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Donofrio, US
Anthony Donofrio, Cambrldge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110245205 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 10-06-2011 |
Anthony Donofrio, Westmont, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20110274667 | METHODS FOR OBTAINING CELL POPULATIONS FROM ADIPOSE TISSUE - Provided herein are methods of efficiently obtaining large numbers of viable, freshly isolated cells from small amounts of adipose tissue, as well as methods of enriching or selecting for target cell populations found therein. In certain embodiments, the method of obtaining a population of cells from adipose tissue comprises incubating the adipose tissue in a solution comprising an enzyme at a concentration which is at least 200 U/ml solution and not more than about 319 U/ml solution. In some embodiments, the method is devoid of any steps which expand the population of cells obtained. In certain aspects, the method further comprises positive or negative selection steps for obtaining an enriched population of target cells from adipose tissue. Related methods of preparing a pharmaceutical composition comprising cells for administration to a patient and methods of treating a disease or medical condition in a patient are further provided herein. | 11-10-2011 |
Chris J. Donofrio, The Woodlands, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090204377 | Method for Constructing Geologic Models of Subsurface Sedimentary Volumes - A method is disclosed for using a three-dimensional seismic image of a subsurface earth volume to construct a geologic model specifying the spatially-varying grain size distribution, porosity, and permeability throughout the volume. The method applies to earth volumes composed of water-lain clastic sedimentary deposits and involves, in one embodiment, (a) identifying the outline forms of geologic bodies in geologic data; (b) using the outline forms of the geologic bodies to determine the spatially-varying grain size distribution within the bodies, guided by assumptions about the nature and behavior of the paleoflow that deposited the bodies; (c) determining rock properties such as, porosity and permeability within the geologic bodies based on grain-size distribution, mineralogy and burial history information. | 08-13-2009 |
| 20090248378 | Method For Geologic Modeling Through Hydrodynamics-Based Gridding (Hydro-Grids) - A method of hydrodynamics-based gridding (Hydro-Grids) for creating geologic models of subsurface volumes, such as reservoirs, is disclosed. Geologic data is obtained. Vertical grid surfaces are created. Lateral grid surfaces are created to correspond to surfaces of constant geologic time during the deposition of sediments in the subsurface volume. Geologic properties within each cell are represented as values within each cell created by the vertical and lateral surfaces. Reservoir performance is simulated using the represented geologic properties of the subsurface volume. A hydrocarbon reservoir is developed based on the simulated reservoir performance. | 10-01-2009 |
Darren Donofrio, Plainfield, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20100048368 | Wall-mounted home fitness training equipment - An overall fitness trainer and can be a wall mounted unit that can utilize clip resistance bands as well as other techniques. These bands generally clip on the unit and onto different handles, bars and attachments to perform exercises. The unit can have a removable/adjustable pull up bar, dip bar and seat. It also includes a spring loaded, pull pin carriage that moves freely up and down a vertical spine. This allows for easy adjustment of the carriage and allows the user to attach the bands at multiple angles, widths and levels. This in turn increases the number of exercises the user can perform on the unit. The unit also typically has an o ring that attaches through the arm of the pull up attachment as well as a ½ O-ring at the bottom of the unit again increasing the number of exercises the user can perform. The unit can be attached to the wall with lag bolts into two or more studs. Some embodiments of the invention have an adjustable swivel foot that takes the stress off of the lag bolts and also adds to the overall load capacity of the unit. The apparatus typically has an optional telescoping central vertical spine that splits in two pieces to make the unit easier to ship. The central vertical spine allows attachments to be added and removed using spring loaded pins or plunger pins. Various embodiments of the invention can have an oscillating and telescopic bench, a dip bar, a seat, a knee stabilizer and a foot rest. All of these accessories can be attached and removed to the central spine adding to the versatility and scope of exercises that can be performed. | 02-25-2010 |
| 20110195822 | Wall-Mounted Home Fitness Training Equipment - An overall fitness trainer and can be a wall mounted unit that can utilize clip resistance bands as well as other techniques. These bands generally clip on the unit and onto different handles, bars and attachments to perform exercises. The unit can have a removable/adjustable pull up bar, dip bar and seat. It also includes a spring loaded, pull pin carriage that moves freely up and down a vertical spine. This allows for easy adjustment of the carriage and allows the user to attach the bands at multiple angles, widths and levels. This in turn increases the number of exercises the user can perform on the unit. The unit can be attached to the wall with lag bolts into two or more studs. Various embodiments of the invention can have an oscillating and telescopic bench, a dip bar, a seat, a knee stabilizer and a foot rest. All of these accessories can be attached and removed to the central spine adding to the versatility and scope of exercises that can be performed. Accessories can also include a baseball bat handle, baseball, medicine ball, boxing gloves, football, squat belt, golf club handle, hockey stick handle, lacrosse stick handle and any other handle of any other sport unit. | 08-11-2011 |
