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Donnelly

Austin Donnelly, Cambridge GB

Patent application numberDescriptionPublished
20090249001Storage Systems Using Write Off-Loading - Improved storage systems which use write off-loading are described. When a request to store some data in a particular storage location is received, if the particular storage location is unavailable, the data is stored in an alternative location. In an embodiment, the particular storage location may be unavailable because it is powered down or because it is overloaded. The data stored in the alternative location may be subsequently recovered and written to the particular storage location once it becomes available.10-01-2009
20090285127SYSTEM AND METHOD FOR NETWORK TOPOLOGY DISCOVERY - A system and method for discovering network topology by various switch training and probing methods. Segments are discovered by having computers enter a promiscuous mode and determining from packets sent to a selected computer which computers see which other computers in the network. From the segments, various switch interconnections are determined, by having different computers train switches as to a training address and seeing which computers receive probe packets sent to that training address from another computer. Various training and probing methods are described that locate intermediate segments, deep switches, switch interconnections, and edge and singleton cases. In one implementation, a master computer coordinates the other computers (and devices) in the network to send the training and probing packets, and report on received packets, in order to determine the network topology.11-19-2009
20110138476Software Fault Isolation Using Byte-Granularity Memory Protection - Software fault isolation methods using byte-granularity memory protection are described. In an embodiment, untrusted drivers or other extensions to a software system are run in a separate domain from the host portion of the software system, but share the same address space as the host portion. Calls between domains are mediated using an interposition library and access control data is maintained for substantially each byte of relevant virtual address space. Instrumentation added to the untrusted extension at compile-time, before load-time, or at runtime and added by the interposition library enforces the isolation between domains, for example by adding access right checks before any writes or indirect calls and by redirecting function calls to call wrappers in the interposition library. The instrumentation also updates the access control data to grant and revoke access rights on a fine granularity according to the semantics of the operation being invoked.06-09-2011
20110179158FINE-GRAINED LOCATION DETERMINATION OF NETWORKED COMPUTERS - Location of a communication network subscriber is determined employing confidence metrics such as remote vs. local computer usage, primary user in a multi-user computing environment, likelihood of forgery, and comparable ones. A fine-grained location determination is then made based on the metric results and directory information for the particular subscriber such that services like emergency services can be provided with accurate location information.07-21-2011
20110213994Reducing Power Consumption of Distributed Storage Systems - Methods for reducing the power consumption of distributed storage systems are described. An embodiment describes a storage system which is adapted to reduce its power consumption at times of low load by reducing the number of active versions of the stored data. The data to be stored in the storage system is divided into chunks and in an example, each chunk is replicated on a number of different servers. At times of low load, the system enters a mode of operation in which the number of active replicas is reduced and servers that do not store any active replicas are put into a low power state. When in this mode, writes are written to a versioned store and the data is subsequently copied to servers storing replicas once all the servers have returned to normal power state.09-01-2011

Patent applications by Austin Donnelly, Cambridge GB

Graham Donnelly, Dublin IE

Patent application numberDescriptionPublished
20100143336TOLL-LIKE RECEPTOR BINDING EPITOPE AND COMPOSITIONS FOR BINDING THERETO - The present invention relates to the identification of an epitope defined by residues of Toll-like Receptor (2). Targeting a binding compound, such as an antibody to the epitope results in antagonism of Toll-like Receptor (2). Further provided by the invention is the use of polypeptide comprising amino acid residues which form the epitope for use in screening for binding compounds which bind thereto, as well as to polypeptide compound which comprise the amino acid sequences of the epitope for use as vaccine compositions, when the generation of antagonistic antibodies which have binding specificity to Toll-like Receptor (2) are required, for example in the treatment of Toll-like Receptor (2) mediated disease conditions.06-10-2010

Ian Abbott Donnelly, Bainton GB

Patent application numberDescriptionPublished
20120022803WATER CONSUMPTION MONITOR - A system and method for monitoring utilization and waste of a natural resource, such as water. Data is received indicating natural resource consumption by a facility. An indication of at least one period of natural resource usage by the facility is received. Natural resource usage corresponding to utilization of the natural resource for a useful purpose. Quantities of the natural resource consumed by the facility during the at least one period of water usage is recorded as a utilized quantity.01-26-2012

