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Desire, FR
Jerome Desire, Tencin FR
| Patent application number | Description | Published |
|---|---|---|
| 20090264637 | PROCESS FOR PREPARING DISULPHIDES AND THIOSULPHINATES AND COMPOUNDS PREPARED - Process for preparing a compound of the formula (I) R1-S(O) | 10-22-2009 |
| 20100075917 | THIONUCLEOSIDES AND PHARMACEUTICAL APPLICATIONS - The invention relates to a pharmaceutical composition containing as an active ingredient at least one compound selected from the compounds of the formula (II), in which the S atom is bonded to the nucleoside carbon at T or to the nucleoside carbon at 3′, and from the compounds of the following formula (III): formulae in which B is a nucleotide natural or modified base, x is 0, 1 or 2, and R1 and R represent a carbonated group or a molecular hydrocarbon remnant that can be substituted and/or interrupted by one or more atoms and/or by one or more groups containing one or more atoms, said atoms being selected from N, O, P, S, Si, X where X is halogen. The invention also relates to pharmaceutically acceptable carrier. | 03-25-2010 |
Laurent Desire, Paris FR
| Patent application number | Description | Published |
|---|---|---|
| 20090093471 | Methods of Treating Nervous Disorders - The invention relates to compositions and methods for treating nervous disorders. More particularly, the invention relates to methods of treating amyloÊd beta peptide-related disorders, particularly Alzheimer's disease, using Rac1 inhibitors. The invention may be used in mammalian subjects, particularly human subjects, at various stages of the disease, including disease onset. The invention also provides methods of producing, identifying, selecting or optimising compounds for use in the treatment of amyloÊd beta peptide-related disorders, based on a determination of the ability of a test compound to inhibit Rac 1. | 04-09-2009 |
| 20090118282 | Compounds and methods for treatment of amyloid-beta-peptide related disorders - The present invention relates to compounds, preparation and uses thereof, particularly in the pharmaceutical industry. The present invention discloses novel compounds more particularly useful for the treatment of Alzheimer's disease and other similar diseases, and more specifically the inventive compounds modulate (in particular, inhibit) the level of amyloid-β peptide (Aβ) exhibited by cells or tissues; Aβ peptide is a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. This invention also relates the use of these inhibitors to prevent, treat or ameliorate the symptoms of Alzheimer's disease or any Amyloid-β-Peptide Related Disorder. | 05-07-2009 |
| 20090285820 | Methods of Treating Degenerative Disorders With Rac 1B Inhibitor - The invention relates to compositions and methods for treating degenerative disorders. More particularly, the invention relates to methods of treating amyloïd beta peptide-related disorders, particularly Alzheimer's disease, using Rac1b inhibitors. The invention may be used in mammalian subjects, particularly human subjects, at various stages of the disease, including disease onset. The invention also provides methods of producing, identifying, selecting or optimising compounds for use in the treatment of amyloïd beta peptide-related disorders, based on a determination of the ability of a test compound to inhibit Rac1b. | 11-19-2009 |
| 20090317842 | Methods and Tools for The Therapy of Neurodegenerative Pathologies - The present invention concerns compositions and methods for the treatment of neurodegenerative diseases in which the cognitive functions are altered, such as observed in Alzheimer's disease. More particularly, the invention presents a strategy for human clinical monitoring of the activity and/or effectiveness of neuroprotective treatments, based on biochemical assay of certain platelet parameters, and thus can be done by blood sampling. The invention also concerns methods, tools, constructions and compositions suitable for implementing these strategies. | 12-24-2009 |
| 20100317830 | BACE455, AN ALTERNATIVE SPLICE VARIANT OF THE HUMAN BETA-SECRETASE - The present invention relates generally to the fields of genetics, biochemistry, medicinal chemistry and medicine. The present invention more particularly discloses the identification of a human gene variant involved in neuropathological conditions, and methods for the diagnosis, prevention and treatment of such diseases and related disorders, as well as for the screening of therapeutically active drugs. The present invention relates to catalytically active beta-secretase (Memapsin2, BACE) variants, and nucleic acids encoding them. The invention is useful in the identification of agents that inhibit the activity of a particular BACE isoform and thus agents and therapies affecting the genesis, development or progression of neuropathological conditions, including Alzheimer's disease and dementia. | 12-16-2010 |
Régis Desire, Sceaux FR
| Patent application number | Description | Published |
|---|---|---|
| 20090128598 | INK COLLECTION DEVICE FOR A SERVICING STATION - An ink collection device for a servicing station of a franking machine, said ink collection device comprising: an ink collection reservoir for receiving the ink ejected, during a servicing stage, by ink ejection nozzles of at least one print module; at least one drainage duct placed above the reservoir and opening out in register with said at least one print module while defining a gap between a top of the drainage duct and the print module; and, mounted across said at least one drainage duct and at a small predetermined distance from the top of the drainage duct, means for causing the fine ink droplets ejected by said ink ejection nozzles to coalesce to form a plurality of thicker ink drops, and for causing said ink drops to drip under gravity into said ink collection reservoir. | 05-21-2009 |
| 20100258406 | HIGH-CAPACITY DEVICE FOR RECEIVING MAILPIECES - A storage device for a mail-handling machine, said storage device comprising a mailpiece-receiving deck along a longitudinal edge of which a referencing wall extends, and through which a conveyor belt passes for the purpose of conveying mailpieces along said referencing wall from an inlet of the device towards a sloping surface against which said mailpieces accumulate, said storage device further comprising a pivot arm that is mounted to move both vertically about hinge pin and horizontally along a slide rail, on which arm firstly a friction roller is mounted for pressing said mailpieces against the conveyor belt, and secondly a holding roller is mounted for pressing said mailpieces against the sloping surface. | 10-14-2010 |
Régis Desire, Sceaux FR
| Patent application number | Description | Published |
|---|---|---|
| 20100258406 | HIGH-CAPACITY DEVICE FOR RECEIVING MAILPIECES - A storage device for a mail-handling machine, said storage device comprising a mailpiece-receiving deck along a longitudinal edge of which a referencing wall extends, and through which a conveyor belt passes for the purpose of conveying mailpieces along said referencing wall from an inlet of the device towards a sloping surface against which said mailpieces accumulate, said storage device further comprising a pivot arm that is mounted to move both vertically about hinge pin and horizontally along a slide rail, on which arm firstly a friction roller is mounted for pressing said mailpieces against the conveyor belt, and secondly a holding roller is mounted for pressing said mailpieces against the sloping surface. | 10-14-2010 |