Gregory M. Donofrio, Clinton Township, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20090011889 | Locking Differential Assembly - An axle assembly with an electric locking differential that can include a one-piece differential case and a locking device. The locking device includes a dog that is nonrotatably but axially slidably received into a pocket that is formed in an end of the differential case. An actuator is mounted on the differential case. Actuation of the actuator moves the dog into engagement with a second dog that is coupled to a side gear of the differential to thereby lock the side gear to the differential case. | 01-08-2009 |
| 20090156346 | ELECTRONICALLY ACTUATED APPARATUS USING SOLENOID ACTUATOR WITH INTEGRATED SENSOR - A locking differential assembly with a differential case, a gearset, a first dog, a second dog and a thrust member. The differential case has a mounting hub. The gearset is disposed in the differential case and has a side gear. The first dog is coupled to the side gear. The thrust member is slidably supported on the mounting hub and has projections that extend through apertures in the differential case and engage the second dog. | 06-18-2009 |
| 20090247350 | ELECTRONIC LOCKING DIFFERENTIAL WITH DIRECT LOCKING STATE DETECTION SYSTEM - An axle assembly with an electronic locking differential that employs a locking mechanism having components that are fixed to one another along an axis such that they co-translate with one another when the actuator that effects the locking and unlocking of the differential is operated. | 10-01-2009 |
| 20110009223 | ELECTRONIC LOCKING DIFFERENTIAL WITH DIRECT LOCKING STATE DETECTION SYSTEM - An axle assembly with an electronic locking differential that employs a locking mechanism having components that are fixed to one another along an axis such that they co-translate with one another when the actuator that effects the locking and unlocking of the differential is operated. | 01-13-2011 |
Kristina Donofrio, Simi Valley, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100095342 | WIRELESS CONTENT TRANSMISSION AND CONTROL - A wireless transmission system is provided. The wireless transmission system can include: (a) a receiver unit capable of being coupled to a display device; and (b) a transmitter unit that sends a wireless signal to the receiver unit, wherein the wireless signal comprises a bandwidth sufficient enough to carry high definition video content. Other embodiments are disclosed. | 04-15-2010 |
Louis V. Donofrio, Harleysville, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080273477 | Method and Apparatus for Streaming Audio Data Across a VOIP Gateway to Digital Handsets - A VoIP telephone system which enables a user to receive and play audio files, such as music, over a telephone handset. The telephone system uses a media terminal adaptor (MTA) to provide voice communications to a telephone base station which communicate with a plurality of telephone handsets. The MTA stores a plurality of audio files which may be streamed to the handsets via the base station to be played back to the users. The audio files may be retrieved from a PC connected to the MTA or downloaded from a server through the IP network. | 11-06-2008 |
Martin Donofrio, Gosport, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20100094087 | Method of and Apparatus for Positioning and Maintaining the Position of Endoscopic Instruments - The present invention provides an apparatus for, and a method of, accurate positioning of endoscopic instruments. Accurate positioning of the instruments is accomplished through the inclusion of a steering ability within the device. After the endoscopic instrument is properly positioned, the present invention may use rapid exchange technology, soft locks, and mechanical locks to maintain the position of the endoscopic instrument. Rapid exchange technology is used to minimize displacement forces present on the guidewire or catheters. Soft locks and mechanical locks resist movements caused by displacement forces. | 04-15-2010 |
Martin G. Donofrio, Gosport, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20090064492 | METHOD OF MANUFACTURING RF ABLATION PROBE WITH UNIBODY ELECTRODE ELEMENT - An ablation probe and method of manufacturing the ablation probe are provided. The probe comprises a probe shaft and a unibody electrode element. The unibody electrode element comprises a common electrode base located at the distal end of the shaft, and a plurality of electrode tines distally extending from the electrode base. The electrode element may be created by forming divisions (such as slits or slots) from a first end of an electrically conductive elongate member towards an opposing second end of the elongate member. Alternatively, the divisions can be formed from a first end of an electrically conductive sheet towards an opposing second end of the sheet, and then bent or rolled to form the elongate member. In either case, the common electrode base can either be separately mounted to a probe shaft, or the probe shaft can be formed from the elongate member, in which case, the electrode base will be integrated with the probe shaft as a unibody structure. The electrode tines can be optionally shaped, e.g., to proximally evert. | 03-12-2009 |
