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Dempsey
Adam Dempsey, Toronto CA
| Patent application number | Description | Published |
|---|---|---|
| 20100143916 | OSTEOARTHRITIS BIOMARKERS AND USES THEREOF - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers of the invention demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). As would be understood, in order to measure the products of biomarkers of the invention, polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease progression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of compounds that bind and/or modulate the activity of the genes of the invention. The compounds identified via such methods are useful for the development of assays to study osteoarthritis and osteoarthritis progression. Further, the compounds identified via such methods are useful as lead compounds in the development of prophylactic and therapeutic compositions for the prevention, treatment, management and/or amelioration of osteoarthritis or a symptom thereof. | 06-10-2010 |
| 20110020809 | MILD OSTEOARTHRITIS BIOMARKERS AND USES THEREOF - The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. | 01-27-2011 |
Caroline Grace Dempsey, Beacon Hill Nsw AU
| Patent application number | Description | Published |
|---|---|---|
| 20110106601 | System And Method For Promotion Processing And Authorization - An example funds facilitation system that facilitates transactions between a payer and payee includes a promotion processing system that facilitates the provision of promotions to account holders on the funds facilitation system. The party offering the promotion may be a merchant/payee that also has an account with the funds facilitation system. The promotion processing system applies promotion rules based on the identity of the merchant/payee and upon conditions placed on the promotion that identify a payer or a group of payers to receive the promotion. A user interface is provided for generating promotion rules and monitoring promotions. A user interface is also provided that displays unused promotion and gift codes and links to merchant/payee websites associated with the unused codes. The funds facilitation system can also provide authorization for purchases based on a condition, such as the age of the payer. | 05-05-2011 |
Dennis A. Dempsey, Newport IE
| Patent application number | Description | Published |
|---|---|---|
| 20080265860 | Low voltage bandgap reference source - A bandgap voltage reference circuit is described. By providing first and second bipolar devices that are operable with different current densities a base emitter voltage difference is created. This voltage difference is increased by coupling first and second cascode circuits to the first and second bipolars, the cascode circuits also being scaled relative to one another. | 10-30-2008 |
| 20110127880 | REACTIVE NETWORKS TO REDUCE ACOUSTIC NOISE AND ENSURE MAXIMUM EFFICIENCIES IN DRIVING PIEZOELECTRIC ELEMENTS IN HAPTIC APPLICATIONS - A device and method are provided to drive piezoelectric elements in haptic applications. In one embodiment, a pattern generator provides user programmable PWM waveforms to a driver. The load of the driver is an inductor in series with the piezoelectric element. The filtration of the inductor in series with the capacitance of the piezoelectric element suppresses the high-frequency components of the PWM pulse train, and recovers a value commensurate with the duty cycle of the PWM pulse train. The resulting waveform across the piezoelectric element is converted to physical motion, thereby creating a haptic effect on a user interface. Advantageously, there is reduced power loss, reduced switching induced noise, and a more haptic rich environment. | 06-02-2011 |
Derek Malcolm Dempsey, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20090222308 | DETECTING FIRST PARTY FRAUD ABUSE - A computerized method includes analyzing data associated with a credit line during an origination stage for predictive variables for use in a model for first party fraud, and flagging an account during the origination stage when at least one or more predictive origination stage variables cause a model score to exceed a pre-defined fraud likelihood threshold. The computerized method also includes analyzing data associated with one or more previously flagged, post-booked stage credit lines for data elements or transactions to be used as variables in a model to predictive of first party fraud at the customer-level or in one or more of the post-booked stage credit lines. | 09-03-2009 |
Kevin J. Dempsey, Tullow IE
| Patent application number | Description | Published |
|---|---|---|
| 20100178414 | SYSTEM AND METHOD FOR MOLDING SOFT FLUID-FILLED IMPLANT SHELLS - Systems and methods for molding shells for fluid-filled prosthetic implants, including spinning and rotating dip- or spray-mandrels during a devolatilization step to ensure an even covering. The mandrels may be spun during the dipping or spraying step, and/or afterward while a solvent evaporates until a gum state is formed. The techniques are particularly useful for forming hollow shells from silicone dispersions for soft implants, such as breast implants. | 07-15-2010 |
Maurice Dempsey, West Kirby GB
| Patent application number | Description | Published |
|---|---|---|
| 20100284526 | REMOTE MONITORING AND CONTROL APPARATUS - A remote monitoring and control apparatus ( | 11-11-2010 |
Ross Ian Dempsey, Calamvale AU
| Patent application number | Description | Published |
|---|---|---|
| 20100005758 | BEAM - A hollow flange channel beam has a planar web with a pair of narrow rectangular cross-section flanges extending along opposite sides of said web and extending perpendicular to a face of said web in the same direction. The section capacity is optimized when Wf=(0.3)Db, Wf=(3.0)Df and WF=(30)t. | 01-14-2010 |
| 20110162320 | BEAM - A hollow flange channel beam has a planar web with a pair of narrow rectangular cross-section flanges extending along opposite sides of said web and extending perpendicular to a face of said web in the same direction. The section capacity is optimized when Wf=(0.3)Db, Wf=(3.0)Df and WF=(30)t. | 07-07-2011 |