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| 20090112785 | SMART BUTTON - The present invention provides for systems and methods that facilitate conveying user information between and among users effectively to thereby create a collaborative filtering environment with maintained user privacy. More specifically, the present invention allows user-profile building to occur coincident with user-browsing, for example. This can be accomplished in part by incorporating an input component on the user interface used for browsing and/or searching. A user who has opted-in to construct a personal profile makes declarations regarding his relationship with at least a portion of the information being currently viewed. The declarations are annotated to the user's profile. At the user's discretion, the user's profile can be disseminated to others in whole or in part such that other people can make use of the user's expertise, experience or opinions. In addition, the user profiles can be machine-readable and searchable. | 04-30-2009 |
| 20090112827 | SYSTEM AND METHOD FOR EMPLOYING SOCIAL NETWORKS FOR INFORMATION DISCOVERY - Systems and methods are provided that enable searches of social networks by acting as a “compass” that assists users in navigating the social network. Individual user participation is not required in response to queries from other users. The systems and methods offer navigational assistance or information as opposed to a traditional search which returns requested information, thus currently acceptable social mechanisms for arbitrating trust can be exploited. As a result, users do not make their personal information publicly searchable, while at the same time, they are protected from potential misrepresentations of facts. | 04-30-2009 |
| 20100149966 | STATELESS, AFFINITY-PRESERVING LOAD BALANCING - The invention relates to an architecture that facilitates load balancing among a plurality of hosts and preserve session affinity to a given host. An incoming stream of data packets that include packet sessions is input to one or more forwarding mechanisms for forwarding to one or more hosts. The forwarders generate a routing function that takes into consideration host availability, and distributes session packets according to the routing function. A session is distributed to the same host to preserve session affinity. When host availability changes, a new routing function is generated, such that any new session is routed according to the new routing function and existing sessions are routed according to the old routing function. When the old routing function becomes irrelevant, it is phased out. An optimization utilizes a maximally backward compatible hash function to minimize the differences between the old and new routing functions. | 06-17-2010 |
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| 20080300799 | System And Method For Multiple-Factor Selection - The disclosed subject matter provides techniques for multiple-factor selection. The factors can be features or elements that are jointly associated with one or more outcomes by their joint presence or absence. There may be a non-causative correlation between the factors, features, or elements and the outcomes. In some embodiments, Entropy Minimization and Boolean Parsimony (EMBP) is used to identify modules of genes jointly associated with disease from gene expression data, and a logic function is provided to connect the combined expression levels in each gene module with the presence of disease. The smallest module of genes whose joint expression levels can predict the presence of disease can be identified. | 12-04-2008 |
| 20090012719 | SYSTEM AND METHOD FOR IDENTIFICATION OF SYNERGISTIC INTERACTIONS FROM CONTINUOUS DATA - Systems and methods for selecting factors from a continuous data set of measurements are provided. The measurements include values of factors and/or outcomes. Two or more factors that are jointly associated with one or more outcomes from the data set are identified. Each of the two or more factors are analyzed to determine at least one cooperative interaction among the factors with respect to an outcome. The two or more factors can be a module of factors serving as a single factor participating in a cooperative interaction with another factor or module of factors. | 01-08-2009 |
| 20090299643 | Computational Analysis Of The Synergy Among Multiple Interacting Factors - Systems and methods for selecting factors from a data set of measurements are provided. The measurements include values of factors and/or outcomes. Two or more factors that are jointly associated with one or more outcomes from the data set are identified. Each of the two or more factors are analyzed to determine at least one cooperative interaction among the factors with respect to an outcome. The two or more factors can be a module of factors. | 12-03-2009 |
| 20110144917 | SYSTEM AND METHOD FOR IDENTIFICATION OF SYNERGISTIC INTERACTIONS FROM CONTINUOUS DATA - Systems and methods for selecting factors from a continuous data set of measurements are provided. The measurements include values of factors and/or outcomes. Two or more factors that are jointly associated with one or more outcomes from the data set are identified. Each of the two or more factors are analyzed to determine at least one cooperative interaction among the factors with respect to an outcome. The two or more factors can be a module of factors serving as a single factor participating in a cooperative interaction with another factor or module of factors. | 06-16-2011 |
