Desantis, CA
Grace Desantis, Del Mar, CA US
Patent application number | Description | Published |
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20130177949 | NITRILASES - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 07-11-2013 |
Grace Desantis, San Diego, CA US
Patent application number | Description | Published |
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20090155238 | XYLANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-ghicanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature. | 06-18-2009 |
20090176976 | NITRILASES - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 07-09-2009 |
20100009426 | Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 01-14-2010 |
20100018658 | Laccases for Bio-Bleaching - Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers. | 01-28-2010 |
20100086986 | Nitrilases and Methods for Making and Using Them - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 04-08-2010 |
20100216214 | Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 08-26-2010 |
20100273659 | Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 10-28-2010 |
20110250657 | Processes for Making [R]-Ethyl 4-Cyano-3 Hydroxybutyric Acid - The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of parameters. | 10-13-2011 |
20110263839 | Nucleic Acids Encoding Nitrilases - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 10-27-2011 |
20120009637 | Nitrilases, Nucleic Acids Encoding Them and Methods For Making and Using Them - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 01-12-2012 |
20120010104 | GROWTH SELECTION METHOD - The invention provides growth selection methods for screening an environmental or a mixed population library of nucleic acids comprising uncharacterized nucleic acids for the presence of a nucleic acid encoding an enzyme of interest. In one aspect, methods for screening and identification of enzymes, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases are provided. Methods for the production and screening of gene libraries generated from nucleic acids isolated from more than one organism for enzymes of interest, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases, are also provided. | 01-12-2012 |
20130126110 | LACCASES FOR BIO-BLEACHING - Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers. | 05-23-2013 |
20130130333 | Processes for Making (R)-Ethyl 4-Cyano-3 Hydroxybutyric Acid - The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of parameters. | 05-23-2013 |
20130230858 | METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations. | 09-05-2013 |
20130316409 | Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 11-28-2013 |
20150125928 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 05-07-2015 |
20150125936 | LACCASES FOR BIO-BLEACHING - Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers. | 05-07-2015 |
20150139977 | XYLANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature. | 05-21-2015 |
Paul Desantis, Santa Monica, CA US
Patent application number | Description | Published |
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20090078658 | OIL FILTER ELEMENT OF WOUND COTTON/PAPER COMPOSITION - A filter element designed for engine oil lubrication and hydraulic oils, comprising a core having a hollow interior and a perforated outer surface, in fluid communication with the hollow interior, an open first end in fluid communication with the hollow interior, and a closed second end. The filter element comprises alternately wrapping one or more layers of flat sheet barrier filter material and, on top of the barrier filter material, winding, in a uniform winding pattern, one or more layers of cotton/cellulose composition yarn over the outer surface of the core, each layer having a progressively finer filtration as the oil moves radially from the exterior of the element inward towards the core. | 03-26-2009 |
Robert Desantis, San Jose, CA US
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20100115390 | AMENDING THE DISPLAY PROPERTY OF GRID ELEMENTS - The present invention relates to a method and system for amending a display property of a grid element. The method for amending a display property of a grid element comprises: receiving a command to amend the display property of at least one grid element; searching grid elements associated with said grid element; amending the display property of said grid elements and said associated grid elements. The present invention improves the operation of adjusting the display property of the grid, and enhances the operational efficiency and feasibility | 05-06-2010 |
20150238341 | NATURAL ORIFICE BARIATRIC PROCEDURE AND APPARATUS FOR USE THEREWITH - A method of performing a bariatric procedure through a natural body orifice is disclosed. The method comprises the step of providing a surgical instrument, comprising a handle portion, an elongated portion extending distally from the handle portion, and an end effector disposed adjacent a distal end of the elongated portion. The method also comprises the steps of inserting the surgical instrument through a natural body orifice of a patient such that the end effector is adjacent a portion of the patient's stomach, and using the surgical instrument to perform a surgical task. | 08-27-2015 |
Robert Desantis, Beverly Hills, CA US
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20110194981 | OZONE DEVICE FOR DEODORIZING DRESSES - An ozone device for deodorizing dresses within a closet, includes an ozone generator. The ozone generator includes a casing formed with first and second ventilation vents, an ozone producing element installed within the casing for generating ozone in order to deodorizing dresses within the closet, a circulating fan installed within the casing for circulating ozone generated by the ozone producing element, and a hanging unit projecting outward from the casing and adapted to be hung onto a suspension member. The closet is sleeved over and cooperates with the casing to define a sealed chamber so that dresses can be kept therein. | 08-11-2011 |
Robert P. Desantis, San Jose, CA US
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20150317208 | CUSTOMIZING BACKUP AND RESTORE OF DATABASES - Backups and restore operations of database are customized by performing partial backups and restores. The database maintains information describing database objects that are backed up by subsequent backup operations. The data set that is backed up by backup operations can be modified by executing alter backup commands. An alter backup command identifies one or more database objects and specifies whether the database object should be excluded or included from backup operations. The alter backup command can specify database objects that do not exist in the database. These objects are included or excluded in accordance with the alter backup command whenever they are created in the database. The alter backup command can associate a criteria with a database object in order for the database object to be included or excluded in accordance with the alter backup command. | 11-05-2015 |
