Dobie, US
Alyce K. Dobie, Williamson, NY US
Patent application number | Description | Published |
---|---|---|
20080275000 | COMPOSITIONS FOR REDUCING, AMELIORATING, TREATING, OR PREVENTING CONDITION OF DRY EYE AND METHODS OF MAKING AND USING SAME - Compositions for relief, treatment, or prevention of a condition of dry eye comprise alginate, a polyol, and a combinations of at least two organic acids or salts thereof, wherein the compositions have pH in the range from about 5 to about 7.5, at least one of the organic acids or salts thereof has a pKa in the range from and 6 to about 10. In some embodiments, the second organic acid or a salt thereof has a pKa that is no more than 1.5 units less than the pH. | 11-06-2008 |
Devin S. Dobie, Saint Paul, MN US
Patent application number | Description | Published |
---|---|---|
20110130624 | SYSTEM AND METHOD FOR ATTACHING A VESSEL IN A VASCULAR ENVIRONMENT - An apparatus is provided in one example embodiment and includes a body section having an upper surface, a lower surface, and an inner edge circumferentially arranged around at least a portion of an open area. The apparatus also includes a tool extending from the body section into the open area for holding a graft vessel. The lower surface of the body section opposes a receiving vessel when the tool is positioned to transfer the graft vessel to the receiving vessel, such that the graft vessel is axially accessible through the open area to be attached to the receiving vessel. In more specific embodiments, the body section has first and second opposing ends defining a gap sized to permit the vessel to pass through. | 06-02-2011 |
20120271336 | SYSTEM AND METHOD FOR MEASURING A VESSEL IN A VASCULAR ENVIRONMENT - An apparatus is provided in one example embodiment including a body section including inner and outer edges with the inner edge surrounding at least a portion of an open area. The body section further includes a lower surface extending between the inner and outer edges, and a handle adjacent to the lower surface. The apparatus also comprises a plurality of arms that include opposing tips and proximal ends received in the body section. The opposing tips define a tip spacing therebetween, and the arms are configured to extend and retract to decrease and increase, respectively, a dimension of the tip spacing. In more specific embodiments, the lower surface of the apparatus includes size markers, and each size marker corresponds to a dimension of the tip spacing when the handle is aligned with the size marker. | 10-25-2012 |
Keith Dobie, Humarock, MA US
Patent application number | Description | Published |
---|---|---|
20140209536 | BIOLOGICAL NITROGEN REMOVAL FEED PROCESS - In a wastewater treatment system comprised of an anoxic tank outputting to a biological reactor and outputting from the reactor to a clear well, a process for controlling the rate and timing of flow through the reactor by means of a floating pump within the anoxic tank. Further enhancement of denitrification is achieved by sending internal recycles into the sludge zone of the anoxic tank via a baffle positioned within the sludge layer. | 07-31-2014 |
20140217018 | Biological Nitrogen Removal Aeration Control - A biological reactor which is intermittently aerated to create an environment that alternates from aerobic to anoxic. A programmable logic controller controls the amount and timing of air flow to the biological reactor linking aeration to incoming load. | 08-07-2014 |
Kenneth Dobie, Del Mar, CA US
Patent application number | Description | Published |
---|---|---|
20090082975 | METHOD OF SELECTING AN ACTIVE OLIGONUCLEOTIDE PREDICTIVE MODEL - The present invention provides a method of identifying a predictor of antisense oligonucleotide activity by identifying properties of oligonucleotides, evaluating oligonucleotide activity of the oligonucleotides, and correlating oligonucleotide activity with the properties. A high correlation between oligonucleotide activity and a property indicates that the property is a predictor of oligonucleotide activity. | 03-26-2009 |
20090192106 | MODULATION OF eIF4E EXPRESSION - Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided. | 07-30-2009 |
20100113573 | MODULATION OF HIF1 BETA EXPRESSION - Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIF1-beta are provided. | 05-06-2010 |
20100130589 | MODULATION OF eIF4E EXPRESSION - Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided. | 05-27-2010 |