| 20100280514 | METHOD OF MANUFACTURING RF ABLATION PROBE WITH UNIBODY ELECTRODE ELEMENT - An ablation probe and method of manufacturing the ablation probe are provided. The probe comprises a probe shaft and a unibody electrode element. The unibody electrode element comprises a common electrode base located at the distal end of the shaft, and a plurality of electrode tines distally extending from the electrode base. The electrode element may be created by forming divisions (such as slits or slots) from a first end of an electrically conductive elongate member towards an opposing second end of the elongate member. Alternatively, the divisions can be formed from a first end of an electrically conductive sheet towards an opposing second end of the sheet, and then bent or rolled to form the elongate member. In either case, the common electrode base can either be separately mounted to a probe shaft, or the probe shaft can be formed from the elongate member, in which case, the electrode base will be integrated with the probe shaft as a unibody structure. The electrode tines can be optionally shaped, e.g., to proximally evert. | 11-04-2010 |
Raymond S. Donofrio, Sun City, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20110266916 | TRITIUM BATTERY - A Tritium battery of parallel and aligned thin plate anodes and cathodes separated by thin dielectric panels and enclosed in a vented case with an external dummy load, an integral internal DC-DC converter providing converted output power to external electrical contacts, and a fuse. Logic switches power to the dummy load if there is no load on the external electrical contacts. The cathodes may be coated with an electrically conductive coating, such as graphene or a compound of carbon nanotubes and metallic micro wire. The cathodes may be superconductors. The anode includes a conductive thin plate coated with a chemically stable Tritium compound. The thin plate may be etched to increase surface area. The cases are scalable in configuration and may have ten electrodes or more on the sides as well as ends, and so encased Tritium batteries can be physically stacked side-to-side to create electrical connections for parallel power. | 11-03-2011 |
Thomas E. Donofrio, Federal Way, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080301799 | Method and apparatus for reliable, high speed data transfers in a high assurance multiple level secure environment - A method, apparatus for passing data from a first application at a first security level to a second application in a second security level higher than the first security level is disclosed. A backchannel communications link is established between the first application and the second application, and the backchannel link is used to transmit information such as an acknowledgement message to from the second application to the first application. | 12-04-2008 |
William T. Donofrio, Cincinnati, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20090118751 | APPARATUS AND METHOD FOR ALERTING GENERATOR FUNCTIONS IN AN ULTRASONIC SURGICAL SYSTEM - The present invention provides a system for surgery which includes an ultrasonic hand piece having a end-effector, a console having a digital signal processor (DSP) for controlling the hand piece, and a memory disposed in the end-effector. The generator console sends a drive current to drive the hand piece which imparts ultrasonic longitudinal movement to the blade. As the generator console reads the memory, the hand piece is authenticated for use with the generator console if a copyrighted data string is present in the memory. In a particular embodiment, the data string is an encrypted code, where the hand piece is authenticated for use with the console by decoding a corresponding encryption algorithm resident in the generator console and providing a responding data pattern. | 05-07-2009 |
| 20100125292 | ULTRASONIC SURGICAL SYSTEM - An ultrasonic surgical system utilizes a digital control system to generate ultrasonic drive current for transducers that are located in a hand piece and are attached to a surgical scalpel or blade in the hand piece so as to vibrate the blade in response to the current. The digital control includes a digital signal processor (DSP) or microprocessor; a direct digital synthesis (DDS) device; a phase detection logic scheme, a control algorithm for seeking and maintaining resonance frequency; and design scheme that allows to regulate current, voltage, and power delivered to an ultrasonic thereby a device. Such system allows the power versus load output curve to be tailored to a specific hand piece, which improves efficiency and reduces heat. Further, the components of the digital system are much less sensitive to temperature variations, thereby allowing it to operate with narrow as needed frequency range around the desired resonance in order to avoid excitation of other resonances. Also, the digital system provides increased flexibility in locating the resonance frequency of the blade and running diagnostic tests. The start of a user initiated diagnostic test that requires movement of the blade is caused by operating two of the system switches, which guards against accidental operation of the blade which could be harmful if in contact with tissue and also generate false diagnostic results. In addition, the system has interlock with an Electrosurgical unit so that it is not effected by the electromagnetic interference generated by that unit. | 05-20-2010 |