| Patent application number | Description | Published |
|---|
| 20080215002 | METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING - A method for cerebral and systemic cooling by circulating a cold liquid through a nasal catheter looped through the patient's nasal cavities and around the nasal septum. The nasal catheter is inserted into the patient's first nostril, advanced through the nasal cavity, around the nasal septum and out of the patient's second nostril. A cold fluid having a temperature between about −20° C. and about 37° C. is flowed though a lumen in the nasal catheter to cool the nasal cavity. The nasal catheter may have one or more flexible balloons mounted on the catheter such that when the catheter is looped around the nasal septum, the balloon(s) are positioned in a portion of the patient's first and second nasal cavities. When a cold liquid is circulated through the catheter lumen, the flexible balloons expand to a contact the inner walls of the nasal cavities and provide direct cooling of the nasal cavities. | 09-04-2008 |
| 20080249188 | METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING - A method for cerebral and systemic cooling by providing a nebulized liquid having a boiling point of 38-300° C. The nebulized liquid is delivered as a mist or a spray via the nasal and/or oral cavities of a patient. The mist causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. Compositions and medical devices for cerebral and systemic cooling are also provided. Cooling assemblies, and methods of use, are also provided that include flexible balloon assemblies that are inserted to various locations in a patient's body. The flexible balloons are then infused with a liquid having a temperature between about −20° C. and about 37° C. The flexible balloon assemblies can be inserted into the nasal cavity, oral cavity, throat, stomach, and other locations to effect cerebral cooling. | 10-09-2008 |
| 20080261893 | TOPICAL CORNEAL ANALGESIA USING NEUROTENSIN RECEPTOR AGONISTS AND SYNERGISTIC NEUROTENSIN COMBINATIONS WITHOUT DELAYING WOUND HEALING - A method for administering an ocular analgesic is described. The method includes the steps of providing a topical analgesic that includes a neo-tryptophan-containing neurotensin analog and applying the topical analgesic to the ocular tissue in a dose of about 0.0001 to about 5 mg alternatively about 0.0001 to about 3 mg, alternatively about 0.0005 to about 1.2 mg, alternatively about 0.0005 to about 1.0 mg, alternatively about 0.00075 to about 1.0 mg, alternatively about 0.001 mg to about 1.0 mg, alternatively about 0.001 mg to about 0.8 mg, alternatively about 0.001 mg to about 0.7 mg, alternatively about 0.001 mg to about 0.6 mg. Methods of administering a topical analgesic containing a neo-tryptophan-containing neurotensin analog are also described. The topical analgesic can be administered in a patch, gel, lotion, spray, or mist. | 10-23-2008 |
| 20100174278 | METHODS OF NASOPHARYNGEAL COOLING FOR AUGMENTING CORONARY PERFUSION PRESSURE - A method for improving the success of resuscitation efforts following cardiac arrest is provided. Return of spontaneous circulation (ROSC) rates following cardiac arrest is directly related to the coronary perfusion pressure during cardiopulmonary resuscitation (CPR). Selective cooling of the nasal cavity, nasopharynx, oral cavity, oropharynx, retrotonsillar space, mouth, neck face, and/or throat of a patient suffering from cardiac arrest, significantly increases the coronary perfusion pressure which improves ROSC rates. Cooling may be initiated before or during resuscitation efforts including chest compressions, defibrillation and/or administering a vasoconstrictor. | 07-08-2010 |
| 20100211140 | METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING - A method for providing and adjusting cerebral cooling in response to changes in a physiological parameter. A spray having a boiling point between 38-300° C. is delivered to the surface of a patient's nasal cavities. The spray causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. A physiological parameter, such as cerebral temperature, changes in cerebral blood flow or brain oxygenation is monitored. The delivery rate of the spray is adjusted in response to the physiological parameter. | 08-19-2010 |
| 20110028938 | METHODS AND DEVICES FOR TREATMENT OF MIGRAINES - Methods for treating a migraine by cooling a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A liquid having a temperature between about −20° C. and about 37° C. is infused through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an elongate member having a plurality of ports is inserted into the nasal cavity. A perfluorocarbon spray and a gas are then delivered onto a surface of the nasal cavity through the plurality of ports. | 02-03-2011 |