Stephen Desantis, Laguna Nigel, CA US
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20160022372 | ILLUMINATED AND MODULAR SOFT TISSUE RETRACTOR - A surgical retractor for illuminating a surgical field includes an ergonomic handle, a retractor blade coupled with the handle, a quick release mechanism, and an illuminator blade. The retractor blade is adapted to engage and retract tissue, and the quick release mechanism is adapted to couple the handle with the retractor blade. The illuminator blade acts as a waveguide to transmit light by total internal reflection. Light is extracted from the illuminator to illuminate the surgical field. The retractor blade is releasable from the handle without requiring uncoupling of the illuminator blade from the handle and also without requiring optical uncoupling of the illuminator blade from a light source. The retractor may also be adapted to evacuate smoke from the surgical field. | 01-28-2016 |
Stephen Desantis, Laguna Niguel, CA US
Patent application number | Description | Published |
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20130267786 | ILLUMINATED AND MODULAR SOFT TISSUE RETRACTOR - A surgical retractor for illuminating a surgical field includes an ergonomic handle, a retractor blade coupled with the handle, a quick release mechanism, and an illuminator blade. The retractor blade is adapted to engage and retract tissue, and the quick release mechanism is adapted to couple the handle with the retractor blade. The illuminator blade acts as a waveguide to transmit light by total internal reflection. Light is extracted from the illuminator to illuminate the surgical field. The retractor blade is releasable from the handle without requiring uncoupling of the illuminator blade from the handle and also without requiring optical uncoupling of the illuminator blade from a light source. The retractor may also be adapted to evacuate smoke from the surgical field. | 10-10-2013 |
20140323811 | METHODS AND APPARATUS FOR RETRACTING TISSUE - A surgical retractor includes a retractor blade and a gripping element releasably coupled to the retractor blade. The gripping element has a textured surface for engaging and gripping tissue. The gripping element may be released from the retractor blade intraoperatively. The surgical retractor may also have an optical illumination element such as an optical waveguide that is magnetically and releasably coupled to the retractor. | 10-30-2014 |
20150018627 | ILLUMINATED AND MODULAR SOFT TISSUE RETRACTOR - A surgical retractor for illuminating a surgical field includes an ergonomic handle, a retractor blade coupled with the handle, a quick release mechanism, and an illuminator blade. The retractor blade is adapted to engage and retract tissue, and the quick release mechanism is adapted to couple the handle with the retractor blade. The illuminator blade acts as a waveguide to transmit light by total internal reflection. Light is extracted from the illuminator to illuminate the surgical field. The retractor blade is releasable from the handle without requiring uncoupling of the illuminator blade from the handle and also without requiring optical uncoupling of the illuminator blade from a light source. The retractor may also be adapted to evacuate smoke from the surgical field. | 01-15-2015 |
Stephen A. Desantis, Laguna Niguel, CA US
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20100298698 | TISSUE SITE MARKERS FOR IN VIVO IMAGING - The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated. | 11-25-2010 |
20130319889 | SKIN CARE AND RESTORATION COMPOSITION AND METHODS - Topical compositions, such as lip balms and other products for lip care, include combinations of ingredients that condition and heal the lips and skin. The topical compositions may be configured to remain in place on the lips or skin for relatively long periods of time. Methods of making topical compositions are also disclosed. | 12-05-2013 |
Stephen A. Desantis, Mission Viejo, CA US
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20140243675 | TISSUE SITE MARKERS FOR IN VIVO IMAGING - The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated. | 08-28-2014 |
Todd Desantis, Livermore, CA US
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20140155283 | MICROARRAY FOR DETECTING VIABLE ORGANISMS - A methodology of microarray using the fluorescent DNA intercalating agent propidium monoazide (PMA) to selectively block DNA of dead cells from amplification and its application in detecting and enumerating viable microbes in complex microbial communities is described. A phylogenetic array is used in the preferred embodiment to enhance the sensitivity of the method. The PMA-Microarray assay is particularly applicable for monitoring samples from environments with extremely low microbial burden such as spacecraft surfaces. | 06-05-2014 |
Todd D. Desantis, Livermore, CA US
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20090291858 | ARRAY FOR DETECTING MICROBES - The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a microarray configured to simultaneously detect a plurality of organisms in a sample at a high confidence level. | 11-26-2009 |
Todd Z. Desantis, Livermore, CA US
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20110212850 | USING PHYLOGENETIC PROBES FOR QUANTIFICATION OF STABLE ISOTOPE LABELING AND MICROBIAL COMMUNITY ANALYSIS - Herein is described methods for a high-sensitivity means to measure the incorporation of stable isotope labeled substrates into RNA following stable isotope probing experiments (SIP). RNA is hybridized to a set of probes such as phylogenetic microarrays and isotope incorporation is quantified such as by secondary ion mass spectrometer imaging (NanoSIMS). | 09-01-2011 |
20120165215 | METHODS AND SYSTEMS FOR PHYLOGENETIC ANALYSIS - The present invention discloses methods and systems for designing and using organism-specific and/or operational taxon unit (OTU)-specific probes. The methods and systems allow for detecting, identifying and quantitating a plurality of biomolecules or microrganisms in a sample based on the hybridization or binding of target molecules in the sample with the probes. Some embodiments provide methods of selecting an oligonucleotide probe specific for a node on a clustering tree. Other embodiments provide methods of selecting organism-specific or OTU-specific oligonucleotide probes for use in accurately detecting a plurality of organisms in a sample with high confidence. Some embodiments provide methods and systems to detect the presence of a rare OTU in a sample. | 06-28-2012 |
20140287961 | ARRAY FOR DETECTING MICROBES - The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a microarray configured to simultaneously detect a plurality of organisms in a sample at a high confidence level. | 09-25-2014 |
20150337363 | ARRAY FOR DETECTING MICROBES - The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a microarray configured to simultaneously detect a plurality of organisms in a sample at a high confidence level. | 11-26-2015 |