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Dreyfuss, US
Gideon Dreyfuss, Wynnewood, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090156789 | Compositions, Methods and Kits Useful for the Diagnosis and Treatment of Spinal Muscular Atrophy - The invention relates to an isolated nucleic acid encoding a eukaryotic Survival of Motor Neuron-Interacting Protein 1 (SIP1), compositions comprising SIP1 and SIP1 and the spinal muscular atrophy (SMA) disease gene product Survival of Motor Neuron protein (SMN), and diagnostic and therapeutic assays directed to SMA. The invention also relates to another protein that specifically interacts with SMN and is a component of gems, designated Gemin3, and the nucleic acid encoding the protein. Additionally, the invention relates to a novel cell line wherein the endogenous SMN genes have been deleted and where an exogenous nucleic acid encoding SMN has been inserted into the cell such that expression of SMN in the cell is under the control of an inducible promoter. This novel cell line provides a stable genetic system for the study of SMA and for the development of SMA therapeutics. | 06-18-2009 |
| 20100197661 | Method of Treating Neurological Diseases and Disorders - The present invention provides methods for treating neurological diseases and disorders. Compounds that replace or enhance the function of SMN or alleviate or reduce a phenotype of cells with low SMN protein levels are provided. Screening methods and kits for identifying such compounds also are provided. | 08-05-2010 |
| 20100234402 | METHODS AND COMPOSITIONS FOR TREATING SPINAL MUSCULAR ATROPHY - This invention provides methods of treating and abrogating spinal muscular atrophy by administering an antioxidant. Additionally, the invention provides a method of protecting the SMN protein by administering an antioxidant. | 09-16-2010 |
| 20100273179 | METHOD FOR TESTING OR SCREENING PROTEIN SYNTHESIS INHIBITORS - This invention provides methods for screening an inhibitor of protein synthesis by measuring the level of relocalization of an SMN complex component from the cytoplasm to the nucleus. Additionally, the invention provides a kit and a system for screening protein synthesis inhibitors in a cell. | 10-28-2010 |
| 20100297665 | METHOD FOR TESTING AND SCREENING P38 MAP KINASE MODIFIERS - This invention provides methods for treating diseases associated with elevated p38 mitogen-activated protein kinase activity. Moreover, the invention provides methods for testing a candidate compound for a p38 mitogen-activated protein kinase modifying activity by calculating the level of relocalization of an SMN complex component from the cytoplasm to the nucleus of a cell. Additionally, the invention provides a kit and a system for calculating the same. | 11-25-2010 |
Jacob A. Dreyfuss, Elkins Park, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100306017 | CREATING, CONFIRMING, AND MANAGING EMPLOYEE SCHEDULES - A system and method for creating, confirming and managing employee schedules comprises creating a schedule having time slots comprising shifts having employees, publishing the schedule on a network to the employees, and receiving a response of a confirmation, a request for shift change, and a null response from each employee. For each employee, if a null response is received, a reminder is sent. If request for shift change is received, an alert is sent to eligible employees using a preferred communication mode, and if one of the eligible employees responds, the shift change may be confirmed automatically or with manager approval. If approved, the employee requesting the change and the eligible employee are notified of the change; if not approved, both employees are notified of the lack of change. The schedule can be published using an employee's preferred communication mode. All steps contain implications for the system's three-step color-coding schema. | 12-02-2010 |
Peter Dreyfuss, Miami, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100268256 | SUTURE PASSER - A device for placing one or more sutures and approximating tissue includes an elongate body member and a suture deployment system. The suture deployment system includes a suture carrier with a sharpened end for piercing tissue. | 10-21-2010 |
Peter Dreyfuss, Naples, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20090145443 | MAGNETIC POSITIONER - An example surgical positioner includes a first support member and a second support member moveably joined to the first support member. A magnet is operative to generate a magnetic force that attracts the first support member toward the second support member to resist relative movement between the first support member and the second support member. | 06-11-2009 |
Richard Dreyfuss, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080314228 | Interactive tool and appertaining method for creating a graphical music display - The invention provides apparatus and a method for creating a visual representation of music that conveys the musical form, structure, event surface, orchestration, and sonic framework of the piece being visualized. The representation comprises visual characters/sprites that move in time according to instructions from the metadata synchronized to the actual musical recording. These characters accurately portray the rhythm, pitch, and timbre of the individual elements in the musical surface (individual lines or performers) and have a hierarchy of representation, e.g. thematic elements that are divided into sub-elements (gestures or phrases) that are further divided into individual notes. The visual representation corresponds to the structure of the music as heard, where simultaneous harmonic events are parsed into individual notes which are then tied together into a rhythmic stream of linked events. Two streams of data (the “musical” and the “sonic”) are synchronized to the musical piece to drive the visualization. | 12-25-2008 |