Dobosz
Michael Dobosz, Penzberg DE
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20120226119 | VIVO TUMOR VASCULATURE IMAGING - The present invention relates to non-invasive methods of and uses for in vivo imaging tumor vasculature in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In a further aspect the present invention relates to non-invasive methods of and uses for in vivo monitoring the therapeutic efficacy of an anti-angiogenic agent in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In addition, a kit for use in the methods of the present invention is provided which comprises a fluorescence labelled anti-CD31 antibody and means for near-infrared fluorescence imaging to detect the antibody in a subject. | 09-06-2012 |
20120230918 | NON-INVASIVE IN VIVO OPTICAL IMAGING METHOD - The present invention relates to a non-invasive method of determining the presence, quantifying the blood level, and/or monitoring or determining the blood clearance of a fluorescent analyte which comprises a fluorescent entity and a second entity, in the blood of a subject, comprising or consisting of the steps: (a) directing excitation light of at least one predetermined wavelength onto a delineated region comprising at least a portion of the pupil of said subject, to excite the fluorescent entity, (b) receiving light emitted from said fluorescent analyte with a wavelength distinguishable from the predetermined wavelength of (a), through the eye of said subject, thereby determining the presence, quantifying the blood level, and/or monitoring or determining the blood clearance of said fluorescent analyte in the blood of said subject. The present invention further relates to a fluorescent analyte or fluorescent label as defined in any one of the preceding claims for use in any one of the preceding methods. The present invention furthermore relates to the use of a fluorescent analyte or fluorescent label as defined in any one of the preceding claims for the preparation of a diagnostic composition which is to be employed in any one of the preceding methods. The present invention furthermore relates to a device for use in any of the methods defined herein. | 09-13-2012 |
20130236906 | DIAGNOSTIC METHOD FOR THE DETECTION OF CELLS EX VIVO - The present invention provides an ex vivo method for detecting a subset of cells with a specific binding domain, the binding domain, diagnostic compositions comprising the binding domain, and kits comprising the binding domain. | 09-12-2013 |
20140093458 | IN VIVO SELECTION OF THERAPEUTICALLY ACTIVE ANTIBODIES - The present invention relates to non-invasive methods of in vivo selecting an antibody against a desired target on the surface of a mammalian cell of a subject by applying near-infrared fluorescence imaging (NIRF) as well as uses of NIRF in such methods. In addition, kits for the use in these methods comprising a panel of potentially therapeutic effective fluorescence labeled antibodies and means for NIRF imaging are provided. | 04-03-2014 |
20140099264 | MEANS AND METHODS FOR IN VIVO TESTING OF THERAPEUTIC ANTIBODIES - The present invention provides methods and means for identifying a cancer-patient disposed to respond favourably to a therapeutic antibody as well as methods for in vivo selecting a xenograft tumor model which is most qualified for preclinical testing of a therapeutic antibody. These methods apply near-infrared fluorescence imaging which is an excellent imaging technology because of its simplicity, fast scanning times and non-hazardous radiation. | 04-10-2014 |
Paul J. Dobosz, Noblesville, IN US
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20080218427 | Multiple mode RF communication system - A multiple mode communications transceiver includes an antenna for receiving and transmitting RF energy and a first circuit selectively coupled to the antenna for transmitting and receiving FM modulated signals for terrestrial based communications. The transceiver also includes at least a second circuit selectively coupled to the antenna for transmitting and receiving satellite signals and a control circuit for selecting which of the first and second circuits are employed by the transceiver for the reception and transmission of information. | 09-11-2008 |
20090221285 | Communications system - A communications system and method thereof is provided, wherein the system includes at least one transmitter configured to transmit at least one signal, and at least one receiver configured to receive at least one of the at least one transmitted signal. The communications system further includes at least one communication device configured to receive and retransmit the at least one transmittal signal, wherein the at least one communication device is mobile and operates at an altitude in a range of approximately 1,000 feet to 65,000 feet with respect to the Earth's surface. | 09-03-2009 |
20100233957 | Vehicle Personalization Using A Near Field Communications Transponder - A vehicle personalization system and method that includes a cell phone and a vehicle. When a vehicle user prepares to use a vehicle, personalization data such as a preferred seat position is quickly transferred from the cell phone to the vehicle and used by the vehicle to adjust a vehicle feature to correspond to the preferences of the vehicle user. The cell phone and the vehicle are both equipped with near field communications (NFC) transponders to facilitate the transfer of personalization data. The vehicle also has a processor coupled to the vehicle NFC transponder to input the received personalization data that is also adapted to personalize the vehicle device in accordance with the received personalization data when the personalization data is downloaded from the cell phone to the vehicle. | 09-16-2010 |
Roman Dobosz, Bielsko-Biala PL
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20100140878 | SLIDING RING - The object of the invention is a sliding ring used in mechanical non-contact face seals. A sliding ring according to the invention is provided with grooves ( | 06-10-2010 |
Stanislaw Dobosz, Shrewsbury, MA US
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20080204928 | Clamping system for a data storage device - A clamping system includes a stack of storage media discs that includes an annular outer disc surface. A clamp includes a clamp surface that faces the outer disc surface. A ring is disposed between the clamp surface and the outer disc surface. The ring has a crested ring face with a circular crest line that contacts the clamp surface. | 08-28-2008 |
Tomasz Dobosz, Tempe, AZ US
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20150308350 | MULTI-AXIS ACCESSORY GEARBOXES OF MECHANICAL DRIVE SYSTEMS AND GAS TURBINE ENGINES INCLUDING THE SAME - Gas turbine engines including multi-axis accessory gearboxes of mechanical drive systems are provided. The gearbox comprises a housing, a drive shaft, bevel pinion and drive shaft bevel gears, and a side bevel gear set operable to directly at least one side accessory device. Housing is disposed about a towershaft operatively coupled to main engine shaft and operable to rotate about a first axis. Drive shaft is skewed to main shaft and operable to rotate about a second axis that intersects the first axis at a first angle. Bevel pinion gear is mounted on the towershaft. Drive shaft bevel gear is mounted on the drive shaft. Side bevel gear set comprises an input gear meshing with one or more side bevel gears each having a side bevel gear axis at a second angle to the first axis and independently positionable relative to input gear. Second angle is independent of other angles. | 10-29-2015 |