Dempsey
Adam Dempsey, London CA
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20130165336 | Biomarkers for Diagnosing Schizophrenia and Bipolar Disorder - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention can be used to diagnose schizophrenia and/or bipolar disorder. Measurement of the expression level of products of biomarkers of the invention using polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are compositions and kits containing said polynucleotides and proteins. Further encompassed by the invention is the use of the polynucleotides and proteins to monitor the efficacy of therapeutic regimens. | 06-27-2013 |
Adam Dempsey, Toronto CA
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20100143916 | OSTEOARTHRITIS BIOMARKERS AND USES THEREOF - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers of the invention demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). As would be understood, in order to measure the products of biomarkers of the invention, polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease progression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of compounds that bind and/or modulate the activity of the genes of the invention. The compounds identified via such methods are useful for the development of assays to study osteoarthritis and osteoarthritis progression. Further, the compounds identified via such methods are useful as lead compounds in the development of prophylactic and therapeutic compositions for the prevention, treatment, management and/or amelioration of osteoarthritis or a symptom thereof. | 06-10-2010 |
20110020809 | MILD OSTEOARTHRITIS BIOMARKERS AND USES THEREOF - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. | 01-27-2011 |
20130017965 | OSTEOARTHRITIS BIOMARKERS AND USES THEREOF - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of OA. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers are within the scope of the invention as are kits containing said polynucleotides and proteins and the use of said polynucleotides and proteins. The biomarker products can be used to identify therapeutic targets for osteoarthritis, and compounds that bind and/or modulate the gene activity. | 01-17-2013 |
20140057258 | METHOD OF DIAGNOSING MILD OSTEOARTHRITIS - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. | 02-27-2014 |
Caroline Grace Dempsey, Beacon Hill Nsw AU
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20110106601 | System And Method For Promotion Processing And Authorization - An example funds facilitation system that facilitates transactions between a payer and payee includes a promotion processing system that facilitates the provision of promotions to account holders on the funds facilitation system. The party offering the promotion may be a merchant/payee that also has an account with the funds facilitation system. The promotion processing system applies promotion rules based on the identity of the merchant/payee and upon conditions placed on the promotion that identify a payer or a group of payers to receive the promotion. A user interface is provided for generating promotion rules and monitoring promotions. A user interface is also provided that displays unused promotion and gift codes and links to merchant/payee websites associated with the unused codes. The funds facilitation system can also provide authorization for purchases based on a condition, such as the age of the payer. | 05-05-2011 |
Daniel P. Dempsey, North Andover, MA US
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20160135537 | CUSTOMIZED FOOTWEAR, AND SYSTEMS AND METHODS FOR DESIGNING AND MANUFACTURING SAME - The invention relates to devices and methods for designing and manufacturing customized footwear, and components thereof. An exemplary method includes a method of designing at least a portion of a sole of an article of footwear customized for a user. The method includes the steps of determining at least one input parameter related to a user, analyzing the at least one input parameter to determine at least one performance metric of a foot of the user, and determining at least one customized structural characteristic of at least a portion of a sole of an article of footwear for the user based on the performance metric. | 05-19-2016 |
Daniel R. Dempsey, Columbus, IN US
