Down, US
Chris Down, Torrance, CA US
Patent application number | Description | Published |
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20110086575 | Toy Vehicle Having Fanciful Facial Expression - A toy vehicle includes a body supported by a plurality of wheels. The body also includes a roof and rear window supporting a plurality of user inputs. Within the toy vehicle body, a microprocessor controller drive and steering mechanism is operative. The operation of the microprocessor is set by the user inputs. The body further supports a movable bumper mouth and movable eyes and eyebrows behind the windshield. | 04-14-2011 |
20130324003 | RACE COURSE PLAY SET FOR FLOATING TOY VEHICLES - Playsets for use on a water surface, including a toy vehicle configured to travel along the water surface and a buoyant race course, where the race course includes a guide that defines the race course on the water surface, a start platform that supports the toy vehicle, a start gate that releases the toy vehicle from the start platform onto the water surface at the start of the race course, and a finish gate that marks the end of the race course. | 12-05-2013 |
Donald A. Down, Brookfield, WI US
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20090063063 | Preventive Maintenance Tapping and Duty Cycle Monitor for Voltage Regulator - The life of load tap changer contacts is monitored by detecting an arcing event; identifying arcing surfaces involved in the arcing event; calculating a per-unit loss of life for the identified arcing surfaces as a result of the arcing event; updating estimates of cumulative erosion for the arcing surfaces; comparing the updated estimates of cumulative erosion to a first threshold value; and signaling for action when at least one of the updated estimates of cumulative erosion exceeds the first threshold value. | 03-05-2009 |
Ed Down, Tucson, AZ US
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20090285624 | APPARATUS FOR PREVENTING INCORRECT INSTALLATION OF MACHINERY COMPONENTS TOGETHER - Apparatus for preventing incorrect installation of machinery components together includes a tab, pin and pin-receiving hole. The tab on the seal plate protrudes angularly from its periphery and laterally beyond it so as to prevent incorrect installation of two seal plates together in a faulty sealing relationship with machinery components by their tabs making interfering contact with one another producing a visible gap between the two seal plates. The pin is mounted on and protrudes axially from a surface of one machinery component facing the seal plate and prevents incorrect installation of the machinery components together in a faulty sealing relationship without the seal plate between them by the pin contacting the surface of the other machinery component and producing a gap between the machinery components. The hole extends through the seal plate to receive the pin within it when one seal plate is correctly installed between the machinery components. | 11-19-2009 |
20110241465 | LOW PROFILE STARTER-GENERATOR - A power system for a vehicle may comprise an electric machine interposed between an engine and a transmission of the vehicle. The electric machine may comprise an exciter generator with exciter armature windings surrounding an axis, a main generator with main field windings surrounding the axis so that the exciter generator and the main generator are concentric and a rotor coaxial with the axis and the rotor supporting the exciter armature windings and the main field windings. The rotor may have a first end attached to the engine power output shaft and a second end adapted to deliver mechanical power from the engine to the transmission. | 10-06-2011 |
Edward M. Down, Tucson, AZ US
Patent application number | Description | Published |
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20080252155 | SPRAY COOLED V-WEDGE FOR AEROSPACE GENERATOR - A high speed generator cooling system directs a cooling oil spray through a chamber inside a coil support wedge assembly, which may be disposed adjacent to the generator coils. Heat from the generator coils may be conducted through the walls of the coil support wedge assembly and into the chamber where it is removed by the cooling oil spray passing through the chamber. The cooling oil passes through a generator rotor shaft and into a cooling passage in least one of the rotor laminations. | 10-16-2008 |
Edward Mark Down, Tucson, AZ US
James Down, Cary, NC US
Patent application number | Description | Published |
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20130263997 | Device for Withdrawing or Administering a Substance and Method of Manufacturing a Device - A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge. | 10-10-2013 |
James A. Down, Randolph, NJ US
Patent application number | Description | Published |
