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Dean, MD

Bruce H. Dean, New Market, MD US

Patent application numberDescriptionPublished
20080296477OPTICAL SYSTEM FOR INDUCING FOCUS DIVERSITY - An optical system includes an optical element defining an optical axis and a focal plane and a defocus element disposed between the optical element and the focal plane. The defocus element includes at least one first lens for producing a positive defocus image of a light beam passing through the optical element, irrespective of a position of the first lens along the optical axis, and at least one second lens for producing a negative defocus image of the light beam passing through the optical element, irrespective of a position of the second lens along the optical axis.12-04-2008
20110049329HYBRID ARCHITECTURE ACTIVE WAVEFRONT SENSING AND CONTROL SYSTEM, AND METHOD - According to various embodiments, provided herein is an optical system and method that can be configured to perform image analysis. The optical system can comprise a telescope assembly and one or more hybrid instruments. The one or more hybrid instruments can be configured to receive image data from the telescope assembly and perform a fine guidance operation and a wavefront sensing operation, simultaneously, on the image data received from the telescope assembly.03-03-2011
20110051990METHOD AND SYSTEM FOR SIGNAL PROCESING NON-UNIFORMLY SAMPLED DATA - According to various embodiments, a method is provided for improving data and a system is provided that is configured to perform the method. The method can comprise processing a data signal by using an optical system comprising a signal processor. The method can comprise collecting data generated by the optical system, wherein the data comprises non-uniformly sampled data. The method can comprise performing an interpolation operation on the non-uniformly sampled data using the signal processor, to generate interpolated data. Further, the method can comprise adjusting the data with the interpolated data using the signal processor, to generate improved data. The improved data can be output to a user, for example, by displaying the improved data on a display unit, or by printing out the improved data. According to various embodiments, the data can comprise any desired data, for example, image data. The method can comprise improving the image resolution, improving the image brightness, improving the image contrast, and/or improving the image focus.03-03-2011
20110054693DISCRETE FOURIER TRANSFORM (DFT) ANALYSIS FOR APPLICATIONS USING ITERATIVE TRANSFORM METHODS - According to various embodiments, a method is provided for determining aberration data for an optical system. The method comprises collecting a data signal, and generating a pre-transformation algorithm. The data is pre-transformed by multiplying the data with the pre-transformation algorithm. A discrete Fourier transform of the pre-transformed data is performed in an iterative loop. The method further comprises back-transforming the data to generate aberration data.03-03-2011
20110055306OPTIMAL PADDING FOR THE TWO-DIMENSIONAL FAST FOURIER TRANSFORM - Padding or adding data to a data signal can increase the speed with which a signal processor can process the data. Methods are provided herein that can accurately predict the optimal pad size of a two dimensional array of data, which can be used to increase the processing speed of a signal processor by optimizing run-time for a two-dimensional (2-D) fast Fourier transform (FFT) operation.03-03-2011