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| 20100019100 | GAS TURBINE ENGINE NACELLE - An initial geometry for a nacelle provides an intake at the upstream end of the nacelle and an exhaust at the downstream end of the nacelle. The intake has in flow series, an intake lip and a diffuser. The intake lip has a highlight defining the boundary between the inner and outer surfaces of the intake lip. On all longitudinal sections containing the axis of the engine (i) the inner and outer surfaces are tangency matched at the highlight, and (ii) the inner and outer surfaces have their maximum curvatures at the highlight. | 01-28-2010 |
| 20100019101 | GAS TURBINE ENGINE NACELLE - A nacelle for a gas turbine engine has an intake at the upstream end of the nacelle and an exhaust at the downstream end of the nacelle. The intake has, an intake lip and a diffuser. The diffuser has a main diffuser section and an optional shorter straight wall diffuser section. The main diffuser section is bounded by an inner wall of the nacelle, the inner wall curving in the airflow direction of the engine. On each longitudinal section containing the engine axis, at the downstream end of the main diffuser section the inner wall has a non zero curvature. Thus each circumferential position on the inner wall at the downstream end of the main diffuser section has a curvature defined by a respective radius of curvature. However, one or more of the radii of curvature differ from the others of the radii of curvature. | 01-28-2010 |
| 20100019102 | GAS TURBINE ENGINE NACELLE - An initial geometry for a nacelle provides an intake at the upstream end of the nacelle and an exhaust at the downstream end of the nacelle. The intake has, in flow series/an intake lip and a diffuser. The intake lip has a highlight defining the boundary between the inner and outer surfaces of the intake lip. On all longitudinal sections containing the axis of the engine (i) the inner and outer surfaces are tangency matched at the highlight, and (ii) the inner and outer surfaces have their maximum curvatures at the highlight. | 01-28-2010 |
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| 20090090776 | SYSTEM FOR SELF CHECKOUT - The present invention relates to a self check-out system which uses contact free tags embedded in a receptacle, e.g., a plate, glass, etc. The system relates the tag to a service area and uses that relationship to associate the receptacle with a charge to be made to a customer. | 04-09-2009 |
| 20090319272 | METHOD AND SYSTEM FOR VOICE ORDERING UTILIZING PRODUCT INFORMATION - A method for voice ordering utilizing catalog taxonomies and hierarchical categorization relationships in product information management (PIM) systems includes: prompting a user with a query to input speech into a speech recognition engine; translating the inputted speech into a series of words; querying a product information management component (PIM) based on the series of words; wherein the querying is performed as a matching algorithm against PIM category and attribute keywords; returning coded results to a voice synthesizer to produce at least one of: a voice response, and a text response to the user; and wherein in the coded results indicate one or more of: a not found message for zero matches, a confirmation of a suitable single match, a request for additional information in the event one or more of the following occurs: more than one matching item, category, and item attribute was found in the PIM. | 12-24-2009 |
| 20090319624 | METHOD AND SYSTEM FOR THE OPTIMIZATION OF ELECTRONIC MAIL DELIVERY - A method for the elimination of duplicate or multiple electronic mail (email) to one or more recipients, the method includes: generating table entries in a mail server that identify users of the mail server; receiving an email at the mail server; determining whether this is the first time the email is received at the mail server; wherein in the event this is the first time the email has been received: recording information about the email in the table; storing a copy of the email in a repository; forwarding the email to the intended recipients; and wherein in the event the email has been received previously: determining which of the intended recipients has not received the email; sending a copy of the email from the repository to the recipients who have not already received the email; and recording which of the recipients have now received the email in the table. | 12-24-2009 |
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| 20090059952 | APPARATUS AND METHOD FOR MANAGING ACCESS TO ONE OR MORE NETWORK RESOURCES - An apparatus is provided that includes a processor configured to receive a captured traffic unit (CTU) intended for a network service, the CTU being one into which incoming traffic has been assembled based on a filter describing which incoming traffic to capture and how to assemble the respective incoming traffic into the CTU. The processor is also configured to determine whether to allow the CTU to pass to one or more applications configured to implement the respective network service based on a passlet including permissions to a particular user. The processor is further configured to instruct a firewall to allow the CTU to pass to the respective one or more applications or to reject the CTU based on the determination. In this regard, the processor is configured to perform the above functions under control of a security framework implemented in middleware between a user-level domain and a system-level domain. | 03-05-2009 |
