Patent application number | Description | Published |
20080279911 | Medical devices having crosslinked polymeric surfaces - According to an aspect of the invention, medical devices are provided which contain at least one polymeric region. The polymeric region contains at least one copolymer, which includes at least one high Tg vinyl aromatic monomer and at least one low Tg monomer. Moreover, the polymeric region contains at least one surface sub-region that is crosslinked and at least one bulk sub-region that is substantially non-crosslinked. According to another aspect of the invention, a method is provided which includes exposing a polymeric region of a medical device to energetic species such that at least one surface sub-region of the polymeric region becomes crosslinked and at least one bulk sub-region remains substantially non-crosslinked. The polymeric region contains at least one copolymer, which includes at least one high Tg vinyl aromatic monomer and at least one low Tg monomer. | 11-13-2008 |
20090177261 | Detachment mechanisms for implantable devices - Disclosed herein are detachment mechanisms for vaso-occlusive devices that allow for rapid operator-controlled release of the vaso-occlusive device into the selected site. Also disclosed are vaso-occlusive assemblies comprising these detachment mechanisms and methods of using these detachment mechanisms and vaso-occlusive assemblies. | 07-09-2009 |
20090198321 | Drug-Coated Medical Devices for Differential Drug Release - The embodiments described herein relate generally to medical devices that are useful for delivering one or more therapeutic agents to a body tissue of a subject, and methods for making and using such devices. In particular, the embodiments relate to a medical device such as a stent having a sidewall structure comprising a plurality of struts, in which one or more therapeutic agents are released from different surfaces of the struts at different release profiles. More particularly, the embodiments relate to a stent having a sidewall structure comprising a plurality of struts, in which the two side surfaces of each strut are coated with a coating composition that is different from the coating composition used to coat the outer surface and/or inner surface of the strut. | 08-06-2009 |
20090299460 | Bifurcated Stent and Delivery System - A delivery system has a stent and a balloon The stent has a first section made of a plurality of interconnected framework members which define a plurality of potential side branches. The balloon is a dual lumen balloon that can inflate from the proximal end to the distal end with a plurality of protrusions and/or herniations. | 12-03-2009 |
20100069837 | Balloon Assembly and Method for Therapeutic Agent Delivery - A balloon assembly includes an elongated balloon, one or more cutting elements engaged to the balloon, and one or more therapeutic agents disposed within an opening defined by the cutting blades. The balloon assembly converts energy into heat to enhance elution of the therapeutic agent at the treatment site | 03-18-2010 |
20100137973 | Layered Bifurcation Stent - An implantable medical device has an outer stent with a tubular body disposed about a longitudinal axis. The outer stent includes members defining openings which are in fluid communication with a flow path. At least one opening is larger than adjacent openings when the outer stent is in an expanded state, and is positioned between the ends of the outer stent. The at least one larger opening is a side branch opening having a perimeter. The device also has an inner stent with a tubular body disposed within the outer stent and about a longitudinal axis. The inner stent has a branch portion with deployable petals positioned adjacent to the side branch opening of the outer stent. The petals are biased against the perimeter of the side branch opening such that the petals are restrained from opening outward when the outer stent is in an unexpanded state. | 06-03-2010 |
20100312322 | Medical Balloon Incorporating Electroactive Polymer and Methods of Making and Using the Same - An expandable medical balloon having at least one static state, at least one expanded state, and at least one deflated state, the expandable medical balloon including at least one active region, the at least one active region including electroactive polymer. | 12-09-2010 |
20110054396 | Balloon Catheter Devices With Drug-Coated Sheath - Medical devices comprising a balloon and a therapeutic agent disposed over the balloon. In one embodiment, an expandable sheath covers the balloon, and the expandable sheath is coated with the therapeutic agent. As the balloon is inflated, the sheath expands and causes the coating of therapeutic agent to break apart. In another embodiment, the balloon has a balloon wall comprising an outermost layer and one or more inner layers. The outermost layer is less compliant than the inner layer(s) such that cracks will form in the outermost layer as the balloon is inflated. The coating of therapeutic agent breaks apart when the relatively less compliant outermost layer cracks with the inflation of the balloon. Also disclosed are methods for making a medical device having a balloon. | 03-03-2011 |
20110150965 | MEDICAL DEVICES HAVING ADHERENT POLYMERIC LAYERS WITH DEPTH-DEPENDENT PROPERTIES - According to one aspect of the invention, a method of forming a medical device is provided, which includes: (a) contacting a substrate with a solution that contains (i) one or more types of polymers, (ii) a solvent that contains one or more types of solvent species, and (iii) one or more optional agents, for example, one or more therapeutic agents, among others; and (b) removing the solvent from the solution, thereby forming a polymeric layer on the substrate. The composition of the solution is changed over the course of forming the polymeric layer. In another aspect of the invention, a medical device is provided, which includes a substrate and a polymeric layer over the substrate. The polymeric layer contains a copolymer that contains differing first and second monomers. The lower surface of the polymeric layer contacting the substrate has a surface concentration of the first monomer relative to the second monomer that is higher than that of the upper surface of the polymeric layer opposite the substrate. | 06-23-2011 |
20110160645 | Cryo Activated Drug Delivery and Cutting Balloons - Physical property changes in materials between body temperature and a cryotreatment temperature are used to benefit auxiliary functional structures on a cryotherapy device. The auxiliary functional structures may be drug delivery coatings, cutting balloon blades, balloon stiffeners or force concentrators. | 06-30-2011 |
20110190863 | Therapeutic Balloon with Systemic Drug Loss Protection and Controlled Particle Size Release - Systemic drug loss protection devices are disclosed. The drug loss protection device includes a balloon and a drug particulate filter. The drug particulate filter has a plurality of openings and is configured to selectively permit transmission of drug particulates through the filter. Consequently, the size of the openings in the filter regulates transmission of the drug particulates. The drug particulate filter can also be used as an embolic filter. | 08-04-2011 |
20130165921 | DEVICE AND METHODS FOR NERVE MODULATION - The disclosure pertains to an intravascular system for nerve modulation through a wall of a blood vessel and methods of use therefor, wherein the system is capable of nerve modulation by one or more ablations of a blood vessel adjacent to the nerve to be modulated. The intravascular system is suited for modulation of renal nerves. | 06-27-2013 |