| Patent application number | Description | Published |
|---|
| 20080261257 | Fluorescent Proteins and Related Methods and Compounds - The invention includes fusion polypeptides including a first fluorescent protein, e.g., a FRET donor protein, a second fluorescent protein, e.g., a FRET acceptor protein, and, linked to at least one of the fluorescent (e.g., FRET donor or FRET acceptor) proteins, an Fc-region of an immunoglobulin. The polypeptide can be immobilized with respect to a surface via the Fc-region even in the absence of antibodies to either the FRET donor protein or FRET acceptor protein, and can be used as a calibration standard for fluorescence resonance energy transfer includes a polypeptide. | 10-23-2008 |
| 20090208501 | Anti-Pathogen Immunoadhesins - Chimeric molecules that include a pathogen recognition module derived from a pathogen binding domain of a pathogen recognition protein, e.g., a toll-like receptor (TLR), CD14, BPI, MD-2, scavenger receptors (SRs), surfactant proteins (SP), C-reactive protein (CRP), Mannan-binding lectin (MBL), or complement Clq globular binding domain, an optional linker, and an Fc portion of an antibody are described and are useful for, e.g., drug discovery and treatment of conditions related to TLR signaling. | 08-20-2009 |
| 20100291577 | Toll-Like Receptor 9 Modulators - TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of identifying compounds that affect translocation and activity of TLR9 and MyD88 are described. | 11-18-2010 |
| Patent application number | Description | Published |
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| 20090282773 | Manufacture of Lattice Truss Structures from Monolithic Materials - Methods and systems to manufacture lattice-based sandwich structures from monolithic material. Such methods and systems eliminate the bonding process which is conventionally used to join lattice based truss cores to facesheets to form sandwich structures. This bonded interface is a key mode of failure for sandwich structures which are subjected to shear or bending loads because the nodes transfer forces from the face sheets to the core members while the topology for a given core relative density dictates the load carrying capacity (assuming adequate node-bond strength exists). An aspect comprises a core and related structures that provide very low density, good crush resistance and high in-plane shear resistance. An aspect of the truss structures may include sandwich panel cores and lattice truss topology that may be designed to efficiently support panel bending loads while maintaining an open topology that facilitates multifunctional applications. | 11-19-2009 |
| 20100236759 | Heat-Managing Composite Structures - Light-weight, heat-managing structures feature open-cell lattice, honeycomb, and/or corrugated (prismatic) arrangements in their substructures, combined with heat pipe/heat plate arrangements for managing heat to which the structures are subjected. The structures are well suited to aerospace applications and may be employed in the leading edge of wings or other airfoil-shaped components; gas turbine engine components; rocket nozzles; and other high-heat, high-stress environments. | 09-23-2010 |
| 20110042512 | Method and Apparatus for Jet Blast Deflection - Methods and apparatuses for passive jet blast deflection or the like. Use of the passive jet blast deflector permits the efficient dispersal of a fast moving local heat source into the environment through passive means while providing a high strength structure. The jet blast deflector system may include a first plate, a second plate, and a cellular core disposed between them adapted to allow cooling ambient air to flow through the cellular core, wherein the first plate, second plate, and core are all seamlessly coupled heat pipes that form a single vapor core to facilitate the spreading and even storing of thermal energy. An ejector plate may be attached to the top of the second plate to create a low pressure zone as the heat source passes over it, thereby pulling the ambient air through the cellular core, facilitating the removal the thermal energy from the system. | 02-24-2011 |
| 20110107904 | Synergistically-Layered Armor Systems and Methods for Producing Layers Thereof - The armor system according to the present invention also exploits synergistic multi-layering to provide different properties as a function of depth within a sandwich panel. Various embodiments of the invention include a combination of composite sandwich topology concepts with hard, strong materials to provide structures that (i) efficiently support static and fatigue loads, (ii) mitigate the blast pressure transmitted to a system that they protect, (iii) provides very effective resistance to projectile penetration, and (iv) minimizes shock (stress wave) propagation within the multi-layered armor sandwich structure. By using small pieces of highly constrained ceramic, the concept has significant multi-hit potential. | 05-12-2011 |
