outer surface of the body. The protrusions can have a first end adapted to break ice. The support system can be adapted to isolate the one or more bodies from the primary structure such that the one or more bodies can absorb at least a portion of ice generated vibrations. | 02-05-2009 |
| 20090151954 | SUBSEA HYDRAULIC AND PNEUMATIC POWER - Systems and methods for providing energy to sub-sea support equipment. Energy can be provided by diverting at least a portion of a fluid from a well producing system to sub-sea support equipment units that can be disposed in the vicinity of the sea-floor, sea-bed, or mud-line. The well producing system can include, but is not limited to, a water injection system, a gas lift system, or combinations thereof. A water injection system designed to provide pressure support to one or more wells can be modified to provide an operational power source to one or more sub-sea support equipment units. | 06-18-2009 |
Rohini D'Souza, Croton On Hudson, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090041728 | Proteoglycan Degrading Mutants for the Treatment of CNS - The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease. | 02-12-2009 |
| 20110250631 | PROTEOGLYCAN DEGRADING MUTANTS FOR TREATMENT OF CNS - The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease. | 10-13-2011 |
Rohit D'Souza, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100121754 | SYSTEM AND METHOD FOR EXECUTING STRATEGY SECURITY TRADING - A computer implemented method and system for executing block trades for a security includes steps or devices for receiving a block trade request, at a computer system. The block request includes data representing a quantity of shares of the security to be traded over a period of time. The computer system divides the period of time into a plurality of time bins. A computer system, for the received block trade request, computes, for each time bin, a number of shares to be traded as a trading target based on at least historical trading volumes using predictive analysis. For a first time bin, a computer system generates executable trade orders for a number of shares to be traded that is substantially equal to the trading target for the first time bin. A computer system executes at least a portion of the executable trade orders in a trade forum within each time bin in the future. | 05-13-2010 |
| 20110276459 | SYSTEM AND METHOD FOR EXECUTING STRATEGY SECURITY TRADING - A computer implemented method and system for executing block trades for a security includes steps or devices for receiving a block trade request, at a computer system. The block request includes data representing a quantity of shares of the security to be traded over a period of time. The computer system divides the period of time into a plurality of time bins. A computer system, for the received block trade request, computes, for each time bin, a number of shares to be traded as a trading target based on at least historical trading volumes using predictive analysis. For a first time bin, a computer system generates executable trade orders for a number of shares to be traded that is substantially equal to the trading target for the first time bin. A computer system executes at least a portion of the executable trade orders in a trade forum within each time bin in the future. | 11-10-2011 |
Susan S. D'Souza, Marlborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090221541 | PHARMACEUTICAL FORMULATIONS - An aspect of the present invention provides for a medicament suitable for administration as a nasal inhalant including an aqueous carrier and suspended therein particulate pleconaril, the aqueous carrier including a thixotropic composition including microcrystalline cellulose and a polymer selected from an alkali metal carboxyalkylcellulose, a polyvinylpyrrolidone polymer, and mixtures thereof. | 09-03-2009 |
| 20090238771 | PHARMACEUTICAL FORMULATIONS - An aspect of the present invention provides for a medicament including a solution containing pleconaril or a pharmaceutically acceptable salt thereof, wherein at least one solvent comprising said solution is a pleconaril-dissolving glyceride oil, and the solution is suitable for inhalation administration as an aerosol mist. | 09-24-2009 |
Warren D'Souza, Timonium, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120004518 | TECHNIQUES FOR COMPENSATING MOVEMENT OF A TREATMENT TARGET IN A PATIENT - One embodiment includes a method of predicting a position of a target site inside a body using surrogates is provided. The method includes transforming surrogate measurements and target positions into different representations by applying an operator, establishing a special relationship between the transformed surrogate measurements and the transformed target positions, and continuously predicting the target position from the transformed surrogate measurements and the established special relationship. | 01-05-2012 |
Warren D. D'Souza, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080212737 | Techniques For Compensating Movement of a Treatment Target in a Patient - Techniques for improving treatment delivered to a target site in a patient include delivering a treatment from a treatment delivery device to a target site in a patient supported by a patient support structure. During the delivery of treatment, a state of the patient is measured to produce real-time measurement data. Measuring the state is non-invasive; and the measured state is a correlated surrogate for position of the target site. Compensating movement data is determined based on the real-time measurement data to cause the target site to maintain a particular spatial relationship with the treatment delivery device. Either the treatment delivery device, or the support structure, or both, are moved based on the compensating movement data. When the delivery device alone is moved, the correlation between measured state and target site is based on partial least squares applied to pre-treatment measurements of both. | 09-04-2008 |
| 20080310590 | AUTOMATED SOFTWARE SYSTEM FOR BEAM ANGLE SELECTION IN TELETHERAPY - A novel approach to generating radiation treatment plans through a nested partitions framework provides an optimization of radiation delivery. The nested partitions approach couples beam angle selection and dose optimization to solve treatment planning problems. An optimal beam angle selection is provided to best treat tumors, while minimizing exposure to the surrounding healthy tissues. | 12-18-2008 |