John Donnelly, Siena IT

Patent application numberDescriptionPublished
20090238841HIV VACCINE FORMULATIONS - Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a subject.09-24-2009
20100035234VACCINE ASSAYS - The present invention is directed to methods, assays and compositions for implementing such methods and assays for assessing efficacy of individual components in multi-component vaccines and for assessing efficacy of a vaccine against a pathogen. In one aspect, the method of assessing efficacy of a vaccine against a pathogen is a quick assay that tests for an activity correlated with efficacy such as binding in an ELISA rather than requiring the time and expense of an assay that detects actual bactericidal activity. In another aspect, the method for testing the efficacy of an individual component in a multi-component vaccine includes obtaining an immune sample from a subject inoculated with the multi-component vaccine; blocking the portion of the immune sample that recognizes the individual component such as by addition of the individual component, and testing the efficacy of the immune sample to respond to the pathogen.02-11-2010
20100086565Vectors for expression of hml-2 polypeptides - A nucleic acid vector comprising: (i) a promoter; (ii) a sequence encoding a HML-2 polypeptide operably linked to said promoter; and (iii) a selectable marker. Preferred vectors comprise: (I) a eukaryotic promoter; (ii) a sequence encoding a HML-2 polypeptide downstream of and operably linked to said promoter, (iii) a prokaryotic selectable marker; (iv) a prokaryotic origin of replication; and (v) a eukaryotic transcription terminator downstream of and operably linked to said sequence encoding a HML-2 polypeptide. Vectors of the invention are particularly useful for expression of HML-2 polypeptides either in vitro (e.g. for later purification). Or in vivo (e.g. for nucleic acid immunization). They are well suited to nucleic acid immunization against prostrate tumors. A preferred HML-2 is PCAV, which is located in chromosome 22 at 20.428 megabases (22q11.2).04-08-2010

Martin Benedict George Donnelly, Nottingham GB

Patent application numberDescriptionPublished
20110060023PARASITICIDAL FORMULATION - The present invention provides a parasiticidal formulation comprising: Fipronil, or a veterinarily acceptable derivative thereof; at least one C03-10-2011

Paul Stephen Donnelly, Victoria AU

Patent application numberDescriptionPublished
20110293517Nitrogen-Containing Macrocyclic Conjugates As Radiopharmaceuticals - The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.12-01-2011
20110305632PROCESS FOR THE PREPARATION OF ASYMMETRICAL BIS(THIOSEMICARBAZONES) - The present invention relates to a method of making asymmetrical bis(thiosemicarbazones), compounds useful as synthetic intermediates in the method, new bis(thiosemicarbazones) that can be readily accessed by use of the method and methods of treatment and imaging utilising some of the new bis(thiosemicarbazones).12-15-2011

Paul Stephen Donnelly, Melbourne AU

Patent application numberDescriptionPublished
20110098353Compounds for Imaging and Therapy - A metal complex of formula (III) wherein: M is a transition metal and A1, A2, X, X′, Y, L1′, R1′ and R2′ are as defined herein, is useful in medical imaging and therapy.04-28-2011

Peter Gerald Donnelly, Victoria AU

Patent application numberDescriptionPublished
20100046732INDUCING B-PARTY DEFINED BEHAVIOURS IN A-PARTY COMMUNICATIONS BY DISTRIBUTION OF USER INTERFACES - A method for inducing B-party defined behaviour in an A-party communications end-point (02-25-2010

Sam Donnelly, Audenshaw GB

Patent application numberDescriptionPublished
20090076032Derivatives of 18Beta-Glycyrrhetinic Acid - The present invention relates to novel derivatives of 18β-glycyrrhetinic acid and methods of synthesising the derivatives. Also included within the scope of the present invention are pharmaceutical compositions comprising the derivatives of the present invention and medical uses of the derivatives, including their use in inhibiting enzymes such as retinol dehydrogenases. The present invention also relates to methods of treating diseases, such as hyperproliferative diseases, neoplasms, cancers and photoageing.03-19-2009

Sheila Mary Donnelly, Ultimo Sydney AU

Patent application numberDescriptionPublished
20110311511CRYSTAL STRUCTURE OF PfA-M1 AND THE PfA-M1 Co4 COMPLEX - The invention relates to the X-ray crystal structure of PfA-M1 aminopeptidase alone, and in complex with the phosphinate dipeptide analogue hPheP[CH12-22-2011

Simon Donnelly, Michelbach-Le-Haut FR

Patent application numberDescriptionPublished
20100200186PROCESS FOR PREPARING HIGH STRENGTH PAPER - The present invention provides a process for the preparation of an aqueous composition comprising polysilicate coated mineral particles, wherein the process comprises subjecting an aqueous composition comprising gelled polysilicate and a mineral to shear of at least 5000 rpm for at least 30 seconds. The present invention also provides polysilicate coated mineral particles obtainable by this process as well as paper filled with these particles.08-12-2010

Patent applications by Simon Donnelly, Michelbach-Le-Haut FR

William James Donnelly, Melbourne AU

Patent application numberDescriptionPublished
20110146828Flexible duct and means of production - A helically formed flexible duct primarily directed to applications in ducted heating, ventilating and air conditioning, of three dimensions including a predetermined length, an inner diameter reinforced with a helically laminated wire member between self laminating substrate, an outwardly radial compartment formation constructed with strip portions of substrate material which form gaps to accommodate outwardly expanding radial dimensions and containing an insulating member, and an outer covering member delivered to a larger radial circumference at an applied circumferential speed exceeding the circumferential speed of the inner diameter substrate tube formation rate.06-23-2011