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| 20090317478 | METHOD OF PREPARING COVERED POROUS BIODEGRADABLE POLYMER MICROSPHERES FOR SUSTAINED-RELEASE DRUG DELIVERY AND TISSUE REGENERATION - The present invention relates to covered porous biodegradable polymer microspheres for sustained-release drug delivery and tissue regeneration which has an interconnected inner open pore structure having a wide surface area and high porosity and an outer closed pore structure in which the surface of the microsphere is covered with a thin layer of a biodegradable polymer, and thereby the pores formed on the surface and exposed to the outside are closed; and methods for preparing the same. Due to such a characteristic pore structure, the covered porous biodegradable polymer microspheres according to the present invention can prevent the biologically active material from being excessively released in the early stage immediately after administration, and after that, can gradually release the biologically active material through the interconnected inner pore structure over a prolonged period as the biodegradable polymer thin layer is degraded. Therefore, the microsphere of the present invention can be effectively used for sustained-release drug delivery and tissue regeneration. | 12-24-2009 |
| 20100098762 | Thermosensitive Pluronic Derivative Hydrogels With High Biodegradability And Biocompatibility For Tissue Regeneration And Preparation Method Thereof - The present invention relates to a thermosensitive pluronic derivative hydrogel for tissue regeneration in which a biodegradable polymer is introduced at one end or both ends of a pluronic polymer, a methacryloxyethyl trimellitic acid anhydride is conjugated to the biodegradable polymer, and a physiologically active substance is fixed to the methacryloxyethyl trimellitic acid anhydride, as well as a method for the preparation thereof. The pluronic derivative hydrogel according to the present invention exhibits high biodegradability due to the introduction of a biodegradable polymer while still maintaining the themosensitivity of the pluronic polymer itself and shows good biocompatibility owing to the coupling with a physiologically active substance capable of improving cell adhesion, proliferation and differentiation. Therefore, the pluronic derivative hydrogel according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs. | 04-22-2010 |
| 20100129422 | POROUS BIODEGRADABLE POLYMER SCAFFOLDS FOR IN SITU TISSUE REGENERATION AND METHOD FOR THE PREPARATION THEREOF - The present invention relates to an intelligent porous biodegradable polymer scaffold for in situ tissue regeneration in which two kinds of physiologically active substances having high differentiation potential and biocompatibility are introduced into the polymer scaffold and conjugated to the surface thereof, respectively, and a method for the preparation thereof. Since the intelligent porous biodegradable polymer scaffold exhibits improved biocompatibility and differentiation potential due to the introduction of physiologically active substances capable of efficiently inducing cell proliferation and differentiation into both the surface and the inside thereof, it can directly induce in situ tissue regeneration of the musculoskeletal system from stem cells in a living tissue after transplanting the polymer scaffold and stem cells into a human body without additional in vitro cultivation. Therefore, the intelligent porous biodegradable polymer scaffold according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs including the musculoskeletal system. | 05-27-2010 |
| 20100168506 | Method For Preparing Drug-Eluting Stent Having Nano-Structured Pattern - This invention relates to a method for preparing a drug-eluting stent using a chemical vapor deposition, the method comprising modifying the surface of a biodegradable polymer with nanostructures through a plasma-assisted chemical vapor deposition so as to improve drug-loading capability and drug elution rate. | 07-01-2010 |
| 20100267143 | Method for Surface Modification of Polymeric Scaffold for Stem Cell Transplantation Using Decellularized Extracellular Matrix - The present invention relates to a method for the surface modification of a polymeric scaffold for stem cell transplantation using a decellularized extracellular matrix. The method for the surface modification of the polymeric scaffold according to the present invention can embody a biomimetic surface environment that is effective for initial cell attachment, cell growth and differentiation of stem cells by modifying the surface of the polymeric scaffold using the decellularized extracellular matrix directly derived from specific tissue cells. | 10-21-2010 |
| 20110015395 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE - Disclosed herein are novel pyrazole compounds, pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof as anticancer agents. | 01-20-2011 |