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20150329119 | VEHICLE COASTING SYSTEMS AND METHODS - A system for a vehicle includes a transmission, an engine, and a controller communicably coupled to the transmission and the engine. The controller is structured to receive a vehicle operating parameter, receive vehicle operation data during operation of the vehicle, determine that the vehicle is in a coasting state based on the vehicle operation data, and provide a command to control at least one of an engine and the transmission during the coasting state to at least one of optimize the vehicle operating parameter and facilitate and maintain the coasting state. | 11-19-2015 |
Dennis A. Dempsey, Newport IE
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20080265860 | Low voltage bandgap reference source - A bandgap voltage reference circuit is described. By providing first and second bipolar devices that are operable with different current densities a base emitter voltage difference is created. This voltage difference is increased by coupling first and second cascode circuits to the first and second bipolars, the cascode circuits also being scaled relative to one another. | 10-30-2008 |
20110127880 | REACTIVE NETWORKS TO REDUCE ACOUSTIC NOISE AND ENSURE MAXIMUM EFFICIENCIES IN DRIVING PIEZOELECTRIC ELEMENTS IN HAPTIC APPLICATIONS - A device and method are provided to drive piezoelectric elements in haptic applications. In one embodiment, a pattern generator provides user programmable PWM waveforms to a driver. The load of the driver is an inductor in series with the piezoelectric element. The filtration of the inductor in series with the capacitance of the piezoelectric element suppresses the high-frequency components of the PWM pulse train, and recovers a value commensurate with the duty cycle of the PWM pulse train. The resulting waveform across the piezoelectric element is converted to physical motion, thereby creating a haptic effect on a user interface. Advantageously, there is reduced power loss, reduced switching induced noise, and a more haptic rich environment. | 06-02-2011 |
20140002289 | MULTI-STAGE STRING DAC | 01-02-2014 |
20140132325 | CONTROL CIRCUIT FOR USE WITH A FOUR TERMINAL SENSOR, AND MEASUREMENT SYSTEM INCLUDING SUCH A CONTROL CIRCUIT - A control circuit for use with a four terminal sensor, the sensor having first and second drive terminals and first and second measurement terminals, the control circuit arranged to drive at least one of the first and second drive terminals with an excitation signal, to sense a voltage difference between the first and second measurement terminals, and control the excitation signal such that the voltage difference between the first and second measurement terminals is within a target range of voltages, and wherein the control circuit includes N poles in its transfer characteristic and N−1 zeros in its transfer characteristic such that when a loop gain falls to unity the phase shift around a closed loop is not substantially 2π radians or a multiple thereof, where N is greater than 1. | 05-15-2014 |
20140132435 | STRING DAC CHARGE BOOST SYSTEM AND METHOD - Embodiments of the present invention may provide a string DAC with charge boosting. The string DAC may include multiple strings, such as an MSB DAC and an LSB DAC, for converting a digital word into a corresponding analog voltage. The string DAC may also include a charge boost system to couple a charge into or out of the DAC during a code transition, such as a MSB code transition. The string DAC may operate in a break-before-make connection technique where all relevant connections are substantially open-circuited before new connections are made. Therefore, the charge boost may shorten the settling time of impedance elements in the string DAC between code transitions and may substantially reduce (or eliminate) glitches. | 05-15-2014 |
20140167997 | STRING DAC LEAKAGE CURRENT CANCELLATION - Embodiments of the present invention may provide a multi-string DAC with leakage current cancellation. A leakage cancellation circuit may be coupled to output node(s) of the—multi-string DAC. The leakage cancellation circuit may replicate leakage current present at the coupled output node(s) and generate a corresponding complementary signal, a leakage cancellation signal. The leakage cancellation signal may be injected into the coupled output node(s) to cancel (or reduce) the net impact of the leakage current. | 06-19-2014 |
20140266838 | DIGITAL TO ANALOG CONVERTER WITH AN INTRA-STRING SWITCHING NETWORK - A multi-string DAC is described and comprises at least two DAC stages. Each DAC stage comprises a string of impedance elements and a switching network. In one configuration, the multi-string DAC is configured to use the voltage change at terminals of a first string separately to the voltage drop across a first switching network that couples the first and second strings to provide an analog output in response to a digital input to the DAC. | 09-18-2014 |
