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Dressman, US
Bruce Anthony Dressman, Indianapolis, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20080300266 | 1-(Hetero)Aryl-3-Amino-Pyrrolidine Derivatives for Use as Mglur3 Antagonists - The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine, pharmaceutical compositions thereof, and methods of using the same. | 12-04-2008 |
Devin Dressman, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090286687 | Method and Compositions for Detection and Enumeration of Genetic Variations - Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to which thousands of copies of DNA identical in sequence to the original are bound. This population of beads then corresponds to a one-to-one representation of the starting DNA molecules. Variation within the original population of DNA molecules can then be simply assessed by counting fluorescently-labeled particles via flow cytometry. Millions of individual DNA molecules can be assessed in this fashion with standard laboratory equipment. Moreover, specific variants can be isolated by flow sorting and employed for further experimentation. This approach can be used for the identification and quantification of rare mutations as well as to study variations in gene sequences or transcripts in specific populations or tissues. | 11-19-2009 |
Holly Dressman, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090186024 | Gene Expression Signatures for Oncogenic Pathway Deregulation - The disclosure relates to identifying deregulated pathways in cancer. In certain embodiments, the methods of the disclosure can be used to evaluate therapeutic agents for the treatment of cancer. | 07-23-2009 |
| 20100009357 | PREDICTION OF LUNG CANCER TUMOR RECURRENCE - The invention provides methods of estimating the likelihood of lung cancer recurrence in a subject, including those afflicted with NSCLC. The methods of the invention are useful for developing a therapeutic treatment plan to prevent cancer recurrence for subjects deemed to be at high risk, and withholding treatments from those subjects deemed to be at low risk. The invention also provides methods of generating and using metagene-based prediction tree models for estimating the likelihood of lung cancer recurrence. The invention also provides reagents, such as DNA microarrays, software and computer systems useful for estimating cancer recurrence, and provides methods of conducting a diagnostic business for the prediction of cancer recurrence. | 01-14-2010 |
| 20110028338 | SIGNATURES OF RADIATION RESPONSE - The present invention relates, in general, to gene expression profiles, and in particular, to a peripheral blood gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods. | 02-03-2011 |
Holly K. Dressman, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100273711 | INDIVIDUALIZED CANCER TREATMENTS - Provided herein are methods for the use of gene expression profiling to determine whether an individual afflicted with cancer will respond to a therapy, and in particular to therapeutic agents such as platinum-based agents and antimetabolite agents. Methods for the treatment of individuals with the therapeutic agents are also provided. Methods of predicting the efficacy of cancer therapeutic agents such as platinum-based and antimetabolite therapeutic agents are also provided. Kits including gene chips and instructions for predicting responsiveness are also provided. | 10-28-2010 |
Richard Herman Dressman, Lexington, KY US
| Patent application number | Description | Published |
|---|---|---|
| 20110017505 | Z-Directed Connector Components for Printed Circuit Boards - A Z-directed connector component for insertion into a printed circuit board and providing electrical connections to internal conductive planes contained with the PCB and/or to external conductive traces on the surface of the PCB.. In one embodiment the Z-directed component is housed within the thickness of the PCB allowing other components to be mounted over it. The body of the Z-directed connector component may contain one or more conductors and may include one or more surface channels or wells extending along at least a portion of the length of the body. Methods for mounting Z-directed components are also provided. | 01-27-2011 |
Richard K. Dressman, Erlanger, KY US
| Patent application number | Description | Published |
|---|---|---|
| 20090093196 | Particle Blast System with Synchronized Feeder and Particle Generator - A particle blast apparatus has a particle generator the speed of which is synchronized with the speed of the feeder which introduces particles into the flow of transport gas. | 04-09-2009 |