| 20110111367 | NANOCOUPLING FOR IMPROVEMENT OF COATING ADHESION OF POLYMER ON METAL SUBSTRATES - Disclosed is nanocoupling of a polymer onto a surface of a metal substrate for improving coating adhesion of the polymer on the metal substrate, and in vivo stability and durability of the polymer. In accordance with the present invention, the polymers can be grafted via a chemical bonding on the surface of the metal substrate by the nanocoupling, by which adhesion, biocompatibility and durability of a polymer-coated layer which is to be formed later on the metal substrate were remarkably improved; therefore, the nanocoupling according to the present invention can be applied to surface modification of a metal implant, such as stents, mechanical valves, and an articular, a spinal, a dental and an orthopedic implants. | 05-12-2011 |
| 20110263018 | CORE-SHELL STRUCTURED DELIVERY SYSTEM FOR GROWTH FACTORS, A PREPARATION METHOD THEREOF, AND USE THEREOF FOR THE DIFFERENTIATION OR PROLIFERATION OF CELLS - The present invention relates to a method of preparing a delivery system capable of loading bioactive growth factors that are essential for the differentiation and proliferation of cells and is characterized as loading at least two types of components comprising growth factors in a single carrier, whereby the release of each of the plurality of growth factors can be temporally controlled. Specifically, the method of preparing a microcapsule type growth factor delivery system according to the present invention includes: (1) preparing a polymeric microsphere comprising a first component, and then encapsulating the microspheres by electrodropping the polymer microsphere into another polymer comprising a second component, thereby manufacturing a core-shell structured, microcapsule type delivery system, or (2) encapsulating a polymer solution comprising a first component by electrodropping the polymer solution into another polymer comprising a second component, thereby manufacturing a core-shell structured microcapsule type delivery system. The present invention also provides a stem cell differentiation method involving bringing a microcapsule type delivery system loaded with multiple growth factors according to the present invention into contact with stem cells. | 10-27-2011 |
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| 20090251983 | SEMICONDUCTOR MEMORY APPARATUS CAPABLE OF REDUCING GROUND NOISE - An apparatus includes a plurality of first driving signal driving units, and generates a first driving signal by driving an input signal, a plurality of second driving signal driving units, each of which drives an input signal and generates a second driving signal, a timing control unit that controls each of the first driving signal driving units such that a predetermined time difference is generated between an enable timing of the first driving signal and an enable timing of the second driving signal, a plurality of sense amplifier driving units, each of which generates a first driving level and a second driving level according to the first driving signal and the second driving signal, and a plurality of sense amplifiers that are provided for respective bit line pairs, and each include first type switching elements operating according to the first driving level and second type switching elements operating according to the second driving level. | 10-08-2009 |
| 20090257302 | Semiconductor memory apparatus capable of reducing ground noise - An apparatus includes a plurality of first driving signal driving units, and generates a first driving signal by driving an input signal, a plurality of second driving signal driving units, each of which drives an input signal and generates a second driving signal, a timing control unit that controls each of the first driving signal driving units such that a predetermined time difference is generated between an enable timing of the first driving signal and an enable timing of the second driving signal, a plurality of sense amplifier driving units, each of which generates a first driving level and a second driving level according to the first driving signal and the second driving signal, and a plurality of sense amplifiers that are provided for respective bit line pairs, and each include first type switching elements operating according to the first driving level and second type switching elements operating according to the second driving level. | 10-15-2009 |
| 20090303825 | SEMICONDUCTOR MEMORY DEVICE - A semiconductor memory device includes a first plurality of banks arranged in a first direction to form a first group of banks; a second plurality of banks arranged in the first direction to form a second group of banks, the first group of banks and the second group of banks arranged in a second direction; a first local data line arranged in the second direction to cross a bank of the second plurality of banks and to transfer input/output data; a second local data line arranged in the second direction to transfer input/output data; a global data line disposed in the first direction that crosses the second direction; and a data exchanger disposed between the second plurality of banks and the global data line for configured to controlling data exchange between the first and second local data lines and the global data line. | 12-10-2009 |