20140285369 | MULTIPLE STRING DIGITAL TO ANALOG CONVERTER COMPRISING A CONTROL CIRCUIT - A multi-string DAC is described and comprises at least two DAC stages. Each DAC stage comprises a string of impedance elements and a switching network. A control loop is provided to control the Ron of the switching network and provide code dependent control of switches in a DAC switching network. | 09-25-2014 |
20140313066 | MULTIPLE STRING DIGITAL TO ANALOG CONVERTER - A multi-string DAC is described and comprises at least two DAC stages. Each DAC stage comprises a string of impedance elements and a switching network. In one configuration, the DAC comprises a first and second switching network, the second switching network providing multiple switched paths which compensate for impedance effects of the second string and provides multiple state changes at the output node of the DAC. | 10-23-2014 |
20140340150 | TRANSCONDUCTANCE CIRCUIT AND A CURRENT DIGITAL TO ANALOG CONVERTER USING SUCH TRANSCONDUCTANCE CIRCUITS - An example transconductance circuit is provided in accordance with one embodiment. The transconductance circuit can comprise: an output node; at least one transistor; a variable resistance; and a differential amplifier; wherein the at least one transistor and the variable resistance are in series connection with the output node, an output of the differential amplifier is connected to a control node of the at least one transistor, a first input of the amplifier is responsive to an input signal, and a second input of the amplifier is responsive to a voltage across the variable resistance. Such a circuit may overcome noise problems in transconductance circuits which operate over a wide range of input signals with a fixed resistor in series with the at least one transistor. | 11-20-2014 |
Derek Malcolm Dempsey, London GB
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20090222308 | DETECTING FIRST PARTY FRAUD ABUSE - A computerized method includes analyzing data associated with a credit line during an origination stage for predictive variables for use in a model for first party fraud, and flagging an account during the origination stage when at least one or more predictive origination stage variables cause a model score to exceed a pre-defined fraud likelihood threshold. The computerized method also includes analyzing data associated with one or more previously flagged, post-booked stage credit lines for data elements or transactions to be used as variables in a model to predictive of first party fraud at the customer-level or in one or more of the post-booked stage credit lines. | 09-03-2009 |
Douglas Ralph Dempsey, Easton, PA US
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20160063267 | TRI-MODULE DATA PROTECTION SYSTEM SPECIFICATION - The present invention provides a system, method and apparatus for protecting data: | 03-03-2016 |
Eithne Dempsey, Dublin IE
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20150336099 | MICRO-REAGENT HANDLER AND CARTRIDGE ASSEMBLY - A planar micro-reagent cartridge comprises a base layer having a fluid receiving cavity formed in a top surface thereof and a fluid disposed within the cavity, and intermediate layer and a top layer. The intermediate membrane layer is bonded to the base layer to seal the fluid receiving cavity and form a fluid reservoir pump chamber. The intermediate layer comprises a resiliently deformable flexible region that overlies the fluid receiving cavity and is configured to be depressed in response to application of pressure, and a rupturable valve region that overlies the fluid receiving cavity. A top layer is bonded to the intermediate layer, the top layer having an opening that exposes the deformable flexible region of the intermediate membrane layer and at least one channel that together with the intermediate membrane layer forms a fluid conduit having an inlet in fluid communication with the rupturable valve region of the intermediate layer. In use, depression of the deformable flexible region actuates the fluid reservoir pump chamber to rupture the rupturable valve region and pump fluid into the capillary. | 11-26-2015 |
Jonathan H. Dempsey, Cambridge GB
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20130183714 | MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM - The present invention relates to a method for culturing mammalian cells in a culture medium which is transferrin free and which contains no lipophilic or synthetic nitrogen-containing chelators. Also provided is the use of the medium and a process for providing a mammalian product by culturing cells capable of producing the product in the medium. | 07-18-2013 |
