Dirksen

Eef Hubert Cecil Dirksen, Eindhoven NL

Patent application number	Description	Published
20100190183	PROTEIN LABELLING WITH TAGS COMPRISING ISOTOPE-CODED SUB-TAGS AND ISOBARIC SUB-TAGS - Subject of the present invention are new isotopic and isobaric tagged molecules, kits comprising them and methods of using them in mass spectrometry.	07-29-2010
20110028330	COMPOUNDS AND METHODS FOR THE LABELLING AND AFFINITY-SELECTION OF PROTEINS - The present invention relates to kits and methods for the isotopic/isobaric labeling and the subsequent affinity selection and analysis of proteinaceous molecules. In particular, the invention relates to a kit-of-parts comprising a combinatorial plurality of labeling reagent for the labeling of proteinaceous molecules, each labeling reagent comprising an isobaric label component, an isotopic label component, and a reactive group capable of reacting with a proteinaceous molecule, wherein the isotopic label component concomitantly is an affinity tag. The invention is also directed to a corresponding method for the analysis of proteinaceous molecules, comprising labeling at least one subset of the proteinaceous molecules present by employing a kit-of-parts as defined herein and subsequently separating the labeled molecules by affinity purification via the affinity tag comprised in the label. Finally, the invention relates to the uses of such methods for protein expression profiling or proteomic analyses.	02-03-2011

Patent application number	Description	Published
20090078157	Inorganic sheet materials - The invention is directed to a synthetic inorganic material, comprising inorganic compounds based on elementary particles with a sheet (phyllosilicate) structure, the elementary particles consisting of a central layer of octahedrally coordinated divalent metal ions between two layers of tetrahedrally surrounded silicon ions, which particles are substantially free of aluminum, free silica and salts and hydroxides of the divalent metal ions, the material not containing any metal ions that can be reduced to the corresponding metals at temperatures of 700° C. or less.	03-26-2009

Patent application number	Description	Published
20080299599	FLUORESCENT PROTEINS FOR MONITORING INTRACELLULAR SUPEROXIDE PRODUCTION - Protein probes and methods for measuring real-time changes in intracellular superoxide formation are provided. The probes include superoxide sensitive variants of yellow fluorescent and green fluorescent proteins. The probes, or nucleic acids encoding the probes, may be delivered to cells or organisms. Changes in the fluorescence of the probes may then be detected using standard real-time fluoroscopy techniques.	12-04-2008