Joseph Allan Dean, Crofton, MD US

Patent application numberDescriptionPublished
20090089135PROVIDING WORK, TRAINING, AND INCENTIVES TO COMPANY REPRESENTATIVES IN CONTACT HANDLING SYSTEMS - Several of the embodiments disclosed herein relate to accessing and tracking real-time data concerning company representative performance, proficiency, training, scheduling, current workflow, and estimated workflow. Moreover, many of the improvements in contact handling systems disclosed herein automatically provide training, work, and incentives to company representatives to improve performance, proficiency, efficiency, effectiveness, automate scheduling, and automated workflow. Thus, as a result of the teachings disclosed herein, customer satisfaction, employee satisfaction, and revenue may be improved in the contact handling industry.04-02-2009
20090089136REAL-TIME ROUTING OF CUSTOMERS TO COMPANY REPRESENTATIVES IN CONTACT HANDLING SYSTEMS - Several of the embodiments disclosed herein relate to accessing and tracking real-time data concerning company representative performance, proficiency, training, scheduling, current work flow, and estimated work flow. Moreover, many of the improvements in contact handling systems disclosed herein automatically provide training, work, and incentives to company representatives to improve performance, proficiency, efficiency, effectiveness, automate scheduling, and automated work flow. More specifically, a method for assigning work to one or more company representatives is disclosed. The method includes assigning a proficiency associated with a training session to the company representative as soon as the training session is completed by a company representative. The method further includes associating the proficiency with increased work capability as soon as the proficiency associated with the training session is assigned to the company representative. As a result of the teachings disclosed herein, customer satisfaction, employee satisfaction, and revenue may be improved in the contact handling industry.04-02-2009
20090089137RAPID DEPLOYMENT OF TRAINING FOR COMPANY REPRESENTATIVES IN CONTACT HANDLING SYSTEMS - Several of the embodiments disclosed herein relate to accessing and tracking real-time data concerning company representative performance, proficiency, training, scheduling, current work flow, and estimated work flow. Moreover, many of the improvements in contact handling systems disclosed herein automatically provide training, work, and incentives to company representatives to improve performance, proficiency, efficiency, effectiveness, automate scheduling, and automated work flow. More specifically, this application discloses a method for delivering training to company representatives. Also disclosed is an automated customer service and training management system. As a result of the teachings disclosed herein, customer satisfaction, employee satisfaction, and revenue may be improved in the contact handling industry.04-02-2009
20090089138REAL-TIME PERFORMANCE BASED INCENTIVES FOR COMPANY REPRESENTATIVES IN CONTACT HANDLING SYSTEMS - Several of the embodiments disclosed herein relate to accessing and tracking real-time data concerning company representative performance, proficiency, training, scheduling, current work flow, and estimated work flow. Moreover, many of the improvements in contact handling systems disclosed herein automatically provide training, work, and incentives to company representatives to improve performance, proficiency, efficiency, effectiveness, automate scheduling, and automated work flow. More specifically, this application discloses, in part, a method for determining an incentive for a company representative. Also disclosed is a graphical interface enabling a user to control training based incentives. As a result of the teachings disclosed herein, customer satisfaction, employee satisfaction, and revenue may be improved in the contact handling industry.04-02-2009
20090089153BROAD-BASED INCREMENTAL TRAINING SESSIONS FOR COMPANY REPRESENTATIVES IN CONTACT HANDLING SYSTEMS - Several of the embodiments disclosed herein relate to accessing and tracking real-time data concerning company representative performance, proficiency, training, scheduling, current work flow, and estimated work flow. Moreover, many of the improvements in contact handling systems disclosed herein automatically provide training, work, and incentives to company representatives to improve performance, proficiency, efficiency, effectiveness, automate scheduling, and automated work flow. More specifically, a method for providing training to company representatives is disclosed. Also disclosed is a system for managing work and training of company representatives. As a result of the teachings disclosed herein, customer satisfaction, employee satisfaction, and revenue may be improved in the contact handling industry.04-02-2009
20090092241CONTACT HANDLING SYSTEMS INCLUDING AUTOMATED RETURN CONTACT RESPONSE REMINDERS - Many of the improvements in contact handling systems which may result from the teachings disclosed herein relate to accessing and tracking real-time data concerning company representative performance, proficiency, training, scheduling, current workflow, response to contacts, and estimated workflow. Moreover, many of the improvements in contact handling systems disclosed herein relate to automatically improving company representative performance proficiency, training, incentives, scheduling, ensuring timely customer response, and workflow. Thus, as a result of the teachings disclosed herein, customer satisfaction, employee satisfaction, and revenue may be improved in the contact handling industry.04-09-2009

Michael Dean, Frederick, MD US

Patent application numberDescriptionPublished
20090029930Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter - The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.01-29-2009
20100093625SMOOTHENED POLYPEPTIDES AND METHODS OF USE - Disclosed is an isolated or purified polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a Smoothened (SMO) protein, wherein the portion comprises an amino acid sequence of any of the intracellular loops of the SMO protein, a functional fragment thereof, or a functional variant of either the portion or the functional fragment, wherein the functional fragment comprises at least 7 contiguous amino acids of the intracellular loops, and wherein the functional fragment or functional variant inhibits proliferation of a diseased cell, or a fatty acid derivative thereof. Related conjugates, nucleic acids, recombinant expression vectors, host cells, and pharmaceutical compositions are further provided. Methods of inhibiting proliferation of a diseased cell, treating or preventing cancer, treating a neoplasm or psoriasis, and inhibiting the expression of genes involved in the Hedgehog signaling pathway, thereby inhibiting the Hedgehog signaling pathway, are furthermore provided by the invention.04-15-2010

Patent applications by Michael Dean, Frederick, MD US

Michael C. Dean, Frederick, MD US

Patent application numberDescriptionPublished
20080261211Variants in complement regulatory genes predict age-related macular degeneration - Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided.10-23-2008
20080280825Protective complement proteins and age-related macular degenration - Methods for identifying a subject at risk for developing AMD are disclosed. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material. Therapeutic compositions and methods are also provided for delaying the progression or onset of the development of AMD in a subject, including treating a subject having signs and/or symptoms of AMD or who has been diagnosed with AMD.11-13-2008
20100267652METHOD OF INHIBITING ABCG2 AND RELATED TREATMENTS - Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.10-21-2010
20100273720Protective Complement Proteins and Age-Related Macular Degeneration - Methods for identifying a subject at risk for developing AMD are disclosed. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material. Therapeutic compositions and methods are also provided for delaying the progression or onset of the development of AMD in a subject, including treating a subject having signs and/or symptoms of AMD or who has been diagnosed with AMD.10-28-2010
20100317732METHOD OF INHIBITING ABCG2 AND OTHER TREATMENT METHODS - Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R12-16-2010