20150329830 | MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM - The present invention relates to a method for culturing mammalian cells in a culture medium which is transferrin free and which contains no lipophilic or synthetic nitrogen-containing chelators. Also provided is the use of the medium and a process for providing a mammalian product by culturing cells capable of producing the product in the medium. | 11-19-2015 |
Joy Dempsey, Campbell AU
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20150031963 | SYSTEM, METHOD AND DEVICE FOR MEASURING A GAS IN THE STOMACH OF A MAMMAL - A gas measurement device for measuring at least one gas in the stomach of a mammal, the device comprises a housing for being located in the mammal's stomach and providing at least one gas sensor for detecting the gas. The housing is impermeable to liquid within the stomach. The device may also comprise a controller disposed within the housing and which is electrically coupled to the at least one gas sensor. The controller is arranged to periodically process an output from the gas sensor(s) to provide data indicative of the amount of the gas within the stomach. The controller can include a wireless transmitter for transmitting the data to a remotely located receiving device disposed exterior to the mammal. | 01-29-2015 |
Kevin J. Dempsey, Tullow IE
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20100178414 | SYSTEM AND METHOD FOR MOLDING SOFT FLUID-FILLED IMPLANT SHELLS - Systems and methods for molding shells for fluid-filled prosthetic implants, including spinning and rotating dip- or spray-mandrels during a devolatilization step to ensure an even covering. The mandrels may be spun during the dipping or spraying step, and/or afterward while a solvent evaporates until a gum state is formed. The techniques are particularly useful for forming hollow shells from silicone dispersions for soft implants, such as breast implants. | 07-15-2010 |
20130234365 | SYSTEM AND METHOD FOR MOLDING SOFT FLUID-FILLED IMPLANT SHELLS - Systems and methods for molding shells for fluid-filled prosthetic implants, including spinning and rotating dip- or spray-mandrels during a devolatilization step to ensure an even covering. The mandrels may be spun during the dipping or spraying step, and/or afterward while a solvent evaporates until a gum state is formed. The techniques are particularly useful for forming hollow shells from silicone dispersions for soft implants, such as breast implants. | 09-12-2013 |
20140203478 | SYSTEM AND METHOD FOR MOLDING SOFT FLUID-FILLED IMPLANT SHELLS - Systems and methods for molding shells for fluid-filled prosthetic implants, including spinning and rotating dip- or spray-mandrels during a devolatilization step to ensure an even covering. The mandrels may be spun during the dipping or spraying step, and/or afterward while a solvent evaporates until a gum state is formed. The techniques are particularly useful for forming hollow shells from silicone dispersions for soft implants, such as breast implants. | 07-24-2014 |
Mark Lee Dempsey, Beckenham GB
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20160081207 | MOUNT FOR PORTABLE ELECTRONIC DEVICES | 03-17-2016 |
20160087370 | ELECTRICAL CONNECTION SYSTEMS - An electrical connector assembly | 03-24-2016 |
Mary Dempsey, Ballinasloe IE
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20130081634 | TRACHEAL TUBE FLANGE MEMBER - Various embodiments of flange members and tracheostomy tube assemblies including such flange members are provided. An embodiment of a flange member includes a base portion adapted to receive a proximal end of a cannula, a first flange disposed on a first side of the base portion, and a second flange member disposed on a second side of the base portion opposite the first side. The first flange and the second flange are adapted to rest against a patient's neck to maintain the flange member outside of a patient's airway. The flange member also includes a biocompatible pad reversibly integrated with at least one of the base portion, the first flange, and the second flange. | 04-04-2013 |
Maurice Dempsey, West Kirby GB
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20100284526 | REMOTE MONITORING AND CONTROL APPARATUS - A remote monitoring and control apparatus ( | 11-11-2010 |
Nora Dempsey, Grenoble FR
