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Dobrovolny
Petr Dobrovolny, Brno CZ
| Patent application number | Description | Published |
|---|---|---|
| 20100250187 | METHOD AND SYSTEM FOR ANALYZING PERFORMANCE METRICS OF ARRAY TYPE CIRCUITS UNDER PROCESS VARIABILITY - A method is disclosed for analyzing a performance metric of an array type electronic circuit under process variability effects. The electronic circuit has an array with a plurality of array elements and an access path being a model of the array type electronic circuit. The model includes building blocks having all hardware to access one array element in the array. Each building block has at least one basic element. In one aspect, the method includes deriving statistics of the access path due to variations in the building blocks under process variability of the basic elements, and deriving statistics of the full array type electronic circuit by combining the results of the statistics of the access path under awareness of the array architecture. | 09-30-2010 |
Petr Dobrovolny, Trebic CZ
| Patent application number | Description | Published |
|---|---|---|
| 20090306387 | METHOD OF MANUFACTURING OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN - The method of manufacturing of 7-ethyl-10-hydroxycamptothecin of formula I characterized in that 7-ethyl-1,2,6,7-tetrahydrocampotothecin of formula IV is oxidized with an oxidizing agent selected from the group comprising iodosobenzene, an ester of iodosobenzene, sodium periodate, potassium periodate, potassium peroxodisulfate and ammonium peroxodisulfate, in a solvent formed by a saturated aliphatic monocarboxylic add containing 1 to 3 carbon atoms, and in the presence of water. | 12-10-2009 |
Walter Dobrovolny, St. Paul, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20090149877 | ROTATIONAL ATHERECTOMY DEVICE WITH PRE-CURVED DRIVE SHAFT - The invention provides a rotational atherectomy system, device and method comprising a flexible, elongated, rotatable drive shaft with an abrasive section within a pre-curved section of the drive shaft. The device may further comprise a concentric or eccentric enlarged diameter section that is at least partially covered with abrasive material to comprise the abrasive section. The abrasive section may further comprise an abrasive crown or burr mounted to the drive shaft. The pre-curved drive shaft allows smaller diameter and/or massive abrasive regions to be used while sweeping larger diameters during high-speed rotation. The pre-curved region is substantially straightened for insertion into vasculature and placement adjacent stenosis by insertion of the guide wire. Removal of guide wire proximally from the pre-curved region allows the drive shaft to return to its pre-curved form for ablation. Reinsertion of the guide wire beyond the pre-curved region straightens the drive shaft for ease of removal. | 06-11-2009 |
| 20100036402 | ROTATIONAL ATHERECTOMY DEVICE WITH PRE-CURVED DRIVE SHAFT - The invention provides a rotational atherectomy system, device and method comprising a flexible, elongated, rotatable drive shaft with an abrasive section within a pre-curved section of the drive shaft. The device may further comprise a concentric or eccentric enlarged diameter section that is at least partially covered with abrasive material to comprise the abrasive section. The abrasive section may further comprise an abrasive crown or burr mounted to the drive shaft. The pre-curved drive shaft allows smaller diameter and/or massive abrasive regions to be used while sweeping larger diameters during high-speed rotation. The pre-curved region is substantially straightened for insertion into vasculature and placement adjacent stenosis by insertion of the guide wire. Removal of guide wire proximally from the pre-curved region allows the drive shaft to return to its pre-curved form for ablation. Reinsertion of the guide wire beyond the pre-curved region straightens the drive shaft for ease of removal. | 02-11-2010 |
Walter John Dobrovolny, St. Paul, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20110077673 | ROTATIONAL ATHERECTOMY DEVICE WITH FRICTIONAL CLUTCH HAVING MAGNETIC NORMAL FORCE - An atherectomy device is disclosed, with a clutch between the motor and the drive shaft. The clutch includes two plates that rely on frictional to transmit torque from one plate to the other. The clutch has an attractive magnetic normal force that holds the plates together. For relatively low torques, as is the case during normal use, a static frictional torque holds the plates together, and the plates spin together without slipping. For relatively high torques, as occurs when the distal end of the drive shaft encounters an obstacle and stops abruptly, the high torque exceeds the maximum possible static frictional torque, and the plates slip. When slipping, the plates transmit a kinetic frictional torque that is low enough to avoid damage to the patient or to the atherectomy device. In some cases, the torque levels associated with a stoppage of the drive shaft distal end are chosen to mimic those of a known atherectomy device, in which a gas-driven turbine is clutchlessly attached to the drive shaft. | 03-31-2011 |