| Patent application number | Description | Published |
|---|
| 20090022693 | METHOD FORISOLATING STEM CELLS FROM CRYOPRESERVED DENTAL TISSUE - The invention relates to a method for isolation of multipotent stem cells from dental tissue in which the stem cells are extracted from a tissue structure and then cultured. The invention also relates to stem cells isolated by means of the method according to the invention as well as bone cells and nerve cells produced by means of the method according to the invention. The invention also relates to a method for producing a bank of stem cells in which the cells are stored by means of the method according to the invention. According to the present invention, the cells of a pad-like soft tissue that can be localized beneath the papilla directly on the apical side of an extracted immature tooth are cryopreserved in the tissue structure such that the tissue structure is disintegrated to extract the stem cells only after thawing. These results show that stem cells/progenitor cells can be isolated even after cryopreservation of the source tissue and these stem cells/progenitor cells respond to osteogenic stimulation. In addition, the response of cells after cryopreservation turns out to be stronger than that without cryopreservation. | 01-22-2009 |
| 20090162326 | METHOD FOR ISOLATING STEM CELLS AND STEM CELLS DERIVED FROM A PAD-LIKE TISSUE OF TEETH - The invention relates to a method for isolating non-embryonic stem cells from a tissue that is located in immediate vicinity of immature, developing teeth or wisdom teeth. The invention further relates to non-embryonic stem cells derived from said tissue. The method according to the invention utilises a living soft tissue residing underneath the dental papilla 12 in immediate vicinity of the apical side of a developing tooth, which is clearly distinguished from other tooth tissue, such as dental papilla 12 or follicle. The pad-like tissue 16 can only be detected in a defined, specific developmental stage in an early phase of root formation. That is, identifying and separating the pad-like tissue 16 is only possible from the appearance of the bony alveolar fundus to the end of the formation of the root of the tooth. | 06-25-2009 |
| 20090324555 | Neural Stem Cells - Subject of the invention is a method for generating neural stem cells in vitro, wherein dental progenitor cells are isolated from soft tissue of tooth or wisdom tooth and cultivated until they form primary spheres which are then dissociated into single cells. These single cells are cultivated until they form spheroids and the spheroid-forming cells are separated to obtain neural stem cells. | 12-31-2009 |