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20150235763 | METHOD FOR PRODUCING A FILM COMPRISING THREE-DIMENSIONAL MAGNETIC MICROSTRUCTURES - A method for producing a film including a non-magnetic matrix and a plurality of three-dimensional magnetic microstructures arranged within the matrix according to a predetermined pattern. The method includes providing a master substrate with a magnetically structured face formed from a plurality of magnetic field micro-sources, having a magnetic field gradient of between 10 | 08-20-2015 |
20150355174 | METHOD FOR CAPTURING, METHOD FOR DETECTING AND KIT FOR CAPTURING A MOLECULE IN A SAMPLE - A method for capturing a molecule in a sample, comprising mixing the sample with magnetic particles. Each of the particles being coupled with an element capable of binding selectively to the molecule for capture, so as to form at least one complex comprising a magnetic particle. The element and the molecule bound to the element, immobilizing the at least one complex on a support comprising ordered magnetic field microsources. | 12-10-2015 |
Nora Dempsey, Genissieu FR
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20130248754 | PRODUCTION METHOD OF RARE EARTH MAGNET - The method of the present invention produces a rare earth magnet, which is represented by a neodymium magnet (Nd | 09-26-2013 |
Richard Dempsey, Centennial, CO US
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20150328003 | COMPOSITE BONE CONSTRUCTS AND METHODS - Embodiments of the present technology include a graft for administration at a treatment site of a patient. The graft may include a human cadaveric bone material bonded together with a polymeric binder. The human cadaveric bone material may include demineralized bone particles. The demineralized bone particles may have an average diameter less than 1.1 mm, less than 750 μm, less than 500 μm, or less than 250 μm. The human cadaveric bone material may include non-demineralized bone, cancellous bone, and/or cortical bone in embodiments. In some embodiments, bone from animals other than humans may be used, and the patient may be an animal other than a human. | 11-19-2015 |
Ross Ian Dempsey, Calamvale AU
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20100005758 | BEAM - A hollow flange channel beam has a planar web with a pair of narrow rectangular cross-section flanges extending along opposite sides of said web and extending perpendicular to a face of said web in the same direction. The section capacity is optimized when Wf=(0.3)Db, Wf=(3.0)Df and WF=(30)t. | 01-14-2010 |
20110162320 | BEAM - A hollow flange channel beam has a planar web with a pair of narrow rectangular cross-section flanges extending along opposite sides of said web and extending perpendicular to a face of said web in the same direction. The section capacity is optimized when Wf=(0.3)Db, Wf=(3.0)Df and WF=(30)t. | 07-07-2011 |
Sean Dempsey, Toronto CA
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20130132175 | MOBILE DEVICE REBATE SYSTEM - A mobile rebate application (mobile rebate APP) to obtain a rebate related to a mobile device or service of the mobile device. The APP submits a rebate request form to a rebate control center which validates, approves and authorizes rebates. The rebate may be applied to the carrier billing system of the mobile device via a mobile application storefront and/or via a social gifting platform. | 05-23-2013 |
Wiliam P. Dempsey, The Woodlands, TX US
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20160051705 | FUNCTIONALIZATION OF AND USE OF FUNCTIONALIZED SECOND HARMONIC GENERATING NANOPROBES - Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processes using a variety of imaging techniques are provided. The functionalized second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging. | 02-25-2016 |
William P. Dempsey, Sunland, CA US
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20160054553 | METHOD AND DEVICE TO ACHIEVE SPATIALLY CONFINED PHOTOINTERACTION AT THE FOCAL VOLUME OF A MICROSCOPE - The invention relates to a method and a system to achieve spatially (e.g. three-dimensionally) confined photomodulation at the focal volume ( | 02-25-2016 |
William P. Dempsey, Issaquah, WA US
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20150252534 | COMPOSITIONS AND METHODS FOR PELLETIZED RECYCLED ASPHALT SHINGLES - Embodiments of the present disclosure are directed to compositions of and methods for pelletized recycled asphalt shingles used in asphalt pavement. In particular, the recycled asphalt shingle pellets include a soft center with a biofuel or bio-oil diluent, and a harder, water-resistant shell coating. It is believed that by using a biofuel, such as biodiesel, more recycled asphalt shingles material may be used in the formulation of asphalt cement without compromising the performance grade of the asphalt cement. | 09-10-2015 |