Patent application number | Description | Published |
20080279768 | Bifunctional Metal Chelating Conjugates - The present invention is directed to metal chelating conjugates for use as metallopharmaceutical diagnostics or therapeutic agents. Specifically, conjugates of the present invention include a carrier, a metal coordinating moiety, and a urea linkage chemically linking the metal coordinating moiety to the carrier. The carrier is generally utilized for targeting the conjugate to a biological tissue or organ. | 11-13-2008 |
20080299038 | Luminescent Metal Complexes for Monitoring Renal Function - Some embodiments of the present invention may be said to be directed to metal complexes of Formula I, wherein at least one of X | 12-04-2008 |
20080312539 | Methods of Using Optical Agents - In certain aspects, the invention relates to processes for using renally excretable optical agents to detect one or more tissues of the renal system of a surgical patient. In certain aspects, the invention relates to a kit including a biocompatible composition containing one or more optical agents and instructions for using the optical agent(s) in a process of the present invention. | 12-18-2008 |
20090010851 | Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function - The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X | 01-08-2009 |
20090036674 | Metal Complexes of Tetraazamacrocycle Derivatives - Improved methods for synthesizing bifunctional chelates of tetraazamacrocycle derivatives and intermediates thereof are disclosed as well as novel tetraazamacrocycle derivatives and intermediates thereof. | 02-05-2009 |
20090053137 | Chelating Conjugates Having a Substituted Aromatic Moiety and Derivatives Thereof - The present invention is directed to metal chelating conjugates for use as metallopharmaceutical diagnostic or therapeutic agents. Specifically, conjugates of the present invention include one or more carriers, a linker, and a metal coordinating moiety comprising a substituted phenyl, pyridyl, or pyrimidyl derivative. | 02-26-2009 |
20090082324 | Bifunctional Resorcinol, Thioresorcinol, and Dithioresorcinol Derivative Metal Chelating Conjugates - The present invention is directed to metal chelating conjugates for use as metallopharmaceutical diagnostic or therapeutic agents. Specifically, conjugates of the present invention include one or more carriers, a linker, and metal coordinating moiety comprising a resorcinol, thioresorcinol, or dithioresorcinol derivative through which the metal coordinating moiety is bonded to the linker. | 03-26-2009 |
20100047173 | Methods for Using Optical Agents - In certain embodiments, the present invention is directed to novel processes for using hepatobiliary cleared optical agents to detect one or more tissues of the biliary tract of a surgical patient. In certain embodiments, the invention is directed to kits that include one or more optical agents and instructions for using the agent(s), for example, in a process of the invention. | 02-25-2010 |
20100055043 | Poly-Halo Metal X-ray Contrast Agents - In certain aspects, the present invention relates to metal coordinating complexes for use as imaging contrast agents. For instance, in some embodiments, the present invention is directed to an imaging contrast agent including a metal chelator and a halogen-substituted phenol, thiophenol, resorcinol, thioresorcinol, or dithioresorcinol derivative. | 03-04-2010 |
20100105899 | Integrated Photoactive Small Molecules and Uses Thereof - This invention is directed to the general method of transforming non-photoactive bioactive small molecule compounds of known structure and function into photoactive analogs of the small molecules which exhibit both photoactivity and the original biological targeting activity. The general method for the design of the photoactive analogs of the small molecules includes: (a) selecting a desired bioactive molecule; (b) identifying the region of the molecule that contains an aromatic or a heteroaromatic motif; and (c) either replacing said motif with a photoactive functional group of similar size, or modifying said motif to make it photoactive. Other aspects include photoactive analog compounds and photodiagnostic and phototherapeutic uses thereof. | 04-29-2010 |
20100111858 | Diangostic and Therapeutic Cyclooxygenase-2 Binding Ligands - The present invention provides conjugates useful for the diagnosis and treatment of diseases associated with the over-expression of COX-2. The conjugates comprise a selective COX-2 targeting carrier, a metal coordinating moiety, and a linker chemically linking the metal coordinating moiety to the carrier. The metals coordinated by the metal coordinating moiety are selected from paramagnetic or radioisotopes. The invention also includes kits comprising a conjugate and a radioisotope solution. | 05-06-2010 |
20100113756 | LUMINESCENT METAL COMPLEXES FOR MONITORING RENAL FUNCTION - Some embodiments of the present invention may be said to be directed to metal complexes of Formula I wherein at least one of X | 05-06-2010 |
20110177004 | Version of FDG Detectable by Single-Photon Emission Computed Tomography - A compound comprising a metal chelate linked to a hexose carrier for use as a metallopharmaceutical diagnostic or therapeutic agent is provided. The compound is suitable for imaging by single-photon emission computed tomography, computer assisted tomography, magnetic resonance spectroscopy, magnetic resonance imaging, positron emission tomography, fluorescence imaging or x-ray. | 07-21-2011 |
20140039191 | Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function - The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X | 02-06-2014 |