| 20090063691 | Access rights used for resource discovery in peer-to-peer networks - Secure resource discover in peer-to-peer networks involves creating a resource discovery record associated with a computing resource of a user device that is made available via the user device to peers of a peer-to-peer network. The resource discovery record describes the computing resource and may be independent of native service discovery mechanisms of the peer-to-peer network. An access right record is created that controls the ability of one or more contacts to gain access to the resource discovery record. The resource discovery record is sent to the one or more contacts via the peer-to-peer network. The one or more contacts can use the resource discovery record to access the computing resource via the peer-to-peer network in accordance with the access right record. | 03-05-2009 |
| 20090222517 | Methods, systems, and apparatus for using virtual devices with peer-to-peer groups - Using virtual devices with P2P groups involves sending a discovery record from a virtual device to an Internet-based broker. A registration message from the peer-to-peer group is received by the virtual device in response to the discovery record. The registration message is used to join the virtual device with the peer-to-peer group. The user is authorized via the Internet-based broker and the virtual device is joined with the peer-to-peer group based on the user authorization and the registration message. Services are then provided to the peer-to-peer group via the virtual device in accordance with the discovery record. The virtual device may include a wide-area network service that is modeled to act as a physical device of the peer-to-peer group. | 09-03-2009 |
| 20090288138 | Methods, systems, and apparatus for peer-to peer authentication - Peer-to-peer authentication involves generating an authenticatable, globally unique, peer-to-peer identifier to associate a device with a user identity. The user identity is associated with one or more peer devices of a user. The peer-to-peer identifier, together with authentication credentials of a legacy Internet service, is sent to an infrastructure authentication service. The legacy Internet service is capable of verifying the user identity based on the authentication credentials. Based on verification of the authentication credentials, a list of authenticatable, globally unique, peer-to-peer identifiers that bind the peer devices to the user identity is received from the infrastructure authentication service. A peer-to-peer identifier that binds the selected peer device to the user identity is received from a selected one of the peer devices, and the selected peer device authenticated as associated with the user identity based on receiving the respective peer-to-peer identifier. | 11-19-2009 |
| 20100069389 | NOVEL FORMS OF REBOXETINE - The invention relates to novel crystalline forms of (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine hydrochloride. In various embodiments, the novel crystalline forms may be substantially enantiopure. The preparation and characterization of the novel crystalline forms of (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine hydrochloride is also described. The invention also relates to pharmaceutical compositions containing novel crystalline forms of (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine hydrochloride, which are useful to treat and/or prevent various conditions such as nervous system and pain disorders. | 03-18-2010 |
| 20110275679 | FLUPIRTINE HYDROCHLORIDE MALEIC ACID COCRYSTAL - The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal. | 11-10-2011 |
| 20110275681 | NOVEL SOLID FORMS OF EPALRESTAT - The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel crystalline salts and cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline salts and cocrystal and the therapeutic use of the novel crystalline salts and cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, inhibiting aldose reductase, and affording cardioprotection in patients who may be non-diabetic. | 11-10-2011 |
| 20110275682 | NOVEL CHOLINE COCRYSTAL OF EPALRESTAT - The invention relates to a novel choline cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel choline cocrystal and the therapeutic use of the novel choline cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, treating and/or preventing homocystinuria reducing levels of homocysteine in blood serum, inhibiting aldose reductase, and affording cardioprotection in non-diabetic patients. | 11-10-2011 |
| 20110275695 | CRYSTALLINE FORMS OF ZOTEPINE HYDROCHLORIDE - The invention relates to crystalline forms of zotepine hydrochloride, including the crystalline hydrochloride salt of zotepine and two cocrystals of zotepine hydrochloride with benzoic acid. The preparation and characterization of these crystalline forms of zotepine hydrochloride is described. The invention also relates to the therapeutic use of the crystalline forms of zotepine hydrochloride to treat central nervous system disorders and to pharmaceutical compositions containing them. | 11-10-2011 |