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20080234656 | METHOD FOR ALTERING DRUG PHARMACOKINETICS BASED ON MEDICAL DELIVERY PLATFORM - A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm. | 09-25-2008 |
20110190725 | METHOD FOR ALTERING DRUG PHARMACOKINETICS BASED ON MEDICAL DELIVERY PLATFORM - A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm. | 08-04-2011 |
20140200547 | Method for Altering Drug Pharmacokinetics Based on Medical Delivery Platform - A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm. | 07-17-2014 |
James A. Down, Cary, NC US
Patent application number | Description | Published |
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20130245601 | INTRADERMAL DELIVERY OF SUBSTANCES - The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage. | 09-19-2013 |
John Harry Down, Lanesborough, MA US
Patent application number | Description | Published |
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20100077830 | ELECTRONIC SELF-CALIBRATION FOR SENSOR CLEARANCE - Self-calibration of a multiple channel clearance sensor system, which in one embodiment includes at least one sensor for measuring at least one clearance parameter signal between a stationary object and a rotating object of a rotating machine. The sensor output is processed as a clearance parameter by an offset correction section configured to determine an offset error in the clearance parameter signal which is used by a level shifter. The level shifter is also switchably coupled to the clearance parameter signal wherein the output of the level shifter, which may be amplified and digitally converted, is processed by a signal level analyzer to determine a channel gain signal. | 04-01-2010 |
20100188100 | AUTOMATED SENSOR SPECIFIC CALIBRATION THROUGH SENSOR PARAMETER DOWNLOAD - A sensor system for measuring a clearance parameter between a stationary component and a rotating component of a rotating machine is provided. The system includes a clearance sensor to output a clearance measurement signal. A sensor memory is attached to the sensor for storing a first sensor information. A second sensor information is stored in a electronics interface memory. The first and the second sensor information are read and the clearance sensor is matched with a respective plurality of calibration data by an electronic interface based on the first and the second sensor information. | 07-29-2010 |
20100191502 | SYSTEM AND METHOD FOR CLEARANCE ESTIMATION BETWEEN TWO OBJECTS - A processing system for clearance estimation in a rotating machine includes one or more sensors and one or more digital signal processors for calculating the estimated clearance. The processing system may include techniques for obtaining real-time clearance estimates and techniques for obtaining averaged clearance estimates. Aspects of the processing system may also include a method of switching between real-time clearance estimates and averaged clearance estimates depending on the operating conditions of the rotating machine. Other aspects of the processing system include the use of two digital signal processors: a first digital signal processor configured to receive signals from a clearance sensor and perform a first set of high speed processing tasks, and a second digital signal processor configured to receive signals from the first digital signal processor and perform a second set of lower speed processing tasks. | 07-29-2010 |
20110295538 | AUTOMATED SENSOR SPECIFIC CALIBRATION THROUGH SENSOR PARAMETER DOWNLOAD - A sensor system for measuring a clearance parameter between a stationary component and a rotating component of a rotating machine is provided. The system includes a clearance sensor to output a clearance measurement signal. A sensor memory is attached to the sensor for storing a first sensor information. A second sensor information is stored in a electronics interface memory. The first and the second sensor information are read and the clearance sensor is matched with a respective plurality of calibration data by an electronic interface based on the first and the second sensor information. | 12-01-2011 |
John Harry Down, Niskayuna, NY US
Patent application number | Description | Published |
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20150025737 | System And Method For Monitoring Braking Effort - A method (e.g., for monitoring a braking system of a vehicle system) includes monitoring fluid pressures of a braking system and modeled braking efforts of the braking system in a vehicle system traveling along a route, identifying one or more time periods at least one of before a brake event of the braking system or after the brake event, calculating residual forces exerted on the vehicle system during the one or more time periods, and determining at least one of an estimated braking effort of the braking system or an estimated propagation rate at which the estimated braking effort is applied by the braking system using the residual forces that are calculated. | 01-22-2015 |