20120283312 | MODULATION OF EIF4E EXPRESSION - Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided. | 11-08-2012 |
20130053431 | MODULATION OF GROWTH HORMONE RECEPTOR EXPRESSION AND INSULIN-LIKE GROWTH FACTOR EXPRESSION - Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided. | 02-28-2013 |
Kenneth J. Dobie, Carlsbad, CA US
Patent application number | Description | Published |
---|---|---|
20090111767 | MODULATION OF INSULIN LIKE GROWTH FACTOR I RECEPTOR EXPRESSION - The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions. | 04-30-2009 |
Kenneth W. Dobie, Solana Beach, CA US
Patent application number | Description | Published |
---|---|---|
20160060625 | MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof. | 03-03-2016 |
20160060626 | MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof. | 03-03-2016 |
Kenneth W. Dobie, Carlsbad, CA US
Patent application number | Description | Published |
---|---|---|
20090286849 | MODULATION OF INSULIN LIKE GROWTH FACTOR I RECEPTOR EXPRESSION - The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory condition. | 11-19-2009 |
20130096176 | MODULATION OF INSULIN LIKE GROWTH FACTOR I RECEPTOR EXPRESSION - The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory condition. | 04-18-2013 |
Kenneth W. Dobie, Delmar, CA US
Patent application number | Description | Published |
---|---|---|
20090270491 | MODULATION OF TUDOR-SN EXPRESSION - Compounds, compositions and methods are provided for modulating the expression of Tudor-SN. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Tudor-SN. Methods of using these compounds for modulation of Tudor-SN expression and for diagnosis and treatment of diseases and conditions associated with expression of Tudor-SN are provided. | 10-29-2009 |
Kenneth W. Dobie, San Diego, CA US
Patent application number | Description | Published |
---|---|---|
20110136889 | COMPOSITIONS AND THEIR USES DIRECTED TO ACEYTL-COA CARBOXYLASES - Disclosed herein are compounds, compositions and methods for modulating the expression of ACC1 or ACC2 or both in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. | 06-09-2011 |
Michael J. Dobie, Lewisville, TX US
Patent application number | Description | Published |
---|---|---|
20140197161 | DOOR SWITCH APPARATUS FOR MICROWAVE OVENS - A door switch apparatus for a microwave oven that disables the microwave system while not requiring any separate “fingers” or tongs on the door face to reach into the main body of the oven to activate a switch. The switch uses stackable switches activated by a single switch lever. The switch lever is preferably made from a solid piece of ultra-high molecular weight polyethylene (UHMV to keep the accuracy of the angular dimensions between the surfaces contacting the door hinge arm and the arm of switch to remain fixed. | 07-17-2014 |
20140202444 | VORTEX SHEDDING HEAT TRANSFER METHOD AND APPARATUS - A heating transfer method and apparatus that has a fixed physical obstruction placed in the air path causing the airflow to cause the airflow to shed into alternating patterns. A column is placed perpendicular to the airflow path to provide an obstruction to the airflow. The cross-section of the column can be round, square or another multi-sided design. The obstruction will affect the velocity and intensity at which the shedding occurs thus, causing motion of the jets to deliver a more uniform cook on the product surface. | 07-24-2014 |
20140205459 | HIGH OUTPUT FAN WHEEL - A high output bent fin type of fan wheel for use in appliances such as but not limited to microwave ovens. The fan wheel is made by single 90-degree bends for each fan blade relative to the flat mounting plate. Unique to fan wheel is the large fan blade surface area in relation to the total area of the metal used in wheel. | 07-24-2014 |
Michael J. Dobie, Double Oak, TX US
Patent application number | Description | Published |
---|---|---|
20080229935 | Selection Systems and Methods - The present invention relates generally to a selection process that is facilitated by a multi-modality controller. The selection process and knob are particularly useful in connection with an oven or other cooking appliance, but the knob and screens described herein can be used with any electronic component that requires a user to select various operating modes. | 09-25-2008 |
20080257700 | Combination Switch - A combination switch is provided for a high-speed oven, the oven having a door. The combination switch has a rotatable cam ( | 10-23-2008 |