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Debrouse
Daniel R. Debrouse, Meeker, OK US
| Patent application number | Description | Published |
|---|---|---|
| 20100226995 | MICROENCAPSULATED BIOACTIVE AGENTS FOR ORAL DELIVERY AND METHODS OF USE THEREOF - The presently claimed and disclosed inventive concept(s) contemplates a novel polymeric oral dosage form (transmucosal delivery vehicle) for delivery of pharmaceutical and nutriceutical bioactive agents to the mucosa and bloodstream of the intestine. The oral dosage form of the presently claimed and disclosed inventive concept(s) comprises a polymeric coating which encapsulates the bioactive agent and inhibits degradation and dissolution of the bioactive agent within the stomach and within the lumen of the intestine until after passing through the mucosal wall of the small and/or large intestine. The enzymatic degradation of the polymeric delivery vehicle containing the bioactive agent is substantially inhibited until after absorption of the polymeric delivery vehicle into blood vessels of the intestinal mucosa. It is a particular object of the presently claimed and disclosed inventive concept(s) to provide a new and improved method for enterically or intestinally encapsulating pharmaceutical and nutriceutical bioactive agent or agents for oral administration of the encapsulated bioactive agent or agents. | 09-09-2010 |
| 20110120350 | ALGINATE-BASED BUILDING MATERIALS - The present disclosure describes various building materials used in the building and construction industry, and to buildings or objects constructed therefrom, and to methods of making these building materials. The building materials comprise a polymeric material, such as sodium alginate and/or calcium alginate which confers significant flame-, fire- and heat-resistance or imperviousness to the materials. Other substances can be added to the materials to improve cross-linking and/or to produce resistance to fungal degradation. The building materials which can be produced, processed, or treated using the alginate polymers of the invention include, but are not limited to, wood products; masonry products; wall, roofing, flooring and siding products; and paint products. Further, sodium alginate in the form of a gel may be used as a firebreak to effectively stop the advance of grass fires, wildfires, and forest fires. | 05-26-2011 |
Daniel R. Debrouse, Oklahoma City, OK US
| Patent application number | Description | Published |
|---|---|---|
| 20090214600 | METHODS AND COMPOSITIONS FOR GASTRIC RESISTANT ORAL FORMULATIONS FOR INTESTINAL DELIVERY - An oral formulation for mammalian administration and treatment utilizing bioactive pharmaceuticals in need of gastric resistance to promote intestinal absorption. The oral formulation utilizes lower dosages to achieve higher plasma levels and delivers permeable solubilized bioactive pharmaceuticals directly to intestinal mucosa, avoiding premature gastric disintegration. Further, it delivers water and lipid soluble bioactives directly to the intestines overcoming the molecular characteristics previously limiting the therapeutic administration. Upon oral ingestion of the formulation, a disaccharide component is hydrolyzed by intestinal enzymes to bring the bioactive pharmaceutical in contact with the surface of intestinal mucosa. A method of administering oral bioactive pharmaceuticals as well as a method for manufacturing the formulation is disclosed. | 08-27-2009 |
| 20090258386 | METHODS FOR SOLID MUTAGENESIS AND SEMI-SOLID FLUID MUTAGENESIS FERMENTATION AND PURIFICATION OF LIPID SOLUBLE VITAMINS AND NUTRIENTS - According to the invention, Applicants have demonstrated methods for improving industrial biosynthesis of lipid soluble vitamins and nutrients. Applicants have also provided methods for cost-efficient and commercially-viable chemotherapeutic biosynthesis and purification. This invention provides novel methods for both solid mutagenesis and semi-solid fluid mutagenesis fermentation and the purification of lipid soluble vitamins and nutrients and increasing fermentation solid yields. | 10-15-2009 |
| 20100112044 | METHOD AND APPARATUS FOR ENCAPSULATING PHARMACEUTICAL AND NUTRICEUTICAL BIOACTIVES FOR INTESTINAL DELIVERY - A method for the encapsulation and subsequent delivery of a biologically, water or lipid soluble, active agent to the human intestinal mucosa. This biochemical pathway to drug delivery includes the steps of forming an aqueous emulsion of the pharmacological or nutriceutical agent, vegetable oil, gum and/or gum resin, absorbent factors, and a sugar; then converting the emulsion into a dry spherical particulate form, having lost its aqueous component; and then drying the resultant particulate to form acid and water insoluble intestinal absorbent biologically active beadlets. | 05-06-2010 |
Daniel R. Debrouse, Wellston, OK US
| Patent application number | Description | Published |
|---|---|---|
| 20090123537 | ORAL DOSAGE FORM OF CEFTRIAXONE AND METHODS OF USE - The present invention contemplates a novel oral dosage form for the intestinal delivery of ceftriaxone sodium. The oral dosage form inhibits enteric degradation of the therapeutic compound by encapsulation within an inner core region and having an outer shell, preventing its dissolution until reaching the small intestine. Furthermore, the enzymatic degradation of the compound is substantially inhibited until absorption at the intestinal mucosa. | 05-14-2009 |
| 20100112659 | FERMENTATION PROCESS - A process for the biosymbiotic fermentation of one or more microbe species selected for production of bioactive molecules. These microbe species (bio-hosts) are fermented together with both botanical sources or bacterial, fungal or algal organisms (growth-symbiots) as promoter stimulants. In this manner yields of the bioactive molecules equivalent to those obtained through the biotechnological generation of expression vectors are possible. Furthermore, the invention contemplates biodegradation processes for the decomposition of the resulting fermentation biomass in such a way as to concentrate the bioactive molecules of interest in a precipitate or oleoresin form. | 05-06-2010 |