| 20110281911 | NOVEL FORMS OF EPERISONE - The invention relates to substantially enantiopure crystalline salt forms of (2RS)-I-(4-Ethylphenyl)-2-methyl-3-piperidin-1-ylpropan-1-one. The preparation and characterization of the substantially enantiopure crystalline salt forms according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the substantially enantiopure crystalline salt forms, which are useful to treat and/or prevent various conditions such as pathological muscle contracture, myotome conditions, and spastic paralysis or spasticity caused by various neurologic conditions, and are also useful for the treatment and/or prevention of various types of pain and pathological muscle tension. | 11-17-2011 |
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| 20100154265 | ATTACHABLE PRICE TAG HOLDER - Display tag holders in one integral part of an injection molded plastic, such as polyurethane, or acrylonitrile butadiene styrene, including an essentially planar display portion, a connecting portion and a ring attachment portion, the ring attachment portion having at least one flexible resilient ring segment including a proximal end closest to the display portion and at least one distal end, the at least one flexible resilient ring segment defining a circumferential direction and a ring plane in which the at least one flexible resilient ring segment essentially extends, wherein the at least one flexible resilient ring segment is attached to the display portion by the connecting portion so that the ring plane is essentially perpendicular to the plane of the planar display portion. | 06-24-2010 |
| 20110174750 | MERCHANDISE DISPLAY AND PUSHER DEVICE - Pushers for displaying merchandise forward on a shelf including shelf attachments including base extending perpendicularly and longitudinally along the end and parallel to shelf edge, a front attachment wall extending essentially vertically from the base disposed at a base front edge, the front attachment wall including base engagement teeth protruding essentially horizontally from the front attachment wall toward the shelf, and an upraised ridge region removed from the vertically extending front attachment wall in the second direction that is offset from the plane of the base, a divider portion including a divider block and an essentially planar divider extending outwardly from the divider block; pusher track having a top surface and two rails, and at least one track tooth disposed at a longitudinal end of the track, the at least one track tooth providing engagement from the track tooth and base engagement teeth; and a resilient pusher member. | 07-21-2011 |
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| 20110189176 | METHODS OF TREATING DISEASES WITH DLL4 ANTAGONISTS - The present invention provides methods of preventing, treating or ameliorating diabetes by administering to a subject in need thereof a therapeutically effective amount of Dll4 antagonists that block Dll4-Notch signal pathways. As observed in a mouse model of diabetes, Dll4 antagonists exhibit protective effects on pancreatic islets, lower blood glucose levels, and block the production of auto-antibodies, including those against insulin and glutamic acid decarboxylase 65 (GAD65), via the expansion of regulatory T cells (Tregs). Thus, the present invention further provides methods of lowering the levels of blood glucose, and/or reducing or blocking the production of auto-antibodies, by administering to a subject in need thereof a therapeutically effective amount of Dll4 antagonists. Suitable Dll4 antagonists for the invention include antibodies or antibody fragments that specifically bind Dll4 and block Dll4-Notch interactions, the extracellular domain of Dll4, and the like. | 08-04-2011 |
| 20110189200 | METHODS OF TREATING AUTOIMMUNE DISEASES WITH DLL4 ANTAGONISTS - The present invention provides methods of treating a disease or disorder, in which increasing the number of regulatory T cell (Treg) is beneficial, by administering to a subject suffering from such a disease or disorder a therapeutically effective amount of DII4 antagonists that block DII4-Notch signal pathways, thereby increasing the number of Treg. Diseases or disorders treatable by the methods of the invention include autoimmune diseases or disorders, such as multiple sclerosis (MS), diabetes, and the like. Suitable DII4 antagonists for the invention include antibodies or antibody fragments that specifically bind DII4 and block DII4-Notch interactions, the extracellular domain of DII4, and the like. The invention also provides methods of preventing an occurrence or recurrence of such diseases or disorders in a subject predisposed or susceptible to developing such diseases or disorders. Furthermore, the methods of the invention are useful in preventing or treating organ transplant rejections or graft-versus-host disease. | 08-04-2011 |
| 20120114654 | HUMAN ANTIBODIES TO HUMAN TNF-LIKE LIGAND 1A (TL1A) - A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human TNF-like ligand 1A (hTL1A) is provided. The human anti-hTL1A antibodies are useful in treating diseases or disorders associated with TL1A, such as inflammatory diseases or disorders, e.g., inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, rheumatoid arthritis, and the like; autoimmune diseases or disorders, such as multiple sclerosis, diabetes, and the like; and allergic reactions, such as asthma and allergic lung inflammation. | 05-10-2012 |
