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Dillin
Andrew Dillin, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090083868 | Increasing lifespan by modulation of WWP-1 and UBC-18 - Ubiquitin ligase wwp-1 and ubiquitin conjugating enzyme ubc-18 are identified in nematodes as mediators of dietary restriction induced longevity and therefore as targets for modulation of lifespan in animals. Methods of screening for compounds that modulate longevity by assaying wwp-1 ubiquitination pathway parameters are provided, as are related systems. In addition, methods of using wwp-1 and/or ubc-18 to modulate longevity or delay onset of age-related diseases are described. | 03-26-2009 |
| 20090092551 | Increasing lifespan by modulation of pha-4 - The roles of the pha-4 and daf-16 genes in diet-restricted induced longevity are described and characterized. Pha-4 acts, e.g., in the absence of daf-16, to increase lifespan, e.g., in nematodes. Given the role that pha-4 and daf-16 play in the mediation of longevity, they represent targets for modulation of life span. Methods of increasing life span and delaying age onset diseases by modulation of pha-4 activity are disclosed, as are screening methods for identifying compounds that modulate pha-4 and/or daf-16 activity. In addition, recombinant animals expressing the pha-4 gene and not the daf-16 gene, and methods of using the pha-4 and/or daf-16 genes to modulate longevity and age-onset diseases are described. | 04-09-2009 |
| 20090208960 | METHODS FOR IDENTIFYNG CELLULAR MODULATORS OF DISAGGREGATION ACTIVITY OR AGGREGATION ACTIVITY IN AN ANIMAL - Methods for identifying a cellular modulator of a biological disaggregation activity or a biological aggregation activity of an animal are provided. Methods for identifying a compound which modulates biological disaggregation activity or a biological aggregation activity in a biological sample are provided. | 08-20-2009 |
| 20100263062 | METHODS FOR SCREENING AND COMPOUNDS THAT PROTECT AGAINST AMYLOID DISEASES - The disclosure provides methods and compositions useful for screening inhibitors of aggregation mediated proteotoxicity. The disclosure provides transgenic animals and cell useful for such screening. Also provided are compounds useful for inhibiting aggregation mediated proteotoxicity in a subject. | 10-14-2010 |
Andrew Dillin, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080249012 | INCREASING LIFE SPAN BY MODULATION OF Smek - The Smek (Suppressor of mek null) gene is described and characterized. Smek acts in the stress response pathway of animals by binding to and enhancing the transcription of FOXO, thereby providing the link between the stress response pathway and the insulin/IGF-1 pathway. Given the link between both the stress response pathway and the insulin/IGF-1 pathway and longevity, Smek | 10-09-2008 |
Andrews Dillin, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120122957 | REGULATION OF AGING BY MODULATION OF MITOCHONDRIAL FUNCTION - The invention relates to the field of longevity enhancement. More particularly, the invention provides compositions and methods relating to modulation of mitochondrial function. In certain embodiments, the invention provides methods and related compositions for the enhancement of longevity in an animal, comprising inhibition of one or more electron transport chain components, such as cco-1 and homologs thereof, in a tissue-specific manner in the animal. | 05-17-2012 |
Kent J. Dillin, Stillwater, OK US
| Patent application number | Description | Published |
|---|---|---|
| 20120018652 | POWER SYSTEM FOR DOSIMETER READER - Described is a portable dosimeter reader that is small in size and light in weight. | 01-26-2012 |
William H. Dillin, Rancho Palos Verdes, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100016903 | POSTERIOR SPINAL FASTENER AND METHOD FOR USING SAME - A posterior spinal fastener is disclosed for insertion into a vertebra of a mammalian body, the vertebra having posterior elements and a vertebral body. The fastener includes an elongate member adapted for insertion into the vertebra. The elongate body has an anterior portion and a posterior portion. The anterior portion is arcuate in shape for placement in the vertebral body. The posterior portion has a length so as to be accessible at the posterior elements of the vertebra when the anterior portion is disposed in the vertebral body. A method of use of the posterior spinal fastener is also disclosed, in which the posterior spinal fastener is introduced into the vertebra at the posterior elements and arcuately extended into the vertebral body. | 01-21-2010 |