John Harry Down, Lanesboro, MA US
Patent application number | Description | Published |
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20090003991 | SYSTEM AND METHOD FOR TURBINE ENGINE CLEARANCE CONTROL WITH RUB DETECTION - A method of detecting rubs during operation of a turbomachine comprising at least one rotating object having a tip and a shelf is provided. The method includes generating signals representative of a sensed parameter and processing the signals to generate height versus time data for the tip. The height of the tip corresponds to the distance between the tip and the shelf. The method further includes monitoring the height versus time data, in order to determine whether a change in the height data exceeds a threshold value, and detecting a rub of the rotating object(s) on a second object, when the change in the height data exceeds the threshold value. A rub detection system for a turbomachine and a turbine engine system with rub detection are also provided. | 01-01-2009 |
Julian Down, Cambridge, MA US
Patent application number | Description | Published |
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20090136521 | Method for Selectively Depleting Hypoxic Cells - An improved method for selectively depleting hypoxic cells within the bone marrow is disclosed. The method can be used to enhance engraftment of hematopoietic stem cells (HSCs) in the bone marrow of a host subject. Also disclosed is a method for treating a cancer within the bone marrow of a host subject. | 05-28-2009 |
20140272925 | Plasma Separation Apparatus, Method and System - A blood fractionating apparatus that enables aseptic fractionation and storing of fractionated blood components, comprises a centrifuge tube including three chambers separated by constricted sealable passages, an open operative upper end chamber, a closed operative lower end chamber and a middle chamber defined between the upper end chamber and the lower end chamber and connected by means of the sealable passages. A stopper with a flapper valve is provided at the opening of the upper end chamber to control flow of fluid to and from the chambers. This apparatus enables separating the chambers to obtain a hermetically sealed operative lower chamber containing the corpuscle component and a hermetically sealed middle chamber containing the plasma component that can be stored at ambient temperature. | 09-18-2014 |
20150037296 | GENE THERAPY VECTORS FOR ADRENOLEUKODYSTROPHY AND ADRENOMYELONEUROPATHY - The present invention provides compositions comprising retroviral vectors, transduced cells, and methods of using the same for gene therapy. In particular, the present invention relates to lentiviral vectors and cells transduced with those vectors to provide gene therapy to subjects having an adrenoleukodystrophy and/or adrenomyeloneuropathy. | 02-05-2015 |
20150064150 | GENE THERAPY VECTORS FOR ADRENOLEUKODYSTROPHY AND ADRENOMYELONEUROPATHY - The present invention provides compositions comprising retroviral vectors, transduced cells, and methods of using the same for gene therapy. In particular, the present invention relates to lentiviral vectors and cells transduced with those vectors to provide gene therapy to subjects having an adrenoleukodystrophy and/or adrenomyeloneuropathy. | 03-05-2015 |
Julian David Down, Cambridge, MA US
Patent application number | Description | Published |
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20140199279 | METHODS FOR ENHANCING THE DELIVERY OF GENE-TRANSDUCED CELLS - The present invention provides novel methods for enhancing the delivery of transduced cells to a subject, which include both methods of selecting for transduced cells and methods of enhancing the reconstitution by transduced cells in a transplant recipient. The present invention further provides transfer vectors, including lentiviral vectors, useful in practicing the methods of the present invention. The methods and vectors of the present invention may be used in gene therapy of a variety of diseases and disorders, including but not limited to hematological diseases and disorders. | 07-17-2014 |
Todd P. Down, Garden City, MI US
Patent application number | Description | Published |
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20140084535 | High Speed Sheet Feeder Sheet Spacing System and Method - A document system and method of moving documents of a stack. The system operates to move documents by rotating a feed wheel and a transport wheel to move a document in a feed direction. The space between documents is maintained by controlling the speed of the feed wheel and the transport wheel independently. | 03-27-2014 |