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Deng, PA

James Z. Deng, Eagleville, PA US

Patent application numberDescriptionPublished
20100113419CGRP RECEPTOR ANTAGONISTS - The present invention is directed to compounds of Formula I:05-06-2010

Jianghe Deng, King Of Prussia, PA US

Patent application numberDescriptionPublished
20090143372CHEMICAL COMPOUNDS - The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I:06-04-2009

Jianghe Deng, Collegeville, PA US

Patent application numberDescriptionPublished
20090264431NOVEL CATHEPSIN C INHIBITORS AND THEIR USE - The invention is directed to compounds according to Formula I:10-22-2009
20090264499Cathepsin C Inhibitors - A compound of formula (IA) or (IB)10-22-2009
20100298387IL-8 Receptor Antagonists - This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).11-25-2010

Jun Deng, Murrysville, PA US

Patent application numberDescriptionPublished
20090032782PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS AND COMPOSITIONS AND ARTICLES INCLUDING THE SAME - Various non-limiting embodiments disclosed herein relate to photochromic materials having extended pi-conjugated systems, such as an indeno-fused naphthopyran, which comprises a group that extends the pi-conjugated system of the indeno-fused naphthopyran bonded at the 11-position thereof. Further, the photochromic materials according to certain non-limiting embodiments disclosed herein may display hyperchromic absorption of electromagnetic radiation as compared to conventional photochromic materials and/or may have a closed-form absorption spectrum that is bathochromically shifted as compared to conventional photochromic materials. Other non-limiting embodiments relate to photochromic compositions and photochromic articles, such as optical elements, made using the disclosed photochromic materials, and methods of making the same.02-05-2009
20090072206OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS - Various non-limiting embodiments disclosed herein relate to ophthalmic devices comprising photochromic materials having extended pi-conjugated systems. For example, various non-limiting embodiments disclosed herein provide a photochromic material, such as an indeno-fused naphthopyran, which comprises a group that extends the pi-conjugated system of the indeno-fused naphthopyran bonded at the 11-position of thereof. Further, the photochromic materials according to certain non-limiting embodiments disclosed herein may display hyperchromic absorption of electromagnetic radiation as compared to conventional photochromic materials and/or may have a closed-form absorption spectrum that is bathochromically shifted as compared to conventional photochromic materials. Other non-limiting embodiments relate to methods of making the ophthalmic devices comprising photochromic materials.03-19-2009
20090246503METHOD FOR PRODUCING MICROPOROUS SHEET - Provided is a method of producing a microporous sheet material of a polymeric matrix of polyolefin, with finely divided and substantially water-insoluble filler distributed throughout the matrix, and a network of interconnecting pores communicating throughout the microporous material. The method includes: (a) forming a mixture of polyolefin, filler and a processing plasticizer composition; (b) extruding the mixture to form a continuous sheet; and (c) contacting the continuous sheet with a non-flammable extraction fluid composition to extract the processing plasticizer composition from the continuous sheet. The extraction fluid has a boiling point of 75° C. or less, and is essentially free of trichloroethylene. The microporous sheet material has Tensile Strength equal to or greater than 800 kPa. A microporous sheet material also is provided.10-01-2009
20110042629PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS AND COMPOSITIONS AND ARTICLES INCLUDING THE SAME - The present invention provides a photochromic material which is an indeno-fused naphthopyran having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic material.02-24-2011
20110049445PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS AND COMPOSITIONS AND ARTICLES INCLUDING THE SAME - The present invention provides ophthalmic devices comprising at least one photochromic material which is an indeno-fused naphthopyran having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic materials. Other non-limiting embodiments relate to methods of making the ophthalmic devices comprising photochromic materials.03-03-2011
20110229645LOW TEMPERATURE CURING POLYURETDIONE COMPOSITIONS - Composition and process for low temperature curing of polyuretdione-polyol compositions in which the polyuretdione is prepared from a polyisocyanate with isocyanate groups and a polyol containing primary hydroxyl groups. The catalyst for the composition and process is an amine catalyst containing the group —N═C—N—, being aprotic, having a pKa greater than 20 and upon addition to the liquid coating composition causing a phase-change of the coating composition from liquid to solid at 25° C. and 1 atm. within one week.09-22-2011

Patent applications by Jun Deng, Murrysville, PA US

Lan Deng, Lansdale, PA US

Patent application numberDescriptionPublished
20110172094RECORDING MATERIAL - A recording material including a certain support and disposed thereon at least one layer including certain core/shell polymeric particles, the particles having, when dry, at least one void is provided. A method for providing an image using the recording sheet is also provided.07-14-2011

Lin Deng, Mont Clare, PA US

Patent application numberDescriptionPublished
20080262228Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof - The present invention relates to novel metabolites of 5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl}quinoline, which can be useful in treating CNS disorders. The present invention further relates to processes for their preparation, to pharmaceutical compositions comprising them, and to methods of using them.10-23-2008

Yijun Deng, Malvern, PA US

Patent application numberDescriptionPublished
20110288116IAP INHIBITORS - The present invention describes compounds of the following formula: processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. The compounds of the present invention inhibit IAPs (inhibitors of apoptosis proteins) and thus are useful in the treatment of cancer, autoimmune diseases and other disorders where a defect in apoptosis is implicated.11-24-2011

Yijun Deng, Dresher, PA US

Patent application numberDescriptionPublished
20090048183IAP BINDING COMPOUNDS - IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a K02-19-2009
20090203675Sulfonyl Semicarbazides, Semicarbazides and Ureas, Pharmaceutical Compositions Thereof, and Methods for Treating Hemorrhagic Fever Viruses, Including Infections Associated with Arena Viruses - Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).08-13-2009
20090281336BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES - The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.11-12-2009
20100075911DIMERIC IAP INHIBITORS - Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inhibitors, NSAIDs, taxanes and platinum containing compounds use broader language03-25-2010
20110003877SMAC Mimetic - A SMAC mimetic and pharmaceutical compositions thereof and methods of use.01-06-2011

Patent applications by Yijun Deng, Dresher, PA US

Zhengwu Deng, Harleysville, PA US

Patent application numberDescriptionPublished
20100266714P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN - The subject invention relates to novel P2X10-21-2010

Zhengwu J. Deng, Eagleville, PA US

Patent application numberDescriptionPublished
20080280857CGRP receptor antagonists - The present invention is directed to compounds of Formula I:11-13-2008
20110206783P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN - The subject invention relates to novel P2X08-25-2011

Patent applications by Zhengwu J. Deng, Eagleville, PA US

Zhengwu James Deng, Eagleville, PA US

Patent application numberDescriptionPublished
20090325936IMIDAZOPYRIDINE ANALOGS AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES - The present invention relates to compounds represented by Formula (I) and Formula (II): (I) (II) or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising the instant compounds. This invention further provides methods to treat and prevent pain, respiratory and non-respiratory diseases.12-31-2009