Patent application number | Description | Published |
20080220512 | Tunable laser-based spectroscopy system for non-invasively measuring body water content - The present disclosure relates to a tunable laser-based spectroscopy system for accurately and non-invasively measuring body water content. The body water content is one of the important health indicators, by which one can quantitatively monitor the hydration level of body and determine if it is necessary to supplement or reduce the body water. The disclosed systems, devices, and/or methods may improve wavelength accuracy, wavelength resolution, optical spectral power density, signal-to-noise ration, and available implementation options for the spectroscopy system. | 09-11-2008 |
20090247853 | Non-Invasive Total Hemoglobin Measurement by Spectral Optical Coherence Tomography - Spectral Optical Coherence Tomography (“SOCT”) utilizes Optical Coherence Tomography (“OCT”) to depth-target two or more optical measurements within a blood vessel. OCT achieves depth resolution by the use of optical interferometry. As the path length of the reference arm of the interferometer is varied, the penetration depth at which maximum interference occurs (zero phase difference) in the sample is correspondingly increased. Depth resolution in the range of 10 μm to 100 μm enables measurements that may be made within more narrow spectral regions (in the range of 1 to 50 nm) in multiple regions of the visible and near infrared spectrum. In one embodiment the light source is configured for three spectral regions centered at 805 nm, 980 nm, and 1050 nm. By comparing the OCT signal at these different spectral positions, the absorption due to tissue and blood analytes may be measured. | 10-01-2009 |
20100076319 | Pathlength-Corrected Medical Spectroscopy - Systems and methods for reducing scattering effects and correcting for patient to patient anatomical variability are provided. The scattering coefficient of an individual patient's tissue may be corrected for by examining the DC light levels of light passing through the tissue. By comparing the intensity of the light leaving the emitter with the light that reaches the detector to generate a DC component of the signal, which is representative of the anatomical structures of a patient, the AC component of the light may be corrected for the scattering coefficient of the tissue. By correcting the AC signal to account for the scattering coefficient of an individual patient's tissue, a medical sensor may be calibrated in situ for every patient. | 03-25-2010 |
Patent application number | Description | Published |
20080221410 | Method for identification of sensor site by local skin spectrum data - A method is provided for determining the location of the sensor. The method comprises determining a physiological parameter based on detected light and determining the location of the sensor based on the physiological parameter. In addition, a method is provided for operating a sensor that includes calibrating a sensor based on a patient-specific physiological parameter, in which the patient-specific physiological parameter is skin color, age, gender, pooled blood, venous blood pulsation, or abnormal tissue. | 09-11-2008 |
20080221412 | Method and apparatus for spectroscopic tissue analyte measurement - Methods and systems for calculating body fluid metrics are provided. In accordance with an exemplary embodiment of the present technique, there is provided a method for calculating body fluid metrics by acquiring an absorbance spectrum of a subject's tissue over a range of near-infrared light, performing a multi-linear regression of the absorbance spectrum of the subject's tissue in relation to absorbance spectra of tissue constituents, and calculating body fluid metrics based on the results of the multi-linear regression. A system is provided having a sensor for emitting the light into the subject's tissue and detecting reflected, scattered, or transmitted light, a spectrometer for processing the detected light and generating the absorbance spectrum of the subject's tissue, memory for storing absorbance spectra of the tissue constituents and a multi-linear regression model, and a processor for performing the multi-linear regression and calculating the body fluid metrics. | 09-11-2008 |
20090075248 | Particle sensor with wide linear range - This invention provides a novel methods and devices for measurement of particle concentration or changes in particle concentration over a wide linear range. The invention comprises one or more radiation sources and one or more detectors contained in a housing which is interfaced to a medium containing particulate matter. The one or more radiation sources are directed into the medium, scattered or transmitted by the particulate matter, and then some portion of the radiation is detected by the one or more detectors. Methods for confining the measurement to a specific volume within the medium are described. Algorithms are provided for combining the signals generated by multiple source-detector pairs in a manner that results in a wide linear range of response to changes in particle concentration. In one embodiment the sensor provides non-invasive measurements of biomass in a bioreactor. In another embodiment an immersible probe design is described, which may be suited for one-time use. In an addition embodiment, a sensor is provided which is well suited to the rapid sequential measurement of particle concentration in multiple vessels, such as assessment of biomass in series of shake flasks. | 03-19-2009 |