| 20100232216 | Phase-Change Memory Device - A phase-change memory device is capable of reducing current consumption and preventing performance deterioration caused due to line load by improving a process of selecting memory cells for a write/read operation. The phase-change memory device has a plurality of cell matrixes and includes word line decoding units that are each shared by a plurality of cell matrixes arranged in a row direction and are configured to activate one of global row signals according to a first row address, local row switch units that are provided to the respective cell matrixes and are configured to connect local current lines to corresponding word lines in response to the activated global row signal, bus connecting units that are provided to the respective cell matrixes and are configured to connect the local current lines to global current lines, and enabling units configured to activate one of the global current lines according to a second row address. | 09-16-2010 |
| 20100259974 | NON-VOLATILE SEMICONDUCTOR MEMORY CIRCUIT - Disclosed is a non-volatile semiconductor memory circuit. The non-volatile semiconductor memory circuit a memory cell array, and a verification sense amplifier controller configured to control switching devices, which receive external input data, depending on a level of the input data such that distribution voltage is changed when controlling a write operation by comparing the input data with cell data written in the memory cell array so as to provide cell data. | 10-14-2010 |
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| 20100133914 | APPARATUS AND METHOD OF CONTROLLING SWITCH UNITS, AND BATTERY PACK AND BATTERY MANAGEMENT APPARATUS COMPRISING SAID APPARATUS - Disclosed are an apparatus and method of controlling switch units between a battery pack and a load, and a battery pack and a battery management system comprising the same. The apparatus comprises a memory for storing the turn-off number and order of first and second switch units connecting the battery pack with the load according to current ranges; and a control unit for equalizing the turn-off order of the first switch unit and the second switch unit with reference to the turn-off number and order in a current range corresponding to a magnitude level of discharge current of a battery. Accordingly, the present invention reduces the frequency of breakdown or malfunction of the switch units and increases the using period of the switch units. | 06-03-2010 |
| 20100156426 | APPARATUS AND METHOD FOR SENSING LEAKAGE CURRENT OF BATTERY, AND BATTERY-DRIVEN APPARATUS AND BATTERY PACK COMPRISING THE APPARATUS - An apparatus for sensing a leakage current of a battery comprises a floating capacitor charged with a voltage detected from a cathode or anode terminal of a battery; a terminal selection switching unit for selecting a voltage detection path for the cathode or anode terminal; a charge switching unit for charging the floating capacitor with a detection voltage of the cathode or anode terminal, detected through the selected voltage detection path; a polarity reverse switching unit for reversing a polarity of the detection voltage of the anode terminal charged to the floating capacitor; and a leakage current determining unit for sensing the detection voltage of the cathode terminal charged to the floating capacitor and the polarity-reversed detection voltage of the anode terminal charged to the floating capacitor to calculate a leakage resistance, and comparing the calculated leakage resistance with a criterion insulation resistance to determine whether a leakage current occurs. | 06-24-2010 |
| 20100237872 | APPARATUS AND METHOD FOR SENSING LEAKAGE CURRENT OF BATTERY - An apparatus for sensing a leakage current of a battery comprises a floating capacitor charged with voltage detected from a cathode or anode terminal of a battery, a cathode terminal selection switching unit for selecting a voltage detection path for the cathode terminal and charging the floating capacitor with a detection voltage of the cathode terminal, an anode terminal selection switching unit for selecting a voltage detection path for the anode terminal and charging the floating capacitor with a detection voltage of the anode terminal, a DC voltage applying unit for applying DC voltage through the voltage detection path for the anode terminal, a voltage measuring unit for measuring the charged detection voltage of the cathode or anode terminal, and a leakage current determining unit for determining the occurrence of leakage current based on the measured detection voltages of the cathode and anode terminals. | 09-23-2010 |
