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Denardo, US
Andrew J. Denardo, Westfield, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20090005816 | Spinal rod, insertion device, and method of using - An apparatus and a method for fixing tissue. | 01-01-2009 |
Gerald Denardo, Livermore, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100184702 | Selective High-Affinity Polydentate Ligands and Methods of Making Such - This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity. | 07-22-2010 |
Gerald L. Denardo, El Macero, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100179303 | SITE-SPECIFIC CONJUGATION OF LIGANDS TO NANOPARTICLES - A new radioconjugate NP has been developed using recombinant antibody fragments, di-scFv-c (111 In-DOTA-di-scFv-NP) for imaging and therapy of anti MUC-1 10 expressing cancers since aberrant MUC-1 Is abundantly expressed on the majority of human epithelial cancers. Selection and engineering of anti-MUC-1 di-scFv-c (50 kDa) was generated to link NP-M (maleimide). DOTA chelate was conjugated with di-scFv-c for the radiometal chelation to trace the RINP at in vivo. This RINP preparation can provide uniquely high tumor cell binding NP for AMF driven tumor hyperthermia. | 07-15-2010 |
| 20110144065 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH - This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity. | 06-16-2011 |
Joseph Denardo, Pagosa Springs, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090101366 | Homeland fire suppression system - A fire suppression system for effectively subduing fires. The fire suppression system comprises an underground water tank having a first predetermined size specifically calculated to meet the needs of such property to be protected. A pre-charged foam proportioning device containing dry foam powder is engageable with the underground water tank. The system includes a system engageable with such underground water tank and with such foam proportioning device for dispensing a water/foam mixture for such property to be protected. | 04-23-2009 |
Joseph Lee Denardo, Bayfield, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20120104008 | Liquefied Gas Evacuation Assembly System for Underground Storage Tanks - An evacuation assembly for empting underground tanks of liquefied gas. The assembly not only provides ease of attaching a coupling to the underground tanks but also increases the safety of the individual attaching the coupling to the underground tank. The evacuation assembly uses a riser extension with a rotatable hose coupling mechanism to allow the coupling to be easily attached to the underground tank without the individual being exposed to volatile vapors that may have accumulated in the dome of the underground tank. | 05-03-2012 |
Matthew B. Denardo, West Roxbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120041258 | IMPLANTABLE ACCESS PORT SYSTEM - An implantable injection port for use with a gastric band for treating obesity and for attaching to a tissue of a patient is disclosed. The implantable injection port includes a base having an anchor opening, a gear coupled to the base and rotatable about a central axis, the gear having a plurality of gear teeth, an anchor coupled to the gear, and a top portion spaced apart from the base and having a plurality of top teeth that engage with the plurality of gear teeth. The top portion is rotatable causing rotation of the gear such that the rotation of the gear causes movement of the anchor through the anchor opening of the base and into the tissue of the patient. | 02-16-2012 |
Sally Denardo, El Macero, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090234105 | Construction of a Multivalent SCFV Through Alkyne-Azide 1,3-Dipolar Cycloaddition - The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking. | 09-17-2009 |
Sally Denardo, Livermoe, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100184702 | Selective High-Affinity Polydentate Ligands and Methods of Making Such - This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity. | 07-22-2010 |
Sally J. Denardo, El Macero, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100179303 | SITE-SPECIFIC CONJUGATION OF LIGANDS TO NANOPARTICLES - A new radioconjugate NP has been developed using recombinant antibody fragments, di-scFv-c (111 In-DOTA-di-scFv-NP) for imaging and therapy of anti MUC-1 10 expressing cancers since aberrant MUC-1 Is abundantly expressed on the majority of human epithelial cancers. Selection and engineering of anti-MUC-1 di-scFv-c (50 kDa) was generated to link NP-M (maleimide). DOTA chelate was conjugated with di-scFv-c for the radiometal chelation to trace the RINP at in vivo. This RINP preparation can provide uniquely high tumor cell binding NP for AMF driven tumor hyperthermia. | 07-15-2010 |
| 20110144065 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH - This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity. | 06-16-2011 |
Scott Denardo, Bethlehem, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090238357 | SYSTEM AND METHOD FOR IMPROVED DIRECTORY ASSISTANCE INCLUDING RE-DIAL FEATURE - A directory assistance system includes a request handling module for receiving a plurality of incoming directory assistance requests from requesters and an agent platform for handling the directory assistance requests by providing at least one listing to the requester. A record database stores a record relating to the first request, and includes a first identifier, a time and a listing entry. An incoming request tracking module tracks second incoming directory assistance requests, by reviewing a second identifier associated with the directory assistance request, comparing the second identifier against the first identifiers in the records, and if a record has a matching first identifier to second identifier from request, then, prior to the second request being sent to the agent platform, offering to automatically provide the stored listing entry from the record to the requester. | 09-24-2009 |