20100016688 | Optical methods for real time monitoring of tissue treatment - The present invention comprises methods and systems/devices for non-invasively measuring baseline collagen and collagen changes during treatment of tissue, e.g., denaturation by the application of RF energy, through linear dichroism, circular dichroism, or birefringence. The invention optionally uses polarization sensitive optical measurements to discriminate between denaturation of unidirectionally oriented strands of collagen, such as a ligament or tendon, and denaturation of planar collagen surfaces, such as the dermal layer of the skin or collagen in joint capsules. | 01-21-2010 |
20110046464 | PHOTOPLETHYSMOGRAPHY WITH CONTROLLED APPLICATION OF SENSOR PRESSURE - Systems, methods, and devices for obtaining consistently reproducible diagnostic measurements with a photoplethysmographic sensor are provided. In one embodiment, a method for obtaining such a diagnostic measurement includes applying a pressure between a photoplethysmographic sensor and a patient, increasing the pressure until the photoplethysmographic sensor outputs a plethysmographic waveform of minimal amplitude, decreasing the pressure by a predetermined fraction, and obtaining a diagnostic measurement using the photoplethysmographic sensor. The pressure may be applied using a pressure device that includes, for example, a clip, a wrap, an inflatable balloon or bladder, or an inflatable cuff or any combination thereof. | 02-24-2011 |
20110144503 | Optical methods for monitoring of birefringent tissues - The present invention comprises methods and systems/devices for non-invasively measuring birefringent tissues (e.g. collagen) and changes during treatment of tissue, e.g., denaturation by the application of RF energy, through linear dichroism, circular dichroism, or birefringence. The invention optionally uses polarization sensitive optical measurements to discriminate between denaturation of unidirectionally oriented strands of collagen, such as a ligament or tendon, and denaturation of planar collagen surfaces, such as the dermal layer of the skin or collagen in joint capsules. | 06-16-2011 |
20120046570 | Methods and devices for real time monitoring of collagen content and for altering collagen status - The present invention comprises methods and systems/devices for non-invasively measuring and/or altering collagen structures before, during and after treatment, e.g., by the application of RF energy, of tissues that comprise such collagen structures. | 02-23-2012 |
20120194800 | Optical Sensor for Rapid Determination of Particulate Concentration - This invention provides methods and devices to measure particle suspension concentrations through the side wall of a container. Particle back-scatter readings are taken at light wavelengths that do not travel far through the medium. Detected scatter is related to actual particle concentration or standard O.D. values. The methods and devices allow particle concentration readings through containers not normally intended for use in such assays. | 08-02-2012 |
20130289371 | PHOTOPLETHYSMOGRAPHY WITH CONTROLLED APPLICATION OF SENSOR PRESSURE - Systems, methods, and devices for obtaining consistently reproducible diagnostic measurements with a photoplethysmographic sensor are provided. In one embodiment, a method for obtaining such a diagnostic measurement includes applying a pressure between a photoplethysmographic sensor and a patient, increasing the pressure until the photoplethysmographic sensor outputs a plethysmographic waveform of minimal amplitude, decreasing the pressure by a predetermined fraction, and obtaining a diagnostic measurement using the photoplethysmographic sensor. The pressure may be applied using a pressure device that includes, for example, a clip, a wrap, an inflatable balloon or bladder, or an inflatable cuff, or any combination thereof. | 10-31-2013 |
20140073901 | Methods and Devices for Real Time Monitoring of Collagen Content and for Altering Collagen Status - The present invention comprises methods and systems/devices for non-invasively measuring and/or altering collagen structures before, during and after treatment, e.g., by the application of RF energy, of tissues that comprise such collagen structures. | 03-13-2014 |
20150038852 | OPTICAL METHODS FOR MONITORING OFBIREFRINGENT TISSUES - The present invention comprises methods and systems/devices for non-invasively measuring birefringent tissues (e.g. collagen) and changes during treatment of tissue, e.g., denaturation by the application of RF energy, through linear dichroism, circular dichroism, or birefringence. The invention optionally uses polarization sensitive optical measurements to discriminate between denaturation of unidirectionally oriented strands of collagen, such as a ligament or tendon, and denaturation of planar collagen surfaces, such as the dermal layer of the skin or collagen in joint capsules. | 02-05-2015 |